The significant role of amino acids during pregnancy: nutritional support

References

• Bröer S, Bröer A. Amino acid homeostasis and signalling in mammalian cells and organisms. Biochem J. 2017;474:1935–1963.
   PubMed Web of Science ®Google Scholar
• Brosnan JT. Interorgan amino acid transport and its regulation. J Nutr. 2003;133:2068S–2072S.
   PubMed Web of Science ®Google Scholar
• Battaglia FC, Meschia G. Fetal nutrition. Annu Rev Nutr. 1988;8:43–61.
   PubMed Web of Science ®Google Scholar
• King JC. Physiology of pregnancy and nutrient metabolism. Am J Clin Nutr. 2000;71:1218S–1225S.
   PubMed Web of Science ®Google Scholar
• Bazer FW, Satterfield MC, Song G. Modulation of uterine function by endocrine and paracrine factors in ruminants. Anim Reprod. 2012;9:305–311.
   Web of Science ®Google Scholar
• Forde N, Simintiras CA, Sturmey R, et al. AAs in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle. Plos One. 2014;9:e100010.
   PubMed Web of Science ®Google Scholar
• Wu G, Imhoff-Kunsch B, Girard AW. Biological mechanisms for nutritional regulation of maternal health and fetal development. Paediatr Perinat Epidemiol. 2012;26:4–26.
   PubMed Web of Science ®Google Scholar
• Bazer FW, Kim JY, Song GW, et al. Roles of selected nutrients on development of the conceptus during pregnancy. Soc Reprod Fertil Suppl. 2013;68:159–174.
   Google Scholar
• Haouzi D, Dechaud H, Assou S, et al. Insights into human endometrial receptivity from transcriptomic and proteomic data. Reprod Biomed Online. 2012;24:23–34.
   PubMed Web of Science ®Google Scholar
• Wen HY, Abbasi S, Kellems RE, et al. mTOR: a placental growth signaling sensor. Placenta. 2005;26:S63–S69.
   PubMed Web of Science ®Google Scholar
• Wu G, Bazer FW, Cudd TA, et al. Maternal nutrition and fetal development. J Nutr. 2004;134:2169–2172.
   PubMed Web of Science ®Google Scholar
• Leese HJ. Metabolism of the preimplantation embryo: 40 years on. Reproduction. 2012;143:417–427.
   PubMed Web of Science ®Google Scholar
• Wu G, Bazer FW, Johnson GA, et al. Maternal and fetal AA metabolism in gestating sows. Soc Reprod Fertil Suppl. 2013;68:185–198.
   Google Scholar
• Wale PL, Gardner DK. Oxygen regulates amino acid turnover and carbohydrate uptake during the preimplantation period of mouse embryo development. Biol Reprod. 2012;87:1–24, 8.
   Web of Science ®Google Scholar
• Kim J, Song GH, Wu G, et al. Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway. Biol Reprod. 2013;88:113.
   PubMed Web of Science ®Google Scholar
• Bazer FW, Wang X, Johnson GA, et al. Select nutrients and their effects on conceptus development in mammals. Anim Nutr. 2015;1:85–95.
   PubMed Web of Science ®Google Scholar
• Kim J, Erikson DW, Burghardt RC, et al. Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells. Matrix Biol. 2010;29:369–382.
   PubMed Web of Science ®Google Scholar
• Jackson MR, Mayhew TM, Boyd PA. Quantitative description of the elaboration and maturation of villi from 10 weeks of gestation to term. Placenta. 1992;13:357–370.
   PubMed Web of Science ®Google Scholar
• Holzman IR, Lemons JA, Meschia G, et al. Uterine uptake of amino acids and placental glutamine–glutamate balance in the pregnant ewe. J Dev Physiol. 1979;1:137–149.
   PubMedGoogle Scholar
• Marconi AM, Battaglia FC, Meschia G, et al. A comparison of amino acid arteriovenous differences across the liver and placenta of the fetal lamb. Am J Physiol. 1989;257:E909–EE915.
   PubMed Web of Science ®Google Scholar
• Smith CH, Adcock EW, Teasdale F, et al. Placental amino acid uptake: tissue preparation, kinetics, and preincubation effect. Am J Physiol. 1973;224:558–564.
   PubMed Web of Science ®Google Scholar
• Cleal JK, Brownbill P, Godfrey KM, et al. Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro. J Physiol. 2007;582:871–882.
   PubMed Web of Science ®Google Scholar
• Regnault TRH, de Vrijer B, Battaglia FC. Transport and metabolism of amino acids in placenta. Endocrine. 2002;19:23–41.
   PubMed Web of Science ®Google Scholar
• Philipps AF, Holzman IR, Teng C, et al. Tissue concentrations of free amino acids in term human placentas. Am J Obstet Gynecol. 1978;131:881–887.
   PubMed Web of Science ®Google Scholar
• Camelo JS, Jr., Jorge SM, Martinez FE. Amino acid composition of parturient plasma, the intervillous space of the placenta and the umbilical vein of term newborn infants. Braz J Med Biol Res. 2004;37:711–717.
   PubMed Web of Science ®Google Scholar
• Battaglia FC, Regnault TRH. Placental transport and metabolism of amino acids. Placenta. 2001;22:145–161.
   PubMed Web of Science ®Google Scholar
• Lager S, Powell TL. Regulation of nutrient transport across the placenta. J Pregnancy. 2012;2012:1.
   Google Scholar
• Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev. 1990;70:43–77.
   PubMed Web of Science ®Google Scholar
• Jansson T. Amino acid transporters in the human placenta. Pediatr Res. 2001;49:141–147.
   PubMed Web of Science ®Google Scholar
• Hoeltzli SD, Smith CH. Alanine transport systems in isolated basal plasma membrane of human placenta. Am J Physiol. 1989;256:C630.
   PubMed Web of Science ®Google Scholar
• Verrey F. System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pflugers Arch Eur J Physiol. 2003;445:529–533.
   PubMed Web of Science ®Google Scholar
• Battaglia FC. In vivo characteristics of placental amino acid transport and metabolism in ovine pregnancy–a review. Placenta. 2002;23:S3–S8.
   PubMed Web of Science ®Google Scholar
• Ueki R, Tatara T, Kariya N, et al. Effect of decreased fetal perfusion on placental clearance of volatile anesthetics in a dual perfused human placental cotyledon model. J Anesth. 2014;28:635–638.
   PubMed Web of Science ®Google Scholar
• Vaughn PR, Lobo C, Battaglia FC, et al. Glutamine-glutamate exchange between placenta and fetal liver. Am J Physiol. 1995;268:E705–E711.
   PubMed Web of Science ®Google Scholar
• Chung M, Teng C, Timmerman M, et al. Production and utilization of amino acids by ovine placenta in vivo. Am J Physiol. 1998;274:E13–E22.
   PubMedGoogle Scholar
• Galan HL, Marconi AM, Paolini CL, et al. The transplacental transport of essential amino acids in uncomplicated human pregnancies. Am J Obstet Gynecol. 2009;200:91.e1–91.e7.
   PubMed Web of Science ®Google Scholar
• Geddie G, Moores R, Meschia G, et al. Comparison of leucine, serine and glycine transport across the ovine placenta. Placenta. 1996;17:619–627.
   PubMed Web of Science ®Google Scholar
• Cetin I, Marconi AM, Baggiani AM, et al. In vivo placental transport of glycine and leucine in human pregnancies. Pediatr Res. 1995;37:571–575.
   PubMed Web of Science ®Google Scholar
• Paolini CL, Marconi AM, Ronzoni S, et al. Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab. 2001;86:5427–5432.
   PubMed Web of Science ®Google Scholar
• Ross JC, Fennessey PV, Wilkening RB, et al. Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol. 1996;270:E491–E503.
   PubMed Web of Science ®Google Scholar
• Kennaugh JM, Bell AW, Teng C, et al. Ontogenetic changes in the rates of protein synthesis and leucine oxidation during fetal life. Pediatr Res. 1987;22:688–692.
   PubMed Web of Science ®Google Scholar
• van Veen LC, Teng C, Hay WW, et al. Leucine disposal and oxidation rates in the fetal lamb. Metabolism. 1987;36:48–53.
   PubMed Web of Science ®Google Scholar
• Van Veen LC, Hay WW, Jr., Battaglia FC, et al. Fetal CO2 kinetics. J Dev Physiol. 1984;6:359–365.
   PubMedGoogle Scholar
• Battaglia FC. New concepts in fetal and placental amino acid metabolism. J Anim Sci. 1992;70:3258–3263.
   PubMed Web of Science ®Google Scholar
• Bell AW, Battaglia FC, Makowski EL, et al. Relationship between metabolic rate and body size in fetal life. Biol Neonate. 1985;47:120–123.
   PubMedGoogle Scholar
• Józwik M, Teng C, Battaglia FC, et al. Fetal supply of amino acids and amino nitrogen after maternal infusion of amino acids in pregnant sheep. Am J Obstet Gynecol. 1999;180:447–453.
   PubMed Web of Science ®Google Scholar
• Gresham EL, Simons PS, Battaglia FC. Maternal-fetal urea concentration difference in man: metabolic significance. J Pediatr. 1971;79:809–811.
   PubMed Web of Science ®Google Scholar
• Lemons JA, Reyman D, Schreiner RL. Fetal and maternal amino acid concentrations during fasting in the ewe. J Pediatr Gastroenterol Nutr. 1984;3:249–255.
   PubMed Web of Science ®Google Scholar
• Lemons JA, Schreiner RL. Metabolic balance of the ovine fetus during the fed and fasted states. Ann Nutr Metab. 1984;28:268–280.
   PubMed Web of Science ®Google Scholar
• Pardi G, Marconi AM, Cetin I. Placental-fetal interrelationship in IUGR fetuses; a review. Placenta. 2002;23:S136–S141.
   PubMed Web of Science ®Google Scholar
• Wu G, Pond WG, Ott T, et al. Maternal dietary protein deficiency decreases amino acid concentrations in fetal plasma and allantoic fluid of pigs. J Nutr. 1998;128:894–902.
   PubMed Web of Science ®Google Scholar
• Lin G, Wang X, Wu G, et al. Improving amino acid nutrition to prevent intrauterine growth restriction in mammals. Amino Acids. 2014;46:1605–1623.
   PubMed Web of Science ®Google Scholar
• Jansson N, Pettersson J, Haafiz A, et al. Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J Physiol. 2006;576:935–946.
   PubMed Web of Science ®Google Scholar
• Medicine Food and Nutrition Board. Dietary reference intakes: energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: The National Academy Press; 2005.
   Google Scholar
• Imdad A, Bhutta ZA. Maternal nutrition and birth outcomes: effect of balanced protein- energy supplementation. Paediatr Perinat Epidemiol. 2012;26:178–190.
   PubMed Web of Science ®Google Scholar
• Food and Agriculture Organization/World Health Organization/United Nations University. Energy and protein requirements. Report of a joint FAO/WHO/UNU consultation. WHO Tech Rep S. 1985;724.
   Google Scholar
• Butte NF, King JC. Energy requirements during pregnancy and lactation. Public Health Nutr. 2005;8:1010–1027.
   PubMed Web of Science ®Google Scholar
• Cetin I, Alvino G. Intrauterine growth restriction: implications for placental metabolism and transport. A review. Placenta. 2009;30:77–S82.
   PubMed Web of Science ®Google Scholar
• Thompson GN, Halliday D. Protein turnover in pregnancy. Eur J Clin Nutr. 1992;46:411–417.
   PubMed Web of Science ®Google Scholar
• Jolly M, Bertie J, Gray R, et al. Increased leucine turnover in women during the third trimester of uncomplicated pregnancy. Metabolism. 2004;53:545–549.
   PubMed Web of Science ®Google Scholar
• Stephens TV, Payne M, Ball RO, et al. Protein requirements of healthy pregnant women during early and late gestation are higher than current recommendations. J Nutr. 2015;145:73–78.
   PubMed Web of Science ®Google Scholar
• Stephens TV, Woo H, Innis SM, et al. Healthy pregnant women in Canada are consuming more dietary protein at 16- and 36-week gestation than currently recommended by the Dietary Reference Intakes, primarily from dairy food sources. Nutr Res. 2014;34:569–576.
   PubMed Web of Science ®Google Scholar
• Elango R, Ball RO. Protein and amino acid requirements during pregnancy. Adv Nutr. 2016;7:839S–844S.
   PubMed Web of Science ®Google Scholar
• Brown LD, Green AS, Limesand SW, et al. Maternal amino acid supplementation for intrauterine growth restriction. Front Biosci (Schol Ed). 2011;3:428–444.
   PubMedGoogle Scholar
• Rush D, Stein Z, Susser M. A randomized controlled trial of prenatal nutritional supplementation in New York City. Pediatrics. 1980;65:683–697.
   PubMed Web of Science ®Google Scholar
• Roseboom TJ, Painter RC, van Abeelen AF, et al. Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas. 2011;70:141–145.
   PubMed Web of Science ®Google Scholar
• Kurpad AV, Dwarkanath P, Thomas T, et al. Comparison of leucine and dispensable amino acid kinetics between Indian women with low or normal body mass indexes during pregnancy. Am J Clin Nutr. 2010;92:320–329.
   PubMed Web of Science ®Google Scholar
• Thame MM, Fletcher HM, Baker TM, et al. Arginine flux, but not nitric oxide synthesis, decreases in adolescent girls compared with adult women during pregnancy. J Nutr. 2011;141:71–74.
   PubMed Web of Science ®Google Scholar
• Abu-Saad K, Fraser D. Maternal nutrition and birth outcomes. Epidemiol Rev. 2010;32:5–25.
   PubMed Web of Science ®Google Scholar
• de Onis M, Blössner M, Villar J. Levels and patterns of intrauterine growth retardation in developing countries. Eur J Clin Nutr. 1998;52:S5–S15.
   PubMed Web of Science ®Google Scholar
• Triunfo S, Lanzone A. Impact of maternal under nutrition on obstetric outcomes. J Endocrinol Invest. 2015;38:31–38.
   PubMed Web of Science ®Google Scholar
• Ganguly A, Touma M, Thamotharan S, et al. Maternal calorie restriction causing uteroplacental insufficiency differentially affects mammalian placental glucose and leucine transport molecular mechanisms. Endocrinology. 2016;157:4041–4054.
   PubMed Web of Science ®Google Scholar
• Devaskar SU, Chu A. Intrauterine growth restriction: hungry for an answer. Physiology (Bethesda). 2016;31:131–146.
   PubMed Web of Science ®Google Scholar
• Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:766–781.
   PubMed Web of Science ®Google Scholar
• Hauguel-de Mouzon S, Lassance L. Endocrine and metabolic adaptations to pregnancy; impact of obesity. Horm Mol Biol Clin Invest. 2015;24:65–72.
   PubMed Web of Science ®Google Scholar
• Jansson N, Rosario FJ, Gaccioli F, et al. Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. J Clin Endocrinol Metab. 2013;98:105–113.
   PubMed Web of Science ®Google Scholar
• Freeman DJ. Effects of maternal obesity on fetal growth and body composition: implications for programming and future health. Semin Fetal Neonat Med. 2010;15:113–118.
   PubMed Web of Science ®Google Scholar
• Catalano PM. The impact of gestational diabetes and maternal obesity on the mother and her offspring. J Devel Orig Health Dis. 2010;1:208–215.
   PubMed Web of Science ®Google Scholar
• Weissgerber TL, Davies GA, Roberts JM. Modification of angiogenic factors by regular and acute exercise during pregnancy. J Appl Physiol. 2010;108:1217–1223.
   PubMed Web of Science ®Google Scholar
• Wang N, Tikellis G, Sun C, et al. The effect of maternal prenatal smoking and alcohol consumption on the placenta-to-birth weight ratio. Placenta. 2014;35:437–441.
   PubMed Web of Science ®Google Scholar
• Black RE, Allen LH, Bhutta ZA, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008;371:243–260.
   PubMed Web of Science ®Google Scholar
• WHO recommendations on antenatal care for a positive pregnancy experience. 2016 [cited 2018 June]. Available from: http://apps.who.int/iris/bitstream/10665/250796/1/9789241549912-eng.pdf.
   Google Scholar
• Sabate J, Ratzin-Turner R, Brown J. Vegetarian diets: descriptions and trends. In: Vegetarian Nutrition, (J Sabate ed.). Boca Raton: CRC Press; 2001. p. 3–18.
   Google Scholar
• Piccoli GB, Clari R, Vigotti FN, et al. Vegan–vegetarian diets in pregnancy: danger or panacea? A systematic narrative review. BJOG. 2015;122:623–633.
   PubMed Web of Science ®Google Scholar
• American DA. Dietitians of Canada. Dietitians of Canada Position of the American Dietetic Association and Dietitians of Canada: vegetarian diets. J Am Diet Assoc. 2003;103:748–765.
   PubMedGoogle Scholar
• Koebnick C, Hoffmann I, Dagnelie PC, et al. Long-term ovo-lacto vegetarian diet impairs vitamin B12 status in pregnant women. J Nutr. 2004;134:3319–3326.
   PubMed Web of Science ®Google Scholar
• Sharma JB, Soni D, Murthy NS, et al. Effect of dietary habits on prevalence of anemia in pregnant women of Delhi. J Obstet Gynaecol Res. 2003;29:73–78.
   PubMed Web of Science ®Google Scholar
• Prick BW, Hop WC, Duvekot JJ. Maternal phenylketonuria and hyperphenylalaninemia in pregnancy: pregnancy complications and neonatal sequelae in untreated and treated pregnancies. Am J Clin Nutr. 2012;95:374–382.
   PubMed Web of Science ®Google Scholar
• Teissier R, Nowak E, Assoun M, et al. Maternal phenylketonuria: low phenylalaninemia might increase the risk of intra uterine growth retardation. J Inherit Metab Dis. 2012;35:993–999.
   PubMed Web of Science ®Google Scholar
• Matalon KM, Acosta PB, Azen C. Role of nutrition in pregnancy with phenylketonuria and birth defects. Pediatrics. 2003;112:1534–1536.
   PubMed Web of Science ®Google Scholar
• Manta-Vogli PD, Schulpis KH. Phenylketonuria dietary management and an emerging development. J Acad Nutr Diet. 2017. DOI: 10.1016/j.jand.2017.05.020
   PubMed Web of Science ®Google Scholar
• van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines on phenylketonuria: diagnosis and treatment. Orphanet J Rare Dis. 2017;12:162.
   PubMed Web of Science ®Google Scholar