Bench to bedside defining calcific aortic valve disease: osteocardiology

References

• Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005–1011.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Evans FJ, Aikawa E, et al., Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease-2011 update. Circulation. 124(16): 1783–1791. 2011. .
   PubMed Web of Science ®Google Scholar
• Rajamannan NM. Osteocardiology: defining the Go/No-Go Time Point for Therapy. Cardiology. 2018;139(3):175–183.
   PubMed Web of Science ®Google Scholar
• O’Brien KD, Reichenbach DD, Marcovina SM, et al. (a), and E accumulate in the morphologically early lesion of ‘degenerative’ valvular aortic stenosis. Arterioscl Throm Vas. 1996;16(4): 523–532.
   Google Scholar
• Hutchens TW, Nelson RW, Li CM, et al. Synthetic metal-binding protein surface domains for metal ion-dependent interaction chromatography. I. Analysis of bound metal ions by matrix-assisted UV laser desorption time-of-flight mass spectrometry. J Chromatogr. 1992;604(1):125–132.
   PubMed Web of Science ®Google Scholar
• Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular health study. J Am Coll Cardiol. 1997;29(3):630–634.
   PubMed Web of Science ®Google Scholar
• Aronow WS, Ahn C, Kronzon I, et al. Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons. Am J Cardiol. 2001;88(6):693–695.
   PubMed Web of Science ®Google Scholar
• Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013;368(6):503–512.
   PubMed Web of Science ®Google Scholar
• Despres AA, Perrot N, Poulin A. et al. Lipoprotein(a), oxidized phospholipids, and aortic valve microcalcification assessed by 18f-sodium fluoride positron emission tomography and computed tomography. CJC Open. 2019;1(3):131–140.
   PubMedGoogle Scholar
• Ross J Jr., Braunwald E. Aortic stenosis. Circulation. 1968;38(1s5):61–67.
   PubMed Web of Science ®Google Scholar
• Nishimura RA, Otto CM, Bonow RO, et al., 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary. J Am Coll Cardiol. 63(22): 2438–2488. 2014.
   PubMed Web of Science ®Google Scholar
• Rosenhek R, Zilberszac R, Schemper M, et al. Natural history of very severe aortic stenosis. Circulation. 2010;121(1):151–156.
   PubMed Web of Science ®Google Scholar
• Bing R, Cavalcante JL, Everett RJ, et al. Imaging and impact of myocardial fibrosis in aortic stenosis. JACC. Cardiovascular Imaging. 2019;12(2):283–296.
   PubMed Web of Science ®Google Scholar
• Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease. J Am Coll Cardiol. 2017;70(2):252–289.
   PubMed Web of Science ®Google Scholar
• Bensahi I, Elfhal A, Magne J, et al. Sténose aortique sévère asymptomatique à fraction d’éjection ventriculaire gauche préservée. Évaluation à l’effort: quels résultats et quelles décisions? Annales de Cardiologie et d’Angéiologie. 2015;64(2):100–108.
   PubMedGoogle Scholar
• Kusljugic Z, Barakovic F, Dilic M, et al. The role of exercise test in stratifying the risk of asymptomatic patients with moderate/severe aortic stenosis. Med Arh. 2010; 64(5): 269–273.
   PubMedGoogle Scholar
• Gencbay M, Degertekin M, Ermeydan C, et al. Exercise electrocardiography test in patients with aortic stenosis. Differential features from that of coronary artery disease. Int J Cardiol. 1999;69(3):281–287.
   PubMed Web of Science ®Google Scholar
• Patel DN, Bailey SR. Role of BNP in patients with severe asymptomatic aortic stenosis. Eur Heart J. 2004;25(22):1972–1973.
   PubMed Web of Science ®Google Scholar
• Bergler-Klein J, Klaar U, Heger M, et al. Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis. Circulation. 2004;109(19):2302–2308.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Subramaniam M, Rickard D, et al., Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 107(17): 2181–2184. 2003. .
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Nealis TB, Subramaniam M, et al. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation. Circulation. 2005;111(24):3296–3301.
   PubMed Web of Science ®Google Scholar
• Mohler ER 3rd, Gannon F, Reynolds C, et al. Bone formation and inflammation in cardiac valves. Circulation. 2001;103(11):1522–1528.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM. Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice. J Cell Biochem. 2012;113(5):1623–1634.
   PubMed Web of Science ®Google Scholar
• Tintut Y, Alfonso Z, Saini T, et al. Multilineage potential of cells from the artery wall. Circulation. 2003;108(20):2505–2510.
   PubMed Web of Science ®Google Scholar
• Liu AC, Joag VR, Gotlieb AI. The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am J Pathol. 2007;171(5):1407–1418.
   PubMed Web of Science ®Google Scholar
• Ducy P, Zhang R, Geoffroy V, et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.[see comment]. Cell. 1997;89(5):747–754.
   PubMed Web of Science ®Google Scholar
• Chen J, Fan J, Wang S, et al. Secreted klotho attenuates inflammation-associated aortic valve fibrosis in senescence-accelerated mice P1. Hypertension. 2018;71(5):877–885.
   PubMed Web of Science ®Google Scholar
• Chen J, Lin Y, Sun Z. Deficiency in the anti-aging gene Klotho promotes aortic valve fibrosis through AMPKalpha-mediated activation of RUNX2. Aging Cell. 2016;15(5):853–860.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Subramaniam M, Springett M, et al. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation. 2002;105(22):2260–2265.
   Web of Science ®Google Scholar
• Kim KM. Calcification of matrix vesicles in human aortic valve and aortic media. Fed Proc. 1976;35(2):156–162.
   PubMedGoogle Scholar
• Yip CY, Chen JH, Zhao R, et al. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol. 2009;29(6):936–942.
   PubMed Web of Science ®Google Scholar
• Shuvy M, Abedat S, Beeri R, et al. Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. Am J Physiol Heart Circ Physiol. 2011;300(5):H1829–1840.
   PubMed Web of Science ®Google Scholar
• Shuvy M, Nyska A, Beeri R, et al. Histopathology and apoptosis in an animal model of reversible renal injury. Exp Toxicol Pathol. 2011;63(4):303–306.
   PubMedGoogle Scholar
• Rajamannan NM, Sangiorgi G, Springett M, et al. Experimental hypercholesterolemia induces apoptosis in the aortic valve. J Heart Valve Dis. 2001;10(3):371–374.
   PubMed Web of Science ®Google Scholar
• Berry JD, Lloyd-Jones DM, Garside DB, et al. Framingham risk score and prediction of coronary heart disease death in young men. Am Heart J. 2007;154(1):80–86.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Wolk A, Hakansson N, et al. Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies. Eur Heart J. 2017;38(28):2192–2197.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Back M, Rees JMB, et al. Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study. Eur Heart J. 2020;41(2):221–226.
   PubMed Web of Science ®Google Scholar
• Vavilis G, Back M, Occhino G, et al. Kidney dysfunction and the risk of developing aortic stenosis. J Am Coll Cardiol. 2019;73(3):305–314.
   PubMed Web of Science ®Google Scholar
• Dweck MR, Kwiecinski J. Emerging sex differences in aortic stenosis. Jacc. 2019;12(1):106–108.
   PubMedGoogle Scholar
• Cramariuc D, Rogge BP, Lonnebakken MT, et al. Sex differences in cardiovascular outcome during progression of aortic valve stenosis. Heart. 2015;101(3):209–214.
   PubMed Web of Science ®Google Scholar
• Olsson M, Thyberg J, Nilsson J. Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler Thromb Vasc Biol. 1999;19(5):1218–1222.
   PubMed Web of Science ®Google Scholar
• Sprecher DL, Schaefer EJ, Kent KM, et al. Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients. Am J Cardiol. 1984;54(1):20–30.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Edwards WD, Spelsberg TC. Hypercholesterolemic aortic-valve disease. N Engl J Med. 2003;349(7):717–718.
   PubMed Web of Science ®Google Scholar
• Alrasadi K, Alwaili K, Awan Z, et al. Aortic calcifications in familial hypercholesterolemia: potential role of the low-density lipoprotein receptor gene. Am Heart J. 2009;157(1):170–176.
   PubMed Web of Science ®Google Scholar
• Bild DE, Detrano R, Peterson D, et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005;111(10):1313–1320.
   PubMed Web of Science ®Google Scholar
• Bild DE, Bluemke DA, Burke GL, et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol. 2002;156(9):871–881.
   PubMed Web of Science ®Google Scholar
• Kronmal RA, McClelland RL, Detrano R, et al. Risk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2007;115(21):2722–2730.
   PubMed Web of Science ®Google Scholar
• Otto CM, Lind BK, Kitzman DW, et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999;341(3):142–147.
   PubMed Web of Science ®Google Scholar
• Zheng KH, Tsimikas S, Pawade T, et al. Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis. J Am Coll Cardiol. 2019;73(17):2150–2162.
   PubMed Web of Science ®Google Scholar
• Bosse Y, Mathieu P, Theriault S. PALMD as a novel target for calcific aortic valve stenosis. Curr Opin Cardiol. 2019;34(2):105–111.
   PubMed Web of Science ®Google Scholar
• Theriault S, Gaudreault N, Lamontagne M, et al. A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis. Nat Commun. 2018;9(1):988.
   PubMedGoogle Scholar
• Theriault S, Dina C, Messika-Zeitoun D, et al. Genetic association analyses highlight IL6, ALPL, and NAV1 As 3 new susceptibility genes underlying calcific aortic valve stenosis. Circ Genom Precis Med. 2019;12(10):e002617.
   PubMed Web of Science ®Google Scholar
• Garg V, Muth AN, Ransom JF, et al. Mutations in NOTCH1 cause aortic valve disease. Nature. 2005;437(7056):270–274.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM. Aortic valve disease is not a monogenetic disorder. JACC Basic Transl Sci. 2017;2(5):626.
   PubMedGoogle Scholar
• Messika-Zeitoun D, Aubry MC, Detaint D, et al. Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography. Circulation. 2004;110(3):356–362.
   PubMed Web of Science ®Google Scholar
• Pohle K, Maffert R, Ropers D, et al. Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors. Circulation. 2001;104(16):1927–1932.
   PubMed Web of Science ®Google Scholar
• Clavel MA, Magne J, Pibarot P. Low-gradient aortic stenosis. Eur Heart J. 2016;37(34):2645–2657.
   PubMed Web of Science ®Google Scholar
• Aortic Stenosis Writing G, Bonow RO, Brown AS, et al. ACC/AATS/AHA/ASE/EACTS/HVS/SCA/SCAI/SCCT/SCMR/STS 2017 Appropriate use criteria for the treatment of patients with severe aortic stenosis: a report of the American college of cardiology appropriate use criteria task force, American association for thoracic surgery, American heart association, American society of echocardiography, European association for cardio-thoracic surgery, heart valve society, society of cardiovascular anesthesiologists, society for cardiovascular angiography and interventions, society of cardiovascular computed tomography, society for cardiovascular magnetic resonance, and society of thoracic surgeons. J Am Soc Echocardiogr. 2018;31(2):117–147.
   PubMedGoogle Scholar
• Kupfahl C, Honold M, Meinhardt G, et al. Evaluation of aortic stenosis by cardiovascular magnetic resonance imaging: comparison with established routine clinical techniques. Heart. 2004;90(8):893–901.
   PubMed Web of Science ®Google Scholar
• Pawade T, Clavel MA, Tribouilloy C, et al. Computed tomography aortic valve calcium scoring in patients with aortic stenosis. Circ Cardiovasc Imaging. 2018;11(3):e007146.
   PubMed Web of Science ®Google Scholar
• Redfors B, Pibarot P, Gillam LD, et al. Stress testing in asymptomatic aortic stenosis. Circulation. 2017;135(20):1956–1976.
   PubMed Web of Science ®Google Scholar
• Annabi MS, Touboul E, Dahou A, et al. Dobutamine stress echocardiography for management of low-flow, low-gradient aortic stenosis. J Am Coll Cardiol. 2018;71(5):475–485.
   PubMed Web of Science ®Google Scholar
• Ramakrishna H, Patel PA, Gutsche JT, et al. Surgical aortic valve replacement-clinical update on recent advances in the contemporary era. J Cardiothorac Vasc Anesth. 2016;30(6):1733–1741.
   PubMed Web of Science ®Google Scholar
• Leon MB, Smith CR, Mack M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363(17):1597–1607.
   PubMed Web of Science ®Google Scholar
• Mack MJ, Leon MB, Smith CR, et al. 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015;385(9986):2477–2484.
   PubMed Web of Science ®Google Scholar
• Douglas PS, Leon MB, Mack MJ, et al. Longitudinal hemodynamics of transcatheter and surgical aortic valves in the PARTNER trial. JAMA Cardiol. 2017;2(11):1197–1206.
   PubMed Web of Science ®Google Scholar
• Bleakley C, Monaghan MJ. The pivotal role of imaging in TAVR procedures. Curr Cardiol Rep. 2018;20(2):9.
   PubMed Web of Science ®Google Scholar
• Bloomfield GS, Gillam LD, Hahn RT, et al. A practical guide to multimodality imaging of transcatheter aortic valve replacement. Jacc. 2012;5(4):441–455.
   Google Scholar
• Hahn RT, Nicoara A, Kapadia S, et al. Echocardiographic imaging for transcatheter aortic valve replacement. J Am Soc Echocardiogr. 2018;31(4):405–433.
   PubMed Web of Science ®Google Scholar
• Shavelle DM, Buljabasic N, Takasu J, et al. Validation of the severity index by cardiac catheterization and Doppler echocardiography in patients with aortic sclerosis and stenosis. Cardiovasc Ultrasound. 2006;4:12.
   PubMedGoogle Scholar
• Cowell SJ, Newby DE, Burton J, et al. Aortic valve calcification on computed tomography predicts the severity of aortic stenosis. Clin Radiol. 2003;58(9):712–716.
   PubMed Web of Science ®Google Scholar
• Rossebo AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359(13):1343–1356.
   PubMed Web of Science ®Google Scholar
• Chan KL, Teo K, Dumesnil JG, et al. Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation. 2010;121(2):306–314.
   PubMed Web of Science ®Google Scholar
• Moura LM, Ramos SF, Zamorano JL, et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol. 2007;49(5):554–561.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Greve AM, Moura LM, et al. SALTIRE-RAAVE: targeting calcific aortic valve disease LDL-density-radius theory. Expert Rev Cardiovasc Ther. 2015;13(4):355–367.
   PubMed Web of Science ®Google Scholar
• Greve AM, Bang CN, Boman K, et al. Effect modifications of lipid-lowering therapy on progression of aortic stenosis (from the Simvastatin and Ezetimibe in Aortic Stenosis [SEAS] study). Am J Cardiol. 2018;121(6):739–745.
   PubMed Web of Science ®Google Scholar
• Hutcheson JD, Aikawa E, Merryman WD. Potential drug targets for calcific aortic valve disease. Nat Rev Cardiol. 2014;11(4):218–231.
   PubMed Web of Science ®Google Scholar