Does placental MDSC-mediated modulation of arginine levels help protect the foetus from auxotrophic pathogens?

References

• Poston L. The control of blood flow to the placenta. Exp Physiol. 1997;82:377–387.
   PubMed Web of Science ®Google Scholar
• Conrad KP, Joffe GM, Kruszyna H, et al. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J. 1993;7:566–571.
   PubMed Web of Science ®Google Scholar
• Morris NH, Eaton BM, Dekker G. Nitric oxide, the endothelium, pregnancy and pre-eclampsia. Br J Obstet Gynaecol. 1996;103:4–15.
   PubMedGoogle Scholar
• Baniyash M. TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response. Nat Rev Immunol. 2004;4:675–687.
   PubMed Web of Science ®Google Scholar
• Ezernitchi AV, Vaknin I, Cohen-Daniel L, et al. TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs. J Immunol. 2006;177:4763–4772.
   PubMed Web of Science ®Google Scholar
• Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162–174.
   PubMed Web of Science ®Google Scholar
• Youn JI, Gabrilovich DI. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Eur J Immunol. 2010;40:2969–2975.
   PubMed Web of Science ®Google Scholar
• Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol. 2009;182:4499–4506.
   PubMed Web of Science ®Google Scholar
• Bronte V, Wang M, Overwijk WW, et al. Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J Immunol. 1998;161:5313–5320.
   PubMed Web of Science ®Google Scholar
• Delano MJ, Scumpia PO, Weinstein JS, et al. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med. 2007;204:1463–1474.
   PubMed Web of Science ®Google Scholar
• Haile LA, Chang S-Y, Ko H-J. Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology. 2008;135:871–881.e5.
   PubMed Web of Science ®Google Scholar
• Makarenkova VP, Bansal V, Matta BM, et al. CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol. 2006;176:2085–2094.
   PubMed Web of Science ®Google Scholar
• Gantt S, Gervassi A, Jaspan H, Horton H. The role of myeloid-derived suppressor cells in immune ontogeny. Front Immunol. 2014;5:387.
   PubMed Web of Science ®Google Scholar
• Kostlin N, Kugel H, Spring B, et al. Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses. Eur J Immunol. 2014;44:2582–2591.
   PubMed Web of Science ®Google Scholar
• Rieber N, Gille C, Köstlin N, et al. Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses. Clin Exp Immunol. 2013;174:45–52.
   PubMed Web of Science ®Google Scholar
• Gervassi A, Lejarcegui N, Dross S, et al. Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PLoS One. 2014;9:e107816.
   PubMed Web of Science ®Google Scholar
• Kim YJ, Park HS, Lee HY, et al. Reduced L-arginine level and decreased placental eNOS activity in preeclampsia. Placenta. 2006;27:438–444.
   PubMed Web of Science ®Google Scholar
• Wang J, Kotani T, Tsuda H, et al. Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension? J Clin Biochem Nutr. 2015;57:74–81.
   PubMed Web of Science ®Google Scholar
• Vadillo-Ortega F, Perichart-Perera O, Espino S, et al. Effect of supplementation during pregnancy with l-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ. 2011;342:d2901.
   PubMed Web of Science ®Google Scholar
• Li YJ, Stallcup MR, Lai MM. Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication. J Virol. 2004;78:13325–13334.
   PubMed Web of Science ®Google Scholar
• Futaki S. Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. Int J Pharm. 2002;245:1–7.
   PubMed Web of Science ®Google Scholar
• Becker Y, Olshevsky U, Levitt J. The role of arginine in the replication of herpes simplex virus. J Gen Virol. 1967;1:471–478.
   PubMedGoogle Scholar
• Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Mol Cell. 2009;33:1–13.
   PubMed Web of Science ®Google Scholar
• Emmett M, Kloos WE. The nature of arginine auxotrophy in cutaneous populations of staphylococci. J Gen Microbiol. 1979;110:305–314.
   PubMedGoogle Scholar
• Martin PR, Mulks MH. Molecular characterization of the argJ mutation in Neisseria gonorrhoeae strains with requirements for arginine, hypoxanthine, and uracil. Infect Immun. 1992;60:970–975.
   PubMed Web of Science ®Google Scholar
• Castanie-Cornet MP, Penfound TA, Smith D, et al. Control of acid resistance in Escherichia coli. J Bacteriol. 1999;181:3525–3535.
   PubMed Web of Science ®Google Scholar
• Weerasinghe JP, Dong T, Schertzberg MR, et al. Stationary phase expression of the arginine biosynthetic operon argCBH in Escherichia coli. BMC Microbiol. 2006;6:14.
   PubMed Web of Science ®Google Scholar
• Degnan BA, Fontaine MC, Doebereiner AH, et al. Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infect Immun. 2000;68:2441–2448.
   PubMed Web of Science ®Google Scholar
• Jakubovics NS, Robinson JC, Samarian DS, et al. Critical roles of arginine in growth and biofilm development by Streptococcus gordonii. Mol Microbiol. 2015;97:281–300.
   PubMed Web of Science ®Google Scholar
• Kloosterman TG, Kuipers OP. Regulation of arginine acquisition and virulence gene expression in the human pathogen Streptococcus pneumoniae by transcription regulators ArgR1 and AhrC. J Biol Chem. 2011;286:44594–44605.
   PubMed Web of Science ®Google Scholar
• Hooven T. The Stringent Response and Arginine Metabolism Play Key Roles in Streptococcus Agalactiae Toxin Expression, in AAP National Conference. 2015.
   Google Scholar
• Talaue MT, Venketaraman V, Hazbón MH, et al. Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection. J Bacteriol. 2006;188:4830–4840.
   PubMed Web of Science ®Google Scholar
• Hovel-Miner G, Faucher SP, Charpentier X, Shuman HA. ArgR-regulated genes are derepressed in the Legionella-containing vacuole. J Bacteriol. 2010;192:4504–4516.
   PubMed Web of Science ®Google Scholar
• Fox BA, Gigley JP, Bzik DJ. Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. Int J Parasitol. 2004;34:323–331.
   PubMed Web of Science ®Google Scholar
• Kieffer F, Wallon M. Congenital toxoplasmosis. Handb Clin Neurol. 2013;112:1099–1101.
   PubMedGoogle Scholar
• Knowles SJ, O’Sullivan NP, Meenan AM, et al. Maternal sepsis incidence, aetiology and outcome for mother and fetus: a prospective study. BJOG. 2015;122:663–671.
   PubMed Web of Science ®Google Scholar
• Michielsen PP, Van Damme P. Viral hepatitis and pregnancy. Acta Gastroenterol Belg. 1999;62:21–29.
   PubMed Web of Science ®Google Scholar
• Petropoulou H, Stratigos AJ, Katsambas AD. Human immunodeficiency virus infection and pregnancy. Clin Dermatol. 2006;24:536–542.
   PubMed Web of Science ®Google Scholar
• Robbins JR, Bakardjiev AI. Pathogens and the placental fortress. Curr Opin Microbiol. 2012;15:36–43.
   PubMed Web of Science ®Google Scholar
• Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014;27:21–47.
   PubMed Web of Science ®Google Scholar