191
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase

, , , , , & show all
Pages 1125-1133 | Received 03 May 2018, Accepted 20 Aug 2018, Published online: 03 Oct 2018

References

  • Red-Horse K, Zhou Y, Genbacev O, et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004;114(6):744–754.
  • Vićovac L, Aplin JD. Epithelial-mesenchymal transition during trophoblast differentiation. Acta Anat. 1996;156(3):202–216.
  • Ji L, Brkić J, Liu M, et al. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Aspects Med. 2013;34(5):981–1023.
  • Steegers EA, von Dadelszen P, Duvekot JJ, et al. Pre-eclampsia. Lancet. 2010;376(9741):631–644.
  • Gerretsen G, Huisjes HJ, Elema JD. Morphological changes of the spiral arteries in the placentae bed in relation to preeclampsia and fetal growth retardation. Br J Obstet Gynaecol. 1981;88(9):876–881.
  • Carreiras M, Montagnani S, Layrisse Z. Preeclampsia: a multifactorial disease resulting from the interaction of the feto-maternal HLA genotype and HCMV infection. Am J Reprod Immunol. 2002;48(3):176–183.
  • Orozco AF, Jorgez CJ, Ramos-Perez WD, et al. Placental release of distinct DNA-associated micro-particles into maternal circulation: reflective of gestation time and preeclampsia. Placenta. 2009;30(10):891–897.
  • Staun-Ram E, Shalev E. Human trophoblast function during the implantation process. Reprod Biol Endocrinol. 2005;3:56.
  • Cohen M, Bischof P. Factors regulating trophoblast invasion. Gynecol Obstet Invest. 2007;64(3):126–130.
  • Walter I, Boos A. Matrix metalloproteinases (MMP-2 and MMP-9) and tissue inhibitor-2 of matrix metalloproteinases (TIMP-2) in the placenta and interplacental uterine wall in normal cows and in cattle with retention of fetal membranes. Placenta. 2001;22(5):473–483.
  • Burton GJ, Jauniaux E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol. 2011;25(3):287–299.
  • Pennington KA, Schlitt JM, Jackson DL, et al. Preeclampsia: multiple approaches for a multifactorial disease. Dis Model Mech. 2012;5(1):9–18.
  • Zhou X, Zhang GY, Wang J, et al. A novel bridge between oxidative stress and immunity: the interaction between hydrogen peroxide and human leukocyte antigen G in placental trophoblasts during preeclampsia. Am J Obstet Gynecol. 2012;206(5):e7–e16.
  • Prieto-Echagüe V, Gucwa A, Craddock BP, et al. Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1. J Biol Chem. 2010;285(14):10605–10615.
  • Nur-E-Kamal MS, Kamal JM, Qureshi MM, et al. The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation. Oncogene. 1999;18(54):7787–7793.
  • Mahajan NP, Whang YE, Mohler JL, et al. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer Res. 2005;65(22):10514–10523.
  • Shinmura K, Kiyose S, Nagura K, et al. TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer. J Surg Oncol. 2014;109(3):189–197.
  • Mahajan K, Coppola D, Chen YA, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012;180(4):1386–1393.
  • Xie B, Zen Q, Wang X, et al. ACK1 promotes hepatocellular carcinoma progression via down regulating WWOX and activating AKT signaling. Int J Oncol. 2015;46(5):2057–2066.
  • Hu F, Liu H, Xie X, et al. Activated cdc42-associated kinase is up-regulated in non-small-cell lung cancer and necessary for FGFR-mediated AKT activation. Mol Carcinog. 2016;55(5):853–863.
  • Mahajan K, Mahajan NP. ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers. Oncogene. 2015;34(32):4162–4167.
  • Mahajan K, Mahajan NP. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J Cell Physiol. 2010;224(2):327–333.
  • Liu Z, Liu Z, Zhang Y, et al. miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway. Biochem Biophys Res Commun. 2017;486(2):211–217.
  • Holtan SG, Creedon DJ, Haluska P, et al. Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents. Mayo Clin Proc. 2009;84(11):985–1000.
  • Halasz M, Polgar B, Berta G, et al. Progesterone-induced blocking factor differentially regulates trophoblast and tumor invasion by altering matrix metalloproteinase activity. Cell Mol Life Sci. 2013;70(23):4617–4630.
  • Yuan Y, Shan N, Tan B, et al. SRC-3 plays a critical role in human umbilical vein endothelial cells by regulating the PI3K/Akt/mTOR pathway in preeclampsia. Reprod Sci. 2018;25(5):748–758.
  • Mahajan NP, Liu Y, Majumder S, et al. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc Natl Acad Sci USA. 2007;104(20):8438–8443.
  • Hung TH, Chen SF, Li MJ, et al. Differential effects of concomitant use of vitamins C and E on trophoblast apoptosis and autophagy between normoxia and hypoxia-reoxygenation. PLoS One. 2010;5(8):e12202.
  • Shan N, Zhang X, Xiao X, et al. Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas. Placenta. 2015;36(8):809–820.
  • Zhong T, Chen J, Ling Y, et al. Down-regulation of neuropathy target esterase in preeclampsia placenta inhibits human trophoblast cell invasion via modulating MMP-9 levels. Cell Physiol Biochem. 2018;45(3):1013–1022.
  • Zhu X, Cao Q, Li X, et al. Knockdown of TACC3 inhibits trophoblast cell migration and invasion through the PI3K/Akt signaling pathway. Mol Med Rep. 2016;14(4):3437–3442.
  • Wang H, Cheng H, Shao Q, et al. Leptin-promoted human extravillous trophoblast invasion is MMP14 dependent and requires the Cross talk between Notch1 and PI3K/Akt signaling. Biol Reprod. 2014;90(4):78.
  • Verlohren S, Geusens N, Morton J, et al. Inhibition of trophoblast-induced spiral artery remodeling reduces placental perfusion in rat pregnancy. Hypertension. 2010;56(2):304–310.
  • Xu Y, Lian Y, Zhang Y, et al. The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell. J Cell Mol Med. 2018;22(2):1272–1282.
  • Appel S, Ankerne J, Appel J, et al. CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells. PLoS One. 2014;9(7):e103216.
  • Graham CH, Hawley TS, Hawley RG, et al. Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res. 1993;206(2):204–211.
  • Yue X, Sun Y, Zhong M, et al. Decreased expression of fibroblast growth factor 13 in early-onset preeclampsia is associated with the increased trophoblast permeability. Placenta. 2018;62:43–49.
  • Rao H, Bai Y, Qi H, et al. The role of SATB1 in HTR8/SVneo cells and pathological mechanism of preeclampsia. J Matern Fetal Neonatal Med. 2018;16:1–10.
  • Moll SJ, Jones CJ, Crocker IP, et al.. Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species. Apoptosis. 2007;12(9):1611–1622.
  • Alaseem A, Alhazzani K, Dondapati P, et al. Matrix metalloproteinases: a challenging paradigm of cancer management. Semin Cancer Biol. 2017. doi:10.1016/j.semcancer.2017.11.008
  • Huppertz B. The critical role of abnormal trophoblast development in the etiology of preeclampsia. CPB. 2018. doi:10.2174/1389201019666180427110547
  • Sharashenidze A, Panchulidze L, Sanikidze T. Alterations in placenta redox-status during experimental model of hypoxia-induced preeclampsia. Georgian Med News. 2017;268–269(268–269):86–90.
  • Rivas S, Gómez-Oro C, Antón IM, et al. Role of Akt isoforms controlling cancer stem cell survival, phenotype and self-renewal. Biomedicines. 2018. doi:10.3390/biomedicines6010029
  • Duan B, Guo T, Sun H, et al. miR-205 as a biological marker in non-small cell lung cancer. Biomed Pharmacother. 2017;91:823–830.
  • Zhang GJ, Zhao J, Jiang ML, et al. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway. Biochem Biophys Res Commun. 2018;496(2):387–393.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.