Advanced search
Publication Cover
Expert Review of Cardiovascular Therapy Volume 15, 2017 - Issue 5
Submit an article Journal homepage
1,279
Views
14
CrossRef citations to date
0
Altmetric
Editorial

Using personalized computer models to custom-tailor ablation procedures for atrial fibrillation patients: are we there yet?

Patrick M. BoyleInstitute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USAView further author information
,
Sohail ZahidInstitute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USAView further author information
&
Natalia A. TrayanovaInstitute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USACorrespondence[email protected]
View further author information
Pages 339-341 | Received 31 Jan 2017, Accepted 05 Apr 2017, Published online: 17 Apr 2017

References

  • Andrade J, Khairy P, Dobrev D, et al. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res. 2014;114:1453–1468.
  • Verma A, Jiang CY, Betts TR, et al. Approaches to catheter ablation for persistent atrial fibrillation. N Engl J Med. 2015;372:1812–1822.
  • Oakes RS, Badger TJ, Kholmovski EG, et al. Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Circulation. 2009;119:1758–1767.
  • Tanaka K, Zlochiver S, Vikstrom KL, et al. Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res. 2007;101:839–847.
  • Shi Y, Lawford P, Hose R. Review of zero-D and 1-D models of blood flow in the cardiovascular system. Biomed Eng Online. 2011;10:33.
  • Anselmino M, Scarsoglio S, Saglietto A, et al. Transient cerebral hypoperfusion and hypertensive events during atrial fibrillation: a plausible mechanism for cognitive impairment. Sci Rep. 2016;6:28635.
  • Crozier A, Augustin CM, Neic A, et al. Image-based personalization of cardiac anatomy for coupled electromechanical modeling. Ann Biomed Eng. 2016;44:58–70.
  • Boyle PM, Williams JC, Ambrosi CM, et al. A comprehensive multiscale framework for simulating optogenetics in the heart. Nat Commun. 2013;4:2370.
  • Vadakkumpadan F, Rantner LJ, Tice B, et al. Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies. J Electrocardiol. 2009;42(157):e151–110.
  • Boyle PM, Zahid S, Trayanova NA. Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia. Europace. 2016;18:iv136–iv145.
  • Parmar BR, Jarrett TR, Burgon NS, et al. Comparison of left atrial area marked ablated in electroanatomical maps with scar in MRI. J Cardiovasc Electrophysiol. 2014;25:457–463.
  • Zahid S, Cochet H, Boyle PM, et al. Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern. Cardiovasc Res. 2016;110:443–454.
  • Zahid S, Whyte KN, Schwarz EL, et al. Feasibility of using patient-specific models and the “minimum cut” algorithm to predict optimal ablation targets for left atrial flutter. Heart Rhythm. 2016;13:1687–1698.
  • McDowell KS, Vadakkumpadan F, Blake R, et al. Methodology for patient-specific modeling of atrial fibrosis as a substrate for atrial fibrillation. J Electrocardiol. 2012;45:640–645.
  • McDowell KS, Vadakkumpadan F, Blake R, et al. Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. Biophys J. 2013;104:2764–2773.
  • McDowell KS, Zahid S, Vadakkumpadan F, et al. Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling. Plos One. 2015;10:e0117110.
  • Bayer JD, Roney CH, Pashaei A, et al. Novel radiofrequency ablation strategies for terminating atrial fibrillation in the left atrium: a simulation study. Front Physiol. 2016;7:108.
  • Roney CH, Bayer JD, Zahid S, et al. Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms. Europace. 2016;18:iv146–iv155.
  • Khurram IM, Beinart R, Zipunnikov V, et al. Magnetic resonance image intensity ratio, a normalized measure to enable interpatient comparability of left atrial fibrosis. Heart Rhythm. 2014;11:85–92.
  • Hansen BJ, Zhao J, Csepe TA, et al. Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts. Eur Heart J. 2015;36:2390–2401.
  • Bayer JD, Blake RC, Plank G, et al. A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models. Ann Biomed Eng. 2012;40:2243–2254.
  • Pashakhanloo F, Herzka DA, Ashikaga H, et al. Myofiber architecture of the human atria as revealed by submillimeter diffusion tensor imaging. Circ Arrhythm Electrophysiol. 2016;9:e004133.
  • Ashikaga H, Arevalo H, Vadakkumpadan F, et al. Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia. Heart Rhythm. 2013;10:1109–1116.
  • Boyle PM, Zahid S, Schwarz E, et al. Emergent mechanisms of AF sustenance after failed reentrant driver (RD) ablation: insights from MRI-based personalized atrial models. Heart Rhythm. 2016;13:S405–406.
  • Bruegmann T, Boyle PM, Vogt CC, et al. Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations. J Clin Invest. 2016;126:3894–3904.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.