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Review

Epidemiology of infective endocarditis: novel aspects in the twenty-first century

ORCID Icon, & ORCID Icon
Pages 45-54 | Received 20 May 2021, Accepted 17 Jan 2022, Published online: 31 Jan 2022

References

  • de Sa DDC, Tleyjeh IM, and Anavekar NS, et al. Epidemiological trends of infective endocarditis: a population-based study in Olmsted County, Minnesota. In: Mayo Clinic Proceedings USA. Elsevier; 2010. p. 422–426.
  • Alkhouli M, Alqahtani F, Alhajji M, et al.Clinical and economic burden of hospitalizations for infective endocarditis in the United States.Mayo Clin Proc.2020;95(5):858–866;Internet].;():. Available from
  • Wilson W, Taubert KA, and Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association. Circulation. 2007;116(15):1736–1754 .
  • Habib G, Lancellotti P, Antunes MJ, et al. 2015. ESC GUIDELINES 2015 ESC guidelines for the management of infective endocarditis the task force for the management of infective endocarditis of the European Society Of Cardiology (ESC) Endorsed by: european Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Available from: https://academic.oup.com/eurheartj/article/36/44/3075/2293384
  • NICE. Prophylaxis against infective endocarditis Antimicrobial prophylaxis against infective endocarditis in adults and children. National Institute for Health and Clinical Excellence. Natl Inst Clin Excell Guidel 64 [Internet]. 2008;(March):1–107. Available from: papers3://publication/uuid/42FCFEA6-9616-44E2-84A0-21074528BE46
  • DeSimone DC, Tleyjeh IM, Correa De Sa DD, et al. Incidence of infective endocarditis due to viridans group streptococci before and after the 2007 american heart association’s prevention guidelines: an extended evaluation of the olmsted county, minnesota, population and nationwide inpatient sample. Mayo Clin Proc. 2015 Jul 1 90(7):874–881.
  • Pant S, Patel NJ, Deshmukh A, et al. Trends in infective endocarditis incidence, microbiology, and valve replacement in the United States from 2000 to 2011. J Am Coll Cardiol. 2015;65(19):2070–2076.
  • Alkhouli M, Alqahtani F, Alhajji M, et al. Clinical and economic burden of hospitalizations for infective endocarditis in the United States. In: Mayo Clinic Proceedings. Elsevier; 2020. p. 858–866.
  • Toyoda N, Chikwe J, Itagaki S, et al. Trends in infective endocarditis in California and New York State, 1998-2013. Jama. 2017;317(16):1652–1660.
  • Bikdeli B, Wang Y, Kim N, et al. Trends in hospitalization rates and outcomes of endocarditis among medicare beneficiaries. J Am Coll Cardiol. 2013;62(23):2217–2226.
  • Yang X, Chen H, and Zhang D, et al. Global magnitude and temporal trend of infective endocarditis, 1990–2019: results from the Global Burden of Disease Study. Eur J Prev Cardiol. 2021. https://doi.org/10.1093/eurjpc/zwab184
  • Naderi HR, Sheybani F, Erfani SS. Errors in diagnosis of infective endocarditis. Epidemiol Infect. 2018;146(3):394–400.
  • Danchin N, Duval X, Leport C. Prophylaxis of infective endocarditis: french recommendations 2002. Heart. 2005;91(6):715–718.
  • Wilson WR, Gewitz M, and Lockhart PB, et al. prevention of viridans group streptococcal infective endocarditis: a scientific statement from the American Heart Association. Circulation. 2021;143:1–16.
  • Thornhill MH, Dayer MJ, Prendergast B, et al. Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis. J Antimicrob Chemother. 2015;70(8):2382–2388.
  • Watkins DA, Johnson CO, Colquhoun SM, et al. Global, regional, and national burden of rheumatic heart disease, 1990–2015. N Engl J Med. 2017;377(8):713–722.
  • Nunes MCP, Gelape CL, Ferrari TCA. Profile of infective endocarditis at a tertiary care center in Brazil during a seven-year period: prognostic factors and in-hospital outcome. Int J Infect Dis. 2010;14(5):e394–8.
  • Longo-Mbenza B, Bayekula M, Ngiyulu R, et al. Survey of rheumatic heart disease in school children of Kinshasa town. Int J Cardiol. 1998;63(3):287–294.
  • Remenyi B, Carapetis J, Wyber R, et al. Position statement of the World Heart Federation on the prevention and control of rheumatic heart disease. Nat Rev Cardiol. 2013;10(5):284.
  • Kumar RK, Antunes MJ, Beaton A, et al. Contemporary diagnosis and management of rheumatic heart disease: implications for closing the gap: a scientific statement from the American heart association. Circulation. 2020;142(20):e337–57.
  • Kaye D. Changing pattern of infective endocarditis. Am J Med. 1985;78(6):157–162.
  • Cherubin CE, Neu HC. Infective endocarditis at the presbyterian hospital in New York City from 1938–1967. Am J Med. 1971;51(1):83–96.
  • Thornhill MH, Jones S, and Prendergast B, et al. Quantifying infective endocarditis risk in patients with predisposing cardiac conditions. [cited 2017 Nov 17]. Available from: http://content.digital.nhs.uk
  • Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association task force and the European Society of Cardiology Com. Europace. 2006;8(9):746–837.
  • Torbica A, Banks H, Valzania C, et al. Investigating regional variation of cardiac implantable electrical device implant rates in European healthcare systems: what drives differences? Health Econ. 2017;26:30–45.
  • Voigt A, Shalaby A, Saba S. Continued rise in rates of cardiovascular implantable electronic device infections in the United States: temporal trends and causative insights. Pacing Clin Electrophysiol. 2010;33(4):414–419.
  • Jensen AD, Bundgaard H, Butt JH, et al. Temporal changes in the incidence of infective endocarditis in Denmark 1997–2017: a nationwide study. Int J Cardiol. 2021;326:145–152.
  • Greenspon AJ, Patel JD, Lau E, et al. 16-Year trends in the infection burden for pacemakers and implantable cardioverter-defibrillators in the United States: 1993 to 2008. J Am Coll Cardiol. 2011;58(10):1001–1006.
  • Le KY, Sohail MR, Friedman PA, et al. Clinical predictors of cardiovascular implantable electronic device-related infective endocarditis. Pacing Clin Electrophysiol. 2011;34(4):450–459.
  • Sohail MR, Henrikson CA, Braid-Forbes MJ, et al. Mortality and cost associated with cardiovascular implantable electronic device infections. Arch Intern Med. 2011;171(20):1821–1828.
  • Morita Y, Haruna T, Haruna Y, et al. Thirty-Day Readmission After Infective Endocarditis: analysis From a Nationwide Readmission Database. J Am Heart Assoc. 2019;8(9). https://doi.org/10.1161/JAHA.118.011598.
  • Pasupula DK, Bhat AG, and Siddappa Malleshappa SK, et al. Trends and predictors of 30-day readmission among patients hospitalized with infective endocarditis in the United States. Cureus. 2019;11(6):e4962 .
  • Han H-C, Hawkins NM, Pearman CM, et al. Epidemiology of cardiac implantable electronic device infections: incidence and risk factors. EP Eur. 2021;23(Supplement_4):iv3–10.
  • Asundi A, Stanislawski M, Mehta P, et al. Real-world effectiveness of infection prevention interventions for reducing procedure-related cardiac device infections: insights from the veterans affairs clinical assessment reporting and tracking program. Infect Control Hosp Epidemiol. 2019;40(8):855–862.
  • Kewcharoen J, Kanitsoraphan C, Thangjui S, et al. Postimplantation pocket hematoma increases risk of cardiac implantable electronic device infection: a meta‐analysis. J Arrhythmia. 2021;37(3):635–644.
  • Martinelli M, Nishioka SAD, Varejão T, et al. Efficacy of antibiotic prophylaxis before the implantation of pacemakers and cardioverter-defibrillators: results of a large, prospective, randomized, double-blinded, placebo-controlled trial. Circ Arrhythmia Electrophysiol. 2009;2(1):29–34.
  • Tarakji KG, Mittal S, Kennergren C, et al. Antibacterial envelope to prevent cardiac implantable device infection. N Engl J Med. 2019;380(20):1895–1905.
  • Rennert-May E, Raj SR, Leal J, et al. Economic evaluation of an absorbable antibiotic envelope for prevention of cardiac implantable electronic device infection. EP Eur. 2021;23(5):767–774.
  • Krahn AD, Longtin Y, Philippon F, et al. Prevention of Arrhythmia Device Infection Trial: the PADIT Trial. J Am Coll Cardiol. 2018;72(24):3098–3109.
  • Birnie DH, Wang J, Alings M, et al. Risk Factors for Infections Involving Cardiac Implanted Electronic Devices.JACC. 2019 [2020 January 07];74(23):2845–2854.
  • Boriani G, Kennergren C, Tarakji KG, et al. Cost-effectiveness analyses of an absorbable antibacterial envelope for use in patients at increased risk of cardiac implantable electronic device infection in Germany, Italy, and England. Value Heal. 2021;24(7):930–938.
  • El-Chami MF, Bonner M, Holbrook R, et al. Leadless pacemakers reduce risk of device-related infection: review of the potential mechanisms. Hear Rhythm. 2020 Aug 1 17(8):1393–1397.
  • Zhou S, Egorova N, Moskowitz G, et al. Trends in MitraClip, mitral valve repair, and mitral valve replacement from 2000 to 2016. J Thorac Cardiovasc Surg. 2020. Internet]. Available from. DOIhttps://doi.org/10.1016/j.jtcvs.2019.12.097.
  • Svensson LG, Ph D, and Tuzcu EM , et al. Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients. N Engl J Med. 2011;364:2187–2198.
  • Reardon MJ, Van Mieghem NM, Popma JJ, et al. Surgical or transcatheter aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2017;376(14):1321–1331.
  • Østergaard L, Valeur N, Ihlemann N, et al. Incidence and factors associated with infective endocarditis in patients undergoing left-sided heart valve replacement. Eur Heart J. 2018;39(28):2668–2675.
  • Erichsen P, Gislason GH, Bruun NE. The increasing incidence of infective endocarditis in Denmark, 1994–2011. Eur J Intern Med. 2016 Nov 1; 35:95–99
  • Amat-Santos IJ, Messika-Zeitoun D, Eltchaninoff H, et al. Infective endocarditis after transcatheter aortic valve implantation results from a large multicenter registry. Circulation. 2015;131(18):1566–1574.
  • Habib G, Hoen B, Tornos P, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30(19):2369–2413.
  • Cecchi E, Parrini I, Chinaglia A, et al. New diagnostic criteria for infective endocarditis: a study of sensitivity and specificity. Eur Heart J. 1997;18(7):1149–1156.
  • Castillo Almeida NE, Gurram P, Esquer Garrigos Z, et al.Diagnostic imaging in infective endocarditis: a contemporary perspective.Expert Rev Anti Infect Ther.2020;18(9):911–925;Internet].;():. Available from
  • Abdelghani M, Nassif M, Blom NA, et al. Infective endocarditis after melody valve implantation in the pulmonary position: a systematic review. J Am Heart Assoc. 2018;7(13):e008163.
  • McElhinney DB, Zhang Y, Aboulhosn JA, et al. Multicenter study of endocarditis after transcatheter pulmonary valve replacement. J Am Coll Cardiol. 2021;78(6):575–589.
  • Malekzadeh-Milani S, Ladouceur M, Patel M, et al. Incidence and predictors of Melody® valve endocarditis: a prospective study. Arch Cardiovasc Dis. 2015;108(2):97–106.
  • V SAS, McAllister DA, Gallacher P, et al. Incidence, microbiology, and outcomes in patients hospitalized with infective endocarditis. Circulation. 2020;141(25):2067–2077.
  • Fernández-Hidalgo N, Larrosa MN, Fernandez-Galera R, et al. Secular trends in the epidemiology and clinical characteristics of Enterococcus faecalis infective endocarditis at a referral center (2007–2018). Eur J Clin Microbiol Infect Dis. 2021;40(6):1137–1148.
  • Regueiro A, Linke A, Latib A, et al. Association between transcatheter aortic valve replacement and subsequent infective endocarditis and in-hospital death. Jama. 2016;316(10):1083–1092.
  • Tortoli E, Rindi L, Garcia MJ, et al. Proposal to elevate the genetic variant MAC-A included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov. Int J Syst Evol Microbiol. 2004;54(4):1277–1285.
  • Achermann Y, Rössle M, Hoffmann M, et al. Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera. J Clin Microbiol. 2013;51(6):1769–1773.
  • Asadi T, Mullin K, Roselli E, et al. Disseminated Mycobacterium chimaera infection associated with heater–cooler units after aortic valve surgery without endocarditis. J Thorac Cardiovasc Surg. 2018;155(6):2369–2374.
  • Administration F and D. Nontuberculous mycobacterium (NTM) infections associated with heater-cooler devices (HCD) during cardiothoracic surgery. In: 2016 Meeting Materials of the Circulatory System Devices Panel, USA. [cited 2018 Mar 29] https://www.fdagov/AdvisoryCommittees/CommitteesMeeting-Materials/MedicalDevices/MedicalDevicesAdvisoryCommittee/CirculatorySystemDevicesPanel/ucm485091htm. 2016.
  • Sax H, Bloemberg G, Hasse B, et al. Prolonged outbreak of Mycobacterium chimaera infection after open-chest heart surgery. Clin Infect Dis. 2015;61(1):67–75.
  • Hasse B, Hannan MM, Keller PM, et al. International society of cardiovascular infectious diseases guidelines for the diagnosis, treatment and prevention of disseminated Mycobacterium chimaera infection following cardiac surgery with cardiopulmonary bypass. J Hosp Infect. 2020;104(2):214–235.
  • Kaluza M, Färber G, May B, et al. Heater–Cooler Devices and Risk of Contamination during Cardiac Surgery. Thorac Cardiovasc Surg. 2021;69(8):703–709.
  • Fleischauer AT, Ruhl L, Rhea S, et al. Hospitalizations for Endocarditis and Associated Health Care Costs Among Persons with Diagnosed Drug Dependence — north Carolina, 2010–2015. MMWR Morb Mortal Wkly Rep. 2017;66(22):569–573.
  • Martin CA, Burgess DR, and Wallace KL, et al. 1026. trends in infective endocarditis during the substance use disorder epidemic at an academic medical center. In: Open Forum Infectious Diseases. USA: Oxford University Press; 2018. p. S306.
  • Wright A, Otome O, Harvey C, et al. The current epidemiology of injecting drug use-associated infective endocarditis in Victoria, Australia in the midst of increasing crystal methamphetamine use. Heart Lung Circ. 2018;27(4):484–488.
  • Dayer MJ, Jones S, Prendergast B, et al. Incidence of infective endocarditis in England, 2000-13: a secular trend, interrupted time-series analysis. Lancet. 2015 Mar 28; 385(9974):1219–1228.
  • Parikh MP, Octaria R, Kainer MA. Methicillin-resistant staphylococcus aureus bloodstream infections and injection drug use, Tennessee, USA, 2015-2017. Emerg Infect Dis. 2020;26(3):446–453.
  • Klietz M-L, Kaiser HW, and Machens H-G, et al. Infective endocarditis among persons aged 18-64 years with HIV, hepatitis C infection, or opioid use disorder — United States, 2007−20. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 2021; 72(10):1767–81. doi:https://doi.org/10.1093/cid/ciaa372.
  • Huang G, Davis KA, Petty SA, et al.Left-sided infective endocarditis in persons who inject drugs.Infection.2020;48(3):375–383;Internet].;():. Available from
  • Pericàs JM, Llopis J, Athan E, et al. Prospective cohort study of infective endocarditis in people who inject drugs. J Am Coll Cardiol. 2021;77(5):544–555.
  • Gray ME, Rogawski Mcquade ET, Scheld WM, et al. Rising rates of injection drug use associated infective endocarditis in Virginia with missed opportunities for addiction treatment referral: a retrospective cohort study. BMC Infect Dis. 2018;18(1):1–9.
  • Rudasill SE, Sanaiha Y, Mardock AL, et al. Clinical outcomes of infective endocarditis in injection drug users. J Am Coll Cardiol. 2019;73(5):559–570.
  • Correa De Sa DD, Tleyjeh IM, Anavekar NS, et al. Epidemiological trends of infective endocarditis: a population-based study in Olmsted County, Minnesota. Mayo Clin Proc. 2010;85(5):422–426.Internet].;():. Available from
  • Ruch Y, Mazzucotelli JP, Lefebvre F, et al. impact of setting up an “endocarditis team” on the management of infective endocarditis. Open Forum Infect Dis. 2019;6(9):1–7.
  • Kaura A, Byrne J, Fife A, et al. Inception of the ‘endocarditis team’ is associated with improved survival in patients with infective endocarditis who are managed medically: findings from a before-and-after study. Open Heart. 2017;4(2):e000699.
  • Thakarar K, Rokas KE, Lucas FL, et al. Mortality, morbidity, and cardiac surgery in injection drug use (IDU)-associated versus non-IDU infective endocarditis: the need to expand substance use disorder treatment and harm reduction services. PLoS One. 2019;14(11):e0225460.
  • Damlin A, Westling K. Patients with infective endocarditis and history of injection drug use in a Swedish referral hospital during 10 years. BMC Infect Dis. 2021;21(1):1–9.
  • Leahey PA, LaSalvia MT, and Rosenthal ES, et al. High morbidity and mortality among patients with sentinel admission for injection drug use-related infective endocarditis. In: Open forum infectious diseases. USA: Oxford University Press US; 2019. p. ofz089.
  • Straw S, Baig MW, Gillott R, et al. Long-term outcomes are poor in intravenous drug users following infective endocarditis, even after surgery. Clin Infect Dis. 2020;71(3):564–571.
  • Suzuki J, Johnson JA, Montgomery MW, et al. Long-term outcomes of injection drug-related infective endocarditis among people who inject drugs. J Addict Med. 2020;14(4):282–286.
  • Halavaara M, Martelius T, and Anttila V-J, et al. Three separate clinical entities of infective endocarditis—a population-based study from Southern Finland 2013–2017. In: Open forum infectious diseases. USA: Oxford University Press US; 2020. p. ofaa334.
  • Mosseler K, Materniak S, Brothers TD, et al. Epidemiology, microbiology, and clinical outcomes among patients with intravenous drug use-associated infective endocarditis in New Brunswick. CJC Open. 2020;2(5):379–385.
  • Meisner JA, Anesi J, Chen X, et al. Changes in infective endocarditis admissions in Pennsylvania during the opioid epidemic. Clin Infect Dis. 2020;71(7):1664–1670.
  • Giannitsioti E, Skiadas I, Antoniadou A, et al. Nosocomial vs. community-acquired infective endocarditis in Greece: changing epidemiological profile and mortality risk. Clin Microbiol Infect. 2007 Aug 1 13(8):763–769.
  • Lomas JM, Martínez-Marcos FJ, Plata A, et al. Healthcare-associated infective endocarditis: an undesirable effect of healthcare universalization. Clin Microbiol Infect. 2010;16(11):1683–1690.
  • Benito N, Miró JM, De Lazzari E, et al. Health care–associated native valve endocarditis: importance of non-nosocomial acquisition. Ann Intern Med. 2009;150(9):586–594.
  • Yang F, Zhang B, Yu J, et al. Epidemiology and the prognosis of healthcare–associated infective endocarditis in China: the significance of non-nosocomial acquisition. Emerg Microbes Infect. 2015;4(1):1–6.
  • Sanghavi DK, Titus A, Caulfield TR, et al. Endotheliitis, endothelin, and endothelin receptor blockers in COVID-19. Med Hypotheses. 2021;150:110564.
  • Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–1418.
  • Khanduri A, Anand U, Doss M, et al. Severe acute mitral valve regurgitation in a COVID-19-infected patient. BMJ Case Reports CP. 2021;14(1):e239782.
  • Toth E, Dancy L, Amin-Youssef G, et al. Collateral implications of the COVID-19 pandemic: belated presentation of infective endocarditis in a young patient. Eur Heart J. 2020;41(45):4365.
  • Hayes DE, Rhee DW, Hisamoto K, et al. Two cases of acute endocarditis misdiagnosed as COVID‐19 infection. Echocardiography. 2021;38(5):798–804.
  • Schizas N, Michailidis T, Samiotis I, et al. Delayed diagnosis and treatment of a critically ill patient with infective endocarditis due to a false-positive molecular diagnostic test for SARS-CoV-2. Am J Case Rep. 2020;21: e925931–1.
  • Skulstad H, Cosyns B, and Popescu BA, et al. COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel. Eur Heart J - Cardiovascular Imaging. 2020;21(6):592–598.
  • Cosyns B, Motoc A, and Arregle F, et al. A plea not to forget infective endocarditis in COVID-19 era. J Am Coll Cardiol Img. 2020;13(11):2470–2471.
  • Van Camp G, De Beenhouwer H, Beles M, et al. Disturbing effect of lockdown for COVID-19 on the incidence of infective endocarditis: a word of caution. Clin Res Cardiol. 2020;109(12):1573–1576.
  • Ramos-Martinez A, Fernández-Cruz A, and Dominguez F, et al. Hospital-acquired infective endocarditis during Covid-19 pandemic. Infect Prev Prac. 2020;2(3):100080.
  • Havers-Borgersen E, Fosbøl EL, Butt JH, et al. Incidence of infective endocarditis during the coronavirus disease 2019 pandemic: a nationwide study. IJC Hear Vasc. 2020;31:100675.
  • Cabral M, Fernandes S, and Santos LG, et al. An outbreak of infective endocarditis during the COVID-19 pandemic?-an observational retrospective single centre study. Eur Hear JAcute Cardiovasc Care. 2021;10(Supplement_1):zuab020–184.
  • Escolà-Vergè L, Cuervo G, de Alarcón A, et al. Impact of the COVID-19 pandemic on the diagnosis, management and prognosis of infective endocarditis. Clin Microbiol Infect. 2021;27(4):660–664.
  • Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435–1486.
  • Durack DT, Lukes AS, Bright DK. Duke endocarditis service. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Am J Med. 1994 Mar 1; 96(3):200–209.
  • Vilardell P, Moral S, Bosch D, et al. 3328 Relationship between streptococcal infective endocarditis and pre-neoplastic colorectal lesions. Eur Heart J. 2019;40(Supplement_1):ehz745–0080.
  • Mahmood M, Kendi AT, Ajmal S, et al. Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis. J Nucl Cardiol. 2019;26(3):922–935.
  • Botelho-Nevers E, Thuny F, Casalta JP, et al. Dramatic reduction in infective endocarditis–related mortality with a management-based approach. Arch Intern Med. 2009;169(14):1290–1298.
  • Chirillo F, Scotton P, Rocco F, et al. Impact of a multidisciplinary management strategy on the outcome of patients with native valve infective endocarditis. Am J Cardiol. 2013;112(8):1171–1176.
  • Habib G, Lancellotti P, Antunes MJ, et al. ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC) endorsed by: european Association for Cardio-Thoracic Surgery (EACTS), the European A. Eur Heart J. 2015;36(44):3075–3128.
  • Nishimura RA, Otto CM, Bonow RO, et al. AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. J Am Coll Cardiol. 2017;70(2):252–289.
  • Weimer MB, Falker CG, Seval N, et al. the need for multidisciplinary hospital teams for injection drug use-related infective endocarditis. J Addict Med. 2021;Publish Ahead of Print. https://doi.org/10.1097/ADM.0000000000000916.
  • Pandey M, Batzloff MR, Good MF. Vaccination against rheumatic heart disease: a review of current research strategies and challenges. Curr Infect Dis Rep. 2012;14(4):381–390.
  • Skolnick P. The opioid epidemic: crisis and solutions. Annu Rev Pharmacol Toxicol. 2018;58(1):143–159.

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