Genotype influence in responses to therapy for atrial fibrillation

References

• January CT, Wann LS, Alpert JS, et al. AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130:2071–2104.
   PubMed Web of Science ®Google Scholar
• Wyse DG, Waldo AL, DiMarco JP, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002;347:1825–1833.
   PubMed Web of Science ®Google Scholar
• Van Gelder IC, Hagens VE, Bosker HA, et al. A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation. N Engl J Med. 2002;347:1834–1840.
   PubMed Web of Science ®Google Scholar
• Corley SD, Epstein AE, DiMarco JP, et al. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation. 2004;109:1509–1513.
   PubMed Web of Science ®Google Scholar
• Singh SN, Singh BN, Reda DJ, et al. Comparison of sotalol versus amiodarone in maintaining stability of sinus rhythm in patients with atrial fibrillation (Sotalol-Amiodarone Fibrillation Efficacy Trial [Safe-T]). Am J Cardiol. 2003;92:468–472.
   PubMed Web of Science ®Google Scholar
• Reimold SC, Cantillon CO, Friedman PL, et al. Propafenone versus sotalol for suppression of recurrent symptomatic atrial fibrillation. Am J Cardiol. 1993;71:558–563.
   PubMed Web of Science ®Google Scholar
• Flaker GC, Blackshear JL, McBride R, et al. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The stroke prevention in atrial fibrillation investigators. J Am Coll Cardiol. 1992;20:527–532.
   PubMed Web of Science ®Google Scholar
• Cox JL, Schuessler RB, D’Agostino HJ Jr, et al. The surgical treatment of atrial fibrillation. III. Development of a definitive surgical procedure. J Thorac Cardiovasc Surg. 1991;101:569–583.
   PubMed Web of Science ®Google Scholar
• Calkins H, Hall J, Ellenbogen K, et al. A new system for catheter ablation of atrial fibrillation. Am J Cardiol. 1999;83:227D–236D.
   PubMed Web of Science ®Google Scholar
• Haissaguerre M, Jais P, Shah DC, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998;339:659–666.
   PubMed Web of Science ®Google Scholar
• Moe GK, Rheinboldt WC, Abildskov JA. A computer model of atrial fibrillation. Am Heart J. 1964;67:200–220.
   PubMed Web of Science ®Google Scholar
• Nattel S. New ideas about atrial fibrillation 50 years on. Nature. 2002;415:219–226.
   PubMed Web of Science ®Google Scholar
• Stillitano F, Lonardo G, Zicha S, et al. Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol. 2008;45:289–299.
   PubMed Web of Science ®Google Scholar
• Qi XY, Yeh YH, Xiao L, et al. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008;103:845–854.
   PubMed Web of Science ®Google Scholar
• Yeh YH, Wakili R, Qi XY, et al. Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol. 2008;1:93–102.
   PubMed Web of Science ®Google Scholar
• Voigt N, Li N, Wang Q, et al. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012;125:2059–2070.
   PubMed Web of Science ®Google Scholar
• Po SS, Li Y, Tang D, et al. Rapid and stable re-entry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation. J Am Coll Cardiol. 2005;45:1871–1877.
   PubMed Web of Science ®Google Scholar
• Comtois P, Kneller J, Nattel S. Of circles and spirals: bridging the gap between the leading circle and spiral wave concepts of cardiac reentry. Europace. 2005;7(Suppl 2):10–20.
   PubMed Web of Science ®Google Scholar
• Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol. 2008;1:62–73.
   PubMed Web of Science ®Google Scholar
• Shiroshita-Takeshita A, Mitamura H, Ogawa S, et al. Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance. Cardiovasc Res. 2009;81:90–97.
   PubMed Web of Science ®Google Scholar
• Wolff L. Familial auricular fibrillation. N Engl J Med. 1943;229:396–398.
   Google Scholar
• Brugada R, Tapscott T, Czernuszewicz GZ, et al. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 1997;336:905–911.
   PubMed Web of Science ®Google Scholar
• Darbar D, Herron KJ, Ballew JD, et al. Familial atrial fibrillation is a genetically heterogeneous disorder. J Am Coll Cardiol. 2003;41:2185–2192.
   PubMed Web of Science ®Google Scholar
• Shah G, Brugada R, Gonzalez O, et al. The cloning, genomic organization and tissue expression profile of the human DLG5 gene. BMC Genomics. 2002;3:6.
   PubMed Web of Science ®Google Scholar
• Ellinor PT, Yoerger DM, Ruskin JN, et al. Familial aggregation in lone atrial fibrillation. Hum Genet. 2005;118:179–184.
   PubMed Web of Science ®Google Scholar
• Fox CS, Parise H, D’Agostino RB Sr, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004;291:2851–2855.
   PubMed Web of Science ®Google Scholar
• Arnar DO, Thorvaldsson S, Manolio TA, et al. Familial aggregation of atrial fibrillation in Iceland. Eur Heart J. 2006;27:708–712.
   PubMed Web of Science ®Google Scholar
• Christophersen IE, Ravn LS, Budtz-Joergensen E, et al. Familial aggregation of atrial fibrillation: a study in Danish twins. Circ Arrhythm Electrophysiol. 2009;2:378–383.
   PubMed Web of Science ®Google Scholar
• Otway R, Vandenberg JI, Guo G, et al. Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation? J Am Coll Cardiol. 2007;49:578–586.
   PubMed Web of Science ®Google Scholar
• Darbar D, Roden DM. Genetic mechanisms of atrial fibrillation: impact on response to treatment. Nat Rev Cardiol. 2013;10:317–329.
   PubMed Web of Science ®Google Scholar
• Shi L, Li C, Wang C, et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet. 2009;126:843–849.
   PubMed Web of Science ®Google Scholar
• Gudbjartsson DF, Arnar DO, Helgadottir A, et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007;448:353–357.
   PubMed Web of Science ®Google Scholar
• Body SC, Collard CD, Shernan SK, et al. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet. 2009;2:499–506.
   PubMed Web of Science ®Google Scholar
• Mommersteeg MT, Brown NA, Prall OW, et al. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res. 2007;101:902–909.
   PubMed Web of Science ®Google Scholar
• Logan M, Pagan-Westphal SM, Smith DM. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell. 1998;94:307–317.
   PubMed Web of Science ®Google Scholar
• Mommersteeg MT, Hoogaars WM, Prall OW, et al. Molecular pathway for the localized formation of the sinoatrial node. Circ Res. 2007;100:354–362.
   PubMed Web of Science ®Google Scholar
• Gage PJ, Suh H, Camper SA. Dosage requirement of Pitx2 for development of multiple organs. Development. 1999;126:4643–4651.
   PubMed Web of Science ®Google Scholar
• Kitamura K, Miura H, Miyagawa-Tomita S, et al. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development. 1999;126:5749–5758.
   PubMed Web of Science ®Google Scholar
• Ellinor PT, Lunetta KL, Albert CM, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012;44:670–675.
   PubMed Web of Science ®Google Scholar
• Ihida-Stansbury K, McKean DM, Gebb SA, et al. Paired-related homeobox gene Prx1 is required for pulmonary vascular development. Circ Res. 2004;94:1507–1514.
   PubMed Web of Science ®Google Scholar
• Dolmatova E, Tucker NR, Lin H, et al. Identification of a functional SNP regulating PRRX1 at the 1q24 locus for atrial fibrillation. Circulation. 2014;130:Abstract 18865.
   Web of Science ®Google Scholar
• Benjamin EJ, Rice KM, Arking DE, et al. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009;41:879–881.
   PubMed Web of Science ®Google Scholar
• Sinner MF, Tucker NR, Lunetta KL, et al. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation. 2014;130:1225–1235.
   PubMed Web of Science ®Google Scholar
• Schotten U, Verheule S, Kirchhof P, et al. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev. 2011;91:265–325.
   PubMed Web of Science ®Google Scholar
• Van Wagoner DR. Electrophysiological remodeling in human atrial fibrillation. Pacing Clin Electrophysiol. 2003;26:1572–1575.
   PubMed Web of Science ®Google Scholar
• Das S, Makino S, Melman YF, et al. Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation. Heart Rhythm. 2009;6:1146–1153.
   PubMed Web of Science ®Google Scholar
• Yang Y, Xia M, Jin Q, et al. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet. 2004;75:899–905.
   PubMed Web of Science ®Google Scholar
• Ravn LS, Aizawa Y, Pollevick GD, et al. Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation. Heart Rhythm. 2008;5:427–435.
   PubMed Web of Science ®Google Scholar
• Xia M, Jin Q, Bendahhou S, et al. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun. 2005;332:1012–1019.
   PubMed Web of Science ®Google Scholar
• Hodgson-Zingman DM, Karst ML, Zingman LV, et al. Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. N Engl J Med. 2008;359:158–165.
   PubMed Web of Science ®Google Scholar
• Disertori M, Quintarelli S, Grasso M, et al. Utosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of natriuretic peptide precursor A. Circ Cardiovasc Genet. 2013;6:27–36.
   PubMed Web of Science ®Google Scholar
• Galimberti ES, Kannankeril P, Kor K, et al. NPPA overexpression in mice increases susceptibility to atrial fibrillation [abstract]. Circulation. 2012;126:A19074.
   Web of Science ®Google Scholar
• Steffensen AB, Refsgaard L, Andersen MN, et al. IKs gain- and loss-of-function in early-onset lone atrial fibrillation. J Cardiovasc Electrophysiol. 2015;26:715–723.
   PubMed Web of Science ®Google Scholar
• Olson TM, Alekseev AE, Liu XK, et al. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet. 2006;15:2185–2191.
   PubMed Web of Science ®Google Scholar
• Yang T, Yang P, Roden DM, et al. Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation. Heart Rhythm. 2010;7:1246–1252.
   PubMed Web of Science ®Google Scholar
• Darbar D, Kannankeril PJ, Donahue BS, et al. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation. 2008;117:1927–1935.
   PubMed Web of Science ®Google Scholar
• Ilkhanoff L, Arking DE, Lemaitre RN, et al. A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans. J Cardiovasc Electrophysiol. 2014;25:1150–1157.
   PubMed Web of Science ®Google Scholar
• Wan E, Abrams J, Weinberg RL, et al. Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest. 2016;126:112–122.
   PubMed Web of Science ®Google Scholar
• Savio-Galimberti E, Weeke P, Muhammad R, et al. SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation. Cardiovasc Res. 2014;104:355–363.
   PubMed Web of Science ®Google Scholar
• Qi B, Wei Y, Chen S, et al. Nav1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility. Cardiovasc Res. 2014;102:480–486.
   PubMed Web of Science ®Google Scholar
• Jennings MM, Donahue J. Connexin remodeling contributes to atrial fibrillation. J Atrial Fibrillation. 2013;6(2):65–71.
   Google Scholar
• Gollob MH, Jones DL, Krahn AD, et al. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med. 2006;354:2677–2688.
   PubMed Web of Science ®Google Scholar
• Wirka RC, Gore S, Van Wagoner DR, et al. A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Circ Arrhythm Electrophysiol. 2011;4:87–93.
   PubMed Web of Science ®Google Scholar
• Yang YQ, Liu X, Zhang XL, et al. Novel connexin40 missense mutations in patients with familial atrial fibrillation. Europace. 2010;12:1421–1427.
   PubMed Web of Science ®Google Scholar
• Gallagher MM, Obel OA, Camm JA. Tachycardia-induced atrial myopathy: an important mechanism in the pathophysiology of atrial fibrillation? J Cardiovasc Electrophysiol. 1997;8:1065–1074.
   PubMed Web of Science ®Google Scholar
• Patti G, Chello M, Candura D, et al. Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) study. Circulation. 2006;114:1455–1461.
   PubMed Web of Science ®Google Scholar
• Akoum N, Daccarett M, McGann C, et al. Atrial fibrosis helps select the appropriate patient and strategy in catheter ablation of atrial fibrillation: a DE-MRI guided approach. J Cardiovasc Electrophysiol. 2011;22:16–22.
   PubMed Web of Science ®Google Scholar
• Kirchhof P, Kahr PC, Kaese S, et al. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Circ Cardiovasc Genet. 2011;4:123–133.
   PubMed Web of Science ®Google Scholar
• Berry FB, Miura Y, Mihara K, et al. Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. J Biol Chem. 2001;276:25057–25065.
   PubMed Web of Science ®Google Scholar
• Beqqali A, Monshouwer-Kloots J, Monteiro R, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 2010;123:1141–1150.
   PubMed Web of Science ®Google Scholar
• Everett BM, Cook NR, Conen D, et al. Novel genetic markers improve measures of atrial fibrillation risk prediction. Eur Heart J. 2013;34:2243–2251.
   PubMed Web of Science ®Google Scholar
• Tada H, Shiffman D, Smith JG, et al. Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke. Stroke. 2014;45:2856–2862.
   PubMed Web of Science ®Google Scholar
• Darbar D, Motsinger AA, Ritchie MD, et al. Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm. 2007;4:743–749.
   PubMed Web of Science ®Google Scholar
• Parvez B, Vaglio J, Rowan S, et al. Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation. J Am Coll Cardiol. 2012;60:539–545.
   PubMed Web of Science ®Google Scholar
• Benjamin Shoemaker M, Muhammad R, Parvez B, et al. Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation. Heart Rhythm. 2013;10:394–400.
   PubMed Web of Science ®Google Scholar
• Husser D, Adams V, Piorkowski C, et al. Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation. J Am Coll Cardiol. 2010;55:747–753.
   PubMed Web of Science ®Google Scholar
• Parvez B, Shoemaker MB, Muhammad R, et al. Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion. Heart Rhythm. 2013;10:849–855.
   PubMed Web of Science ®Google Scholar
• Podd SJ, Freemantle N, Furniss SS, et al. First clinical trial of specific IKACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation. Europace. 2016;18:340–346.
   PubMed Web of Science ®Google Scholar
• Campbell CM, Campbell JD, Thompson CH, et al. Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillation. Circ Arrhythm Electrophysiol. 2013;6:960–966.
   PubMed Web of Science ®Google Scholar
• Haugaard MM, Hesselkilde EZ, Pehrson S, et al. Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses. Heart Rhythm. 2015;12:825–835.
   PubMed Web of Science ®Google Scholar
• Olivotto I, Girolami F, Ackerman MJ, et al. Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy. Mayo Clin Proc. 2008;83:630–638.
   PubMed Web of Science ®Google Scholar
• Bongini C, Ferrantini C, Girolami F, et al. Impact of genotype on the occurrence of atrial fibrillation in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2016;117:1151–1159.
   PubMed Web of Science ®Google Scholar
• Tsu LV, Lee S. Use of ranolazine in the prevention and treatment of postoperative atrial fibrillation in patients undergoing cardiac surgery. Ann Pharmacother. 2014;48:633–637.
   PubMed Web of Science ®Google Scholar
• Murdock DK, Kaliebe J, Larrain G. The use of ranolazine to facilitate electrical cardioversion in cardioversion-resistant patients: a case series. Pacing Clin Electrophysiol. 2012;35:302–307.
   PubMed Web of Science ®Google Scholar
• Reiffel JA, Camm AJ, Belardinelli L, et al. The HARMONY trial: combined ranolazine and dronedarone in the management of paroxysmal atrial fibrillation: mechanistic and therapeutic synergism. Circ Arrhythm Electrophysiol. 2015;8:1048–1056.
   PubMed Web of Science ®Google Scholar
• Faggioni M, Savio-Galimberti E, Venkataraman R, et al. Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts. Circ Arrhythm Electrophysiol. 2014;7:313–320.
   PubMed Web of Science ®Google Scholar
• Elvan A, Huang XD, Pressler ML, et al. Radiofrequency catheter ablation of the atria eliminates pacing-induced sustained atrial fibrillation and reduces connexin 43 in dogs. Circulation. 1997;96:1675–1685.
   PubMed Web of Science ®Google Scholar
• Guerra JM, Everett TH, Lee KW, et al. Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation. Circulation. 2006;114:110–118.
   PubMed Web of Science ®Google Scholar
• Shiroshita-Takeshita A, Sakabe M, Haugan K, et al. Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs. Circulation. 2007;115:310–318.
   PubMed Web of Science ®Google Scholar
• Dobrev D, Carlsson L, Nattel S. Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov. 2012;11:275–291.
   PubMed Web of Science ®Google Scholar
• Igarashi T, Finet JE, Takeuchi A, et al. Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation. Circulation. 2012;125:216–225.
   PubMed Web of Science ®Google Scholar
• Kumar K, Nearing BD, Carvas M, et al. Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. J Cardiovasc Electrophysiol. 2009;20:796–802.
   PubMed Web of Science ®Google Scholar
• Choi EK, Park JH, Lee JY, et al. Korean Atrial Fibrillation (AF) network: genetic variants for AF do not predict ablation success. J Am Heart Assoc. 2015;4:e002046.
   Web of Science ®Google Scholar
• Mohanty S, Hall AW, Mohanty P, et al. Novel association of polymorphic genetic variants with predictors of outcome of catheter ablation in atrial fibrillation: new directions from a prospective study (DECAF). J Interv Card Electrophysiol. 2015;12:1162–1168.
   Google Scholar
• Verheule S, Sato T, Everett T, et al. Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1. Circ Res. 2004;94:1458–1465.
   PubMed Web of Science ®Google Scholar
• Mabuchi M, Kataoka H, Miura Y, et al. Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. Biochem Biophys Res Commun. 2010;398:321–325.
   PubMed Web of Science ®Google Scholar
• Chinchilla A, Daimi H, Lozano-Velasco E, et al. PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis. Circ Cardiovasc Genet. 2011;4:269–279.
   PubMed Web of Science ®Google Scholar
• Lubitz SA, Lunetta KL, Lin H, et al. Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. J Am Coll Cardiol. 2014;63:1200–1210.
   PubMed Web of Science ®Google Scholar
• Lubitz SA, Sinner MF, Lunetta KL, et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation. 2010;122:976–984.
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang C, Yao Y, et al. Molecular basis of gene-gene interaction: cyclic cross-regulation of gene expression and post-GWAS gene-gene interaction involved in atrial fibrillation. PLoS Genet. 2015;11:e1005393.
   PubMed Web of Science ®Google Scholar