Managing the patient undergoing transcatheter aortic valve replacement with ongoing mitral regurgitation

References

• Iung B, Baron G, Tornos P, et al. Valvular heart disease in the community: a European experience. Curr Probl Cardiol. 2007;32:609–661.
   PubMed Web of Science ®Google Scholar
• Liu Z, Kidney E, Bem D, et al. Transcatheter aortic valve implantation for aortic stenosis in high surgical risk patients: a systematic review and meta-analysis. PLoS One. 2018;13:e0196877.
   PubMed Web of Science ®Google Scholar
• Singh K, Carson K, Rashid MK, et al. Transcatheter aortic valve implantation in intermediate surgical risk patients with severe aortic stenosis: a systematic review and meta-analysis. Heart Lung Circ. 2018;27:227–234.
   PubMed Web of Science ®Google Scholar
• Kolkailah AA, Doukky R, Pelletier MP, et al. Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Cochrane Database Syst Rev. 2019;12:CD013319.
   PubMedGoogle Scholar
• Testa L, Popolo Rubbio A, Casenghi M, et al. Transcatheter mitral valve replacement in the transcatheter aortic valve replacement era. J Am Heart Assoc. 2019;8:e013352.
   PubMed Web of Science ®Google Scholar
• Taramasso M, Feldman T, Maisano F. Transcatheter mitral valve repair: review of the clinical evidence. EuroIntervention. 2018;14:AB91–AB100.
   PubMed Web of Science ®Google Scholar
• Bedogni F, Latib A, De Marco F, et al. Interplay between mitral regurgitation and transcatheter aortic valve replacement with the CoreValve Revalving System: a multicenter registry. Circulation. 2013;128:2145–2153.
   PubMed Web of Science ®Google Scholar
• De Chiara B, Moreo A, De Marco F, et al. Influence of CoreValve ReValving System implantation on mitral valve function: an echocardiographic study in selected patients. Catheter Cardiovasc Interv. 2011;78:638–644.
   PubMed Web of Science ®Google Scholar
• Nombela-Franco L, Ribeiro HB, Urena M, et al. Significant mitral regurgitation left untreated at the time of aortic valve replacement: a comprehensive review of a frequent entity in the transcatheter aortic valve replacement era. J Am Coll Cardiol. 2014;63:2643–2658.
   PubMed Web of Science ®Google Scholar
• Chiche O, Rodes-Cabau J, Campelo-Parada F, et al. Significant mitral regurgitation in patients undergoing TAVR: mechanisms and imaging variables associated with improvement. Echocardiography. 2019;36:722–731.
   PubMed Web of Science ®Google Scholar
• D’Onofrio A, Gasparetto V, Napodano M, et al. Impact of preoperative mitral valve regurgitation on outcomes after transcatheter aortic valve implantation. Eur J Cardiothorac Surg. 2012;41:1271–1276, discussion 6–7
   PubMed Web of Science ®Google Scholar
• Di Mario C, Eltchaninoff H, Moat N, et al. The 2011-12 pilot European Sentinel Registry of Transcatheter Aortic Valve Implantation: in-hospital results in 4,571 patients. EuroIntervention. 2013;8:1362–1371.
   PubMed Web of Science ®Google Scholar
• Tunick PA, Gindea A, Kronzon I. Effect of aortic valve replacement for aortic stenosis on severity of mitral regurgitation. Am J Cardiol. 1990;65:1219–1221.
   PubMed Web of Science ®Google Scholar
• de Agustin JA, Marcos-Alberca P, Fernandez-Golfin C, et al. Direct measurement of proximal isovelocity surface area by single-beat three-dimensional color Doppler echocardiography in mitral regurgitation: a validation study. J Am Soc Echocardiogr. 2012;25:815–823.
   PubMed Web of Science ®Google Scholar
• Grigioni F, Enriquez-Sarano M, Zehr KJ, et al. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation. 2001;103:1759–1764.
   PubMed Web of Science ®Google Scholar
• Kindya B, Ouzan E, Lerakis S, et al. Degenerative mitral regurgitation predicts worse outcomes in patients undergoing transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 2018;92:574–582.
   PubMed Web of Science ®Google Scholar
• Garg P, Swift AJ, Zhong L, et al. Assessment of mitral valve regurgitation by cardiovascular magnetic resonance imaging. Nat Rev Cardiol. 2020;17:298–312.
   PubMed Web of Science ®Google Scholar
• Jamieson WR, Edwards FH, Schwartz M, et al. Risk stratification for cardiac valve replacement. National Cardiac Surgery Database. database committee of the society of thoracic surgeons. Ann Thorac Surg. 1999;67:943–951.
   PubMed Web of Science ®Google Scholar
• Hannan EL, Racz MJ, Jones RH, et al. Predictors of mortality for patients undergoing cardiac valve replacements in New York State. Ann Thorac Surg. 2000;70:1212–1218.
   PubMed Web of Science ®Google Scholar
• Astor BC, Kaczmarek RG, Hefflin B, et al. Mortality after aortic valve replacement: results from a nationally representative database. Ann Thorac Surg. 2000;70:1939–1945.
   PubMed Web of Science ®Google Scholar
• Boudoulas KD, Ravi Y, Garcia D, et al. Type of valvular heart disease requiring surgery in the 21st century: mortality and length-of-stay related to surgery. Open Cardiovasc Med J. 2013;7:104–109.
   PubMedGoogle Scholar
• Barbanti M, Webb JG, Hahn RT, et al. Impact of preoperative moderate/severe mitral regurgitation on 2-year outcome after transcatheter and surgical aortic valve replacement: insight from the Placement of Aortic Transcatheter Valve (PARTNER) trial cohort A. Circulation. 2013;128:2776–2784.
   PubMed Web of Science ®Google Scholar
• Moazami N, Diodato MD, Moon MR, et al. Does functional mitral regurgitation improve with isolated aortic valve replacement? J Card Surg. 2004;19:444–448.
   PubMed Web of Science ®Google Scholar
• Barreiro CJ, Patel ND, Fitton TP, et al. Aortic valve replacement and concomitant mitral valve regurgitation in the elderly: impact on survival and functional outcome. Circulation. 2005;112:I443–7.
   PubMed Web of Science ®Google Scholar
• Jilaihawi H, Chakravarty T, Weiss RE, et al. Meta-analysis of complications in aortic valve replacement: comparison of Medtronic-Corevalve, Edwards-Sapien and surgical aortic valve replacement in 8,536 patients. Catheter Cardiovasc Interv. 2012;80:128–138.
   PubMed Web of Science ®Google Scholar
• Bilbija I, Matkovic M, Cubrilo M, et al. The prospects of secondary moderate mitral regurgitation after aortic valve replacement -meta-analysis. Int J Environ Res Public Health. 2020;17:733.
   Web of Science ®Google Scholar
• Caballero-Borrego J, Gomez-Doblas JJ, Cabrera-Bueno F, et al. Incidence, associated factors and evolution of non-severe functional mitral regurgitation in patients with severe aortic stenosis undergoing aortic valve replacement. Eur J Cardiothorac Surg. 2008;34:62–66.
   PubMed Web of Science ®Google Scholar
• Ruel M, Kapila V, Price J, et al. Natural history and predictors of outcome in patients with concomitant functional mitral regurgitation at the time of aortic valve replacement. Circulation. 2006;114:I541–6.
   PubMed Web of Science ®Google Scholar
• Zhou YX, Leobon B, Berthoumieu P, et al. Long-term outcomes following repair or replacement in degenerative mitral valve disease. Thorac Cardiovasc Surg. 2010;58:415–421.
   PubMed Web of Science ®Google Scholar
• Goldstein D, Moskowitz AJ, Gelijns AC, et al. Two-year outcomes of surgical treatment of severe ischemic mitral regurgitation. N Engl J Med. 2016;374:344–353.
   PubMed Web of Science ®Google Scholar
• Li B, Chen S, Sun H, et al. Mitral valve annuloplasty versus replacement for severe ischemic mitral regurgitation. Sci Rep. 2018;8:1537.
   PubMed Web of Science ®Google Scholar
• Leon MB, Smith CR, Mack M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363:1597–1607.
   PubMed Web of Science ®Google Scholar
• Smith CR, Leon MB, Mack MJ, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011;364:2187–2198.
   PubMed Web of Science ®Google Scholar
• Leon MB, Smith CR, Mack MJ, et al. Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2016;374:1609–1620.
   PubMed Web of Science ®Google Scholar
• Feldt K, De Palma R, Bjursten H, et al. Change in mitral regurgitation severity impacts survival after transcatheter aortic valve replacement. Int J Cardiol. 2019;294:32–36.
   PubMed Web of Science ®Google Scholar
• Zahn R, Gerckens U, Linke A, et al. Predictors of one-year mortality after transcatheter aortic valve implantation for severe symptomatic aortic stenosis. Am J Cardiol. 2013;112:272–279.
   PubMed Web of Science ®Google Scholar
• Holmes DR Jr., Brennan JM, Rumsfeld JS, et al. Clinical outcomes at 1 year following transcatheter aortic valve replacement. JAMA. 2015;313:1019–1028.
   PubMed Web of Science ®Google Scholar
• Mack MJ, Leon MB, Thourani VH, et al. Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med. 2019;380:1695–1705.
   PubMed Web of Science ®Google Scholar
• Gilard M, Eltchaninoff H, Iung B, et al. Registry of transcatheter aortic-valve implantation in high-risk patients. N Engl J Med. 2012;366:1705–1715.
   PubMed Web of Science ®Google Scholar
• Sabate M, Canovas S, Garcia E, et al. In-hospital and mid-term predictors of mortality after transcatheter aortic valve implantation: data from the TAVI national registry 2010-2011. Rev Esp Cardiol (Engl Ed). 2013;66:949–958.
   PubMed Web of Science ®Google Scholar
• Rodes-Cabau J, Webb JG, Cheung A, et al. Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience. J Am Coll Cardiol. 2010;55:1080–1090.
   PubMed Web of Science ®Google Scholar
• Mavromatis K, Thourani VH, Stebbins A, et al. Transcatheter aortic valve replacement in patients with aortic stenosis and mitral regurgitation. Ann Thorac Surg. 2017;104:1977–1985.
   PubMed Web of Science ®Google Scholar
• Nombela-Franco L, Eltchaninoff H, Zahn R, et al. Clinical impact and evolution of mitral regurgitation following transcatheter aortic valve replacement: a meta-analysis. Heart. 2015;101:1395–1405.
   PubMed Web of Science ®Google Scholar
• Chakravarty T, Van Belle E, Jilaihawi H, et al. Meta-analysis of the impact of mitral regurgitation on outcomes after transcatheter aortic valve implantation. Am J Cardiol. 2015;115:942–949.
   PubMed Web of Science ®Google Scholar
• Sannino A, Losi MA, Schiattarella GG, et al. Meta-analysis of mortality outcomes and mitral regurgitation evolution in 4,839 patients having transcatheter aortic valve implantation for severe aortic stenosis. Am J Cardiol. 2014;114:875–882.
   PubMed Web of Science ®Google Scholar
• Tamburino C, Capodanno D, Ramondo A, et al. Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis. Circulation. 2011;123:299–308.
   PubMed Web of Science ®Google Scholar
• Abdelghani M, Abdel-Wahab M, Hemetsberger R, et al. Fate and long-term prognostic implications of mitral regurgitation in patients undergoing transcatheter aortic valve replacement. Int J Cardiol. 2019;288:39–43.
   PubMed Web of Science ®Google Scholar
• Ben-Assa E, Biner S, Banai S, et al. Clinical impact of post procedural mitral regurgitation after transcatheter aortic valve replacement. Int J Cardiol. 2020;299:215–221.
   PubMed Web of Science ®Google Scholar
• Mauri V, Korber MI, Kuhn E, et al. Prognosis of persistent mitral regurgitation in patients undergoing transcatheter aortic valve replacement. Clin Res Cardiol. 2020;109:1261–1270.
   PubMed Web of Science ®Google Scholar
• Witberg G, Codner P, Landes U, et al. Effect of transcatheter aortic valve replacement on concomitant mitral regurgitation and its impact on mortality. JACC Cardiovasc Interv. 2021;14:1181–1192.
   PubMed Web of Science ®Google Scholar
• Itabashi Y, Shibayama K, Mihara H, et al. Significant reduction in mitral regurgitation volume is the main contributor for increase in systolic forward flow in patients with functional mitral regurgitation after transcatheter aortic valve replacement: hemodynamic analysis using echocardiography. Echocardiography. 2015;32:1621–1627.
   PubMed Web of Science ®Google Scholar
• Muratori M, Fusini L, Tamborini G, et al. Mitral valve regurgitation in patients undergoing TAVI: impact of severity and etiology on clinical outcome. Int J Cardiol. 2020;299:228–234.
   PubMed Web of Science ®Google Scholar
• Hekimian G, Detaint D, Messika-Zeitoun D, et al. Mitral regurgitation in patients referred for transcatheter aortic valve implantation using the Edwards Sapien prosthesis: mechanisms and early postprocedural changes. J Am Soc Echocardiogr. 2012;25:160–165.
   PubMed Web of Science ®Google Scholar
• Kiramijyan S, Koifman E, Asch FM, et al. Impact of functional versus organic baseline mitral regurgitation on short- and long-term outcomes after transcatheter aortic valve replacement. Am J Cardiol. 2016;117:839–846.
   PubMed Web of Science ®Google Scholar
• Toggweiler S, Boone RH, Rodes-Cabau J, et al. Transcatheter aortic valve replacement: outcomes of patients with moderate or severe mitral regurgitation. J Am Coll Cardiol. 2012;59:2068–2074.
   PubMed Web of Science ®Google Scholar
• Tzikas A, Piazza N, van Dalen BM, et al. Changes in mitral regurgitation after transcatheter aortic valve implantation. Catheter Cardiovasc Interv. 2010;75:43–49.
   PubMed Web of Science ®Google Scholar
• Shibayama K, Harada K, Berdejo J, et al. Effect of transcatheter aortic valve replacement on the mitral valve apparatus and mitral regurgitation: real-time three-dimensional transesophageal echocardiography study. Circ Cardiovasc Imaging. 2014;7:344–351.
   PubMed Web of Science ®Google Scholar
• Cortes C, Amat-Santos IJ, Nombela-Franco L, et al. Mitral regurgitation after transcatheter aortic valve replacement: prognosis, imaging predictors, and potential management. JACC Cardiovasc Interv. 2016;9:1603–1614.
   PubMedGoogle Scholar
• Durst R, Avelar E, McCarty D, et al. Outcome and improvement predictors of mitral regurgitation after transcatheter aortic valve implantation. J Heart Valve Dis. 2011;20:272–281.
   PubMed Web of Science ®Google Scholar
• Okuno T, Asami M, Khan F, et al. Does isolated mitral annular calcification in the absence of mitral valve disease affect clinical outcomes after transcatheter aortic valve replacement? Eur Heart J Cardiovasc Imaging. 2020;21:522–532.
   PubMed Web of Science ®Google Scholar
• Hayashida K, Lefevre T, Chevalier B, et al. Impact of post-procedural aortic regurgitation on mortality after transcatheter aortic valve implantation. JACC Cardiovasc Interv. 2012;5:1247–1256.
   PubMed Web of Science ®Google Scholar
• Boerlage-van Dijk K, Wiegerinck EM, Takama T, et al. Mitral regurgitation prior to transcatheter aortic valve implantation influences survival but not symptoms. Int J Cardiol. 2016;204:95–100.
   PubMed Web of Science ®Google Scholar
• Giordana F, Capriolo M, Frea S, et al. Impact of TAVI on mitral regurgitation: a prospective echocardiographic study. Echocardiography. 2013;30:250–257.
   PubMed Web of Science ®Google Scholar
• O’Sullivan CJ, Stortecky S, Butikofer A, et al. Impact of mitral regurgitation on clinical outcomes of patients with low-ejection fraction, low-gradient severe aortic stenosis undergoing transcatheter aortic valve implantation. Circ Cardiovasc Interv. 2015;8:e001895.
   PubMed Web of Science ®Google Scholar
• Freitas-Ferraz AB, Lerakis S, Barbosa Ribeiro H, et al. Mitral regurgitation in low-flow, low-gradient aortic stenosis patients undergoing TAVR: insights from the TOPAS-TAVI registry. JACC Cardiovasc Interv. 2020;13:567–579.
   PubMed Web of Science ®Google Scholar
• Unger P, Magne J, Vanden Eynden F, et al. Impact of prosthesis-patient mismatch on mitral regurgitation after aortic valve replacement. Heart. 2010;96:1627–1632.
   PubMed Web of Science ®Google Scholar
• Angeloni E, Melina G, Pibarot P, et al. Impact of prosthesis-patient mismatch on the regression of secondary mitral regurgitation after isolated aortic valve replacement with a bioprosthetic valve in patients with severe aortic stenosis. Circ Cardiovasc Imaging. 2012;5:36–42.
   PubMed Web of Science ®Google Scholar
• Zorn GL 3rd, Little SH, Tadros P, et al. Prosthesis-patient mismatch in high-risk patients with severe aortic stenosis: a randomized trial of a self-expanding prosthesis. J Thorac Cardiovasc Surg. 2016;151:1014–22, 23 e1–3.
   PubMed Web of Science ®Google Scholar
• Pibarot P, Weissman NJ, Stewart WJ, et al. Incidence and sequelae of prosthesis-patient mismatch in transcatheter versus surgical valve replacement in high-risk patients with severe aortic stenosis: a PARTNER trial cohort--a analysis. J Am Coll Cardiol. 2014;64:1323–1334.
   PubMed Web of Science ®Google Scholar
• Murdoch DJ, Sathananthan J, Hensey M, et al. Mitral regurgitation in patients undergoing transcatheter aortic valve implantation for degenerated surgical aortic bioprosthesis: insights from PARTNER 2 valve-in-valve registry. Catheter Cardiovasc Interv. 2020;96:981–986.
   PubMed Web of Science ®Google Scholar
• Feldman T, Kar S, Elmariah S, et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST II. J Am Coll Cardiol. 2015;66:2844–2854.
   PubMed Web of Science ®Google Scholar
• Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med. 2018;379:2307–2318.
   PubMed Web of Science ®Google Scholar
• Obadia JF, Messika-Zeitoun D, Leurent G, et al. Percutaneous repair or medical treatment for secondary mitral regurgitation. N Engl J Med. 2018;379:2297–2306.
   PubMed Web of Science ®Google Scholar
• Rudolph V, Schirmer J, Franzen O, et al. Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation. Int J Cardiol. 2013;167:716–720.
   PubMed Web of Science ®Google Scholar
• D’Ancona G, Kische S, Senges J, et al. Combined mitro-aortic pathology: impact of previous aortic valve replacement upon outcomes of MitraClip therapy (from the German transcatheter mitral valve interventions registry). EuroIntervention. 2017;13:475–482.
   PubMed Web of Science ®Google Scholar
• Witberg G, Codner P, Landes U, et al. Transcatheter treatment of residual significant mitral regurgitation following TAVR: a multicenter registry. JACC Cardiovasc Interv. 2020;13:2782–2791.
   PubMed Web of Science ®Google Scholar