Current status of mechanical circulatory support for treatment of advanced end-stage heart failure: successes, shortcomings and needs

References

• Mozaffarian D, Benjamin EJ, Go AS, et al. American Heart Association Statistics Committee; Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics–2016 update: a report from the American Heart Association. Circulation. 2016;133:447–454.
   PubMed Web of Science ®Google Scholar
• Ahn SA, Jong P, Yusuf S, et al. Early versus delayed enalapril in patients with left ventricular systolic dysfunction: impact on morbidity and mortality 15 years after the SOLVD trial. J Am Coll Cardiol. 2006;47:1904–1905.
   PubMed Web of Science ®Google Scholar
• Otterstad JE, Ford I. The effect of carvedilol in patients with impaired left ventricular systolic function following an acute myocardial infarction. How do the treatment effects on total mortality and recurrent myocardial infarction in CAPRICORN compare with previous beta-blocker trials? Eur J Heart Fail. 2002;4:501–506.
   PubMed Web of Science ®Google Scholar
• Dargie HJ. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet. 2001;357:1385–1390.
   PubMed Web of Science ®Google Scholar
• Tang AS, Wells GA, Talajic M, et al. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med. 2010;363:2385–2395.
   PubMed Web of Science ®Google Scholar
• Levy WC, Mozaffarian D, Linker DT, et al.; REMATCH Investigators. Can the Seattle heart failure model be used to risk-stratify heart failure patients for potential left ventricular assist device therapy? J Heart Lung Transplant. 2009;28:231–236.
   PubMed Web of Science ®Google Scholar
• Rose EA, Gelijns AC, Moskowitz AJ, et al. for the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345:1435–1443.
   PubMed Web of Science ®Google Scholar
• Frazier OH, Rose EA, Oz MC, et al. HeartMate LVAS Investigators. Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation. J Thorac Cardiovasc Surg. 2001;122:1186–1195.
   PubMed Web of Science ®Google Scholar
• Slaughter MS, Rogers JG, Milano CA, et al.; HeartMate II Investigators. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241–2251.
   PubMed Web of Science ®Google Scholar
• Pagani FD, Miller LW, Russell SD, et al.; HeartMate II Investigators. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009;54:312–321.
   PubMed Web of Science ®Google Scholar
• Miller LW, Pagani FD, Russell SD, et al.; HeartMate II Clinical Investigators. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357:885–896.
   PubMed Web of Science ®Google Scholar
• Tsiouris A, Paone G, Nemeh HW, et al. Lessons learned from 150 continuous-flow left ventricular assist devices: a single institutional 7 year experience. ASAIO J. 2015;61:266–273.
   PubMed Web of Science ®Google Scholar
• Islam S, Cevik C, Madonna R, et al. Left ventricular assist devices and gastrointestinal bleeding: a narrative review of case reports and case series. Clin Cardiol. 2013;36:190–200.
   PubMed Web of Science ®Google Scholar
• Kormos RL, Teuteberg JJ, Pagani FD, et al.; HeartMate II Clinical Investigators. Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes. J Thorac Cardiovasc Surg. 2010;139:1316–1324.
   PubMed Web of Science ®Google Scholar
• Jorde UP, Uriel N, Nahumi N, et al. Prevalence, significance, and management of aortic insufficiency in continuous flow left ventricular assist device recipients. Circ Heart Fail. 2014;7:310–319.
   PubMed Web of Science ®Google Scholar
• Sharma V, Deo SV, Stulak JM, et al. Driveline infections in left ventricular assist devices: implications for destination therapy. Ann Thorac Surg. 2012;94:1381–1386.
   PubMed Web of Science ®Google Scholar
• Starling RC, Moazami N, Silvestry SC, et al. Unexpected abrupt increase in left ventricular assist device thrombosis. N Engl J Med. 2014;370:33–40.
   PubMed Web of Science ®Google Scholar
• Lazar RM, Shapiro PA, Jaski BE, et al. Neurological events during long-term mechanical circulatory support for heart failure: the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) experience. Circulation. 2004;109:2423–2427.
   PubMed Web of Science ®Google Scholar
• Cohn LH. Cardiac surgery in the adult. 4th ed. New York (NY): McGraw-Hill Medical; 2011.
   Google Scholar
• Goldstein BA, Thomas L, Zaroff JG, et al. Assessment of heart transplant waitlist time and pre- and post-transplant failure: a mixed methods approach. Epidemiology. 2016;27:469–476.
   PubMed Web of Science ®Google Scholar
• Kirklin JK, Naftel DC, Pagani FD, et al. Seventh INTERMACS annual report: 15,000 patients and counting. J Heart Lung Transplant. 2015;34:1495–1504.
   PubMed Web of Science ®Google Scholar
• Estep JD, Starling RC, Horstmanshof DA, et al.; ROADMAP Study Investigators. Risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients: results from the ROADMAP study. J Am Coll Cardiol. 2015;66:1747–1761.
   PubMed Web of Science ®Google Scholar
• Morgan JA, Park Y, Kherani AR, et al. Does bridging to transplantation with a left ventricular assist device adversely affect posttransplantation survival? A comparative analysis of mechanical versus inotropic support. J Thorac Cardiovasc Surg. 2003;126:1188–1190.
   PubMed Web of Science ®Google Scholar
• Frazier OH, Rose EA, McCarthy P, et al. Improved mortality and rehabilitation of transplant candidates treated with a long-term implantable left ventricular assist system. Ann Surg. 1995;222:327–336. discussion 336–338
   PubMed Web of Science ®Google Scholar
• Kamdar F, John R, Eckman P, et al. Postcardiac transplant survival in the current era in patients receiving continuous-flow left ventricular assist devices. J Thorac Cardiovasc Surg. 2013;145:575–581.
   PubMed Web of Science ®Google Scholar
• Okamoto F, Allen BS, Buckberg GD, et al. Reperfusion conditions: importance of ensuring gentle versus sudden reperfusion during relief of coronary occlusion. J Thorac Cardiovasc Surg. 1986;92(3 Pt 2):613–620.
   PubMed Web of Science ®Google Scholar
• James KB, McCarthy PM, Thomas JD, et al. Effect of the implantable left ventricular assist device on neuroendocrine activation in heart failure. Circulation. 1995;92(9 Suppl):II191–195.
   PubMed Web of Science ®Google Scholar
• Mann DL, Young JB. Basic mechanisms in congestive heart failure. Recognizing the role of proinflammatory cytokines. Chest. 1994;105:897–904.
   PubMed Web of Science ®Google Scholar
• Bryant D, Becker L, Richardson J, et al. Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation. 1998;97:1375–1381.
   PubMed Web of Science ®Google Scholar
• Li YY, Feng Y, McTiernan CF, et al. Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices. Circulation. 2001;104:1147–1152.
   PubMed Web of Science ®Google Scholar
• Dipla K, Mattiello JA, Jeevanandam V, et al. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation. 1998;97:2316–2322.
   PubMed Web of Science ®Google Scholar
• Ogletree-Hughes ML, Stull LB, Sweet WE, et al. Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart. Circulation. 2001;104:881–886.
   PubMed Web of Science ®Google Scholar
• Bruckner BA, Stetson SJ, Perez-Verdia A, et al. Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant. 2001;20:457–464.
   PubMed Web of Science ®Google Scholar
• Birks EJ, George RS, Hedger M, et al. Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study. Circulation. 2011;123:381–390.
   PubMed Web of Science ®Google Scholar
• Frazier OH, Baldwin AC, Demirozu ZT, et al. Ventricular reconditioning and pump explantation in patients supported by continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2015;34:766–772.
   PubMed Web of Science ®Google Scholar
• Dandel M, Weng Y, Siniawski H, et al. Prediction of cardiac stability after weaning from left ventricular assist devices in patients with idiopathic dilated cardiomyopathy. Circulation. 2008;118(14 Suppl):S94–105.
   PubMed Web of Science ®Google Scholar
• Strueber M, O’Driscoll G, Jansz P, et al.; HeartWare Ivestigators. Multicenter evaluation of an intrapericardial left ventricular assist system. J Am Coll Cardiol. 2011;57:1375–1382.
   PubMed Web of Science ®Google Scholar
• Centers for Medicare & Medicaid Services. National coverage determination (NCD) for ventricular assist devices (20.9.1). [cited 2016 Nov 11]. Available from: https://www.cms.gov/medicare-coverage-database/details/ncd-details.aspx?NCDId=360&ver=1
   Google Scholar
• Cruz VB, Steffen R, Hoercher K, et al. Outcomes of patients designated bridge to candidacy (BTC) at time of LVAD with and without psychosocial risks factors: implications for CMS coverage [abstract]. ISHLT 34th annual meeting. San Diego, CA; April 10–13, 2014; abstract 160. J Heart Lung Transplant. 2014;33(4Suppl):S64.
   Google Scholar
• Teuteberg JJ, Stewart GC, Jessup M, et al. Stevenson LW. Implant strategies change over time and impact outcomes: insights from the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). JACC Heart Fail. 2013;1:369–378.
   PubMed Web of Science ®Google Scholar
• Hasin T, Marmor Y, Kremers W, et al. Readmissions after implantation of axial flow left ventricular assist device. J Am Coll Cardiol. 2013;61:153–163.
   PubMed Web of Science ®Google Scholar
• Forest SJ, Bello R, Friedmann P, et al. Readmissions after ventricular assist device: etiologies, patterns, and days out of hospital. Ann Thorac Surg. 2013;95:1276–1281.
   PubMed Web of Science ®Google Scholar
• Smedira NG, Hoercher KJ, Lima B, et al. Unplanned hospital readmissions after HeartMate II implantation: frequency, risk factors, and impact on resource use and survival. JACC Heart Fail. 2013;1:31–39.
   PubMed Web of Science ®Google Scholar
• Akhter SA, Badami A, Murray M, et al. Hospital readmissions after continuous-flow left ventricular assist device implantation: incidence, causes, and cost analysis. Ann Thorac Surg. 2015;100:884–889.
   PubMed Web of Science ®Google Scholar
• Crow S, John R, Boyle A, et al. Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices. J Thorac Cardiovasc Surg. 2009;137:208–215.
   PubMed Web of Science ®Google Scholar
• Draper KV, Huang RJ, Gerson LB. GI bleeding in patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis. Gastrointest Endosc. 2014;80:435–446.e1.
   PubMed Web of Science ®Google Scholar
• Shrode CW, Draper KV, Huang RJ, et al. Significantly higher rates of gastrointestinal bleeding and thromboembolic events with left ventricular assist devices. Clin Gastroenterol Hepatol. 2014;12:1461–1467.
   PubMed Web of Science ®Google Scholar
• Aggarwal A, Pant R, Kumar S, et al. Incidence and management of gastrointestinal bleeding with continuous flow assist devices. Ann Thorac Surg. 2012;93:1534–1540.
   PubMed Web of Science ®Google Scholar
• Bartoli CR, Restle DJ, Zhang DM, et al. Pathologic von Willebrand factor degradation with a left ventricular assist device occurs via two distinct mechanisms: mechanical demolition and enzymatic cleavage. J Thorac Cardiovasc Surg. 2015;149:281–289.
   PubMed Web of Science ®Google Scholar
• Letsou GV, Shah N, Gregoric ID, et al. Gastrointestinal bleeding from arteriovenous malformations in patients supported by the Jarvik 2000 axial-flow left ventricular assist device. J Heart Lung Transplant. 2005;24:105–109.
   PubMed Web of Science ®Google Scholar
• Demirozu ZT, Radovancevic R, Hochman LF, et al. Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device. J Heart Lung Transplant. 2011;30:849–853.
   PubMed Web of Science ®Google Scholar
• Wever-Pinzon O, Selzman CH, Drakos SG, et al. Pulsatility and the risk of nonsurgical bleeding in patients supported with the continuous-flow left ventricular assist device HeartMate II. Circ Heart Fail. 2013;6:517–526.
   PubMed Web of Science ®Google Scholar
• Klovaite J, Gustafsson F, Mortensen SA, et al. Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II). J Am Coll Cardiol. 2009;53:2162–2167.
   PubMed Web of Science ®Google Scholar
• Crow S, Chen D, Milano C, et al. Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. Ann Thorac Surg. 2010;90:1263–1269; discussion 1269.
   PubMed Web of Science ®Google Scholar
• Lampert BC, Teuteberg JJ. Right ventricular failure after left ventricular assist devices. J Heart Lung Transplant. 2015;34:1123–1130.
   PubMed Web of Science ®Google Scholar
• Atluri P, Goldstone AB, Fairman AS, et al. Predicting right ventricular failure in the modern, continuous flow left ventricular assist device era. Ann Thorac Surg. 2013;96:857–863; discussion 863–864.
   PubMed Web of Science ®Google Scholar
• Hoffman D, Sisto D, Frater RW, et al. Left-to-right ventricular interaction with a noncontracting right ventricle. J Thorac Cardiovasc Surg. 1994;107:1496–1502.
   PubMed Web of Science ®Google Scholar
• Li KS, Santamore WP. Contribution of each wall to biventricular function. Cardiovasc Res. 1993;27:792–800.
   PubMed Web of Science ®Google Scholar
• Goldstein JA, Tweddell JS, Barzilai B, et al. Importance of left ventricular function and systolic ventricular interaction to right ventricular performance during acute right heart ischemia. J Am Coll Cardiol. 1992;19:704–711.
   PubMed Web of Science ®Google Scholar
• Takeda K, Naka Y, Yang JA, et al. Timing of temporary right ventricular assist device insertion for severe right heart failure after left ventricular assist device implantation. ASAIO J. 2013;59:564–569.
   PubMed Web of Science ®Google Scholar
• Morgan JA, Paone G, Nemeh HW, et al. Impact of continuous-flow left ventricular assist device support on right ventricular function. J Heart Lung Transplant. 2013;32:398–403.
   PubMed Web of Science ®Google Scholar
• MacGowan GA, Schueler S. Right heart failure after left ventricular assist device implantation: early and late. Curr Opin Cardiol. 2012;27:296–300.
   PubMed Web of Science ®Google Scholar
• Ochiai Y, McCarthy PM, Smedira NG, et al. Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation. 2002;106(12 Suppl 1):I198–202.
   PubMed Web of Science ®Google Scholar
• Matthews JC, Koelling TM, Pagani FD, et al. The right ventricular failure risk score: a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates. J Am Coll Cardiol. 2008;51:2163–2172.
   PubMed Web of Science ®Google Scholar
• Kirklin JK, Naftel DC, Kormos RL, et al. Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients. J Heart Lung Transplant. 2013;32:141–156.
   PubMed Web of Science ®Google Scholar
• Karimov JH, Sunagawa G, Horvath D, et al. Limitations to chronic right ventricular assist device support. Ann Thorac Surg. 2016;102:651–658.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick JR 3rd, Frederick JR, Hiesinger W, et al. Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device. J Thorac Cardiovasc Surg. 2009;137:971–977.
   PubMed Web of Science ®Google Scholar
• Morgan JA, John R, Lee BJ, et al. Is severe right ventricular failure in left ventricular assist device recipients a risk factor for unsuccessful bridging to transplant and post-transplant mortality. Ann Thorac Surg. 2004;77:859–863.
   PubMed Web of Science ®Google Scholar
• Cowger JA, Aaronson KD, Romano MA, et al. Consequences of aortic insufficiency during long-term axial continuous-flow left ventricular assist device support. J Heart Lung Transplant. 2014;33:1233–1240.
   PubMed Web of Science ®Google Scholar
• May-Newman K, Hillen B, Dembitsky W. Effect of left ventricular assist device outflow conduit anastomosis location on flow patterns in the native aorta. ASAIO J. 2006;52:132–139.
   PubMed Web of Science ®Google Scholar
• Tuzun E, Rutten M, Dat M, et al. Continuous-flow cardiac assistance: effects on aortic valve function in a mock loop. J Surg Res. 2011;171:443–447.
   PubMed Web of Science ®Google Scholar
• Rose AG, Park SJ, Bank AJ, et al. Partial aortic valve fusion induced by left ventricular assist device. Ann Thorac Surg. 2000;70:1270–1274.
   PubMed Web of Science ®Google Scholar
• Mudd JO, Cuda JD, Halushka M, et al. Fusion of aortic valve commissures in patients supported by a continuous axial flow left ventricular assist device. J Heart Lung Transplant. 2008;27:1269–1274.
   PubMed Web of Science ®Google Scholar
• Cowger J, Rao V, Massey T, et al. Comprehensive review and suggested strategies for the detection and management of aortic insufficiency in patients with a continuous-flow left ventricular assist device. J Heart Lung Transplant. 2015;34:149–157.
   PubMed Web of Science ®Google Scholar
• Grinstein J, Kruse E, Sayer G, et al. Accurate quantification methods for aortic insufficiency severity in patients with LVAD: role of diastolic flow acceleration and systolic-to-diastolic peak velocity ratio of outflow cannula. JACC Cardiovasc Imaging. 2016;9:641–651.
   PubMed Web of Science ®Google Scholar
• Aggarwal A, Raghuvir R, Eryazici P, et al. The development of aortic insufficiency in continuous-flow left ventricular assist device-supported patients. Ann Thorac Surg. 2013;95:493–498.
   PubMed Web of Science ®Google Scholar
• Pak SW, Uriel N, Takayama H, et al. Prevalence of de novo aortic insufficiency during long-term support with left ventricular assist devices. J Heart Lung Transplant. 2010;29:1172–1176.
   PubMed Web of Science ®Google Scholar
• Patil NP, Sabashnikov A, Mohite PN, et al. De novo aortic regurgitation after continuous-flow left ventricular assist device implantation. Ann Thorac Surg. 2014;98:850–857.
   PubMed Web of Science ®Google Scholar
• Holley CT, Fitzpatrick M, Roy SS, et al. Aortic insufficiency in continuous-flow left ventricular assist device support patients is common but does not impact long-term mortality. J Heart Lung Transplant. 2017;36:91–96.
   PubMed Web of Science ®Google Scholar
• Schaffer JM, Allen JG, Weiss ES, et al. Infectious complications after pulsatile-flow and continuous-flow left ventricular assist device implantation. J Heart Lung Transplant. 2011;30:164–174.
   PubMed Web of Science ®Google Scholar
• Topkara VK, Kondareddy S, Malik F, et al. Infectious complications in patients with left ventricular assist device: etiology and outcomes in the continuous-flow era. Ann Thorac Surg. 2010;90:1270–1277.
   PubMed Web of Science ®Google Scholar
• Gordon RJ, Quagliarello B, Lowy FD. Review. Ventricular assist device-related infections. The Lancet Infect Dis. 2006;6:426–437.
   PubMed Web of Science ®Google Scholar
• Hannan MM, Husain S, Mattner F, et al. International Society for Heart and Lung Transplantation. Working formulation for the standardization of definitions of infections in patients using ventricular assist devices. J Heart Lung Transplant. 2011;30:375–384.
   PubMed Web of Science ®Google Scholar
• Califano S, Pagani FD, Malani PN. Left ventricular assist device-associated infections. Infect Dis Clin North Am. 2012;26:77–87.
   PubMed Web of Science ®Google Scholar
• Koval CE, Thuita L, Moazami N, et al. Evolution and impact of drive-line infection in a large cohort of continuous-flow ventricular assist device recipients. J Heart Lung Transplant. 2014;33:1164–1172.
   PubMed Web of Science ®Google Scholar
• Cagliostro B, Levin AP, Fried J, et al. Continuous-flow left ventricular assist devices and usefulness of a standardized strategy to reduce drive-line infections. J Heart Lung Transplant. 2016;35:108–114.
   PubMed Web of Science ®Google Scholar
• Najjar SS, Slaughter MS, Pagani FD, et al.; HVAD Bridge to Transplant ADVANCE Trial Investigators. An analysis of pump thrombus events in patients in the HeartWare ADVANCE bridge to transplant and continued access protocol trial. J Heart Lung Transplant. 2014;33:23–34.
   PubMed Web of Science ®Google Scholar
• Upshaw JN, Kiernan MS, Morine KJ, et al. Incidence, management, and outcome of suspected continuous-flow left ventricular assist device thrombosis. ASAIO J. 2016;62:33–39.
   PubMed Web of Science ®Google Scholar
• Stulak JM, Davis ME, Haglund N, et al. Adverse events in contemporary continuous-flow left ventricular assist devices: a multi-institutional comparison shows significant differences. J Thorac Cardiovasc Surg. 2016;151:177–189.
   PubMed Web of Science ®Google Scholar
• Kirklin JK, Naftel DC, Kormos RL, et al. Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of pump thrombosis in the HeartMate II left ventricular assist device. J Heart Lung Transplant. 2014;33:12–22.
   PubMed Web of Science ®Google Scholar
• Shah P, Mehta VM, Cowger JA, et al. Diagnosis of hemolysis and device thrombosis with lactate dehydrogenase during left ventricular assist device support. J Heart Lung Transplant. 2014;33:102–104.
   PubMed Web of Science ®Google Scholar
• Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Pedimacs. Protocol 3.0 Archive. Appendix A - adverse event definitions. [cited 2016 Nov 11]. Available from: https://www.Uab.Edu/medicine/intermacs/protocol-3-0-archive-pedimacs1/appendices-pedimacs/appendix-a-pedimacs
   Google Scholar
• Cowger JA, Romano MA, Shah P, et al. Hemolysis: a harbinger of adverse outcome after left ventricular assist device implant. J Heart Lung Transplant. 2014;33:35–43.
   PubMed Web of Science ®Google Scholar
• Sylvia LM, Ordway L, Pham DT, et al. Bivalirudin for treatment of LVAD thrombosis: a case series. ASAIO J. 2014;60:744–747.
   PubMed Web of Science ®Google Scholar
• Badiye A, Hernandez GA, Chaparro S. Argatroban as novel therapy for suspected thrombosis in patients with continuous-flow left ventricle assist device and hemolysis. ASAIO J. 2014;60:361–365.
   PubMed Web of Science ®Google Scholar
• Tellor BR, Smith JR, Prasad SM, et al. The use of eptifibatide for suspected pump thrombus or thrombosis in patients with left ventricular assist devices. J Heart Lung Transplant. 2014;33:94–101.
   PubMed Web of Science ®Google Scholar
• Kiernan MS, Pham DT, DeNofrio D, et al. Management of HeartWare left ventricular assist device thrombosis using intracavitary thrombolytics. J Thorac Cardiovasc Surg. 2011;142:712–714.
   PubMed Web of Science ®Google Scholar
• Ota T, Yerebakan H, Akashi H, et al. Continuous-flow left ventricular assist device exchange: clinical outcomes. J Heart Lung Transplant. 2014;33:65–70.
   PubMed Web of Science ®Google Scholar
• Oezpeker C, Zittermann A, Ensminger S, et al. Systemic thrombolysis versus device exchange for pump thrombosis management: a single-center experience. ASAIO J. 2016;62:246–251.
   PubMed Web of Science ®Google Scholar
• Raffa GM, D’Ancona G, Sciacca S, et al. Systemic or endoventricular thrombolysis to treat HeartWare left ventricular assist device thrombosis: a clinical dilenma. Artif Organs. 2015;39:526–529.
   PubMed Web of Science ®Google Scholar
• Patlolla V, Mogulla V, DeNofrio D, et al. Outcomes in patients with symptomatic cerebrovascular disease undergoing heart transplantation. J Am Coll Cardiol. 2011;58:1036–1041.
   PubMed Web of Science ®Google Scholar
• Yuan N, Arnaoutakis GJ, George TJ, et al. The spectrum of complications following left ventricular assist device placement. J Card Surg. 2012;27:630–638.
   PubMed Web of Science ®Google Scholar
• Willey JZ, Demmer RT, Takayama H, et al. Cerebrovascular disease in the era of left ventricular assist devices with continuous flow: risk factors, diagnosis, and treatment. J Heart Lung Transplant. 2014;33:878–887.
   PubMed Web of Science ®Google Scholar
• Morgan JA, Brewer RJ, Nemeh HW, et al. Stroke while on long-term left ventricular assist device support: incidence, outcome, and predictors. ASAIO J. 2014;60:284–289.
   PubMed Web of Science ®Google Scholar
• Harvey L, Holley C, Roy SS, et al. Stroke after left ventricular assist device implantation: outcomes in the continuous-flow era. Ann Thorac Surg. 2015;100:535–541.
   PubMed Web of Science ®Google Scholar
• Feldman D, Pamboukian SV, Teuteberg JJ, et al.; International Society for Heart and Lung Transplantation. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant. 2013;32:157–187.
   PubMed Web of Science ®Google Scholar
• Boyle AJ, Russell SD, Teuteberg JJ, et al. Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation. J Heart Lung Transplant. 2009;28:881–887.
   PubMed Web of Science ®Google Scholar
• Nassif ME, LaRue SJ, Raymer DS, et al. Relationship between anticoagulation intensity and thrombotic or bleeding outcomes among outpatients with continuous-flow left ventricular assist devices. Circ Heart Fail. 2016 May;9(5):pii: e002680.
   PubMed Web of Science ®Google Scholar
• Farrar DJ, Bourque K, Dague CP, et al. Design features, developmental status, and experimental results with the HeartMate III centrifugal left ventricular assist system with a magnetically levitated rotor. ASAIO J. 2007;53:310–315.
   PubMed Web of Science ®Google Scholar
• Netuka I, Sood P, Pya Y, et al. Fully magnetically levitated left ventricular assist system for treating advanced HF: a multicenter study. J Am Coll Cardiol. 2015;66:2579–2589.
   PubMed Web of Science ®Google Scholar
• Heatley G, Sood P, Goldstein D, et al. Clinical trial design and rationale of the Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy with HeartMate 3 (MOMENTUM 3) investigational device exemption clinical study protocol. J Heart Lung Transplant. 2016;35:528–536.
   PubMed Web of Science ®Google Scholar
• ClinicalTrials.gov. MOMENTUM 3 IDE clinical study protocol (HM3™). ClinicalTrials.gov identifier: NCT02224755. [cited 2016 Nov 11]. Available from: https://clinicaltrials.gov/ct2/show/study/nct02224755
   Google Scholar
• HeartWare (press release). HeartWare International Announces First Human Implants Of The MVAD® System In CE Mark International Clinical Trial. [cited 2016 Nov 11]. Available from: http://ir.Heartware.Com/phoenix.Zhtml?C=187755&p=irol-newsarticle&id=2068959
   Google Scholar
• Cheung A, Chorpenning K, Tamez D, et al. Design concepts and preclinical results of a miniaturized HeartWare platform: the MVAD system. Innovations (Phila.). 2015;10:151–156.
   PubMedGoogle Scholar
• McGee E Jr., Chorpenning K, Brown MC, et al. In vivo evaluation of the HeartWare MVAD pump. J Heart Lung Transplant. 2014;33:366–371.
   PubMed Web of Science ®Google Scholar
• Medical Device and Diagnostic Industry website. Longer Timeline, Little Clarity for HeartWare’s MVAD. [cited 2016 Nov 11]. Available from: http://www.Mddionline.Com/article/longer-timeline-little-clarity-heartware-mvad-01-12-16
   Google Scholar
• ReliantHeart. The aVAD™. [cited 2016 Nov 11]. Available from: http://www.reliantheart.com/
   Google Scholar
• Chiu WC, Girdhar G, Xenos M, et al. Thromboresistance comparison of the HeartMate II ventricular assist device with the device thrombogenicity emulation-optimized HeartAssist 5 VAD. J Biomech Eng. 2014;136:021014.
   PubMed Web of Science ®Google Scholar
• Connellan M, Iyer A, Robson D, et al. The HeartWare transvalvular miniature ventricular assist device used for right ventricular support [abstract]. ISHLT 33rd annual meeting & scientific sessions. Montreal, Canada: april 24–27, 2013; abstract 387. J Heart Lung Transplant. 2013;32(Suppl):S149. [[cited 2016 Nov 11]. Available from: http://www.Sciencedirect.Com/science/article/pii/s1053249813003525
   Google Scholar
• Meyns B, Ector J, Rega F, et al. First human use of partial left ventricular heart support with the CircuLite synergy micro-pump as a bridge to cardiac transplantation. Eur Heart J. 2008;29:2582.
   PubMed Web of Science ®Google Scholar
• Meyns B, Klotz S, Simon A, et al. Proof of concept: hemodynamic response to long-term partial ventricular support with the Synergy Pocket Micro-pump. J Am Coll Cardiol. 2009;54:79–86.
   PubMed Web of Science ®Google Scholar
• Barbone A, Pini D, Rega F, et al. discussion 212. Circulatory support in elderly chronic heart failure patients using the CircuLite® Synergy® system. Eur J Cardiothorac Surg. 2013;44:207–212.
   PubMed Web of Science ®Google Scholar
• Fukamachi K, Horvath DJ, Byram N, et al. Advanced ventricular assist device with pulse augmentation and automatic regurgitant-flow shut-off. J Heart Lung Transplant. 2016;35:1519–1521.
   PubMed Web of Science ®Google Scholar
• Slaughter MS, Rogers J. Editorial commentary: determining the cost-effectiveness of mechanical circulatory support. J Heart Lung Transplant. 2012;31:448–449.
   PubMed Web of Science ®Google Scholar
• Rogers JG, Bostic RR, Tong KB, et al. Cost-effectiveness analysis of continuous-flow left ventricular assist device as destination therapy. Circ Heart Fail. 2012;5:10–16.
   PubMed Web of Science ®Google Scholar
• Long EF, Swaine GW, Mangi AA. Comparative survival and cost-effectiveness of advanced therapies for end-stage heart failure. Circ Heart Fail. 2014;7:470–478.
   PubMed Web of Science ®Google Scholar
• Baras Shreibati J, Goldhaber-Fiebert JD, Banerjee D, et al. Cost-effectiveness of left ventricular assist device in ambulatory patients with advanced heart failure. JACC Heart Fail. 2017;5:110–119.
   PubMed Web of Science ®Google Scholar
• Seco M, Zhao DF, Byrom MJ, et al. Long-term prognosis and cost-effectiveness of left ventricular assist device as bridge to transplantation: a systemic review. Int J Cardiol. 2017;235:22–32.
   PubMedGoogle Scholar
• Lund LH, Edwards LB, Kucheryavaya AY, et al.; International Society of H. The registry of the International Society for Heart and Lung Transplantation: thirty-first official adult heart transplant report–2014; Focus theme: retransplantation. J Heart Lung Transplant. 2014;33:996–1008.
   PubMed Web of Science ®Google Scholar
• Baldwin JT, Mann DL. NHLBI’s program for VAD therapy for moderately advanced heart failure: the REVIVE-IT pilot trial. J Card Fail. 2010;16:855–858.
   PubMed Web of Science ®Google Scholar
• ClinicalTrials.gov. Registry Evaluation of Vital Information for VADs in Ambulatory Life (REVIVAL). ClinicalTrials.gov Identifier: NCT01369407. [cited 2016 Nov 11]. Available from: https://www.Clinicaltrials.Gov/ct2/show/study/nct01369407
   Google Scholar
• Miller LW, Guglin M. Patient selection for ventricular assist devices: a moving target. J Am Coll Cardiol. 2013;61:1209–1221.
   PubMed Web of Science ®Google Scholar
• Moazami N, Dembitsky WP, Adamson R, et al. Does pulsatility matter in the era of continuous-flow blood pumps? J Heart Lung Transplant. 2015;34:999–1004.
   PubMed Web of Science ®Google Scholar