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Review Article

Placental and fetal effects of antenatal exposure to antidepressants or untreated maternal depression

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Pages 1189-1199 | Received 12 May 2016, Accepted 30 Jun 2016, Published online: 21 Jul 2016

References

  • Gentile S. The safety of newer antidepressants in pregnancy and breastfeeding. Drug Saf 2005;28:137–52
  • Pawlby S, Hay D, Sharp D, et al. Antenatal depression and offspring psychopathology: the influence of childhood maltreatment. Br J Psychiatry 2011;199:106–12
  • Bérard A, Zhao JP, Sheehy O. Sertraline use during pregnancy and the risk of major malformations. Am J Obstet Gynecol 2015;212:e1–e12
  • Gentile S. On categorizing gestational birth, and neonatal complications following late in utero expossure to antidepressants. The prenatal antidepressant exposure syndrome. CNS Spectr 2010;15:167–85
  • Croen LA, Grether JK, Yoshida CK, et al. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011;68:1104–12
  • Gentile S. Prenatal antidepressant exposure and the risk of autism spectrum disorders in children. Are we looking at the fall of Gods? J Affect Disord 2015;182:132–7
  • Colvin L, Slack-Smith L, Stanley FJ, Bower C. Early morbidity and mortality following in utero exposure to selective serotonin reuptake inhibitors. A population-based study in western Australia. CNS Drugs 2012;26:e1–e14
  • Einarson A, Choi J, Einarson TR, Koren G. Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 2009;54:242–6
  • Gentile S, Galbally M. Prenatal exposure to antidepressant medications and neurodevelopmental outcomes: a systematic review. J Affect Disord 2011;128:1–9
  • Laine K, Heikkinen T, Ekblad U, Kero P. Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations. Arch Gen Psychiatry 2003;60:720–6
  • Pawluski JL, Galea LAM, Brain U, et al. Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors. Pediatrics 2009;124:e662
  • Gonzalez-Martinez T, Perez-Pinera P, Diaz-Esnal B, Vega JA. S-100 proteins in the human peripheral nervous system. Microsc Res Technol 2003;60:633–8
  • Selinfreund RH, Barger SW, Pledger WJ, Van Eldik LJ. Neurotrophic protein s100 beta stimulates glial cell proliferation. Proc Natl Acad Sci USA 1991;88:3554–8
  • Brummelte S, Galea LAM, Devlin AM, Oberlander TF. Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) affect newborn serum reelin levels. Dev Psychobiol 2013;55:518–29
  • Kivistö J, Lehto SM, Halonen K, et al. Maternal use of selective serotonin reuptake inhibitors and lengthening of the umbilical cord: indirect evidence of increased foetal activity – a retrospective cohort study. PLoS One 2016;4:1–11
  • Miller ME, Jones MC, Smith DW. Tension: the basis of umbilical cord growth. J Pediatr 1982;101:844
  • Del Rio J, Montero D, De Ceballos ML. Long lasting changes after perinatal exposure to antidepressants. Prog Brain Res 1988;73:173–87
  • Monk D, Newport J, Korotkin JH, et al. Uterine blood flow in a psychiatric population: impact of maternal depression, anxiety, and psychotropic medication. Biol Psychiatry 2012;72:483–90
  • Pawluski JL, Brain UM, Underhill CM, et al. Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function. Psychoneuroendocrinology 2012;37:1019–28
  • Davis EP, Glynn LM, Schetter CD, et al. Prenatal exposure to maternal depression and cortisol influences infant temperament. J Am Acad Child Adolesc Psychiatry 2007;46:737–46
  • Diego MA, Field T, Hernandez-Reif M, et al. Prepartum, postpartum, and chronic depression effects on newborns. Psychiatry 2004;67:63–80
  • Jones NA, Field T, Fox N, et al. Newborns of mothers with depressive symptoms are psychologically less developed. Inf Behav Dev 1998;21:537–41
  • Jha SC, Meltzer-Brody S, Steiner RJ, et al. Antenatal depression, treatmentwith selective serotonin reuptake inhibitors, and neonatal brain structure: a propensity-matched cohort study. Psychiatr Res Neuroimag 2016;253:43–53
  • Lundy B, Field T, Pickens J. Newborns of mothers with depressive symptoms are less expressive. Inf Behav Dev 1996;19:419–24
  • Diego MA, Field T, Hernandez-Reif M. Prepartum, postpartum and chronic depression effects on neonatal behavior. Inf Behav Dev 2005;28:155–64
  • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264–9
  • Macleod MR, Fisher M, O’Collins V, et al. Collaborative approach to meta analysis and review of animal data from experimental studies (CAMARADES). Edinburg: CAMARADES; 2011. Available from: http://www.dcn.ed.ac.uk/camarades/research.html#protocols [last accessed 10 Dec 2014]
  • Olivier JDA, Åkerud H, Skalkidou A, et al. The effects of antenatal depression and antidepressant treatment on placental gene expression. Front Cell Neurosci 2015;8:1–17
  • Schroeder JW, Smith AK, Brennan PA, et al. DNA methylation in neonates born to women receiving psychiatric care. Epigenetics 2012;7:1–6
  • Gurnot C, Martin-Subero I, Mah SM, et al. Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics 2015;10:361–72
  • Dalmizrak O, Kulaksiz-Erkmen G, Ozer N. The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine. Mol Cell Biochem 2011;355:223–31
  • Kaihola H, Olivier J, Sundström Poromaa I, Åkerud H. The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on Nerve Growth Factor signaling in human placenta. PLoS One 2015;10:e0116459
  • Bellissima V, Visser GHA, Ververs TF, et al. Antenatal maternal antidepressants drugs affect Activin A concentrations in maternal blood, in amniotic fluid and in fetal cord blood. J Matern Fetal Neonatal Med 2011;24:31–4
  • Gazzolo D, Bruschettini M, Corvino V, et al. S100B protein concentrations in amniotic fluid are correlated with gestational age and with cerebral ultrasound scanning parameters results in healthy fetuses. Clin Chem 2011;47:954–6
  • Bellissima V, Visser GH, Ververs TF, et al. Antenatal maternal antidepressants drugs affect S100B concentrations in fetal-maternal biological fluids. CNS Neurol Disord Drug Targets 2015;14:49–54
  • Hannerfor AK, Hellgren C, Schijven D, et al. J. Treatment with serotonin reuptake. Inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels. Psychoneuroendocrinology 2015;58:104–13
  • Mulder EJ, Ververs FFT, de Heus R, Visser GH. Selective serotonin reuptake inhibitors affect neurobehavioral development in the human fetus. Neuropsychopharmacology 2011;36:1961–71
  • Salisbury AL, DiPietro J, Pearlstein T. Prenatal serotonin reuptake inhibitor exposure: fetal and infant outcomes. 39th Annual Meeting; 2006 Oct 11–14. Atlanta, GA; International Society for Developmental Psychobiology. Abstract book: p. 624
  • Salisbury AL, Ponder KL, Padbury JF, Lester BM. Fetal effects of psychoactive drugs. Clin Perinatol 2009;36:595–619
  • Emory EK, Dieter JNI. Maternal depression and psychotropic medication effects on the human fetus. Ann NY Acad Sci 2006;1094:287–91
  • Lim F, Sanders A, Brain U, et al. Third trimester fetal pulmonary artery Doppler blood flow velocity characteristics following prenatal selective serotonin reuptake inhibitor (SSRI) exposure. Early Hum Dev 2012;88:609–15
  • Kieler H, Artama M, Engeland A, et al. Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries. Br Med J 2012;344:d8012
  • Rurak D, Lim K, Sanders A, et al. Third trimester fetal heart rate and Doppler middle cerebral artery blood flow velocity characteristics during prenatal selective serotonin reuptake inhibitor exposure. Pediatr Res 2011;70:96–101
  • Leventhal K, Byatt N, Lundquist R. Fetal cardiac arrhythmia during bupropion use. Acta Obstet Gynecol Scand 2010;89:980–1
  • Prentice A, Brown R. Fetal tachyarrhythmia and maternal antidepressant treatment. BMJ 1989;298:190
  • Ponder KL, Salisbury A, McGonnigal B, et al. Maternal depression and anxiety are associated with altered gene expression in the human placenta without modifications by antidepressant use: implications for fetal programming. Dev Psychobiol 2011;53:711–23
  • Non AL, Binder AM, Kubzansky LD, Michels KB. Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy. Epigenetics 2014;9:1–9
  • Allister L, Lester BM, Carr S, Jing Liu J. The effects of maternal depression on fetal heart rate response to vibroacoustic stimulation. Dev Neuropsychol 2001;20:639–51
  • Dieter JNI, Field T, Hernandez-Reif M, et al. Maternal depression and increased fetal activity. J Obstet Gynaecol 2001;21:468–73
  • Sodhi MS, Sanders-Bush E. Serotonin and brain development. Int Rev Neurobiol 2004;59:111–74
  • Gingrich JA, Ansorge MS, Merker R, et al. New lessons from knockout mice: the role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders. CNS Spectr 2007;8:572–7
  • Lesch KP, Mossner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 1998;44:179–92
  • Whitaker-Azmitia PM. Serotonin and brain development: role in human developmental diseases. Brain Res Bull 2001;56:479–85
  • Whittle N, Sartori SB, Dierssen M, et al. Fetal Down Syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics 2007;120:e1465–71
  • Winzer-Serhan UH, Raymon HK, Broide RS, et al. Expression of alpha 2 adrenoceptors during rat brain development-I. Alpha 2A messenger RNA expression. Neuroscience 1997;7:241–60
  • Goyal R, Mittal A, Chu N, et al. alpha(1)-adrenergic receptor subtype function in fetal and adult cerebral arteries. Am J Physiol Heart Circ Physiol 2010;298:H1797–806
  • Ganapathy V. Drugs of abuse and human placenta. Life Sci 2011;88:926–30
  • Tometten M, Blois S, Arck PC. Nerve growth factor in reproductive biology: link between the immune, endocrine, and nervous system? Chem Immunol Allergy 2005;89:135–48
  • Tretter YP, Hertel M, Munz B, et al. Induction of Activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo. Nat Med 2000;6:812–15
  • Florio P, Frigiola A, Battista R, et al. Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. Front Biosci (Elite Ed) 2019;2:36–42
  • Nikolaev A, McLaughlin T, O’Leary DD, Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009;457:981–9
  • Tabarés-Seisdedos R, Rubinstein JL. Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism, and cancer. Mol Psychiatry 2009;14:563–89
  • Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;44:151–62
  • Baschat AA. Fetal responses to placental insufficiency: an update. BJOG 2004;111:1031–41
  • Spiller HA, Ramoska EA, Krenzelok EP, et al. Bupropion overdose: a 3-year multi-center retrospective analysis. Am J Emerg Med 1994;12:43–5
  • Watanabe N, Omori IM, Nakagawa A, et al. MANGA (Meta-Analysis of New Generation Antidepressants) Study Group. Safety reporting and adverse-event profile of mirtazapine described in randomized controlled trials in comparison with other classes of antidepressants in the acute-phase treatment of adults with depression: systematic review and meta-analysis. CNS Drugs 2010;24:35–53
  • Gentile S. Serotonin reuptake inhibitor-induced perinatal complications. Paediatr Drugs 2007;9:97–106
  • Michetti M, Corvino V, Geloso MC, et al. The S100B protein in biological fluids: more than a lifelong biomarker of brain distress. J Neurochem 2012;120:644–59
  • Nijhuis IJM, ten Hof J, Nijhuis JG, et al. Temporal organization of fetal behavior from 24-weeks gestation onwards in normal and complicated pregnancies. Dev Psychobiol 1999;34:257–68
  • DiPietro J, Hodgson D, Costigan K, Johnson T. Fetal antecedents of infant temperament. Child Dev 1996;67:2568–83
  • Klinger G, Frankenthal D, Merlob P, et al. Long-term outcome following selective serotonin reuptake inhibitor induced neonatal abstinence syndrome. J Perinatol 2011;31:615–20
  • Gentile S. Bipolar disorder and pregnancy: to treat or not to treat? Br Med J 2012;345:e7367
  • Wacker-Gussmann A, Strasburger JF, Cuneo BF, Wakai RT. Diagnosis and treatment of fetal arrhythmia. Am J Perinatol 2014;7:617–28
  • Hauben M, Aronson JK. Defining signal and its subtypes in pharmacovigilance based on a systematic review of previous definitions. Drug Saf 2009;32:99–110
  • Bar-Peled O, Gross-Isseroff R, Ben-Hur H, et al. Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors. Neurosci Lett 1991;127:173–6
  • Wai MS, Lorke DE, Kwong WH, et al. Profiles of serotonin receptors in the developing human thalamus. Psychiatry Res 2011;185:238–42
  • del Olmo E, Guirao-Piñeyro M, del Arco C, et al. Transient localization of 5-HT1A receptors in human cerebellum during development. Neurosci Lett 1994;166:149–52
  • Paterson DS, Belliveau R, Trachtenberg F, Kinney HC. Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla. J Comp Neurol 2004;472:221–31
  • del Olmo E, Guirao-Piñeyro M, Vilàro MT. Early localization of mRNA coding for 5-HT1A receptors in human brain during development. Brain Res Mol Brain Res 1968;60:123–6
  • Araki KY, Sims JR, Bhide PG. Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during pre- and postnatal development. Brain Res 2007;1156:31–45
  • Witter FR, Zimmerman AW, Reichmann JP, Connors SL. In utero beta 2 adrenergic agonist exposure and adverse neurophysiologic and behavioral outcomes. Am J Obstet Gynecol 2009;201:553–9
  • del Olmo E, del Arco C, Diaz A, et al. Ontogenetic development of 5-HT 1D receptors in human brain: an autoradiographic study. Eur J Neurosci 1996;8:56–60

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