Fractional flow reserve in 2017: current data and everyday practice

References

• Central Statistics Office: Statistical Yearbook of Ireland. 2015. Available from:  http://www.cso.ie/en/releasesandpublications/ep/p-syi/statisticalyearbookofireland2015/
   Google Scholar
• British Heart Foundation Statistics Database. Mortality. [cited 2008 Jan 20]. Available from: http://www.heartstats.org/temp/2008.Chaptersp1.pdf
   Google Scholar
• Tonino PA, Fearon WF, De Bruyne B, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol. 2010 Jun 22;55(25):2816–2821.
   PubMed Web of Science ®Google Scholar
• Zir LM, Miller SW, Dinsmore RE, et al. Interobserver variability in coronary angiography. Circulation. 1976 Apr;53(4):627–632.
   PubMed Web of Science ®Google Scholar
• Beauman GJ, Vogel RA. Accuracy of individual and panel visual interpretations of coronary arteriograms: implications for clinical decisions. J Am Coll Cardiol. 1990;16:108–113.
   PubMed Web of Science ®Google Scholar
• Shaw LJ, Berman DS, Maron DJ, et al.; COURAGE Investigators. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischaemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation. 2008;117:1283–1291.
   PubMed Web of Science ®Google Scholar
• Davies RF, Goldberg AD, Forman S, et al. Asymptomatic Cardiac Ischaemia Pilot (ACIP) study two-year follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularization. Circulation. 1997;95:2037–2043.
   PubMed Web of Science ®Google Scholar
• Erne P, Schoenenberger AW, Burckhardt D, et al. Effects of percutaneous coronary interventions in silent ischaemia after myocardial infarction: the SWISSI II randomized controlled trial. JAMA. 2007;297:1985–1991.
   PubMed Web of Science ®Google Scholar
• Boden WE, O’Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007 Apr 12;356(15):1503–1516. Epub 2007 Mar 26.
   PubMed Web of Science ®Google Scholar
• Pijls NH, Van Gelder B, Van d V, et al. Fractional flow reserve. A useful index to evaluate the influence of an epicardial coronary stenosis on myocardial blood flow. Circulation. 1995;92:3183–3193.
   PubMed Web of Science ®Google Scholar
• Barton M, Grüntzig J, Husmann M, et al. Balloon angioplasty – the legacy of Andreas Grüntzig, M.D. (1939–1985). Front Cardiovasc Med. 2014;1:15.
   PubMedGoogle Scholar
• Beller GA, Zaret BL. Contributions of nuclear cardiology to diagnosis and prognosis of patients with coronary artery disease. Circulation. 2000;101:1465–1478.
   PubMed Web of Science ®Google Scholar
• Shaw LJ, Iskandrian AE. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol. 2004;11:171–185.
   PubMed Web of Science ®Google Scholar
• Layland J, Carrick D, Lee M, et al. Adenosine. JACC Cardiovasc Interv. 2014 Jun;7(6):581–591.
   PubMed Web of Science ®Google Scholar
• Lim WH, Koo BK, Nam CW, et al. Variability of fractional flow reserve according to the methods of hyperemia induction. Catheter Cardiovasc Interv. 2015 May;85(6):970–976.
   PubMed Web of Science ®Google Scholar
• Schlundt C, Bietau C, Klinghammer L, et al. Comparison of intracoronary versus intravenous administration of adenosine for measurement of coronary fractional flow reserve. Circulation. 2015;8:e001781.
   PubMed Web of Science ®Google Scholar
• Adjedj J, Toth GG, Johnson NP, et al. Intracoronary adenosine: dose-response relationship with hyperemia. JACC Cardiovasc Interv. 2015 Sep;8(11):1422–1430.
   PubMed Web of Science ®Google Scholar
• Kern MJ, Lerman A, Bech JW, et al. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation. 2006;114:1321–1341.
   PubMed Web of Science ®Google Scholar
• Cerqueira MD. The future of pharmacologic stress: selective a2a adenosine receptor agonists. Am J Cardiol. 2004;94(2):33–40.
   Web of Science ®Google Scholar
• Nair PK, Marroquin OC, Mulukutla SR, et al. Clinical utility of regadenoson for assessing fractional flow reserve. JACC Cardiovasc Interv. 2011 Oct;4(10):1085–1092.
   PubMed Web of Science ®Google Scholar
• Prasad A, Zareh M, Doherty R, et al. Use of regadenoson for measurement of fractional flow reserve. Catheter Cardiovasc Interv. 2014 Feb 15;83(3):369–374.
   PubMed Web of Science ®Google Scholar
• Guzman SV. Cardiac effects of intracoronary arterial injections of various roentgenographic contrast media. AM Heart J. 1959 Oct;58(4):597–607.
   PubMed Web of Science ®Google Scholar
• Johnson NP, Jeremias A, Zimmermann FM, et al. Contrast hyperemia for FFR. JACC Cardiovasc Interv. 2016 Apr 25;9(8):757–767.
   PubMed Web of Science ®Google Scholar
• Klocke FJ. Measurements of coronary blood flow and degree of stenosis: current clinical implications and continuing uncertainties. J Am Coll Cardiol. 1983;1:31–41.
   PubMed Web of Science ®Google Scholar
• Pyxaras SA, Tu S, Barbato E, et al. Quantitative Angiography and Optical Coherence Tomography for the Functional Assessment of Nonobstructive Coronary Stenoses: Comparison With Fractional Flow Reserve. Am Heart J. 2013;166(6):1010-1018.e1. Available from: https://www.ncbi.nlm.nih.gov/labs/articles/24268215/
   Google Scholar
• Morton J. Kern coronary physiology revisited. Circulation. 2000;101:1344–1351.
   PubMed Web of Science ®Google Scholar
• Fearon WF, Balsam LB, Farouque HM, et al. Novel index for invasively assessing the coronary microcirculation. Circulation. 2003;107:3129–3132.
   PubMed Web of Science ®Google Scholar
• Layland J, MacIsaac AI, Burns AT, et al. When collateral supply is accounted for epicardial stenosis does not increase microvascular resistance. Circ Cardiovasc Interv. 2012;5(1):97–102.
   PubMed Web of Science ®Google Scholar
• Yong AS, Layland J, Fearon WF, et al. Calculation of the index of microcirculatory resistance without coronary wedge pressure measurement in the presence of epicardial stenosis. JACC Cardiovasc Interv. 2013;6(1):53–58.
   PubMed Web of Science ®Google Scholar
• Pijls NH, van Schaardenburgh P, Manoharan G, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. J Am Coll Cardiol. 2007 May 29;49(21):2105–2111.
   PubMed Web of Science ®Google Scholar
• Zimmermann FM, Ferrara A, Johnson NP, et al. Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial. Eur Heart J. 2015 Dec 1;36(45):3182–3188.
   PubMed Web of Science ®Google Scholar
• Tonino PAL, De Bruyne B, Pijls NHJ, et al. for the FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009 Jan 15;360(3):213–224.
   PubMed Web of Science ®Google Scholar
• De Bruyne B, Pijls NHJ, Kalesan B, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367(11):991–1001.
   PubMed Web of Science ®Google Scholar
• Zimmermann FM, De Bruyne B, Pijls NHJ, et al. Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 trial: a comparison of fractional flow reserve-guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease. Am Heart J. 2015 Oct;170(4):619–626.e2.
   PubMed Web of Science ®Google Scholar
• Yeung AC, Leon MB, Jain A, et al. Clinical evaluation of the resolute zotarolimus-eluting coronary stent system in the treatment of de novo lesions in native coronary arteries: the RESOLUTE US clinical trial. J Am Coll Cardiol. 2011;57:1778–1783.
   PubMed Web of Science ®Google Scholar
• Novara M, D’Ascenzo F, Gonella A, et al. Changing of SYNTAX score performing fractional flow reserve in multivessel coronary artery disease. J Cardiovasc Med (Hagerstown). 2012 Jun;13(6):368–375.
   PubMed Web of Science ®Google Scholar
• Smits PC, Abdel-Wahab M, Neumann FJ, et al. Fractional flow reserve–guided multivessel angioplasty in myocardial infarction. N Engl J Med. 2017 Mar 30;376:1234–1244.
   PubMed Web of Science ®Google Scholar
• Engstrøm T, Kelbæk H, Helqvist S, et al. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3—PRIMULTI): an open-label, randomised controlled trial. Lancet. 9994;386:665–671.
   Google Scholar
• Baptista S. POST-IT (Portuguese Study on The Evaluation of FFR Guided Treatment of Coronary Disease) registry. Presented at Congress of the European Association of Percutaneous Cardiovascular Interventions; 2014 May 23; Paris, France.
   Google Scholar
• Van Belle E, Rioufol G, Pouillot C, et al.; Investigators of the Registre Français de la FFR–R3F. Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry. Circulation. 2014;129:173–185.
   PubMed Web of Science ®Google Scholar
• De Backer O, Biasco L, Lønborg J, et al. Long-term outcome of FFR-guided PCI for stable coronary artery disease in daily clinical practice: a propensity score-matched landmark analysis. EuroIntervention. 2016 Feb;11(11):e1257–e1266.
   PubMed Web of Science ®Google Scholar
• Zhang D, Lv S, Song X, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention: a meta-analysis. Heart. 2015 Mar;101(6):455–462.
   PubMed Web of Science ®Google Scholar
• Johnson NP, Tóth GG, Lai D, et al. Prognostic value of fractional flow reserve. J Am Coll Cardiol. 2014 Oct;64(16):1641–1654.
   PubMed Web of Science ®Google Scholar
• Kang S-J, Ahn J-M, Song H, et al. Usefulness of minimal luminal coronary area determined by intravascular ultrasound to predict functional significance in stable and unstable angina pectoris. Am J Cardiol. 2012;109(7):947–953.
   PubMed Web of Science ®Google Scholar
• Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation. 2011;124:e574–e651.
   Google Scholar
• Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease. Circulation. 2012;126:e354–e471.
   PubMed Web of Science ®Google Scholar
• Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease. Circulation. 2014;130:1749–1767.
   PubMed Web of Science ®Google Scholar
• Lotfi A, Jeremias A, Fearon WF, et al.; Society of Cardiovascular Angiography and Interventions. Expert consensus statement on the use of fractional flow reserve, intravascular ultrasound, and optical coherence tomography: a consensus statement of the Society of Cardiovascular Angiography and Interventions. Catheter Cardiovasc Interv. 2014 Mar 1;83(4):509–518.
   PubMed Web of Science ®Google Scholar
• Windecker S, Kolh P, Alfonso F, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2014;35(37):2541–2619.
   PubMed Web of Science ®Google Scholar
• Opsens Medical. Data on File. 2Chambers, Jeff. Electric or Optical Fibers Based Pressure Measurements. Presention sponsored by Boston Scientific at 19th Tremblant Interventional Cardiology Meeting; 2016 Feb 1st 2017; Quebec, Canada.
   Google Scholar
• Menon M, Jaffe W, Webster M; for the ACCESS-NZ Investigators. Poster: FFR measurement using a new ultra-thin monorail catheter based system EuroPCR 2013; 2013 May 21–24; Paris, France.
   Google Scholar
• Fearon WF, Bornschein B, Tonino PA, et al.; Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) Study Investigators. Economic evaluation of fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease. Circulation. 2010 Dec 14;122(24):2545–2550. Epub 2010 Nov 29.
   PubMed Web of Science ®Google Scholar
• Marzilli M, Merz CN, Boden WE, et al. Obstructive coronary atherosclerosis and ischemic heart disease: an elusive link! J Am Coll Cardiol. 2012 Sep 11;60(11):951–956.
   PubMed Web of Science ®Google Scholar
• Filippo Crea PG, Camici CN, Merz B. Coronary microvascular dysfunction: an update. Eur Heart J May. 2014;35(17):1101–1111.
   PubMed Web of Science ®Google Scholar
• van de Hoef TP, van Lavieren MA, Damman P, et al. Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity. Circ Cardiovasc Interv. 2014;7:301–311.
   PubMed Web of Science ®Google Scholar
• Johnson, et al. The distal evaluation of functional performance with intravascular sensors to assess the narrowing effect—combined pressure and Doppler FLOW Velocity Measurements (DEFINE-FLOW). Available from: https://clinicaltrials.gov/ct2/show/NCT02328820.
   Google Scholar
• Arbab-Zadeh A. Fractional flow reserve–guided percutaneous coronary intervention is not a valid concept. Circulation. 2014;129:1871–1878.
   PubMed Web of Science ®Google Scholar
• Rioufol G, Mewton N, Rabilloud M, et al. The FUnctional Testing Underlying Coronary REvascularization (FUTURE) Study: a “Real World” comparison of fractional flow reserve-guided management versus conventional management in multi vessel coronary artery disease patients. Paper presented at: American Heart Association Scientific Sessions 2016; 2016 Nov 12–16; New Orleans, LA.
   Google Scholar
• Pijls NHJ, De Bruyne B, Bech GJW, et al. Coronary pressure measurement to assess the hemodynamic significance of serial stenoses within one coronary artery. Circulation. 2000;102:2371–2377. originally published November 7, 2000.
   PubMed Web of Science ®Google Scholar
• Kushner FG, Hand M, Smith SC Jr, et al. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (Updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2009;54(23):2205–2241.
   PubMed Web of Science ®Google Scholar
• Silber S, Albertsson P, Aviles FF, et al. Guidelines for percutaneous coronary interventions. Eur Heart J. 2005;26(8):804–847.
   PubMed Web of Science ®Google Scholar
• Eagle KA, Guyton RA, Davidoff R, et al. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery summary article: a Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2004;110:1168–1176.
   PubMedGoogle Scholar
• Chaitman BR, Fisher LD, Bourassa MG, et al. Effect of coronary bypass surgery on survival patterns in subsets of patients with left main coronary artery disease. Report of the Collaborative Study in Coronary Artery Surgery (CASS). Am J Cardiol. 1981;48:765–777. Prospective randomised study of coronary artery bypass surgery in stable angina pectoris. European Coronary Surgery Study Group, Lancet, 1980;316(8193):491–95.)
   PubMed Web of Science ®Google Scholar
• Hamilos M, Muller O, Cuisset T, et al. Long-term clinical outcome after fractional flow reserve-guided treatment in patients with angiographically equivocal left main coronary artery stenosis. Circulation. 2009;120:1505–1512.
   PubMed Web of Science ®Google Scholar
• Aqel R, Zoghbi GJ, Hage F, et al. Hemodynamic evaluation of coronary artery bypass graft lesions using fractional flow reserve. Catheter Cardiovasc Interv. 2008 Oct 1;72(4):479–485.
   PubMed Web of Science ®Google Scholar
• Picchi A, Leone AM, Zilio F, et al. Outcome of coronary lesions with deferred revascularization due to negative fractional flow reserve in subjects with acute coronary syndrome. Int J Cardiol. 2017;230:335–338.
   PubMed Web of Science ®Google Scholar
• Abdullah A, Hamra M, McKevitt K, et al. 50 Clinical and economic outcomes of fractional flow reserve guided PCI in contemporary practice. Heart. 2015;101:A26–A27.
   Web of Science ®Google Scholar
• Sen S, Escaned J, Malik IS, et al. Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol. 2012 Apr 10;59(15):1392–1402.
   PubMed Web of Science ®Google Scholar
• Götberg M, Christiansen EH, Gudmundsdottir IJ, et al.; for the iFR-SWEDEHEART Investigators. Instantaneous wave-free ratio versus fractional flow reserve to guide PCI. N Engl J Med. 2017.
   PubMed Web of Science ®Google Scholar
• Davies JE, Sen S, Dehbi HM, et al.; for the DEFINE-FLAIR Investigators. Use of the instantaneous wave-free ratio or fractional flow reserve in PCI. N Engl J Med. 2017 Mar 18.
   Web of Science ®Google Scholar
• Koo BK, Erglis A, Doh JH, et al. Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter discover-flow (diagnosis of ischemia-causing stenoses obtained via noninvasive fractional flow reserve) study. J Am Coll Cardiol. 2011;58:1989–1997.
   PubMed Web of Science ®Google Scholar
• Min JK, Leipsic J, Pencina MJ, et al. Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA. 2012;308:1237–1245.
   PubMed Web of Science ®Google Scholar
• Nørgaard BL, Leipsic J, Gaur S, et al. NXT trial study group Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (analysis of coronary blood flow using CT angiography: next steps). J Am Coll Cardiol. 2014;63:1145–1155.
   PubMed Web of Science ®Google Scholar
• Renker M, Schoepf UJ, Wang R, et al. Comparison of diagnostic value of a novel noninvasive coronary computed tomography angiography method versus standard coronary angiography for assessing fractional flow reserve. Am J Cardiol. 2014;114:1303–1308.
   PubMed Web of Science ®Google Scholar
• Baumann S, Wang R, Schoepf UJ, et al. Coronary CT angiography-derived fractional flow reserve correlated with invasive fractional flow reserve measurements – initial experience with a novel physician-driven algorithm. Eur Radiol. 2015;25:1201–1207.
   PubMed Web of Science ®Google Scholar
• Wang R, Renker M, Schoepf UJ, et al. Diagnostic value of quantitative stenosis predictors with coronary CT angiography compared to invasive fractional flow reserve. Eur J Radiol. 2015;84:1509–1515.
   PubMed Web of Science ®Google Scholar
• Li SJ, Ge Z, Kan J, et al. Cutoff value and long-term prediction of clinical events by FFR measured immediately after implantation of a drug-eluting stent in patients with coronary artery disease. JACC Cardiovasc Interv. 2017 Apr. In Press. DOI:10.1016/j.jcin.2017.02.012
   PubMedGoogle Scholar
• Tu S, Barbato E, Köszegi Z, et al. Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMI frame count: a fast computer model to quantify the functional significance of moderately obstructed coronary arteries. JACC Cardiovasc Interv. 2014 Jul;7(7):768–777.
   PubMed Web of Science ®Google Scholar