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Original Article

The effects of the tocolytics atosiban and nifedipine on fetal movements, heart rate and blood flow

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Pages 485-490 | Received 01 Oct 2008, Accepted 18 Dec 2008, Published online: 21 Jul 2009

References

  • Slattery M M, Morrison J J. Preterm delivery. Lancet 2002; 360: 1489–1497
  • Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2007; 19(3)CD004454
  • King J F, Flenady V J, Papatsonis D N, Dekker G A, Carbonne B. Calcium channel blockers for inhibiting preterm labour. Cochrane Database Syst Rev 2003; 1: CD002255
  • Oei S G, Oei S K, Brolmann H A. Myocardial infarction during nifedipine therapy for preterm labor. N Engl J Med 1999; 340: 154
  • Verhaert D, Van Acker R. Acute myocardial infarction during pregnancy. Acta Cardiol 2004; 59: 331–339
  • van Geijn H P, Lenglet J E, Bolte A C. Nifedipine trials: effectiveness and safety aspects. BJOG 2005; 112(Suppl. 1)79–83
  • , et al. French/Australian Atosiban Investigators Group. Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. Eur J Obstet Gynecol Reprod Biol 2001; 98: 177–185
  • The Worldwide Atosiban versus Beta-agonists Study Group. Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. BJOG 2001; 108: 133–142
  • Romero R, Sibai B M, Sanchez-Ramos L, Valenzuela G J, Veille J C, Tabor B, Perry K G, Varner M, Goodwin T M, Lane R, et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 2000; 182: 1173–1183
  • Moutquin J M, Sherman D, Cohen H, Mohide P T, Hochner-Celnikier D, Fejgin M, Liston R M, Dansereau J, Mazor M, Shalev E, et al. Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. Am J Obstet Gynecol 2000; 182: 1191–1199
  • Derks J B, Mulder E J, Visser G H. The effects of maternal betamethasone administration on the fetus. Br J Obstet Gynaecol 1995; 102: 40–46
  • Mulder E J, Derks J B, Zonneveld M F, Bruinse H W, Visser G H. Transient reduction in fetal activity and heart rate variation after maternal betamethasone administration. Early Hum Dev 1994; 36: 49–60
  • Koenen S V, Mulder E J, Wijnberger L D, Visser G H. Transient loss of the diurnal rhythms of fetal movements, heart rate, and its variation after maternal betamethasone administration. Pediatr Res 2005; 57: 662–666
  • Dawes G S, Moulden M, Redman C W. System 8000: computerized antenatal FHR analysis. J Perinat Med 1991; 19: 47–51
  • Mulder E J, O'Brien M J, Lems Y L, Visser G H, Prechtl H F. Body and breathing movements in near-term fetuses and newborn infants of type-1 diabetic women. Early Hum Dev 1990; 24: 131–152
  • Valenzuela G J, Craig J, Bernhardt M D, Holland M L. Placental passage of the oxytocin antagonist atosiban. Am J Obstet Gynecol 1995; 172: 1304–1306
  • Greig P C, Massmann G A, Demarest K T, Weglein R C, Holland M L, Figueroa J P. Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep. Am J Obstet Gynecol 1993; 169: 897–902
  • Nathanielsz P W, Honnebier M B, Mecenas C, Jenkins S L, Holland M L, Demarest K. Effect of the oxytocin antagonist atosiban (1-deamino-2-d-tyr(OET)-4-thr-8-orn-vasotocin/oxytocin) on nocturanl myometrial contractions, maternal cardiovascular function, transplacental passage, and fetal oxygenation in the pregnant baboon during the last third of gestation. Biol Reprod 1997; 57: 320–324
  • Manninen A K, Juhakoski A. Nifedipine concentrations in maternal and umbilical serum, amniotic fluid, breast milk and urine of mothers and offspring. Int J Clin Pharmacol Res 1991; 11: 231–236
  • Ferguson J E, 2nd, Schutz T, Pershe R, Stevenson D K, Blaschke T. Nifedipine pharmacokinetics during preterm labor tocolysis. Am J Obstet Gynecol 1989; 161: 1485–1490
  • Furuhashi N, Tsujiei M, Kimura H, Yajima A. Effects of nifedipine on normotensive rat placental blood flow, placental weight and fetal weight. Gynecol Obstet Invest 1991; 32: 1–3
  • Harake B, Gilbert R D, Ashwal S, Power G G. Nifedipine: effects on fetal and maternal hemodynamics in pregnant sheep. Am J Obstet Gynecol 1987; 157: 1003–1008
  • Holbrook R H, Jr., Lirette M, Katz M. Cardiovascular and tocolytic effects of nicardipine HCl in the pregnant rabbit: comparison with ritodrine HCl. Obstet Gynecol 1987; 69: 83–87
  • Blea C W, Barnard J M, Magness R R, Phernetton T M, Hendricks S K. Effect of nifedipine on fetal and maternal hemodynamics and blood gases in the pregnant ewe. Am J Obstet Gynecol 1997; 176: 922–930
  • Rizzo G, Arduini D, Mancuso S, Romanini C. Effects of nifedipine on umbilical artery velocity waveforms in healthy human fetuses. Gynecol Obstet Invest 1987; 24: 151–154
  • Mari G, Kirshon B, Moise K J, Jr., Lee W, Cotton D B. Doppler assessment of the fetal and uteroplacental circulation during nifedipine therapy for preterm labor. Am J Obstet Gynecol 1989; 161: 1514–1518
  • Pirhonen J P, Erkkola R U, Ekblad U U, Nyman L. Single dose of nifedipine in normotensive pregnancy: nifedipine concentrations, hemodynamic responses, and uterine and fetal flow velocity waveforms. Obstet Gynecol 1990; 76: 807–811
  • Guclu S, Saygili U, Dogan E, Demir N, Baschat A A. The short-term effect of nifedipine tocolysis on placental, fetal cerebral and atrioventricular Doppler waveforms. Ultrasound Obstet Gynecol 2004; 24: 761–765
  • de Heus R, Mulder E J, Derks J B, Koenen S V, Visser G H. Differential effects of betamethasone on the fetus between morning and afternoon recordings. J Matern Fetal Neonatal Med 2008; 21: 549–554
  • Moise A A, Wearden M E, Kozinetz C A, Gest A L, Welty S E, Hansen T N. Antenatal steroids are associated with less need for blood pressure support in extremely premature infants. Pediatrics 1995; 95: 845–850
  • Derks J B, Giussani D A, Jenkins S L, Wentworth R A, Visser G H, Padbury J F, Nathanielsz P W. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol 1997; 499(Part 1)217–226
  • Koenen S V, Mecenas C A, Smith G S, Jenkins S, Nathanielsz P W. Effects of maternal betamethasone administration on fetal and maternal blood pressure and heart rate in the baboon at 0.7 of gestation. Am J Obstet Gynecol 2002; 186: 812–817
  • Lunshof M S, Boer K, Wolf H, Koppen S, Velderman J K, Mulder E J. Short-term (0-48 h) effects of maternal betamethasone administration on fetal heart rate and its variability. Pediatr Res 2005; 57: 545–549
  • Nijhuis I J, ten Hof J, Mulder E J, Nijhuis J G, Narayan H, Taylor D J, Visser G H. Fetal heart rate in relation to its variation in normal and growth retarded fetuses. Eur J Obstet Gynecol Reprod Biol 2000; 89: 27–33
  • Kashanian M, Akbarian A R, Soltanzadeh M. Atosiban and nifedipin for the treatment of preterm labor. Int J Gynaecol Obstet 2005; 91: 10–14

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