197
Views
0
CrossRef citations to date
0
Altmetric
Original Article

The effect of parental 5,10-methylenetetrahydrofolate reductase 677C/T and 1298A/C gene polymorphisms on response to single-dose methotrexate in tubal ectopic pregnancy

, , , , &
Pages 1232-1237 | Received 27 May 2016, Accepted 02 Jul 2016, Published online: 02 Aug 2016

References

  • Ectopic pregnancy mortality – Florida, 2009–2010. MMWR Morb Mortal Wkly Rep 2012;61:106–9
  • Mol F, Mol BW, Ankum WM, et al. Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis. Hum Reprod Update 2008;14:309–19
  • Sowter MC, Farquhar CM, Petrie KJ, Gudex G. A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy. BJOG 2001;108:192–203
  • Hajenius PJ, Mol F, Mol BW, et al. Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev 2007;(1):CD000324
  • Capmas P, Fernandez H. Effectiveness of gefitinib in combination with methotrexate in the treatment of ectopic pregnancy. Int J Womens Health 2015;7:673–6
  • Fujioka S, Yamashita Y, Kawabe S, et al. A case of a methotrexate-resistant ectopic pregnancy in which dactinomycin was effective as a second-line chemotherapy. Fertil Steril 2009;91:929.e13–15
  • Skubisz MM, Tong S. Of leaves and butterflies: how methotrexate came to be the savior of women. Obstet Gynecol 2011;118:1169–73
  • Bleyer WA. The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 1978;41:36–51
  • Karri S, G V. Effect of methotrexate and leucovorin on female reproductive tract of albino rats. Cell Biochem Funct 2011;29:1–21
  • DeLoia JA, Stewart-Akers AM, Creinin MD. Effects of methotrexate on trophoblast proliferation and local immune responses. Hum Reprod 1998;13:1063–9
  • Creinin MD, Vittinghoff E. Methotrexate and misoprostol vs misoprostol alone for early abortion. A randomized controlled trial. JAMA 1994;272:1190–5
  • Wang N, Guan M, Zheng W. [Effects of methotrexate on early pregnancy in mice]. Yao Xue Xue Bao 1998;33:10–13
  • Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification. Nat Genet 1994;7:551
  • Födinger M, Hörl WH, Sunder-Plassmann G. Molecular biology of 5,10-methylenetetrahydrofolate reductase. J Nephrol 2000;13:20–33
  • Goyette P, Frosst P, Rosenblatt DS, Rozen R. Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency. Am J Hum Genet 1995;56:1052–9
  • Sibani S, Christensen B, O’Ferrall E, et al. Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria. Hum Mutat 2000;15:280–7
  • Stovall TG, Ling FW. Single-dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol 1993;168:1759–62 (discussion 1762–5)
  • Di Carlo F, Reboani C, Conti G, Genazzani E. Changes in the concentration of uterine cytoplasmic oestrogen receptors induced by doxorubicin and methotrexate. J Endocrinol 1978;79:201–8
  • Chiusolo P, Reddiconto G, Farina G, et al. MTHFR polymorphisms’ influence on outcome and toxicity in acute lymphoblastic leukemia patients. Leuk Res 2007;31:1669–74
  • Gemmati D, Ongaro A, Tognazzo S, et al. Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin’s lymphoma patients: association with toxicity and survival. Haematologica 2007;92:478–85
  • Toffoli G, Rossi D, Gaidano G, et al. Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase. Int J Biol Markers 2003;18:218–21
  • Lopez-Lopez E, Martin-Guerrero I, Ballesteros J, Garcia-Orad A. A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia. Pharmacogenomics J 2013;13:498–506
  • Tuková J, Chládek J, Hroch M, et al. 677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: treatment outcome, erythrocyte concentrations of MTX and folates, and MTHFR polymorphisms. J Rheumatol 2010;37:2180–6
  • Lee YH, Song GG. Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. Clin Drug Investig 2010;30:101–8
  • Scheuern A, Fischer N, McDonald J, et al. Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis. Pediatr Rheumatol Online J 2016;14:11
  • Lasecka L, Dixon PH, Molokhia M, et al. 667C > T and 1298A > C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia. Gynecol Oncol 2011;123:605–9
  • Tanaka T, Hayashi H, Kutsuzawa T, et al. Treatment of interstitial ectopic pregnancy with methotrexate: report of a successful case. Fertil Steril 1982;37:851–2
  • Kutuk MS, Uysal G, Dolanbay M, Ozgun MT. Successful medical treatment of cesarean scar ectopic pregnancies with systemic multidose methotrexate: single-center experience. J Obstet Gynaecol Res 2014;40:1700–6
  • Lam PM, Lo KW, Lau TK. Unsuccessful medical treatment of cesarean scar ectopic pregnancy with systemic methotrexate: a report of two cases. Acta Obstet Gynecol Scand 2004;83:108–11
  • Navarro-Costa P, Nogueira P, Carvalho M, et al. Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm. Hum Reprod 2010;25:2647–54
  • Pacheco SE, Houseman EA, Christensen BC, et al. Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS One 2011;6:e20280
  • Wu H, D’Alessio AC, Ito S, et al. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev 2011;25:679–84
  • Kumar M, Kumar K, Jain S, et al. Novel insights into the genetic and epigenetic paternal contribution to the human embryo. Clinics (Sao Paulo) 2013;68:5–14
  • Sukla KK, Jaiswal SK, Rai AK, et al. Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: a triad study. Hum Reprod 2015;30:1982–93
  • Tsang BL, Devine OJ, Cordero AM, et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. Am J Clin Nutr 2015;101:1286–94
  • Tawfiq A, Agameya AF, Claman P. Predictors of treatment failure for ectopic pregnancy treated with single-dose methotrexate. Fertil Steril 2000;74:877–80
  • van Mello NM, Mol F, Mol BW, Hajenius PJ. Conservative management of tubal ectopic pregnancy. Best Pract Res Clin Obstet Gynaecol 2009;23:509–18
  • Hamed HO, Ahmed SR, Alghasham AA. Comparison of double- and single-dose methotrexate protocols for treatment of ectopic pregnancy. Int J Gynaecol Obstet 2012;116:67–71
  • Lipscomb GH, McCord ML, Stovall TG, et al. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med 1999;341:1974–8
  • Bixby S, Tello R, Kuligowska E. Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. J Ultrasound Med 2005;24:591–8
  • Menon S, Colins J, Barnhart KT. Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. Fertil Steril 2007;87:481–4
  • Krissi H, Peled Y, Eitan R, et al. Single-dose methotrexate injection for treatment of ectopic pregnancy in women with relatively low levels of human chorionic gonadotropin. Int J Gynaecol Obstet 2013;121:141–3
  • Cohen A, Bibi G, Almog B, et al. Second-dose methotrexate in ectopic pregnancies: the role of beta human chorionic gonadotropin. Fertil Steril 2014;102:1646–9
  • Cirik DA, Kinay T, Keskin U, et al. Success rates of single-dose methotrexate and additional dose requirements among women with first and previous ectopic pregnancies. Int J Gynaecol Obstet 2016;133:49–52
  • Buster JE, Krotz S. Reproductive performance after ectopic pregnancy. Semin Reprod Med 2007;25:131–3
  • Rai V, Yadav U, Kumar P, et al. Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies. PLoS One 2014;9:e108552

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.