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Review

Current challenges in managing comorbid heart failure and COPD

, , , , , , , & show all
Pages 653-673 | Received 29 May 2018, Accepted 07 Aug 2018, Published online: 03 Sep 2018

References

  • Vetrano DL, Palmer K, Marengoni A, et al. Frailty and multimorbidity: a systematic review and meta-analysis. J Gerontol A Biol Sci Med Sci. 2018 May 3.
  • Savarese G, Lund LH. Global public health burden of heart failure. Card Fail Rev. 2017;3:7–11.
  • Coronel R, De Groot JR, van Lieshout JJ. Defining heart failure. Cardiovasc Res. 2001;50:419–422.
  • Dubé B-P, Agostoni P, Laveneziana P. Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors. Eur Respir Rev. 2016;25:317–332.
  • Ponikowski P, Voors AA, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016;18:891–975.
  • Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Oct 15;62:e147–239.
  • Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136:e137–61.
  • Rutten FH, Cramer M-JM, Lammers J-WJ, et al. Heart failure and chronic obstructive pulmonary disease: an ignored combination? Eur J Heart Fail. 2006;8:706–711.
  • Maclay JD, MacNee W. Cardiovascular disease in COPD: mechanisms. Chest. 2013;143:798–807.
  • Oliveira MF, Zelt JTJ, Jones JH, et al. Does impaired O2 delivery during exercise accentuate central and peripheral fatigue in patients with coexistent COPD-CHF? Front Physiol. 2014;5:514.
  • Baldwin ED, Cournand A, Richards DW. Pulmonary insufficiency; a study of 122 cases of chronic pulmonary emphysema. Medicine. 1949;28:201–237.
  • Lazzarini V, Mentz RJ, Fiuzat M, et al. Heart failure in elderly patients: distinctive features and unresolved issues. Eur J Heart Fail. 2013;15:717–723.
  • Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013 ;15:347–365.
  • Roversi S, Fabbri LM, Sin DD, et al. Chronic obstructive pulmonary disease and cardiac diseases. An urgent need for integrated care. Am J Respir Crit Care Med. 2016;1:1319–1336.
  • Iversen KK, Kjaergaard J, Akkan D, et al. Chronic obstructive pulmonary disease in patients admitted with heart failure. J Intern Med. 2008;264:361–369.
  • Pellicori P, Salekin D, Pan D, et al. This patient is not breathing properly: is this COPD, heart failure, or neither? Expert Rev Cardiovasc Ther. 2017;15:389–396.
  • Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004;21(364):709–721.
  • Milic-Emili J. Expiratory flow limitation: Roger S. Mitchell lecture. Chest. 2000;117:219S–23S.
  • O’Donnell DE, Elbehairy AF, Berton DC, et al. Advances in the evaluation of respiratory pathophysiology during exercise in chronic lung diseases. Front Physiol. 2017;8:82.
  • O’Donnell DE, Laveneziana P, Webb K, et al. Chronic obstructive pulmonary disease: clinical integrative physiology. Clin Chest Med. 2014;35:51–69.
  • Langer D, Ciavaglia CE, Neder JA, et al. Lung hyperinflation in chronic obstructive pulmonary disease: mechanisms, clinical implications and treatment. Expert Rev Respir Med.  2014;8:731-749.
  • Langer D, Ciavaglia CE, Faisal A, et al. Inspiratory muscle training reduces diaphragm activation and dyspnea during exercise in COPD. J Appl Physiol. 2018;125:381-392.
  • Ribeiro JP, Chiappa GR, Neder JA, et al. Respiratory muscle function and exercise intolerance in heart failure. Curr Heart Fail Rep. 2009;(6):95–101.
  • Agostoni P, Cattadori G, Bussotti M, et al. Cardiopulmonary interaction in heart failure. Pulm Pharmacol Ther. 2007;20:130–134.
  • Magnussen H, Canepa M, Zambito PE, et al. What can we learn from pulmonary function testing in heart failure? Eur J Heart Fail. 2017;19:1222–1229.
  • Apostolo A, Giusti G, Gargiulo P, et al. Lungs in heart failure. Pulm Med. 2012;2012:952741.
  • Wasserman K, Zhang YY, Gitt A, et al. Lung function and exercise gas exchange in chronic heart failure. Circulation. 1997;7:2221–2227.
  • Olson TP, Denzer DL, Sinnett WL, et al. Prognostic value of resting pulmonary function in heart failure. Clin Med Insights Circ Respir Pulm Med. 2013;7:35–43.
  • Souza AS, Sperandio PA, Mazzuco A, et al. Influence of heart failure on resting lung volumes in patients with COPD. J Bras Pneumol. 2016;42:273–278.
  • Agostoni P, Pellegrino R, Conca C, et al. Exercise hyperpnea in chronic heart failure: relationships to lung stiffness and expiratory flow limitation. J Appl Physiol. 2002;92:1409–1416.
  • Hosenpud JD, Stibolt TA, Atwal K, et al. Abnormal pulmonary function specifically related to congestive heart failure: comparison of patients before and after cardiac transplantation. Am J Med. 1990;88:493–496.
  • Ries AL, Gregoratos G, Friedman PJ, et al. Pulmonary function tests in the detection of left heart failure: correlation with pulmonary artery wedge pressure. Respiration. 1986;49:241–250.
  • Olson TP, Beck KC, Johnson BD. Pulmonary function changes associated with cardiomegaly in chronic heart failure. J Card Fail. 2007;13:100–107.
  • Kelley RC, Ferreira LF. Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology. Heart Fail Rev. 2017;22:191–207.
  • Torchio R, Gulotta C, Greco-Lucchina P, et al. Closing capacity and gas exchange in chronic heart failure. Chest. 2006;129:1330–1336.
  • O’Donnell DE, Guenette JA, Maltais F, et al. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise. Chest. 2012;141:753–762.
  • Chase SC, Taylor BJ, Cross TJ, et al. Influence of thoracic fluid compartments on pulmonary congestion in chronic heart failure. J Card Fail. 2017;23:690–696.
  • Chase SC, Fermoyle CC, Wheatley CM, et al. The effect of diuresis on extravascular lung water and pulmonary function in acute decompensated heart failure. ESC Heart Fail. 2018;5:364–371.
  • Brenner S, Güder G, Berliner D, et al. Airway obstruction in systolic heart failure–COPD or congestion? Int J Cardiol. 2013;3(168):1910–1916.
  • Wiener-Kronish JP, Broaddus VC. Interrelationship of pleural and pulmonary interstitial liquid. Annu Rev Physiol. 1993;55:209–226.
  • Clark AL, Cleland JGF. Causes and treatment of oedema in patients with heart failure. Nat Rev Cardiol. 2013;10:156–170.
  • Brenner S, Christa M, Berliner D, et al. Frequency and prognostic impact of mid-expiratory flow reduction in stable patients six months after hospitalisation for heart failure with reduced ejection fraction. Int J Cardiol. 2017;15:727–733.
  • Agostoni P, Bussotti M, Cattadori G, et al. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006;27:2538–2543.
  • Wright RS, Levine MS, Bellamy PE, et al. Ventilatory and diffusion abnormalities in potential heart transplant recipients. Chest. 1990;98:816–820.
  • Woods PR, Olson TP, Frantz RP, et al. Causes of breathing inefficiency during exercise in heart failure. J Card Fail. 2010;16:835–842.
  • Poon C-S, Tin C. Mechanism of augmented exercise hyperpnea in chronic heart failure and dead space loading. Respir Physiol Neurobiol. 2013;1:114–130.
  • O’Donnell DE, Neder JA, Elbehairy AF. Physiological impairment in mild COPD. Respirology. 2016 ;21:211–223.
  • Cooper BG, Stocks J, Hall GL, et al. The Global Lung Function Initiative (GLI) network: bringing the world’s respiratory reference values together. Breathe (Sheff). 2017;13:e56–64.
  • Minasian AG, van den Elshout FJJ, Dekhuijzen PNR, et al. COPD in chronic heart failure: less common than previously thought? Heart Lung. 2013;42:365–371.
  • Güder G, Brenner S, Störk S, et al. Chronic obstructive pulmonary disease in heart failure: accurate diagnosis and treatment. Eur J Heart Fail. 2014;16:1273–1282.
  • O’Donnell DE, Ciavaglia CE, Neder JA. When obesity and chronic obstructive pulmonary disease collide. Physiological and clinical consequences. Ann Am Thorac Soc. 2014;11:635–644.
  • Pirina P, Martinetti M, Spada C, et al. Prevalence and management of COPD and heart failure comorbidity in the general practitioner setting. Respir Med. 2017;131:1–5.
  • Güder G, Rutten FH, Brenner S, et al. The impact of heart failure on the classification of COPD severity. J Card Fail. 2012;18:637–644.
  • Minasian AG, van den Elshout FJ, Dekhuijzen PR, et al. Serial pulmonary function tests to diagnose COPD in chronic heart failure. Transl Respir Med. 2014;12(2):Dec.
  • Rocha A, Arbex FF, Sperandio PA, et al., Excess ventilation in COPD-heart failure overlap: implications for dyspnea and exercise intolerance. Am J Respir Crit Care Med. 2017 ;196:1264-1274.
  • O’Donnell DE, Elbehairy AF, Faisal A, et al. Exertional dyspnoea in COPD: the clinical utility of cardiopulmonary exercise testing. Eur Respir Rev. 2016;25:333–347.
  • Guazzi M, Bandera F, Ozemek C, et al. Cardiopulmonary exercise testing: what is its value? J Am Coll Cardiol. 2017;26:1618–1636.
  • Arena R, Sietsema KE. Cardiopulmonary exercise testing in the clinical evaluation of patients with heart and lung disease. Circulation. 2011;15(123):668–680.
  • Corrà U. Exercise oscillatory ventilation in heart failure. Int J Cardiol. 2016;206 Suppl:S13-5.
  • Johnson BD, Beck KC, Olson LJ, et al. Ventilatory constraints during exercise in patients with chronic heart failure. Chest. 2000;117:321–332.
  • Hansen JE, Ulubay G, Chow BF, et al. Mixed-expired and end-tidal CO2 distinguish between ventilation and perfusion defects during exercise testing in patients with lung and heart diseases. Chest. 2007;132:977–983.
  • Piepoli MF, Corrà U, Agostoni P. Cardiopulmonary exercise testing in patients with heart failure with specific comorbidities. Ann Am Thorac Soc. 2017;14:S110–5.
  • Arbex FF, Alencar MC, Souza A, et al. Exercise ventilation in COPD: influence of systolic heart failure. COPD. 2016;13:693-699.
  • Oliveira MF, Arbex F, Alencar MC, et al. Heart failure impairs muscle blood flow and endurance exercisetolerance in COPD. COPD. 2016;13:407-415.
  • Apostolo A, Laveneziana P, Palange P, et al. Impact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failure. Int J Cardiol. 2015;15:134–140.
  • Alencar MC, Arbex F, O’Donnell DE, et al. Does exercise ventilatory inefficiency predict poor outcome in heart failure patients with COPD? J Cardiopulm Rehab Prev. 2016;36:454-459.
  • Rocha A, Arbex FF, Alencar MCN, et al. Physiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPD. Int J Cardiol. 2016;24:447–453.
  • Mahler DA, O’Donnell DE. Recent advances in dyspnea. Chest. 2015;147:232–241.
  • Oliveira MF, Arbex F, Alencar MCN, et al. Heart failure impairs cerebral oxygenation during exercise in patients with COPD. Eur Respir J. 2013;42:1423–1426.
  • Oliveira MF, Alencar MC, Arbex F, et al. Effects of heart failure on cerebral blood flow in COPD: rest and exercise. Respir Physiol Neurobiol. 2016;15:41–48.
  • Treptow E, Oliveira MF, Soares A, et al. Cerebral microvascular blood flow and CO2 reactivity in pulmonary arterial hypertension. Respir Physiol Neurobiol. 2016;233:60–65.
  • Olson TP, Joyner MJ, Johnson BD. Influence of locomotor muscle metaboreceptor stimulation on the ventilatory response to exercise in heart failure. Circ Heart Fail. 2010; 3:212–219.
  • Hirai DM, Musch TI, Poole DC. Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization. Am J Physiol Heart Circ Physiol. 2015;309:H1419-39.
  • Floras JS, Ponikowski P. The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction. Eur Heart J. 2015;7:1974–1982b.
  • Leitao Filho FS, Alotaibi NM, Yamasaki K, et al. The role of beta-blockers in the management of chronic obstructive pulmonary disease. Expert Rev Respir Med. 2018;12:125–135.
  • Mohammed J, Meeus M, Derom E, et al. Evidence for autonomic function and its influencing factors in subjects with COPD: a systematic review. Respir Care. 2015;60:1841–1851.
  • Matera MG, Martuscelli E, Cazzola M. Pharmacological modulation of beta-adrenoceptor function in patients with coexisting chronic obstructive pulmonary disease and chronic heart failure. Pulm Pharmacol Ther. 2010;23:1–8.
  • Hawkins NM, Petrie MC, Macdonald MR, et al. Heart failure and chronic obstructive pulmonary disease the quandary of beta-blockers and beta-agonists. J Am Coll Cardiol. 2011;24:2127–2138.
  • Hawkins NM, Virani S, Ceconi C. Heart failure and chronic obstructive pulmonary disease: the challenges facing physicians and health services. Eur Heart J. 2013;34:2795–2803.
  • Agostoni P, Palermo P, Contini M. Respiratory effects of beta-blocker therapy in heart failure. Cardiovasc Drugs Ther. 2009;23:377–384.
  • Mentz RJ, Wojdyla D, Fiuzat M, et al. Association of beta-blocker use and selectivity with outcomes in patients with heart failure and chronic obstructive pulmonary disease (from OPTIMIZE-HF). Am J Cardiol. 2013;15:582–587.
  • Jabbour A, Macdonald PS, Keogh AM, et al. Differences between beta-blockers in patients with chronic heart failure and chronic obstructive pulmonary disease: a randomized crossover trial. J Am Coll Cardiol. 2010;27:1780–1787.
  • Agostoni P, Contini M, Cattadori G, et al. Lung function with carvedilol and bisoprolol in chronic heart failure: is beta selectivity relevant? Eur J Heart Fail. 2007;9:827–833.
  • Magrì D, Palermo P, Cauti FM, et al. Chronotropic incompentence and functional capacity in chronic heart failure: no role of beta-blockers and beta-blocker dose. Cardiovasc Ther. 2012;30:100–108.
  • Ellison DH, Felker GM. Diuretic treatment in heart failure. N Engl J Med. 2018;15;378:684–685.
  • Chen HH, Schrier RW. Pathophysiology of volume overload in acute heart failure syndromes. Am J Med. 2006;119:S11–16.
  • Lorenzi-Filho G, Azevedo ER, Parker JD, et al. Relationship of carbon dioxide tension in arterial blood to pulmonary wedge pressure in heart failure. Eur Respir J. 2002;19:37–40.
  • Barr RG, Bluemke DA, Ahmed FS, et al. Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med. 2010;21:217–227.
  • Aaron CP, Hoffman EA, Lima JAC, et al. Pulmonary vascular volume, impaired left ventricular filling and dyspnea: the MESA lung study. PLoS One. 2017;12:e0176180.
  • Barr RG. Rethinking chronic obstructive pulmonary disease. Chronic pulmonary insufficiency and combined cardiopulmonary insufficiency. Ann Am Thorac Soc. 2018;15:S30–4.
  • Hill NS. Fluid and electrolyte considerations in diuretic therapy for hypertensive patients with chronic obstructive pulmonary disease. Arch Intern Med. 1986;146:129–133.
  • Hypokalaemia induced by inhalation of fenoterol. - PubMed - NCBI [Internet]. [cited 2018 May 15]. Available from: https://www-ncbi-nlm-nih-gov.proxy.queensu.ca/pubmed/2860336
  • Brijker F, Heijdra YF, van den Elshout FJJ, et al. Discontinuation of furosemide decreases PaCO(2) in patients with COPD. Chest. 2002;121:377–382.
  • Prieto de Paula JM, Franco Hidalgo S, Borge Gallardo L, et al. The importance of identifying the association between metabolic alkalosis and respiratory acidosis. Arch Bronconeumol. 2012;48:65–66.
  • Palange P. Renal and hormonal abnormalities in chronic obstructive pulmonary disease (COPD). Thorax. 1998;53:989–991.
  • Anand IS, Chandrashekhar Y, Ferrari R, et al. Pathogenesis of congestive state in chronic obstructive pulmonary disease. Studies of body water and sodium, renal function, hemodynamics, and plasma hormones during edema and after recovery. Circulation. 1992;86:12–21.
  • von Lueder TG, Sangaralingham SJ, Wang BH, et al. Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure. Circ Heart Fail. 2013;6:594–605.
  • Marshall RP. The pulmonary renin-angiotensin system. Curr Pharm Des. 2003;9:715–722.
  • Parikh MA, Aaron CP, Hoffman EA, et al. Angiotensin-converting inhibitors and angiotensin II receptor blockers and longitudinal change in percent emphysema on computed tomography. The multi-ethnic study of atherosclerosis lung study. Ann Am Thorac Soc. 2017;14:649–658.
  • Petersen H, Sood A, Meek PM, et al. Rapid lung function decline in smokers is a risk factor for COPD and is attenuated by angiotensin-converting enzyme inhibitor use. Chest. 2014;145:695–703.
  • Mancini GBJ, Etminan M, Zhang B, et al. Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease. J Am Coll Cardiol. 2006;20:2554–2560.
  • Sebastian JL, McKinney WP, Kaufman J, et al. Angiotensin-converting enzyme inhibitors and cough. Prevalence in an outpatient medical clinic population. Chest. 1991;99:36–39.
  • Dicpinigaitis PV. Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Chest. 2006;129:169S–173S.
  • Guazzi M, Melzi G, Marenzi GC, et al. Angiotensin-converting enzyme inhibition facilitates alveolar-capillary gas transfer and improves ventilation-perfusion coupling in patients with left ventricular dysfunction. Clin Pharmacol Ther. 1999;65:319–327.
  • Guazzi M, Palermo P, Pontone G, et al. Synergistic efficacy of enalapril and losartan on exercise performance and oxygen consumption at peak exercise in congestive heart failure. Am J Cardiol. 1999 ;1:1038–1043.
  • Guazzi M, Agostoni P, Guazzi MD. Modulation of alveolar-capillary sodium handling as a mechanism of protection of gas transfer by enalapril, and not by losartan, in chronic heart failure. J Am Coll Cardiol. 2001;37:398–406.
  • Di Marco F, Guazzi M, Vicenzi M, et al. Effect of enalapril on exercise cardiopulmonary performance in chronic obstructive pulmonary disease: A pilot study. Pulm Pharmacol Ther. 2010;23:159–164.
  • Contini M, Compagnino E, Cattadori G, et al. ACE-inhibition benefit on lung function in heart failure is modulated by ACE insertion/deletion polymorphism. Cardiovasc Drugs Ther. 2016;30:159–168.
  • Jjv M, Packer M, Desai AS, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;11:993–1004.
  • de Man FS, Tu L, Handoko ML, et al. Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012;15:780–789.
  • Domenig O, Manzel A, Grobe N, et al. Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney. Sci Rep. 2016;21:33678.
  • Shenoy V, Ferreira AJ, Qi Y, et al. The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension. Am J Respir Crit Care Med. 2010;182:1065–1072.
  • Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004; 11:2049–2057.
  • Cohn JN, Archibald DG, Francis GS, et al. Veterans administration cooperative study on vasodilator therapy of heart failure: influence of prerandomization variables on the reduction of mortality by treatment with hydralazine and isosorbide dinitrate. Circulation. 1987;75:IV49–54.
  • Rubin LJ, Peter RH. Hemodynamics at rest and during exercise after oral hydralazine in patients with cor pulmonale. Am J Cardiol. 1981;47:116–122.
  • Lupi-Herrera E, Seoane M, Verdejo J. Hemodynamic effect of hydralazine in advanced, stable chronic obstructive pulmonary disease with cor pulmonale. Immediate and short-term evaluation at rest and during exercise. Chest. 1984;85:156–163.
  • Brent BN, Berger HJ, Matthay RA, et al. Contrasting acute effects of vasodilators (nitroglycerin, nitroprusside, and hydralazine) on right ventricular performance in patients with chronic obstructive pulmonary disease and pulmonary hypertension: a combined radionuclide-hemodynamic study. Am J Cardiol. 1983;51:1682–1689.
  • Hori M, Okamoto H. Heart rate as a target of treatment of chronic heart failure. J Cardiol. 2012 ;60:86–90.
  • Jensen MT, Marott JL, Lange P, et al. Resting heart rate is a predictor of mortality in COPD. Eur Respir J. 2013;42:341–349.
  • Tavazzi L, Swedberg K, Komajda M, et al. Clinical profiles and outcomes in patients with chronic heart failure and chronic obstructive pulmonary disease: an efficacy and safety analysis of SHIFT study. Int J Cardiol. 2013;10:182–188.
  • Vamos M, Erath JW, Hohnloser SH. Digoxin-associated mortality: a systematic review and meta-analysis of the literature. Eur Heart J. 2015;21:1831–1838.
  • Rathore SS, Curtis JP, Wang Y, et al. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA. 2003;19:871–878.
  • Guazzi M, Gatto P, Giusti G, et al. Pathophysiology of cardiorenal syndrome in decompensated heart failure: role of lung-right heart-kidney interaction. Int J Cardiol. 2013;30:379–384.
  • Dudgeon D, Baracos VE. Physiological and functional failure in chronic obstructive pulmonary disease, congestive heart failure and cancer: a debilitating intersection of sarcopenia, cachexia and breathlessness. Curr Opin Support Palliat Care. 2016;10:236–241.
  • Goudis CA, Konstantinidis AK, Ntalas IV, et al. Electrocardiographic abnormalities and cardiac arrhythmias in chronic obstructive pulmonary disease. Int J Cardiol. 2015;15:264–273.
  • Epstein AE, DiMarco JP, Ellenbogen KA, et al. 2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology foundation/American Heart Association task force on practice guidelines and the heart rhythm society. J Am Coll Cardiol. 2013;61:e6–75.
  • Bilchick KC, Stukenborg GJ, Kamath S, et al. Prediction of mortality in clinical practice for medicare patients undergoing defibrillator implantation for primary prevention of sudden cardiac death. J Am Coll Cardiol. 2012;23:1647–1655.
  • Granfeldt A, Wissenberg M, Hansen SM, et al. Severity of chronic obstructive pulmonary disease and presenting rhythm in patients with out-of-hospital cardiac arrest. Resuscitation. 2018;126:111–117.
  • Naksuk N, Kunisaki KM, Benditt DG, et al. Implantable cardioverter-defibrillators in patients with COPD. Chest. 2013;144:778–783.
  • Daubert JP, Zareba W, Cannom DS, et al. Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact. J Am Coll Cardiol. 2008 ;8:1357–1365.
  • Barold SS, Herweg B. Cardiac resynchronization in patients with atrial fibrillation. J Atr Fibrillation. 2015;8:1383.
  • Kirubakaran S, Ladwiniec A, Arujuna A, et al. Male gender and chronic obstructive pulmonary disease predict a poor clinical response in patients undergoing cardiac resynchronisation therapy. Int J Clin Pract. 2011;65:281–288.
  • Laveneziana P, O’Donnell DE, Ofir D, et al. Effect of biventricular pacing on ventilatory and perceptual responses to exercise in patients with stable chronic heart failure. J Appl Physiol. 2009;106:1574–1583.
  • Kunisaki KM, Dransfield MT, Anderson JA, et al. Exacerbations of chronic obstructive pulmonary disease and cardiac events: a cohort analysis. Am J Respir Crit Care Med. 2018;198:51-57.
  • Miravitlles M, D’Urzo A, Singh D, et al. Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review. Respir Res. 2016;17:112.
  • O’Donnell DE. Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful? Chest. 2000;117:42S–7S.
  • Hohlfeld JM, Vogel-Claussen J, Biller H, et al. Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial. Lancet Respir Med. 2018;6:368–378.
  • Dempsey JA, Romer L, Rodman J, et al. Consequences of exercise-induced respiratory muscle work. Respir Physiol Neurobiol. 2006;28:242–250.
  • Borghi-Silva A, Carrascosa C, Oliveira CC, et al. Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure. Am J Physiol Heart Circ Physiol. 2008;294:H2465–2472.
  • Matera MG, Rogliani P, Calzetta L, et al. Safety considerations with dual bronchodilator therapy in copd: an update. Drug Saf. 2016;39:501–508.
  • Singh S, Loke YK, Enright P, et al. Pro-arrhythmic and pro-ischaemic effects of inhaled anticholinergic medications. Thorax. 2013;68:114–116.
  • Taylor BJ, Snyder EM, Richert ML, et al. Effect of beta2-adrenergic receptor stimulation on lung fluid in stable heart failure patients. J Heart Lung Transplant. 2017;36:418–426.
  • Chase SC, Wheatley CM, Olson LJ, et al. Impact of chronic systolic heart failure on lung structure-function relationships in large airways. Physiol Rep. 2016;4. pii: e12867.
  • Stone IS, Barnes NC, James W-Y, et al. Lung deflation and cardiovascular structure and function in chronic obstructive pulmonary disease. A randomized controlled trial. Am J Respir Crit Care Med. 2016;193:717–726.
  • Segreti A, Fiori E, Calzetta L, et al. The effect of indacaterol during an acute exacerbation of COPD. Pulm Pharmacol Ther. 2013;26:630–634.
  • Cosentino ER, Degli Esposti D, Miceli R, et al. Coexisting heart failure and chronic obstructive pulmonary disease: report of two cases treated with indacaterol/glycopyrronium. Respiration. 2018;95:3–5.
  • Calzetta L, Rogliani P, Matera MG, et al. A systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable chronic obstructive pulmonary disease. Chest. 2016;149:1181–1196.
  • Rinaldi B, Donniacuo M, Sodano L, et al. Effects of chronic treatment with the new ultra-long-acting beta2-adrenoceptor agonist indacaterol alone or in combination with the beta1-adrenoceptor blocker metoprolol on cardiac remodelling. Br J Pharmacol. 2015;172:3627–3637.
  • Gavaldà A, Ramos I, Carcasona C, et al. The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide. Pulm Pharmacol Ther. 2014;28:114–121.
  • Dumitru L, Iliescu A, Dinu H, et al. Disability in COPD and chronic heart failure is the skeletal muscle the final common pathway? Maedica (Buchar). 2013;8:206–213.
  • Singh D, Barnes PJ, Stockley R, et al. Pharmacological treatment of COPD: the devil is always in the detail. Eur Respir J.  2018;51. pii: 1800263.
  • Iannella H, Luna C, Waterer G. Inhaled corticosteroids and the increased risk of pneumonia: what’s new? A 2015 updated review. Ther Adv Respir Dis. 2016;10:235–255.
  • Kew KM, Seniukovich A. Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2018. pii: S0003-9993(18)30234-X.
  • Janson C, Stratelis G, Miller-Larsson A, et al. Scientific rationale for the possible inhaled corticosteroid intraclass difference in the risk of pneumonia in COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:3055–3064.
  • Leung JM, Sin DD. Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets. BMJ. 2017;25;358:j3772.
  • Molenaar P, Christ T, Hussain RI, et al. PDE3, but not PDE4, reduces beta1- and beta2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. Br J Pharmacol. 2013;169:528–538.
  • Eschenhagen T. PDE4 in the human heart - major player or little helper? Br J Pharmacol. 2013 ;169:524–527.
  • Watz H, Bagul N, Rabe KF, et al. Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:813–822.
  • Guo D, Cai Y, Chai D, et al. The cardiotoxicity of macrolides: a systematic review. Pharmazie. 2010;65:631–640.
  • Cazzola M, Calzetta L, Barnes PJ, et al. Efficacy and safety profile of xanthines in COPD: a network meta-analysis. Eur Respir Rev. 2018; 30:27.
  • Cirillo R, Grossi E, Franzone JS. Doxofylline, an adenosine-nonblocking xanthine, does not induce cardiostimulant effects. Res Commun Chem Pathol Pharmacol. 1989;65:21–34.
  • Dini FL, Pasini G, Cortellini G, et al. Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline. Int J Clin Pharmacol Res. 1993;13:305–316.
  • Bongrani S, Razzetti R, Papotti M, et al. Lack of cardiostimulant effects of bamifylline in in vitro and in vivo models. Arzneimittelforschung. 1990;40:169–174.
  • O’Donnell DE, Webb KA, Harle I, et al. Pharmacological management of breathlessness in COPD: recent advances and hopes for the future. Expert Rev Respir Med. 2016;10:823–834.
  • Evans RA. Developing the model of pulmonary rehabilitation for chronic heart failure. Chron Respir Dis. 2011;8:259–269.
  • Palmer K, Bowles K-A, Paton M, et al. Chronic heart failure and exercise rehabilitation: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2018 Apr 23.
  • Rochester CL, Vogiatzis I, Holland AE, et al. An official American Thoracic Society/European Respiratory Society policy statement: enhancing implementation, use, and delivery of pulmonary rehabilitation. Am J Respir Crit Care Med. 2015;192:1373–1386.
  • Franssen FME, Rochester CL. Comorbidities in patients with COPD and pulmonary rehabilitation: do they matter? Eur Respir Rev. 2014;23:131–141.
  • Desveaux L, Harrison S, Lee A, et al. “We are all there for the same purpose”: support for an integrated community exercise program for older adults with HF and COPD. Heart Lung. 2017;46:308–312.
  • Vogiatzis I, Nanas S, Kastanakis E, et al. Dynamic hyperinflation and tolerance to interval exercise in patients with advanced COPD. Eur Respir J. 2004;24:385–390.
  • Tunsupon P, Lal A, Abo Khamis M, et al. Comorbidities in patients with chronic obstructive pulmonary disease and pulmonary rehabilitation outcomes. J Cardiopulm Rehabil Prev. 2017;37:283–289.
  • Mahler DA, Gifford AH, Waterman LA, et al. Mechanism of greater oxygen desaturation during walking compared with cycling in patients with COPD. Chest. 2011;140:351–358.
  • Zacarias EC, Neder JA, Cendom SP, et al. Heart rate at the estimated lactate threshold in patients with chronic obstructive pulmonary disease: effects on the target intensity for dynamic exercise training. J Cardiopulm Rehabil. 2000;20:369–376.
  • Louvaris Z, Vogiatzis I. Physiological basis of cardiopulmonary rehabilitation in patients with lung or heart disease. Breathe (Sheff). 2015;11:120–127.
  • Palange P, Forte S, Onorati P, et al. Ventilatory and metabolic adaptations to walking and cycling in patients with COPD. J Appl Physiol. 2000;88:1715–1720.
  • Kortianou EA, Nasis IG, Spetsioti ST, et al. Effectiveness of interval exercise training in patients with COPD. Cardiopulm Phys Ther J. 2010;21:12–19.
  • Bravo DM, Gimenes AC, Amorim BC, et al. Excess ventilation in COPD: implications for dyspnoea and tolerance to interval exercise. Respir Physiol Neurobiol. 2018;250:7–13.
  • Evans RA, Dolmage TE, Mangovski-Alzamora S, et al. One-legged cycle training for chronic obstructive pulmonary disease. A pragmatic study of implementation to pulmonary rehabilitation. Ann Am Thorac Soc. 2015;12:1490–1497.
  • Neder JA, Sword D, Ward SA, et al. Home based neuromuscular electrical stimulation as a new rehabilitative strategy for severely disabled patients with chronic obstructive pulmonary disease (COPD). Thorax. 2002;57:333–337.
  • Borghi-Silva A, Oliveira CC, Carrascosa C, et al. Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD. Thorax. 2008;63:910–915.
  • Chiappa GR, Queiroga F, Meda E, et al. Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179:1004–1010.
  • Charususin N, Dacha S, Gosselink R, et al. Respiratory muscle function and exercise limitation in patients with chronic obstructive pulmonary disease: a review. Expert Rev Respir Med. 2018;12:67–79.
  • Casaburi R, Patessio A, Ioli F, et al. Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. Am Rev Respir Dis. 1991;143:9–18.
  • Guazzi M, Belletti S, Tumminello G, et al. Exercise hyperventilation, dyspnea sensation, and ergoreflex activation in lone atrial fibrillation. Am J Physiol Heart Circ Physiol. 2004;287:H2899–2905.
  • Morganroth M, Pape G, Rozenfeld Y, et al. Multidisciplinary COPD disease management program: impact on clinical outcomes. Postgrad Med. 2016;128:239–249.
  • Güder G, Störk S, Gelbrich G, et al. Nurse-coordinated collaborative disease management improves the quality of guideline-recommended heart failure therapy, patient-reported outcomes, and left ventricular remodelling. Eur J Heart Fail. 2015;17:442–452.
  • Gandhi S, Mosleh W, Sharma UC, et al. Multidisciplinary Heart failure clinics are associated with lower heart failure hospitalization and mortality: systematic review and meta-analysis. Can J Cardiol. 2017;33:1237–1244.
  • Boylan P, Joseph T, Hale G, et al. Chronic obstructive pulmonary disease and heart failure self-management kits for outpatient transitions of care. Consult Pharm. 2018;1:152–158.
  • Lipson DA, Barnhart F, Brealey N, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378:1671–1680.

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