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The Journal of Maternal-Fetal & Neonatal Medicine Volume 35, 2022 - Issue 20
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Maternal high-dose valacyclovir and its correlation with newborn blood viral load and outcome in congenital cytomegalovirus infection

Anna Goncéa Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain;b Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, SpainCorrespondence[email protected]
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Ameth Hawkins-Villarreala Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain;c Fetal Medicine Service, Obstetrics Department, Hospital “Santo Tomás”, University of Panama, Panama City, Panamá. On behalf of the Iberoamerican Research Network in Translational, Molecular and Maternal Fetal Medicine, Barcelona, SpainView further author information
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Laura Salazara Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, SpainView further author information
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Laura Guiradoa Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, SpainView further author information
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Maria-Angeles Marcosd Department of Clinical Microbiology, Hospital Clinic, University of Barcelona; Institute for Global Health (ISGlobal), Barcelona, SpainView further author information
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Jara Pascual Manchoe Department of Obstetrics, Prenatal Diagnosis, Miguel Servet University Hospital, Zaragoza, SpainView further author information
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Pilar Pratsf Obstetrics Service, Department of Obstetrics, Gynaecology and Reproduction, Institut Universitari Dexeus, Barcelona, SpainView further author information
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Marta Lópeza Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain;b Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, SpainView further author information
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Elisenda Eixarcha Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain;b Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, SpainView further author information
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Maria-Dolors Salviaa Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, SpainView further author information
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Claudia Fortunyg Department of Pediatric Infectious Diseases, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, SpainView further author information
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Francesc Figuerasa Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Institut Clínic de Ginecología, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain;b Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, SpainView further author information
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Pages 4004-4008 | Received 07 Feb 2020, Accepted 23 Oct 2020, Published online: 03 Nov 2020

References

  • Kenneson A, Cannon MJ. Aileen; Cannon, review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17(4):253–276.
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  • Leruez-Ville M, Ghout I, Bussières L, et al. In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study. Am J Obstet Gynecol. 2016;215(4):462.e1–462.e10. doi:10.1016/j.ajog.2016.04.003.
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  • Hawkins-Villarreal A, Moreno-Espinosa AL, Eixarch E, et al. Blood parameters in fetuses infected with cytomegalovirus according to the severity of brain damage and trimester of pregnancy at cordocentesis. J Clin Virol. 2019;119:37–43.
  • Marsico C, Aban I, Kuo H, et al. Blood viral load in symptomatic congenital cytomegalovirus infection. J Infect Dis. 2019;219(9):1398–1406.
  • Boppana SB, Fowler KB, Pass RF, et al. Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss. J Pediatr. 2005;146(6):817–823. doi:10.1016/j.jpeds.2005.01.059.
  • Lanari M, Lazzarotto T, Venturi V, et al. Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics. 2006;117(1):e76–e83. doi:10.1542/peds.2005-0629.

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