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The Journal of Maternal-Fetal & Neonatal Medicine Volume 32, 2019 - Issue 17
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Original Article

Breast milk oligosaccharides: effects of 2′-fucosyllactose and 6′-sialyllactose on the adhesion of Escherichia coli and Salmonella fyris to Caco-2 cells

Bruna FacinelliDepartment of Biomedical Sciences and Public Health, Unit of Microbiology, Polytechnic University of Marche, Ancona, Italy; View further author information
,
Emanuela MariniDepartment of Biomedical Sciences and Public Health, Unit of Microbiology, Polytechnic University of Marche, Ancona, Italy; View further author information
,
Gloria MagiDepartment of Biomedical Sciences and Public Health, Unit of Microbiology, Polytechnic University of Marche, Ancona, Italy; View further author information
,
Lucia ZampiniDepartment of Clinical Sciences, Pediatric Division, Polytechnic University of Marche, Ospedali Riuniti, Ancona, ItalyView further author information
,
Lucia SantoroDepartment of Clinical Sciences, Pediatric Division, Polytechnic University of Marche, Ospedali Riuniti, Ancona, ItalyView further author information
,
Carlo CatassiDepartment of Clinical Sciences, Pediatric Division, Polytechnic University of Marche, Ospedali Riuniti, Ancona, ItalyView further author information
,
Chiara MonachesiDepartment of Clinical Sciences, Pediatric Division, Polytechnic University of Marche, Ospedali Riuniti, Ancona, ItalyView further author information
,
Orazio GabrielliDepartment of Clinical Sciences, Pediatric Division, Polytechnic University of Marche, Ospedali Riuniti, Ancona, ItalyCorrespondence[email protected]
View further author information
&
Giovanni V. CoppaDepartment of Clinical Sciences, Pediatric Division, Polytechnic University of Marche, Ospedali Riuniti, Ancona, ItalyView further author information
 show all
Pages 2950-2952 | Received 26 Feb 2018, Accepted 07 Mar 2018, Published online: 21 Mar 2018

References

  • Stahl B, Thurl S, Henker J, et al. Detection of four human milk groups with respect to Lewis-blood-group-dependent oligosaccharides by serologic and chromatographic analysis. Adv Exp Med Biol. 2001;501:299–306.
  • Bode L. The functional biology of human milk oligosaccharides. Early Hum Dev. 2015;91:619–622.
  • Newburg DS, Grave G. Recent advances in human milk glycobiology. Pediatr Res. 2014;75:675–679.
  • Yu ZT, Chen C, Newburg DS. Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes. Glycobiology. 2013;23:1281–1292.
  • Weichert S, Jennewein S, Hüfner E, et al. Bioengineered 2’-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines. Nutr Res. 2013;33:831–838.
  • Weichert S, Koromyslova A, Singh BK, et al. Structural basis for Norovirus inhibition by human milk oligosaccharides. J Virol. 2016;90:4843–4848.
  • Cilieborg MS, Sangild PT, Jensen ML, et al. α1,2-Fucosyllactose does not improve intestinal function or prevent Escherichia coli F18 diarrhea in newborn pigs. J Pediatr Gastroenterol Nutr. 2017;64:310–318.
  • Coppa GV, Zampini L, Galeazzi T, et al. Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris. Pediatr Res. 2006;59:377–382.
  • Lanata CF, Fischer-Walker CL, Olascoaga AC, et al. Global causes of diarrheal disease mortality in children <5 years of age: a systematic review. PLoS One. 2013;8:e72788.
  • Ruiz-Palacios GM, Cervantes LE, Ramos P, et al. Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. J Biol Chem. 2003;278:14112–14120.
  • Coppa GV, Facinelli B, Magi G, et al. Human milk glycosaminoglycans inhibit in vitro the adhesion of Escherichia coli and Salmonella fyris to human intestinal cells. Pediatr Res. 2016;79:603–607.
  • Snoeck V, Verdonck F, Cox E, et al. Inhibition of adhesion of F18+ Escherichia coli to piglet intestinal villous enterocytes by monoclonal antibody against blood group H-2 antigen. Vet Microbiol. 2004;100:241–246.
  • Marriage BJ, Buck RH, Goehring KC, et al. Infants fed a lower calorie formula with 2’-FL show growth and 2’-FL uptake like breast-fed infants. J Pediatr Gastroenterol Nutr. 2015;61:649–658.
  • Puccio G, Alliet P, Cajozzo C, et al. Effects of infant formula with human milk oligosaccharides on growth and morbidity: a randomized multicenter trial. J Pediatr Gastroenterol Nutr. 2017;64:624–631.

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