Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery? A small-scale longitudinal study

References

• Rioux FM, Lindmark G, Hernell O. Does inadequate maternal iron or DHA status have a negative impact on an infant’s functional outcomes? Acta paediatr. 2006;95(2):137–144.
   PubMed Web of Science ®Google Scholar
• Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71(5 Suppl): 1280S–1284S.
   PubMed Web of Science ®Google Scholar
• Hallberg L. Iron balance in pregnancy. In: Berger H, editor. Vitamins and minerals in pregnancy and lactation Nutrition Workshop Series. Vol. 16. New York: Vevey/Raven Press: Nestlé Nutrition Workshop Series; 1988. p. 115–127.
   Google Scholar
• Hoppe M, Lönnerdal B, Hossain B, et al. Hepcidin, interleukin-6 and hematological iron markers in males before and after heart surgery. J Nutr Biochem. 2009;20(1):11–16.
   PubMed Web of Science ®Google Scholar
• Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271–1276.
   PubMed Web of Science ®Google Scholar
• Leong WI, Lönnerdal B. Hepcidin, the recently identified peptide that appears to regulate iron absorption. J Nutr. 2004;134(1):1–4.
   PubMed Web of Science ®Google Scholar
• Nemeth E, Valore EV, Territo M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101(7): 2461–2463.
   PubMed Web of Science ®Google Scholar
• Hulthén L, Lindstedt G, Lundberg PA, et al. Effect of a mild infection on serum ferritin concentration – clinical and epidemiological implications. Eur J Clin Nutr. 1998;52(5):376–379.
   PubMed Web of Science ®Google Scholar
• Ritchie RF, Palomaki GE, Neveux LM, et al. Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort. J Clin Lab Anal. 1999;13(6):273–279.
   PubMed Web of Science ®Google Scholar
• Ferguson BJ, Skikne BS, Simpson KM, et al. Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med. 1992;119(4):385–390.
   PubMed Web of Science ®Google Scholar
• Sweet DG, Savage GA, Tubman R, et al. Cord blood transferrin receptors to assess fetal iron status. Arch Dis Child Fetal Neonatal Ed. 2001;85(1):F46–F48.
   PubMed Web of Science ®Google Scholar
• Akesson A, Bjellerup P, Berglund M, et al. Serum transferrin receptor: a specific marker of iron deficiency in pregnancy. Am J Clin Nutr. 1998;68(6):1241–1246.
   PubMed Web of Science ®Google Scholar
• Young A, Thomson AJ, Ledingham M, et al. Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term. Biol Reprod. 2002;66(2): 445–449.
   PubMed Web of Science ®Google Scholar
• Terzidou V. Preterm labour. Biochemical and endocrinological preparation for parturition. Best Pract Res Clin Obstet Gynaecol. 2007;21(5):729–756.
   PubMed Web of Science ®Google Scholar
• Marchini G, Berggren V, Djilali-Merzoug R, et al. The birth process initiates an acute phase reaction in the fetus-newborn infant. Acta paediatr. 2000;89(9): 1082–1086.
   PubMed Web of Science ®Google Scholar
• Lee S, Guillet R, Cooper EM, et al. Maternal inflammation at delivery affects assessment of maternal iron status. J Nutr. 2014;144(10):1524–1532.
   PubMed Web of Science ®Google Scholar
• Hedengran KK, Nelson D, Andersen MR, et al. Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency – a prospective cohort study. J Matern Fetal Neonatal Med. 2016;29(9):1506–1508.
   PubMed Web of Science ®Google Scholar
• Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990;75(9):1870–1876.
   PubMed Web of Science ®Google Scholar
• Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003;329(1–2):9–22.
   PubMed Web of Science ®Google Scholar
• Kulik-Rechberger B, Kościesza A, Szponar E, et al. Hepcidin and iron status in pregnant women and full-term newborns in first days of life. Ginekol Pol. 2016;87(4):288–292.
   PubMed Web of Science ®Google Scholar
• Garcia-Valdes L, Campoy C, Hayes H, et al. The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy. Int J Obes. 2015; 39(4):571–578.
   PubMed Web of Science ®Google Scholar
• Altinkaynak S, Alp H, Bastem A, et al. Serum ferritin and hemoglobin levels of mothers and their newborns. Turk J Pediatr. 1994;36(4):289–293.
   PubMed Web of Science ®Google Scholar
• Rehu M, Punnonen K, Ostland V, et al. Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol. 2010;85(4):345–352.
   PubMed Web of Science ®Google Scholar
• Yang A, Zhao J, Lu M, et al. Expression of hepcidin and ferroportin in the placenta, and ferritin and transferrin receptor 1 levels in maternal and umbilical cord blood in pregnant women with and without gestational diabetes. Int J Environ Res Public Health. 2016;13(8).
   Web of Science ®Google Scholar
• Basu S, Kumar N, Srivastava R, et al. Maternal and cord blood hepcidin concentrations in severe iron deficiency anemia. Pediatr Neonatol. 2016;57(5): 413–419.
   PubMed Web of Science ®Google Scholar
• Ervasti M, Sankilampi U, Luukkonen S, et al. Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth. Eur J Obstet Gynecol Reprod Biol. 2009;147(2):161–165.
   PubMed Web of Science ®Google Scholar
• Lao TT, Loong EP, Chin RK, et al. Relationship between newborn and maternal iron status and haematological indices. Biol Neonate. 1991;60(5): 303–307.
   PubMedGoogle Scholar
• Bratlid D, Moe PJ. Hemoglobin and serum ferritin levels in mothers and infants at birth. Eur J Pediatr. 1980;134(2):125–127.
   PubMed Web of Science ®Google Scholar
• Pavelka R, Kofler E, Linkesch W, et al. Serum ferritin in pregnancy at term and in newborn (author’s transl). Padiatr Padol. 1981;16(4):443–450.
   PubMed Web of Science ®Google Scholar
• Kelly AM, MacDonald DJ, McDougall AN. Observations on maternal and fetal ferritin concentrations at term. Br J Obstet Gynaecol. 1978;85(5):338–343.
   PubMedGoogle Scholar
• Cao C, Pressman EK, Cooper EM, et al. Prepregnancy body mass index and gestational weight gain have no negative impact on maternal or neonatal iron status. Reprod Sci. 2016;23(5):613–622.
   PubMed Web of Science ®Google Scholar
• Lee S, Guillet R, Cooper EM, et al. Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents. Pediatr Res. 2016;79(1–1):42–48.
   PubMed Web of Science ®Google Scholar
• Briana DD, Boutsikou T, Baka S, et al. Perinatal role of hepcidin and iron homeostasis in full-term intrauterine growth-restricted infants. Eur J Haematol. 2013; 90(1):37–44.
   PubMed Web of Science ®Google Scholar
• Lorenz L, Herbst J, Engel C, et al. Gestational age-specific reference ranges of hepcidin in cord blood. Neonatology. 2014;106(2):133–139.
   PubMed Web of Science ®Google Scholar