786
Views
14
CrossRef citations to date
0
Altmetric
Review Article

Treatment of preeclampsia with hydroxychloroquine: a review

, , ORCID Icon & ORCID Icon
Pages 525-529 | Received 22 Nov 2016, Accepted 29 Jan 2017, Published online: 21 Feb 2017

References

  • Wallace DJ. The history of antimalarials. Lupus 1996;5:S2–3.
  • Page F. Treatment of lupus erythematosus with mepacrine. The Lancet 1951;2:755–8.
  • Miyachi Y, Yoshioka A, Imamura S, et al. Antioxidant action of antimalarials. Ann Rheum Dis 1986;45:244–8.
  • Ziegler H, Unanue E. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc Natl Acad Sci USA 1982;79:175–8.
  • Cohen S, Yielding K. Spectrophotometric studies of the interaction of chloroquine with deoxyribonucleic acid. J Biol Chem 1965;240:3123–31.
  • Lesiak A, Narbutt J, Sysa-Jedrzejowska A, et al. Effect of chloroquine phosphate treatment on serum MMP-9 and TIMP-1 levels in patients with systemic lupus erythematosus. Lupus 2010;19:683–8.
  • Kuznik A, Bencina M, Svajger U, et al. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol 2011;186:4794–804.
  • Singh A, Chowdhary V. Pregnancy-related issues in women with systemic lupus erythematosus. Int J Rheum Dis 2015;18:172–81.
  • Hung T-H, Burton G. Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwan J Obstet Gynecol 2006;45:189–200.
  • Shen F, Wei J, Snowise S, et al. Trophoblast debris extruded from preeclamptic placentae activates endothelial cells: a mechanism by which the placenta communicates with the maternal endothelium. Placenta 2014;35:839–47.
  • Mandang S, Manuelpillai U, Wallace EM. Oxidative stress increases placental and endothelial cell activin A secretion. J Endocrinol 2007;192:485–93.
  • Gu Y, Lewis DF, Wang Y. Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies. J Clin Endocrinol Metab 2008;93:260–6.
  • Roberts L, LaMarca BB, Fournier L, et al. Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion. Hypertension 2006;47:615–18.
  • Murphy SR, LaMarca BB, Cockrell K, et al. Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats. Hypertension 2010;55:394–8.
  • LaMarca BB, Cockrell K, Sullivan E, et al. Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats. Hypertension 2005;46:82–6.
  • Ryan MJ, McLemore GR Jr. Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol 2007;292:R736–42.
  • Sun S, Rao N, Venable J, et al. TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets 2007;6:223–35.
  • Sacre K, Criswell LA, McCune JM. Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther 2012;14:R155.
  • Knight M, Redman C, Linton E. Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol 1998;105:632–40.
  • Scharfe-Nugent A, Corr SC, Carpenter SB, et al. TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia. J Immunol 2012;188:5706–12.
  • Lim R, Acharya R, Delpachitra P, et al. Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies. Am J Obstet Gynecol 2015;212:86.e1–12.
  • Lim R, Adhikari S, Gurusinghe S, et al. Inhibition of activin A signalling in a mouse model of pre-eclampsia. Placenta 2015;36:926–31.
  • Mansour R, Lassoued S, Elgaied A, et al. Enhanced reactivity to malondialdehyde-modified proteins by systemic lupus erythematosus autoantibodies. Scand J Rheumatol 2010;39:247–53.
  • Gomez-Guzman M, Jimenez R, Romero M, et al. Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus. Hypertension 2014;64:330–7.
  • Virdis A, Tani C, Duranti E, et al. Early treatment with hydroxychloroquine prevents the development of endothelial dysfunction in a murine model of systemic lupus erythematosus. Arthritis Res Ther 2015;17:277.
  • Raijmakers MT, Burton GJ, Jauniaux E, et al. Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy. Placenta 2006;27:158–63.
  • Mohazzab K, Kaminski P, Wolin M. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol 1994;266:H2568–72.
  • De Keulenaer G, Alexander R, Ushio-Fukai M, et al. Tumour necrosis factor a activates a p22phox-based NADH oxidase in vascular smooth muscle. Biochem J 1998;329:653–7.
  • Ushio-Fukai M, Zafari A, Fukui T, et al. p22phox Is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 1996;271:23317–21.
  • Sundaresan M, Yu Z-X, Ferrans V, et al. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995;270:296–9.
  • Hobson SR, Acharya R, Lim R, et al. Role of activin A in the pathogenesis of endothelial cell dysfunction in preeclampsia. Pregnancy Hypertens 2016;6:130–3.
  • Selzer F, Sutton-Tyrrell K, Fitzgerald S, et al. Vascular stiffness in women with systemic lupus erythematosus. Hypertension 2001;37:1075–82.
  • Hart C, Naunton R. The ototoxicity of chloroquine phosphate. Arch Otolaryngol 1964;80:407–12.
  • Suhonen R. Hydroxychloroquine administration in pregnancy. Arch Dermatol 1983;119:185–6.
  • Costedoat-Chalumeau N, Amoura Z, Duhaut P, et al. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group. Arthritis Rheum 2003;48:3207–11.
  • Motta M, Tincani A, Faden D, et al. Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation. J Perinatol 2005;25:86–9.
  • Motta M, Ciardelli L, Marconi M, et al. Immune system development in infants born to mothers with autoimmune disease, exposed in utero to immunosuppressive agents. Am J Perinatol 2007;24:441–7.
  • Costedoat-Chalumeau N, Amoura Z, Aymard G, et al. Evidence of transplacental passage of hydroxychloroquine in humans. Arthritis Rheum 2002;46:1121–3.
  • Ostensen M, Brown N, Chiang P, et al. Hydroxychloroquine in human breast milk. Eur J Clin Pharmacol 1985;28:357.
  • American Academy of Pediatrics Committee of Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776–89.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.