367
Views
4
CrossRef citations to date
0
Altmetric
Review

Ventricular-arterial coupling: definition, pathophysiology and therapeutic targets in cardiovascular disease

, &
Pages 753-761 | Received 06 Apr 2021, Accepted 09 Jul 2021, Published online: 21 Jul 2021

References

  • Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. The task force for the management of arterial hypertension of the european society of cardiology and the european society of hypertension. J Hypertens. 2018;36:1953–2041.
  • Saeed S, Waje-Andreassen U, Nilsson PM. The Association of the Metabolic Syndrome with Target Organ Damage: focus on the Heart, Brain and Central Arteries. Expert Rev of Cardiovasc Ther. 2020;18:601–614.
  • Ikonomidis I, Aboyans V, Blacher J, et al. The role of ventricular-arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions: a consensus document of the European society of cardiology working group on aorta & peripheral vascular diseases, European association of cardiovascular imaging, and heart failure association. Eur J Heart Fail. 2019;21:402–424.
  • Nilsson PM, Laurent S, Cunha PG, et al. Metabolic syndrome, Arteries REsearch (MARE) Consortium. Characteristics of healthy vascular ageing in pooled population-based cohort studies: the global metabolic syndrome and artery research consortium. J Hypertens. 2018;36:2340–2349.
  • Kotsis V, Stabouli S, Karafillis I, et al. Early vascular aging and the role of central blood pressure. J Hypertens. 2011;29:1847–1853.
  • O’Rourke MF, Safar ME, Dzau V. The Cardiovascular Continuum extended: aging effects on the aorta and microvasculature. Vasc Med. 2010;15:461–468.
  • Chirinos JA, Rietzschel ER, Shiva-Kumar P, et al. Effective arterial elastance is insensitive to pulsatile arterial load. Hypertension 2014;64:1022–1031.
  • Chang MC, Mondy JS, Meredith JW, et al. Clinical application of ventricular end-systolic elastance and the ventricular pressure–volume diagram. Shock 1997;413:413–419.
  • Borlaug BA, Lam CS, Roger VL, et al. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009;54:410–418.
  • Lam CS, Shah AM, Borlaug BA, et al. Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. European Heart Journal. 2013;34(9):676–683.
  • Chen C-H, Fetics B, Nevo E, et al. Noninvasive single-beat determination of left ventricular end-systolic elastance in humans. Journal of the American College of Cardiology. 2001;38(7):2028–2034.
  • De Tombe PP, Jones S, Burkhoff D, et al. Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading. Am J Physiol. 1993;264:1817–1824.
  • Antonini-Canterin F, Pavan D, Bello V, et al. The ventricular-arterial coupling: from basic pathophysiology to clinical application in the echocardiography laboratory. Journal of Cardiovascular Echography. 2013;23(4):91–95.
  • Redfield MM, Jacobsen SJ, Borlaug BA, et al. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation 2005;112:2254–2262.
  • Borlaug BA, Redfield MM, Melenovsky V, et al. Longitudinal changes in left ventricular stiffness: a community-based study. Circ Heart Fail. 2013;6:944–952.
  • Kobayashi H, Kobayashi Y, Giles JT, et al. Tocilizumab treatment increases left ventricular ejection fraction and decreases left ventricular mass index in patients with rheumatoid arthritis without cardiac symptoms: assessed using 3.0 Tesla cardiac magnetic resonance imaging. J Rheumatol. 2014;41:1916–1921.
  • Russo C, Jin Z, Takei Y, et al. Arterial wave reflection and subclinical left ventricular systolic dysfunction. J Hypertens. 2011;29:574–582.
  • Fernandes VRS, Polak JF, Susang C, et al. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction - the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2008;28:194–201.
  • Ikonomidis I, Katsanos S, Triantafyllidi H, et al. Pulse wave velocity to global longitudinal strain ratio in hypertension. Eur J Clin Invest. 2019;49:e13049.
  • Yang H, Wright L, Negishi T, et al. Research to practice: assessment of left ventricular global longitudianal strain for surveillance of cancer chemitherapeuticc-related cardiac dysfuntion. Jacc Cardiovasc Imaging. 2018;11:1196–1201.
  • Chan J, Edwards NFA, Khandheria BK, et al. A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2019;20:31–39.
  • Hickson SS, Butlin M, Graves M, et al. The relationship of age with regional aortic stiffness and diameter. Jacc Cardiovasc Imaging. 2010;3:1247–1255.
  • Soulat G, Gencer U, Kachenoura N, et al. Changes in segmental pulse wave velocity of the thoracic aorta with age and left ventricular remodelling. An MRI 4D flow study. J Hypertens. 2020;38:118–126.
  • Quinaglia T, Bensalah MZ, Bollache E, et al. Differential impact of local and regional aortic stiffness on left ventricular remodeling: a cardiovascular magnetic resonance study. J Hypertens. 2018;36:552–559.
  • Wilkinson IB, McEniery CM. Arteriosclerosis: inevitable or self-inflicted? Hypertension 2012;60:3–5.
  • Nilsson PM, Boutouyrie P, Cunha P, et al. Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention. J Hypertens. 2013;31:1517–1526.
  • O’Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005;46:200–204.
  • Messerli FH, Rimoldi SF, Bangalore S, et al. When an increase in central systolic pressure overrides the benefits of heart rate lowering. J Am Coll Cardiol. 2016;68:754–762.
  • Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol (1985). 2008;105:1652–1660.
  • Fok H, Guilcher A, Brett S, et al. Dominance of the forward compression wave in determining pulsatile components of blood pressure: similarities between inotropic stimulation and essential hypertension. Hypertension 2014;64:1116–1123.
  • Mitchell GF. Arterial stiffness: insights from Framingham and Iceland. Curr Opin Nephrol Hypertens. 2015;24:1–7.
  • Cecelja M, Keehn L, Ye L, et al. Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization. Eur Heart J. 2020;41:3314–3322.
  • Kelly RP, Ting CT, Yang TM, et al. Effective arterial elastance as index of arterial vascular load in humans. Circulation 1992;86:513–521.
  • Chirinos JA, Rietzschel ER, De Buyzere ML, et al. Arterial load and ventricular-arterial coupling: physiologic relations with body size and effect of obesity. Hypertension 2009;54:558–566.
  • De Simone G, Roman M, Koren MJ, et al. Stroke volume/pulse pressure ratio and cardiovascular risk in arterial hypertension. Hypertension 1999;33:800–805.
  • Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–2605.
  • Bell V, McCabe EL, Larson MG. Relations between aortic stiffness and left ventricular mechanical function in the community. J Am Heart Assoc. 2017;6(1–9):e004903.
  • Hayashi K, Yamamoto T, Takahara A, et al. Clinical assessment of arterial stiffness with cardio-ankle vascular index: theory and applications. J Hypertens. 2015;33:1742–1757.
  • Vlachopoulos C, Aznaouridis K, Stefanadis C. Aortic stiffness for cardiovarscular risk prediction: just measure it, just do it!.J Am Coll Cardiol. 2013;63:647–649.
  • Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–1327.
  • Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236–1241.
  • Yannoutsos A, Ahouah M, Dreyfuss Tubiana C, et al. Aortic stiffness improves the prediction of both diagnosis and severity of coronary artery disease. Hypertension Res. 2018;41:118–125.
  • Saeed S, Waje-Andreassen U, Fromm A, et al. Early vascular aging in young and middle-aged ischemic stroke patients: the Norwegian stroke in the young study. PLoS One. 2014;9:e112814.
  • Tsao CW, Lyass A, Larson MG, et al. Relation of central arterial stiffness to incident heart failure in the community. J Am Heart Assoc. 2015;4:e002189.
  • Lilly SM, Jacobs D, Bluemke DA, et al. Resistive and pulsatile arterial hemodynamics and cardiovascular events: the multiethnic study of atherosclerosis. J Am Heart Assoc. 2014;3:e001223.
  • Chirinos JA, Segers P, Rietzschel ER, et al. for the asklepios investigators. Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the Asklepios study. Hypertension. 2013;61:296–303.
  • Weber T, Wassertheurer S, O’Rourke MF, et al. Pulsatile hemodynamics in patients with exertional dyspnea: potentially of value in the diagnostic evaluation of suspected heart failure with preserved ejection fraction. J Am Coll Cardiol. 2013;61:1874–1883.
  • Chirinos JA, Kips JG, Jacobs DR Jr, et al. Arterial wave reflections and incident cardiovascular events and heart failure: MESA (Multiethnic Study of Atherosclerosis). J Am Coll Cardiol. 2012;60:2170–2177.
  • Zamani P, Bluemke DA, Jacobs DR Jr, et al. Resistive and pulsatile arterial load as predictors of left ventricular mass and geometry: the multi-ethnic study of atherosclerosis. Hypertension. 2015;65:85–92.
  • Wohlfahrt P, Redfield MM, Melenovsky V, et al. Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans. Eur J Heart Fail. 2015;17:27–34.
  • Tartiere-Kesri L, Tartiere JM, Logeart D. Increased proximal arterial stiffness and cardiac response with moderate exercise in patients with heart failure and preserved ejection fraction. J Am Coll Cardiol. 2012;59:455–461.
  • Alagiakrishnan K, Banach M, Jones LG, et al. Update on diastolic heart failure or heart failure with preserved ejection fraction in the older adults. Ann Med. 2013;45:37–50.
  • Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Heart Fail Clin. 2008;4:23–36.
  • Maréchaux S, Samson R, Van Belle E, et al. Vascular and microvascular endothelial function in heart failure with preserved ejection fraction. J Card Fail. 2016;22:3–11.
  • Hundley WG, Kitzman DW, Morgan TM, et al. Cardiac cycle dependent changes in aortic area and aortic distensibility are reduced in older patients with reduced diastolic heart failure and correlate with exercise intolerance. J Am Coll Cardiol. 2001;38:796–802.
  • Desai AS, Mitchell GF, Fang JC, et al. Central aortic stiffness is increased in patients with heart failure and preserved ejection fraction. J Card Fail. 2009;15:658–664.
  • Mohammed SF, Borlaug BA, Roger VL, et al. Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction. A community-based study. Circ Heart Fail. 2012;5:710–719.
  • Wang J, Khoury DS, Yue Y, et al. Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. Eur Heart J. 2008;29:1283–1289.
  • Vinereanu D, Lim PO, Frenneaux MP, et al. Reduced myocardial velocities of left ventricular long-axis contraction identify both systolic and diastolic heart failure—a comparison with brain natriuretic peptide. Eur J Heart Fail. 2005;7:512–519.
  • Cauwenberghs N, Knez J, Tikhonoff V, et al. Doppler indexes of left ventricular systolic and diastolic function in relation to the arterial stiffness in a general population. J Hypertens. 2016;34:762–771.
  • Einarsen E, Gerdts E, Waje-Andreassen U, et al. Association of increased arterial stiffness with diastolic dysfunction in ischemic stroke patients: the Norwegian stroke in the young study. J Hypertens. 2020;38:467–473.
  • Ky B, French B, May Khan A, et al. Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. J Am Coll Cardiol. 2013;62:1165–1172.
  • Otsuki T, Maeda S, Kesen Y, et al. Age-related reduction of systemic arterial compliance induces excessive myocardial oxygen consumption during sub-maximal exercise. Hypertens Res. 2006;29:65–73.
  • Haluska BA, Matthys K, Fathi R, et al. Influence of arterial compliance on presence and extent of ischaemia during stress echocardiography. Heart 2006;92:40–43.
  • Nichols WW, Denardo SJ, Davidson JB, et al. Association of aortic stiffness and wave reflections with coronary flow reserve in women without obstructive coronary artery disease: an ancillary study from the national heart, lung, and blood institute-sponsored women’s Ischemia syndrome evaluation (WISE). Am Heart J. 2015;170:1243–1254.
  • Osranek M, Eisenach JH, Khandheria BK, et al. Arterioventricular coupling and ventricular efficiency after antihypertensive therapy: a noninvasive prospective study. Hypertension 2008;51:275–281.
  • Guarracino F, Ferro B, Baldassarri R, et al. Non-invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure. Cardiovasc Ultrasound. 2013;11:13.
  • Antonini-Canterin F, Enache R, Popescu BA, et al. Prognostic value of ventriculararterial coupling and B-type natriuretic peptide in patients after myocardial infarction: a five-year follow-up study. J Am Soc Echocardiogr. 2009;22:1239–1245.
  • Mehra MR, Milani RV, Richie MB, et al. Ventricular-vascular uncoupling increases expression of B-type natriuretic peptide in heart transplantation. Transplant Proc. 2004;36:3149–3151.
  • Her AY, Kim JY, Choi EY, et al. Value of ventricular stiffness index and ventriculoarterial interaction in patients with nonischemic dilated cardiomyopathy. Circ J. 2009;73:1683–1690.
  • Zanon F, Aggio S, Baracca E, et al. Ventricular-arterial coupling in patients with heart failure treated with cardiac resynchronization therapy: may we predict the long-term clinical response? Eur J Echocardiogr. 2009;10:106–111.
  • Reil JC, Tardif JC, Ford I, et al. Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients. J Am Coll Cardiol. 2013;62:1977–1985.
  • Lancellotti P, Donal E, Magne J, et al. Risk stratification in asymptomatic moderate to severe aortic stenosis: the importance of the valvular, arterial and ventricular interplay. Heart 2010;96:1364–1371.
  • Hachicha Z, Dumesnil JG, Pibarot P. Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis. J Am Coll Cardiol. 2009;54:1003–1011.
  • Schram MT, Henry RM, van Dijk RA, et al. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension 2004;43:176–181.
  • Zelniker TA, Wiviott SD, Raz I, et al. Comparison of the effects of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular and renal outcomes in type 2 diabetes mellitus. Circulation 2019;139:2022–2031.
  • Elharram M, Moura CS, Abrahamowicz M, et al. Novel glucose lowering agents are associated with a lower risk of cardiovascular and adverse events in type 2 diabetes: a population based analysis. Int J Cardiol. 2020;310::147–154.
  • Ikonomidis I, Pavlidis G, Thymis J, et al. Effects of glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and their combination on endothelial glycocalyx, arterial function, and myocardial work index in patients with type 2 diabetes mellitus after 12-month treatment. J Am Heart Assoc. 2020;9:e015716.
  • Beanlands RS, Nahmias C, Gordon E, et al. The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: a double-blind, placebo-controlled, positron-emission tomography study. Circulation 2000;102:2070–2075.
  • Wallace SM, Mäki-Petäjä KM, Cheriyan J, et al. Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunction. Br J Clin Pharmacol. 2010;70:799–806.
  • D’elia L, La Fata E, Iannuzzi A, et al. Effect of statin therapy on pulse wave velocity: a meta-analysis of randomized controlled trials. Clin Exp Hypertens. 2018;40:601–608.
  • Grigoropoulou P, Tentolouris A, Eleftheriadou I, et al. Effect of 12-month intervention with lowdose atorvastatin on pulse wave velocity in subjects with type 2 diabetes and dyslipidaemia. Diabetes Vasc Dis Res. 2019;16:38–46.
  • Wohlfahrt P, Redfield MM, Lopez-Jimenez F, et al. Impact of general and central adiposity on ventricular-arterial aging in women and men. JACC Heart Fail. 2014;2:489–499.
  • Sunagawa K, Maughan WL, Sagawa K. Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle. Circ Res. 1985;56:586–595.
  • Burkhoff D, Sagawa K. Ventricular efficiency predicted by an analytical model. Am J Physiol. 1986;250:R1021–7.
  • de Bruijn RF, Bos MJ, Portegies ML, et al. The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam study. BMC Med. 2015;13:132.
  • Kivipelto M, Helkala EL, Laakso MP, et al. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Inter Med. 2002;137:149–155.
  • Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005;4:487–499.
  • Chirinos JA, Sweitzer N. Ventricular-arterial coupling in chronic heart failure. Card Fail Rev. 2017;3:12–18.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.