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Review

Irreversible electroporation for the treatment of cardiac arrhythmias

, , , , , & show all
Pages 349-360 | Received 15 Oct 2017, Accepted 27 Mar 2018, Published online: 09 Apr 2018

References

  • Wilkinson HA, Bryant GD, Orgain ES. The supraventricular tachycardias. Management by interruption of cardiac sympathetics. JAMA. 1961 Feb 25;175:672–676. PubMed PMID: 13785324; eng.
  • Gallagher JJ. Surgical treatment of arrhythmias: current status and future directions. Am J Cardiol. 1978 May 22;41(6):1035–1044. PubMed PMID: 352123; eng.
  • Garcia R, Arciniegas E. Recurrent atrial flutter. Treatment with a surgically induced atrioventricular block and ventricular pacing. Arch Intern Med. 1973 Nov;132(5):754–757. PubMed PMID: 4750228; eng.
  • Edmonds JH, Ellison RG, Crews TL. Surgically induced atrioventricular block as treatment for recurrent atrial tachycardia in Wolff-Parkinson-White syndrome. Circulation. 1969;39(5S1):I-105-I-111.
  • Harrison L, Gallagher JJ, Kasell J, et al. Cryosurgical ablation of the AV node-His bundle: a new method for producing AV block. Circulation. 1977;55(3):463–470.
  • Gallagher JJ, Svenson RH, Kasell JH, et al. Catheter technique for closed-chest ablation of the atrioventricular conduction system: a therapeutic alternative for the treatment of refractory supraventricular tachycardia. New England J Med. 1982;306(4):194–200.
  • Ward DE, Davies M. Transvenous high energy shock for ablating atrioventricular conduction in man. Observations on the histological effects. Heart. 1984;51(2):175–178.
  • Olgin JE, Scheinman MM. Comparison of high energy direct current and radiofrequency catheter ablation of the atrioventricular junction. J Am Coll Cardiol. 1993;21(3):557–564.
  • Calkins H, Leon AR, Deam AG, et al. Catheter ablation of atrial flutter using radiofrequency energy. Am J Cardiol. 1994;73(5):353–356.
  • Swartz J. A catheter-based curative approach to atrial fibrillation in humans. Circulation. 1994;90:I–335.
  • Haissaguerre M, Gencel L, Fischer B, et al. Successful catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 1994 Dec;5(12):1045–1052. PubMed PMID: 7697206; eng.
  • Gonska B, Brune S, Bethge K, et al. Radiofrequency catheter ablation in recurrent ventricular tachycardia. Eur Heart J. 1991;12(12):1257–1265.
  • Martin RC, McFarland K, Ellis S, et al. Irreversible electroporation in locally advanced pancreatic cancer: potential improved overall survival. Ann Surg Oncol. 2013;20(3):443–449.
  • Paiella S, Butturini G, Frigerio I, et al. Safety and feasibility of irreversible electroporation (IRE) in patients with locally advanced pancreatic cancer: results of a prospective study. Dig Surg. 2015;32(2):90–97.
  • Valerio M, Stricker PD, Ahmed HU, et al. Initial assessment of safety and clinical feasibility of irreversible electroporation in the focal treatment of prostate cancer. Prostate Cancer Prostatic Dis. 2014;17(4):343.
  • Scheffer HJ, Nielsen K, De Jong MC, et al. Irreversible electroporation for nonthermal tumor ablation in the clinical setting: a systematic review of safety and efficacy. J Vasc Interv Radiol. 2014;25(7):997–1011.
  • DeSimone CV, Kapa S, Asirvatham SJ. Electroporation: past and future of catheter ablation. Am Heart Assoc. 2014;7(4): 573–575.
  • Weaver JC, Chizmadzhev YA. Theory of electroporation: a review. Bioelectrochem Bioenerg. 1996;41:135–160. PubMed PMID: 10465736
  • Neumann E. Membrane electroporation and direct gene transfer. Bioelectrochem Bioenerg. 1992;28:247–267.
  • Barba FJ, Parniakov O, Pereira SA, et al. Current applications and new opportunities for the use of pulsed electric fields in food science and industry. Food Res Int. 2015;77:773–798.
  • Mali B, Jarm T, Snoj M, et al. Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis. Eur J Surg Oncol. 2013;39:4–16. PubMed PMID: 22980492.
  • Heller R, Heller LC. Gene electrotransfer clinical trials. Adv Genet. 2015;89:235–262. PubMed PMID: 25620013.
  • Teissie J, Golzio M, Rols MP. Mechanisms of cell membrane electropermeabilization: a minireview of our present (lack of ?) knowledge. Biochim Biophy Acta Gen Subjects. 2005;1724:270–280. PubMed PMID: 15951114.
  • Chen C, Smye SW, Robinson MP, et al. Membrane electroporation theories: a review. Med Biol Eng Comput. 2006;44:5–14. PubMed PMID: 16929916.
  • Chang DC, Reese TS. Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys J. 1990;58:1–12. PubMed PMID: 2383626.
  • Tarek M. Membrane electroporation: a molecular dynamics simulation. Biophys J. 2005;88:4045–4053.
  • Vernier PT, Levine ZA, Ho MC, et al. Picosecond and Terahertz perturbation of interfacial water and electropermeabilization of biological membranes. J Membr Biol. 2015;248:837–847. PubMed PMID: 25796485.
  • Yarmush ML, Golberg A, Serša G, et al. Electroporation-based technologies for medicine: principles, applications, and challenges. Annu Rev Biomed Eng. 2014;16:295–320. PubMed PMID: 24905876.
  • José A, Sobrevals L, Ivorra A, et al. Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models. Cancer Lett. 2012;317:16–23. PubMed PMID: 22079741.
  • Lee EW, Chen C, Prieto VE, et al. Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology. 2010;255:426–433.
  • Choi YS, Kim HB, Chung J, et al. Preclinical analysis of irreversible electroporation on rat liver tissues using a microfabricated electroporator. Tissue Eng Part C Methods. 2010;16:1245–1253.
  • Siddiqui IA, Latouche EL, DeWitt MR, et al. Induction of rapid, reproducible hepatic ablations using next-generation, high frequency irreversible electroporation (H-FIRE) in vivo. Hpb. 2016;18:726–734. PubMed PMID: 27593589.
  • Beebe SJ, Sain NM, Ren W. Induction of cell death mechanisms and apoptosis by nanosecond pulsed electric fields (nsPEFs). Cells. 2013;2:136–162. PubMed PMID: 24709649.
  • Markelc B, Sersa G, Cemazar M. Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels. PLoS ONE. 2013;8:e59557. PubMed PMID: 23555705.
  • Ivorra A. Tissue electroporation as a bioelectric phenomenon: basic concepts. In: Rubinsky B, editor. Irreversible electroporation. Berlin, Heidelberg: Springer Berlin Heidelberg; 2010. p. 23–61.
  • Faroja M, Ahmed M, Appelbaum L, et al. Irreversible electroporation ablation: is all the damage nonthermal? Radiology. 2013 Feb;266(2):462–470. PubMed PMID: 23169795.
  • Davalos RV, Mir IL, Rubinsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng. 2005 Feb;33(2):223–231. PubMed PMID: 15771276.
  • Van Den Bos W, Scheffer HJ, Vogel JA, et al. Thermal energy during irreversible electroporation and the influence of different ablation parameters. J Vasc Interv Radiol. 2016 Mar;27(3):433–443. PubMed PMID: 26703782.
  • Chen C, Evans J, Robinson MP, et al. Electroporation of cells using EM induction of ac fields by a magnetic stimulator. Phys Med Biol. 2010;55:1219–1229. PubMed PMID: 20124654.
  • Novickij V, Dermol J, Grainys A, et al. Membrane permeabilization of mammalian cells using bursts of high magnetic field pulses. PeerJ. 2017;5:e3267.
  • Guo F, Yao C, Bajracharya C, et al. Simulation study of delivery of subnanosecond pulses to biological tissues with an impulse radiating antenna. Bioelectromagnetics. 2014;35:145–159.
  • Dev SB, Dhar D, Krassowska W. Electric field of a six-needle array electrode used in drug and DNA delivery in vivo: analytical versus numerical solution. IEEE Trans Biomed Eng. 2003;50:1296–1300.
  • Pavliha D, Kos B, Marčan M, et al. Planning of electroporation-based treatments using web-based treatment-planning software. J Membr Biol. 2013;246:833–842. PubMed PMID: 23780414.
  • Bertacchini C, Margotti PM, Bergamini E, et al. Irreversible electroporation systems for clinical use. In: Rubinsky B, editor. Irreversible electroporation. Berlin, Heidelberg: Springer Berlin Heidelberg; 2010. p. 255–272.
  • Jiang C, Davalos RV, Bischof JC. A review of basic to clinical studies of irreversible electroporation therapy. IEEE Trans Biomed Eng. 2015;62(1):4–20.
  • Thiagalingam A, D’Avila A, Foley L, et al. Importance of catheter contact force during irrigated radiofrequency ablation: evaluation in a porcine ex vivo model using a force‐sensing catheter. J Cardiovasc Electrophysiol. 2010;21(7):806–811.
  • Reddy VY, Shah D, Kautzner J, et al. The relationship between contact force and clinical outcome during radiofrequency catheter ablation of atrial fibrillation in the TOCCATA study. Heart Rhythm. 2012;9(11):1789–1795.
  • Natale A, Reddy VY, Monir G, et al. Paroxysmal AF catheter ablation with a contact force sensing catheter: results of the prospective, multicenter SMART-AF trial. J Am Coll Cardiol. 2014;64(7):647–656.
  • Reddy VY, Dukkipati SR, Neuzil P, et al. A randomized controlled trial of the safety and effectiveness of a contact force sensing irrigated catheter for ablation of paroxysmal atrial fibrillation: results of the TOCCASTAR study. Circulation. 2015. DOI:10.1161/Circulationaha.114.014092.
  • Pappone C, Oral H, Santinelli V, et al. Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial fibrillation. Circulation. 2004;109(22):2724–2726.
  • Black-Maier E, Pokorney SD, Barnett AS, et al. Risk of atrioesophageal fistula formation with contact force-sensing catheters. Heart Rhythm. 2017 Sep;14(9):1328–1333. PubMed PMID: 28416466; eng.
  • Sacher F, Monahan KH, Thomas SP, et al. Phrenic nerve injury after atrial fibrillation catheter ablation: characterization and outcome in a multicenter study. J Am Coll Cardiol. 2006;47(12):2498–2503.
  • Park SY, Camilleri M, Packer D, et al. Upper gastrointestinal complications following ablation therapy for atrial fibrillation. Neurogastroenterol Motil. 2017 May 19;29:e13109. PubMed PMID: 28524623; eng.
  • Calkins H, Reynolds MR, Spector P, et al. Treatment of atrial fibrillation with anti–arrhythmic drugs or radio frequency ablation: two systematic literature reviews and meta–analyses. Circulation. 2009. DOI:10.1161/CIRCEP.108.824789
  • Khairy P, Chauvet P, Lehmann J, et al. Lower incidence of thrombus formation with cryoenergy versus radiofrequency catheter ablation. Circulation. 2003;107(15):2045–2050.
  • Medi C, Evered L, Silbert B, et al. Subtle post-procedural cognitive dysfunction after atrial fibrillation ablation. J Am Coll Cardiol. 2013 Aug 06;62(6):531–539. PubMed PMID: 23684686; eng.
  • Vermeer SE, Prins ND, Den Heijer T, et al. Silent brain infarcts and the risk of dementia and cognitive decline. New England J Med. 2003;348(13):1215–1222.
  • Andrade JG, Dubuc M, Guerra PG, et al. The biophysics and biomechanics of cryoballoon ablation. Pacing Clin Electrophysiol. 2012;35(9):1162–1168.
  • Furnkranz A, Bordignon S, Bohmig M, et al. Reduced incidence of esophageal lesions by luminal esophageal temperature-guided second-generation cryoballoon ablation. Heart Rhythm. 2015 Feb;12(2):268–274. PubMed PMID: 25446159; eng.
  • Narui R, Tokuda M, Matsushima M, et al. Incidence and factors associated with the occurrence of pulmonary vein narrowing after cryoballoon ablation. Circ Arrhythmia Elec. 2017 Jun;10(6). PubMed PMID: 28630168; eng. DOI:10.1161/circep.116.004588.
  • Thomas D, Katus HA, Voss F. Asymptomatic pulmonary vein stenosis after cryoballoon catheter ablation of paroxysmal atrial fibrillation. J Electrocardiol. 2011 Jul-Aug;44(4):473–476. PubMed PMID: 21146833; eng.
  • Guiot A, Savoure A, Godin B, et al. Collateral nervous damages after cryoballoon pulmonary vein isolation. J Cardiovasc Electrophysiol. 2012 Apr;23(4):346–351. PubMed PMID: 22081875; eng.
  • Ichihara N, Miyazaki S, Iwasawa J, et al. Prevalence and pre-procedural predictors associated with right phrenic nerve injury in electromyography-guided, second-generation cryoballoon ablation. JACC. 2016;2(4):508–514.
  • van Opstal JM, Timmermans C, Blaauw Y, et al. Bronchial erosion and hemoptysis after pulmonary vein isolation by cryoballoon ablation. Heart Rhythm. 2011 Sep;8(9):1459. PubMed PMID: 20601153; eng.
  • Aksu T, Ebru Golcuk S, Yalin K. Haemoptysis and pulmonary haemorrhage associated with cryoballoon ablation. Europace. 2015 Aug;17(8):1240. PubMed PMID: 25712979; eng.
  • Liem L, Mead RH, Shenasa M, et al. Microwave catheter ablation using a clinical prototype system with a lateral firing antenna design. Pacing Clin Electrophysiol. 1998;21(4):714–721.
  • Nazer B, Gerstenfeld EP, Hata A, et al. Cardiovascular applications of therapeutic ultrasound. J Interv Card Electrophysiol. 2014 Apr;39(3):287–294. PubMed PMID: 24297498; PubMed Central PMCID: PMCPMC5215834. eng.
  • Koruth JS, Dukkipati S, Carrillo RG, et al. Safety and efficacy of high-intensity focused ultrasound atop coronary arteries during epicardial catheter ablation. J Cardiovasc Electrophysiol. 2011 Nov;22(11):1274–1280. PubMed PMID: 21676047; eng.
  • Nazer B, Salgaonkar V, Diederich CJ, et al. Epicardial catheter ablation using high-intensity ultrasound: validation in a Swine model. Circ Arrhythmia Elec. 2015 Dec;8(6):1491–1497. PubMed PMID: 26546345; eng.
  • Neven K, Schmidt B, Metzner A, et al. Fatal end of a safety algorithm for pulmonary vein isolation with use of high-intensity focused ultrasound. Circulation. 2010. DOI:10.1161/CIRCEP.109.922930
  • Reddy VY, Neuzil P, Themistoclakis S, et al. Visually-guided balloon catheter ablation of atrial fibrillation: experimental feasibility and first-in-human multicenter clinical outcome. Circulation. 2009 Jul 07;120(1):12–20. PubMed PMID: 19546385; eng.
  • Dukkipati SR, Neuzil P, Kautzner J, et al. The durability of pulmonary vein isolation using the visually guided laser balloon catheter: multicenter results of pulmonary vein remapping studies. Heart Rhythm. 2012;9(6):919–925.
  • Bordignon S, Boehmer MC, Klostermann A, et al. Visually guided pulmonary vein isolation in patients with persistent atrial fibrillation. Europace. 2016 Apr;18(4):538–542. PubMed PMID: 26316147; eng.
  • Witt C, Livia C, Witt T, et al. Electroporative myocardial ablation utilizing a non-contact, virtual electrode: proof of concept in ex-vivo and in-vivo canine hearts [Abstract; C-PO02-17]. Heart Rhythm. 2017;14(5):S144–S234.
  • Neven K, van Driel V, van Wessel H, et al. Safety and feasibility of closed chest epicardial catheter ablation using electroporation. Circulation. 2014 DOI:10.1161/CIRCEP.114.001607
  • Hong J, Stewart MT, Cheek DS, et al., editors. Cardiac ablation via electroporation. Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE; 2009: IEEE.
  • van Driel VJ, Neven K, van Wessel H, et al. Low vulnerability of the right phrenic nerve to electroporation ablation. Heart Rhythm. 2015;12(8):1838–1844.
  • Edd JF, Davalos RV. Mathematical modeling of irreversible electroporation for treatment planning. Technol Cancer Res Treat. 2007;6:275–286. PubMed PMID: 17668934.
  • Lavee J, Onik G, Mikus P, et al. A novel nonthermal energy source for surgical epicardial atrial ablation: irreversible electroporation. Heart Surg Forum . 2007;10(2):E162–E167. PubMed PMID: 17597044; eng.
  • Wittkampf FH, van Driel VJ, van Wessel H, et al. Feasibility of electroporation for the creation of pulmonary vein ostial lesions. J Cardiovasc Electrophysiol. 2011;22(3):302–309.
  • van Driel VJ, Neven KG, van Wessel H, et al. Pulmonary vein stenosis after catheter ablation: electroporation versus radiofrequency. Circulation. 2014 DOI:10.1161/CIRCEP.113.001111
  • DeSimone CV, Ebrille E, Syed FF, et al. Novel balloon catheter device with pacing, ablating, electroporation, and drug-eluting capabilities for atrial fibrillation treatment–preliminary efficacy and safety studies in a canine model. Transl Res. 2014 Dec;164(6):508–514. PubMed PMID: 25092516; PubMed Central PMCID: PMCPMC4470560.
  • Wittkampf FH, van Driel VJ, van Wessel H, et al. Myocardial lesion depth with circular electroporation ablation. Circulation. 2012. 10.1161/CIRCEP. 111.970079
  • Du Pré BC, van Driel VJ, van Wessel H, et al. Minimal coronary artery damage by myocardial electroporation ablation. Europace. 2012;15(1):144–149.
  • Zager Y, Kain D, Landa N, et al. Optimization of irreversible electroporation protocols for in-vivo myocardial decellularization. PloS One. 2016;11(11):e0165475.
  • Witt C, Padmanabhan D, Killu A, et al. Successful electroporation of the pulmonary veins in canines using a balloon catheter [Abstract; C-PO06-49] [Abstract]. Heart Rhythm. 2017;14(5):S514–S563.
  • Kanjwal K, Yeasting R, Maloney JD, et al. Retro-cardiac esophageal mobility and deflection to prevent thermal injury during atrial fibrillation ablation: an anatomic feasibility study. J Interv Card Electrophysiol. 2011;30(1):45–53.
  • Bahnson TD. Strategies to minimize the risk of esophageal injury during catheter ablation for atrial fibrillation. Pacing Clin Electrophysiol. 2009;32(2):248–260.
  • Neven K, van Es R, van Driel V, et al. Acute and long-term effects of full-power electroporation ablation directly on the porcine esophagus. Circulation. 2017;10(5):e004672.
  • Onik G, Mikus P, Rubinsky B. Irreversible electroporation: implications for prostate ablation. Technol Cancer Res Treat. 2007;6(4):295–300.
  • Kamrani M, Shahryar R, Ashtiani M, et al. Effect of electroporation on sciatic nerve of the rat (A primary report on an animal study). Iranian J Orthopaedic Surg. 2014;12(3):103–110.
  • Schoellnast H, Monette S, Ezell PC, et al. The delayed effects of irreversible electroporation ablation on nerves. Eur Radiol. 2013;23(2):375–380.
  • Schoellnast H, Monette S, Ezell PC, et al. Acute and subacute effects of irreversible electroporation on nerves: experimental study in a pig model. Radiology. 2011;260(2):421–427.
  • Li W, Fan Q, Ji Z, et al. The effects of irreversible electroporation (IRE) on nerves. PloS One. 2011;6(4):e18831.
  • Lu Z, Scherlag BJ, Lin J, et al. Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexi. Cardiovasc Res. 2009 Nov 01;84(2):245–252. PubMed PMID: 19520703; PubMed Central PMCID: PMCPMC2764506.
  • Katritsis DG, Pokushalov E, Romanov A, et al. Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol. 2013 Dec 17;62(24):2318–2325. PubMed PMID: 23973694.
  • Pokushalov E, Romanov A, Katritsis DG, et al. Ganglionated plexus ablation vs linear ablation in patients undergoing pulmonary vein isolation for persistent/long-standing persistent atrial fibrillation: a randomized comparison. Heart Rhythm. 2013 Sep;10(9):1280–1286. PubMed PMID: 23608592.
  • Driessen AH, Berger WR, Krul SP, et al. Ganglion plexus ablation in advanced atrial fibrillation: the AFACT study. J Am Coll Cardiol. 2016 Sep 13;68(11):1155–1165. PubMed PMID: 27609676.
  • Oh S, Choi EK, Zhang Y, et al. Botulinum toxin injection in epicardial autonomic ganglia temporarily suppresses vagally mediated atrial fibrillation. Circ Arrhythmia Elec. 2011 Aug;4(4):560–565. PubMed PMID: 21659633.
  • Madhavan M, Venkatachalam K, Swale MJ, et al. Novel percutaneous epicardial autonomic modulation in the canine for atrial fibrillation: results of an efficacy and safety study. Pacing Clin Electrophysiol. 2016;39(5):407–417.
  • Maor E, Ivorra A, Mitchell JJ, et al. Vascular smooth muscle cells ablation with endovascular nonthermal irreversible electroporation. J Vasc Interv Radiol. 2010;21(11):1708–1715.
  • Maor E, Ivorra A, Rubinsky B. Non thermal irreversible electroporation: novel technology for vascular smooth muscle cells ablation. PloS One. 2009;4(3):e4757.
  • Maor E, Ivorra A, Leor J, et al. The effect of irreversible electroporation on blood vessels. Technol Cancer Res Treat. 2007;6(4):307–312.
  • Maor E, Ivorra A, Leor J, et al. Irreversible electroporation attenuates neointimal formation after angioplasty. IEEE Trans Biomed Eng. 2008;55(9):2268–2274.
  • Nogami A, Sugiyasu A, Kubota S, et al. Mapping and ablation of idiopathic ventricular fibrillation from the Purkinje system. Heart Rhythm. 2005 Jun;2(6):646–649. PubMed PMID: 15922276.
  • Haissaguerre M, Shoda M, Jais P, et al. Mapping and ablation of idiopathic ventricular fibrillation. Circulation. 2002 Aug 20;106(8):962–967. PubMed PMID: 12186801.
  • Santoro F, Di Biase L, Hranitzky P, et al. Ventricular fibrillation triggered by PVCs from papillary muscles: clinical features and ablation. J Cardiovasc Electrophysiol. 2014 Nov;25(11):1158–1164. PubMed PMID: 24946987.
  • Livia C, Witt T, Polkinghorne M, et al. Electroporative elimination of Purkinje fibers reduces vulnerability to ventricular fibrillation [Abstract; C-PO04-139]. Heart Rhythm. 2017;14(5):S327–S417.
  • Asirvatham SJ. Cardiac Electroporation: the promise of the unknown. J Cardiovasc Electrophysiol. 2018 Feb 25. DOI:10.1111/jce.13466. [Epub ahead of print].
  • Neven K, van Driel V, van Wessel H, et al. Epicardial linear electroporation ablation and lesion size. Heart Rhythm. 2014 Aug;11(8):1465–1470. PubMed PMID: 24768609.
  • van Driel VJ, Neven KG, van Wessel H, et al. Pulmonary vein stenosis after catheter ablation: electroporation versus radiofrequency. Circ Arrhythmia Elec. 2014 Aug;7(4):734–738. PubMed PMID: 24958397.
  • Srimathveeravalli G, Wimmer T, Monette S, et al. Evaluation of an endorectal electrode for performing focused irreversible electroporation ablations in the swine rectum. J Vasc Interv Radiol. 2013;24:1249–1256. PubMed PMID: 23796856.
  • High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction, (2011).
  • Miklavčič D, Pucihar G, Pavlovec M, et al. The effect of high frequency electric pulses on muscle contractions and antitumor efficiency in vivo for a potential use in clinical electrochemotherapy. Bioelectrochemistry. 2005;65:121–128.
  • Okino M, Tomie H, Kanesada H, et al. Optimal electric conditions in electrical impulse chemotherapy. Jpn J Cancer Res. 1992;83:1095–1101. PubMed PMID: 1280635.
  • Haines DE, Watson DD. Tissue heating during radiofrequency catheter ablation: a thermodynamic model and observations in isolated perfused and superfused canine right ventricular free wall. Pacing Clin Electrophysiol. 1989 Jun;12(6):962–976. PubMed PMID: 2472624.
  • Wittkampf FH, van Driel VJ, van Wessel H, et al. Myocardial lesion depth with circular electroporation ablation. Circ Arrhythmia Elec. 2012 Jun 01;5(3):581–586. PubMed PMID: 22492429.
  • van Gemert MJ, Wagstaff PG, de Bruin DM, et al. Irreversible electroporation: just another form of thermal therapy? Prostate. 2015 Feb 15;75(3):332–335. PubMed PMID: 25327875; PubMed Central PMCID: PMCPMC4305196.
  • Halbfass P, Pavlov B, Muller P, et al. Progression from esophageal thermal asymptomatic lesion to perforation complicating atrial fibrillation ablation: a single-center registry. Circ Arrhythmia Elec. 2017 Aug;10(8):e005233. PubMed PMID: 28798021.

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