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Review

Atrial fibrillation in young patients

, , , , , , , , , , , , & show all
Pages 489-500 | Received 20 Feb 2018, Accepted 15 Jun 2018, Published online: 02 Jul 2018

References

  • Miyasaka Y, Barnes ME, Gersh BJ, et al. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation. 2006;114:119–125
  • Kopecky SL, Gersh BJ, McGoon MD, et al. The natural history of lone atrial fibrillation. New England J Med. 1987;317:669–674.
  • Dm L-J, Tj W, Ep L, et al. Lifetime risk for development of atrial fibrillation the Framingham Heart Study. Circulation. 2004;110:1042–1046.
  • Lca R-J, Arntz RM, Maaijwee NAM, et al. Long-term mortality after stroke among adults aged 18 to 50 years. JAMA. 2013;309:1136–1144.
  • Wilke T, Groth A, Mueller S, et al. Incidence and prevalence of atrial fibrillation: an analysis based on 8.3 million patients. Europace. 2013;15:486–493.
  • Šaňák D, Hutyra M, Král M, et al. Atrial fibrillation in young ischemic stroke patients: an underestimated cause? Eur Neurol. 2015;73:158–163.
  • Kerr CR, Humphries KH, Talajic M, et al. Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: results from the Canadian Registry of Atrial Fibrillation. Am Heart J. 2005;149:489–496.
  • Mills LC, Gow RM, Myers K, et al. Lone atrial fibrillation in the pediatric population. Can J Cardiol. 2013;29:1227–1233.
  • Sankaranarayanan R, Kirkwood G, Dibb K, et al. Comparison of atrial fibrillation in the young versus that in the elderly: a review. Cardiol Res Pract 2013; [cited 2016 Feb 17]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564268/
  • Ceresnak SR, Liberman L, Silver ES, et al. Lone atrial fibrillation in the young - perhaps not so “lone”? J.Pediatr. 2013;162:827–831.
  • Gami AS, Hodge DO, Herges RM, et al. Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol. 2007;49:565–571.
  • Foy AJ, Mandrola J, Liu G, et al. Relation of obesity to new-onset atrial fibrillation and atrial flutter in adults. Am J Cardiol. 2018;121:1072–1075.
  • Shulman E, Chudow JJ, Shah T, et al. Relation of Body Mass Index to development of atrial fibrillation in hispanics, blacks, and non-Hispanic whites. Am J Cardiol. 2018;121:1177–1181.
  • Schmidt M, Bøtker HE, Pedersen L, et al. Comparison of the frequency of atrial fibrillation in young obese versus young nonobese men undergoing examination for fitness for military service. Am J Cardiol. 2014;113:822–826.
  • Mahajan R, Lau DH, Brooks AG, et al. Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity. J Am Coll Cardiol. 2015;66:1–11.
  • Lee JJ, Yin X, Hoffmann U, et al. Relation of pericardial fat, intrathoracic fat, and abdominal visceral fat with incident atrial fibrillation (from the Framingham Heart Study). Am J Cardiol. 2016;118:1486–1492.
  • Evans CA, Selvadurai H, Baur LA, et al. Effects of obstructive sleep apnea and obesity on exercise function in children. Sleep. 2014;37:1103–1110
  • Sorof J, Daniels S Obesity hypertension in children: a problem of epidemic proportions. Hypertension. 2002;40:441–447.
  • Amin R, Somers VK, McConnell K, et al. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension. 2008;51:84–91.
  • Mah DY, Shakti D, Gauvreau K, et al. Relation of left atrial size to atrial fibrillation in patients aged ≤22 Years. Am J Cardiol. 2017;119:52–56.
  • Karjalainen J, Kujala UM, Kaprio J, et al. Lone atrial fibrillation in vigorously exercising middle aged men: case-control study. BMJ. 1998;316:1784–1785.
  • Molina L, Mont L, Marrugat J, et al. Long-term endurance sport practice increases the incidence of lone atrial fibrillation in men: a follow-up study. Europace. 2008;10:618–623
  • Elosua R, Arquer A, Mont L, et al. Sport practice and the risk of lone atrial fibrillation: a case-control study. Int J Cardiol. 2006;108:332–337.
  • Andersen K, Rasmussen F, Held C, et al. Exercise capacity and muscle strength and risk of vascular disease and arrhythmia in 1.1 million young Swedish men: cohort study. BMJ. 2015;351: h4543.
  • Mukamal KJ, Tolstrup JS, Friberg J, et al. Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study. Circulation. 2005;112:1736–1742
  • Van Der Hooft CS, Heeringa J, van Herpen G, et al. Drug-induced atrial fibrillation. J Am Coll Cardiol. 2004;44:2117–2124.
  • Kirchhof P, Benussi S, Kotecha D, et al. ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016;37:2893–2962.
  • Lubitz SA, Yin X, Rienstra M, et al. Long-term outcomes of secondary atrial fibrillation in the community: the Framingham Heart Study. Circulation. 2015;131:1648–1655.
  • Lubitz SA, Yin X, Fontes JD, et al. Association between familial atrial fibrillation and risk of new-onset atrial fibrillation. JAMA. 2010;304:2263–2269.
  • Fox CS, Parise H, Agostino.D, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004;291:2851–2855.
  • Brugada R, Tapscott T, Czernuszewicz GZ, et al. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 1997;336:905–911.
  • Chen Y-H, Xu S-J, Bendahhou S, et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003;299:251–254
  • Yang Y, Xia M, Jin Q, et al. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet. 2004;75:899–905.
  • Christophersen IE, Ellinor PT. Genetics of atrial fibrillation: from families to genomes. J Hum Genet. 2015; [cited 2015 Dec 10]. Available from: http://www.nature.com/jhg/journal/vaop/ncurrent/full/jhg201544a.html
  • Ye J, Tucker NR, Weng L-C, et al. A functional variant associated with atrial fibrillation regulates PITX2c expression through TFAP2a. Am J Hum Genet. 2016;99:1281–1291.
  • Nielsen JB, Fritsche LG, Zhou W, et al. Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development. Am J Hum Genet. 2018;102:103–115.
  • Giustetto C, Cerrato N, Gribaudo E, et al. Atrial fibrillation in a large population with Brugada electrocardiographic pattern: prevalence, management, and correlation with prognosis. Heart Rhythm. 2014;11:259–265.
  • Bordachar P, Reuter S, Garrigue S, et al. Incidence, clinical implications and prognosis of atrial arrhythmias in Brugada syndrome. Eur Heart J. 2004;25:879–884.
  • Sacher F, Probst V, Maury P, et al. Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study-part 2. Circulation. 2013;128:1739–1747.
  • Andorin A, Behr ER, Denjoy I, et al. The impact of clinical and genetic findings on the management of young Brugada syndrome patients. Heart Rhythm. 2016;13:1274–1282.
  • Einbinder T, Lowenthal A, Fogelman R. Ventricular fibrillation storm in a child. Europace. 2014;16:1654.
  • Stumpf C, Simon M, Wilhelm M, et al. Left atrial remodeling, early repolarization pattern, and inflammatory cytokines in professional soccer players. J Cardiol. [cited 2016 Mar 16]. Available from: http://www.sciencedirect.com/science/article/pii/S0914508715002713
  • Francis J, Antzelevitch C. Atrial fibrillation and Brugada syndrome. J Am Coll Cardiol. 2008;51:1149–1153.
  • Choi K-J, Kim J, Kim S-H, et al. Increased dispersion of atrial repolarization in Brugada syndrome. Europace. 2011;13:1619–1624.
  • Barajas-Martínez H, Hu D, Ferrer T, et al. Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8. Heart Rhythm. 2012;9:548–555.
  • Haïssaguerre M, Chatel S, Sacher F, et al. Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel. J Cardiovasc Electrophysiol. 2009;20:93–98
  • Delaney JT, Muhammad R, Blair MA, et al. A KCNJ8 mutation associated with early repolarization and atrial fibrillation. Europace. 2012;14:1428–1432
  • Medeiros-Domingo A, Tan B-H, Crotti L, et al. Gain-of-function mutation S422L in the KCNJ8-encoded cardiac KATP channel Kir6.1 as a pathogenic substrate for J-wave syndromes. Heart Rhythm. 2010;7:1466–1471.
  • Probst V, Denjoy I, Meregalli PG, et al. Clinical aspects and prognosis of Brugada syndrome in children. Circulation. 2007;115:2042–2048
  • Gourraud J-B, Barc J, Thollet A, et al. Brugada syndrome: diagnosis, risk stratification and management. Arch Cardiovasc Dis. 2017;110:188–195.
  • Conte G, Dewals W, Sieira J, et al. Drug-induced brugada syndrome in children: clinical features, device-based management, and long-term follow-up. J Am Coll Cardiol. 2014;63:2272–2279.
  • Sorgente A, Sarkozy A, De Asmundis C, et al. Ajmaline challenge in young individuals with suspected Brugada syndrome. Pacing Clin Electrophysiol. 2011;34:736–741.
  • Therasse D, Sacher F, Petit B, et al. Sodium-channel blocker challenge in the familial screening of Brugada syndrome: safety and predictors of positivity. Heart Rhythm. 2017;10:1442–1448.
  • Therasse D, Sacher F, Babuty D, et al. Value of the sodium-channel blocker challenge in Brugada syndrome. Int J Cardiol. 2017;245:178–180.
  • Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS Expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm. 2013;10:1932–1963.
  • Johnson JN, Tester DJ, Perry J, et al. Prevalence of early-onset atrial fibrillation in congenital long QT syndrome. Heart Rhythm. 2008;5:704–709.
  • Zellerhoff S, Pistulli R, Mönnig G, et al. Atrial arrhythmias in long-QT syndrome under daily life conditions: a nested case control study. J Cardiovasc Electrophysiol. 2009;20:401–407
  • Benito B, Brugada R, Perich RM, et al. A mutation in the sodium channel is responsible for the association of long-QT syndrome and familial atrial fibrillation. Heart Rhythm. 2008;5:1434–1440.
  • Olesen MS, Yuan L, Liang B, et al. High prevalence of long-QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation. Circ Cardiovasc Genet. 2012;5:450–459.
  • Robaei D, Ford T, Ooi S-Y. Ankyrin-B syndrome: a case of sinus node dysfunction, atrial fibrillation and prolonged QT in a young adult. Heart Lung Circ. 2015;24:e31–34.
  • Kirchhof P, Eckardt L, Franz MR, et al. Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long-QT syndrome. J Cardiovasc Electrophysiol. 2003;14:1027–1033
  • Schott -J-J, Charpentier F, Peltier S, et al. Mapping of a gene for long QT syndrome to chromosome 4q25-27. Am J Hum Genet. 1995;57:1114–1122.
  • Andreasen L, Nielsen JB, Christophersen IE, et al. Genetic modifier of the QTc interval associated with early-onset atrial fibrillation. Can J Cardiol. 2013;29:1234–1240
  • Mandyam MC, Soliman EZ, Alonso A, et al. The QT interval and risk of incident atrial fibrillation. Heart Rhythm. 2013;10:1562–1568.
  • Zareba W, Moss AJ, Schwartz PJ, et al. Influence of genotype on the clinical course of the long-QT syndrome International Long-QT Syndrome Registry Research Group. . N. Engl. J. Med. 1998;339:960–965.
  • Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 2001;103:89–95.
  • El Yaman M, Perry J, Makielski JC, et al. Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome. Heart Rhythm. 2008;5:472–474.
  • Koponen M, Marjamaa A, Hiippala A, et al. Follow-Up of 316 molecularly defined pediatric long-QT syndrome patients clinical course, treatments, and side effects. Circ Arrhythm Electrophysiol. 2015;8:815–823
  • Rodday AM, Triedman JK, Alexander ME, et al. Electrocardiogram screening for disorders that cause sudden cardiac death in asymptomatic children: a meta-analysis. Pediatrics. 2012;129:e999–e1010.
  • Phan DQ, Silka MJ, Lan Y-T, et al. Comparison of formulas for calculation of the corrected QT interval in infants and young children. J Pediatr. 2015;166(960–964):e1–2.
  • Gussak I, Brugada P, Brugada J, et al. Idiopathic short QT interval: a new clinical syndrome? Cardiology. 2000;94:99–102.
  • Villafañe J, Atallah J, Gollob MH, et al. Long-term follow-up of a pediatric cohort with short QT syndrome. J Am Coll Cardiol. 2013;61:1183–1191.
  • Schimpf R, Borggrefe M, Wolpert C. Clinical and molecular genetics of the short QT syndrome. Curr Opin Cardiol. 2008;23:192–198.
  • Hong K, Piper DR, Diaz-Valdecantos A, et al. De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero. Cardiovasc Res. 2005;68:433–440.
  • Hong K, Bjerregaard P, Gussak I, et al. Short QT Syndrome and atrial fibrillation caused by mutation in KCNH2. J Cardiovasc Electrophysiol. 2005;16:394–396.
  • Priori SG, Pandit SV, Rivolta I, et al. A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res. 2005;96:800–807.
  • Giustetto C, Di Monte F, Wolpert C, et al. Short QT syndrome: clinical findings and diagnostic-therapeutic implications. Eur Heart J. 2006;27:2440–2447.
  • Steer AC, Carapetis JR. Prevention and treatment of rheumatic heart disease in the developing world. Nat Rev Cardiol. 2009;6:689–698.
  • Saxena A, Ramakrishnan S, Roy A, et al. Prevalence and outcome of subclinical rheumatic heart disease in India: the RHEUMATIC (Rheumatic Heart Echo Utilisation and Monitoring Actuarial Trends in Indian Children) study. Heart. 2011;97:2018–2022.
  • Mondésert B, Abadir S, Khairy P. Arrhythmias in adult congenital heart disease: the year in review. Curr Opin Cardiol. 2013;28:354–359.
  • Khairy P, Aboulhosn J, Gurvitz MZ, et al. Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study. Circulation. 2010;122:868–875.
  • Kannel WB, Wolf PA, Benjamin EJ, et al. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates 1. Am J Cardiol. 1998;82:2N–9N.
  • Maisel WH, Stevenson LW. Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol. 2003;91:2D-8D.
  • Olivotto I, Cecchi F, Casey SA, et al. Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy. Circulation. 2001;104:2517–2524.
  • Maron BJ, Olivotto I, Bellone P, et al. Clinical profile of stroke in 900 patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2002;39:301–307.
  • Rosenberg MA, Gottdiener JS, Heckbert SR, et al. Echocardiographic diastolic parameters and risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012;33:904–912.
  • Van Berlo JH, de Voogt WG, van Der Kooi AJ, et al. Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? JMol Med. 2005;83:79–83.
  • Amin AS, Bhuiyan ZA. SCN5A mutations in atrial fibrillation. Heart Rhythm. 2010;7:1870–1871.
  • Olesen MS, Andreasen L, Jabbari J, et al. Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation. Heart Rhythm. 2014;11:246–251.
  • Ilkhanoff L, Arking DE, Lemaitre RN, et al. A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans. J Cardiovasc Electrophysiol. 2014;25:1150–1157.
  • Parks SB, Kushner JD, Nauman D, et al. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. Am Heart J. 2008;156:161–169.
  • McNair WP, Ku L, Taylor MRG, et al. SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation. 2004;110:2163–2167.
  • Iaw VR, Arbustini E, Elliott PM, et al. Risk factors for malignant ventricular arrhythmias in lamin A/C mutation carriers a European cohort study. J Am Coll Cardiol. 2012;59:493–500.
  • Hasselberg NE, Edvardsen T, Petri H, et al. Risk prediction of ventricular arrhythmias and myocardial function in Lamin A/C mutation positive subjects. Europace. 2014;16:563–571.
  • Strieper MJ, Frias P, Fischbach P, et al. Catheter ablation of primary supraventricular tachycardia substrate presenting as atrial fibrillation in adolescents. Congenit Heart Dis. 2010;5:465–469.
  • Wutzler A, von Ulmenstein S, Attanasio P, et al. Where there’s smoke, there’s fire? Significance of atrial fibrillation in young patients. Clin Cardiol. 2016;39:229–233.
  • Sciarra L, Rebecchi M, Ruvo ED, et al. How many atrial fibrillation ablation candidates have an underlying supraventricular tachycardia previously unknown? Efficacy of isolated triggering arrhythmia ablation. Europace. 2010;12:1707–1712.
  • Weiss R, Knight BP, Bahu M, et al. Long-term follow-up after radiofrequency ablation of paroxysmal supraventricular tachycardia in patients with tachycardia-induced atrial fibrillation. Am J Cardiol. 1997;80:1609–1610.
  • Cohen MI, Triedman JK, Cannon BC, et al. PACES/HRS Expert consensus statement on the management of the asymptomatic young patient with a Wolff-Parkinson-White (WPW, Ventricular Preexcitation) Electrocardiographic pattern: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology Foundation (ACCF), the American Heart Association (AHA), the American Academy of Pediatrics (AAP), and the Canadian Heart Rhythm Society (CHRS). Heart Rhythm. 2012;9:1006–1024.
  • Klein GJ, Bashore TM, Sellers TD, et al. Ventricular fibrillation in the Wolff-Parkinson-White syndrome. N Engl J Med. 1979;301:1080–1085.
  • Sharma AD, Klein GJ, Guiraudon GM, et al. Atrial fibrillation in patients with Wolff-Parkinson-White syndrome: incidence after surgical ablation of the accessory pathway. Circulation. 1985;72:161–169
  • Munger TM, Packer DL, Hammill SC, et al. A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953-1989. Circulation. 1993;87:866–873.
  • Centurión OA, Shimizu A, Isomoto S, et al. Mechanisms for the genesis of paroxysmal atrial fibrillation in the Wolff Parkinson-White syndrome: intrinsic atrial muscle vulnerability vs Electrophysiological Properties of the Accessory Pathway. Europace. 2008;10:294–302.
  • Hamada T, Hiraki T, Ikeda H, et al. Mechanisms for atrial fibrillation in patients with Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 2002;13:223–229
  • Iesaka Y, Yamane T, Takahashi A, et al. Retrograde multiple and multifiber accessory pathway conduction in the Wolff-Parkinson-White syndrome: potential precipitating factor of atrial fibrillation. J Cardiovasc Electrophysiol. 1998;9:141–151.
  • Haissaguerre M, Fischer B, Labbé T, et al. Frequency of recurrent atrial fibrillation after catheter ablation of overt accessory pathways. Am J Cardiol. 1992;69:493–497.
  • Jordaens L, Trouerbach J, Calle P, et al. Conversion of atrial fibrillation to sinus rhythm and rate control by digoxin in comparison to placebo. Eur Heart J. 1997;18:643–648
  • Ramusovic S, Läer S, Meibohm B, et al. Pharmacokinetics of intravenous amiodarone in children. Arch Dis Child. 2013;98:989–993
  • Saul JP, Scott WA, Brown S, et al. Intravenous amiodarone for incessant tachyarrhythmias in children: a randomized, double-blind, antiarrhythmic drug trial. Circulation. 2005;112:3470–3477.
  • Wiesfeld AC, Remme WJ, Look MP, et al. Acute hemodynamic and electrophysiologic effects and safety of high-dose intravenous diltiazem in patients receiving metoprolol. Am J Cardiol. 1992;70:997–1003.
  • Freemantle N, Lafuente-Lafuente C, Mitchell S, et al. Mixed treatment comparison of dronedarone, amiodarone, sotalol, flecainide, and propafenone, for the management of atrial fibrillation. Europace. 2011;13:329–345.
  • Wyse DG, Waldo AL, DiMarco JP, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002;347:1825–1833.
  • Corley SD, Epstein AE, DiMarco JP, et al. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation. 2004;109:1509–1513.
  • Suman-Horduna I, Roy D, Frasure-Smith N, et al. Quality of life and functional capacity in patients with atrial fibrillation and congestive heart failure. J Am Coll Cardiol. 2013;61:455–460.
  • Lafuente-Lafuente C, Valembois L, Bergmann J-F, et al. Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database Syst Rev. 2015;3:CD005049.
  • Haïssaguerre M, Jaïs P, Shah DC, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. New England J Med. 1998;339:659–666.
  • Andrade JG, Macle L, Nattel S, et al. Contemporary atrial fibrillation management: a comparison of the current AHA/ACC/HRS, CCS, and ESC guidelines. Can J Cardiol. 2017;33:965–976.
  • Saguner AM, Maurer T, Wissner E, et al. ablation of atrial fibrillation in very young adults: a 5-year follow-up study. Europace. 2018 Jan 1;20:58–64.
  • Kato Y, Horigome H, Takahashi-Igari M, et al. Isolation of pulmonary vein and superior vena cava for paroxysmal atrial fibrillation in a young adult with left ventricular non-compaction. Europace. 2010;12:1040–1041.
  • Conte G, Chierchia G-B, Levinstein M, et al. Ice vs. fire: cryoballoon ablation for the prevention of inappropriate implantable cardioverter-defibrillator shocks in a 14-year-old girl with Brugada syndrome. Europace. 2013;15:1804.
  • Nanthakumar K, Lau YR, Plumb VJ, et al. Electrophysiological findings in adolescents with atrial fibrillation who have structurally normal hearts. Circulation. 2004;110:117–123
  • Balaji S, Kron J, Stecker EC. Catheter ablation of recurrent lone atrial fibrillation in teenagers with a structurally normal heart. Pacing Clin Electrophysiol. 2016;39:60–64.
  • Leong-Sit P, Zado E, Callans DJ, et al. Efficacy and risk of atrial fibrillation ablation before 45 years of age. Circ Arrhythm Electrophysiol. 2010;3:452–457.
  • Zhang X-D, Gu J, Jiang W-F, et al. The impact of age on the efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation. Int J Cardiol. 2013;168:2693–2698.
  • Wasmer K, Breithardt G, Eckardt L. The young patient with asymptomatic atrial fibrillation: what is the evidence to leave the arrhythmia untreated? Eur Heart J. 2014;35:1439–1447.
  • Khairy P, Guerra PG, Rivard L, et al. Enlargement of catheter ablation lesions in infant hearts with cryothermal versus radiofrequency energy: an animal study. Circ Arrhythm Electrophysiol. 2011;4:211–217.
  • Nasso G, Bonifazi R, Fiore F, et al. Minimally invasive epicardial ablation of lone atrial fibrillation in pediatric patient. Ann Thorac Surg. 2010;90:e49–e51.
  • Vermond RA, Geelhoed B, Verweij N, et al. Incidence of atrial fibrillation and relationship with cardiovascular events, heart failure, and mortality: A community-based study from the Netherlands. J Am Coll Cardiol. 2015;66:1000–1007.
  • Benjamin EJ, Wolf PA, D’Agostino RB, et al. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation. 1998;98:946–952.
  • Lakshminarayan K, Solid CA, Collins AJ, et al. Atrial fibrillation and stroke in the general medicare population: a 10-year perspective (1992 to 2002). Stroke. 2006;37:1969–1974
  • Maaijwee NAMM, Lca R-J, Schaapsmeerders P, et al. Ischaemic stroke in young adults: risk factors and long-term consequences. Nat Rev Neurol. 2014;10:315–325
  • Kleemann T, Becker T, Strauss M, et al. Prevalence of left atrial thrombus and dense spontaneous echo contrast in patients with short-term atrial fibrillation < 48 hours undergoing cardioversion: value of transesophageal echocardiography to guide cardioversion. J Am Soc Echocardiography. 2009;22:1403–1408.
  • Airaksinen KEJ, Grönberg T, Nuotio I, et al. Thromboembolic complications after cardioversion of acute atrial fibrillation: the FinCV (Finnish CardioVersion) Study. J Am Coll Cardiol. 2013;62:1187–1192.
  • Nuotio I, Hartikainen JEK, Grönberg T, et al. Time to cardioversion for acute atrial fibrillation and thromboembolic complications. JAMA. 2014;312:647–649.
  • Lip GYH, Nieuwlaat R, Pisters R, et al., Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on atrial fibrillation. Chest. 2010;137:263–272.
  • Macle L, Cairns J, Leblanc K, et al. Focused update of the canadian cardiovascular society guidelines for the management of atrial fibrillation. Can J Cardiol. 2016;32:1170–1185.
  • Khairy P, Aboulhosn J, Broberg CS, et al. Thromboprophylaxis for atrial arrhythmias in congenital heart disease: a multicenter study. Int J Cardiol. 2016;223:729–735.
  • Gaita F, Corsinovi L, Anselmino M, et al. Prevalence of silent cerebral ischemia in paroxysmal and persistent atrial fibrillation and correlation with cognitive function. J Am Coll Cardiol. 2013;62:1990–1997.
  • Horner JM, Horner MM, Ackerman MJ. The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome. Heart Rhythm. 2011;8:1698–1704.
  • Benjamin EJ, Levy D, Vaziri SM, et al. Independent risk factors for atrial fibrillation in a population-based cohort: the Framingham Heart Study. JAMA. 1994;271:840–844.
  • Heeringa J, Kors JA, Hofman A, et al. Cigarette smoking and risk of atrial fibrillation: the Rotterdam Study. Am Heart J. 2008;156:1163–1169.
  • Chaker L, Heeringa J, Dehghan A, et al. Normal Thyroid Function and the risk of atrial fibrillation: the Rotterdam Study. J Clin Endocrinol Metab. 2015;100:3718–3724.
  • Mitchell GF, Vasan RS, Keyes MJ, et al. Pulse pressure and risk of new-onset atrial fibrillation. JAMA. 2007;297:709–715.
  • Marcus GM, Alonso A, Peralta CA, et al. European ancestry as a risk factor for atrial fibrillation in African Americans. Circulation. 2010;122:2009–2015
  • Oyen N, Ranthe MF, Carstensen L, et al. Familial aggregation of lone atrial fibrillation in young persons. J Am Coll Cardiol. 2012;60:917–921.
  • Kirchhof P, Eckardt L, Mönnig G, et al. A patient with “atrial torsades de pointes.”. J Cardiovasc Electrophysiol. 2000;11:806–811

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