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Expert Review of Cardiovascular Therapy Volume 20, 2022 - Issue 6
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Systematic Review

Differences in ejection fraction as inclusion criterion in randomized controlled trials among patients with heart failure with reduced ejection fraction: a systematic review

Hussein Al Sudania Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2486-8977View further author information
ORCID Icon,
Kevin Bryan Loa Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAORCID Iconhttps://orcid.org/0000-0001-7088-6677View further author information
ORCID Icon,
Hani Essab Department of Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK;c Liverpool Centre for Cardiovascular Science, Liverpool Heart & Chest Hospital, Liverpool, UK;d Department of Cardiology, University of Liverpool, Liverpool, UKView further author information
,
Ammaar Wattooa Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAView further author information
,
Asma Gulaba Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAORCID Iconhttps://orcid.org/0000-0002-4167-4947View further author information
ORCID Icon,
Hamza Akhtara Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAView further author information
,
Lucas Angelima Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAView further author information
,
Beth Helfmana Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAView further author information
,
Eric Petersona Department of Internal Medicine, Einstein Medical Center, Philadelphia, PA, USAView further author information
,
Sophia Brousasb Department of Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UKView further author information
,
Isabel Whybrow-Huppatzb Department of Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UKView further author information
,
Ali Yazdanyare Lehigh Valley Hospital- Cedar Crest, Tampa, FL, USAView further author information
,
Sandeep Somanf Department of Nephrology, Henry Ford Hospital, Detroit, MI, USAView further author information
,
Rajiv Sankaranarayananb Department of Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK;c Liverpool Centre for Cardiovascular Science, Liverpool Heart & Chest Hospital, Liverpool, UK;d Department of Cardiology, University of Liverpool, Liverpool, UKView further author information
&
Janani Rangaswamig School of Medicine, George Washington University, Washington, DC, USAView further author information
 show all
Pages 481-484 | Received 19 Dec 2021, Accepted 31 May 2022, Published online: 06 Jun 2022

References

  • Bozkurt B, Coats AJ, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the heart failure society of America, heart failure association of the European society of cardiology, Japanese heart failure society and writing committee of the universal definition of heart failure. J Card Fail. 2021;23(3): 352–380.
  • Lo KB, Essa H, Wattoo A, et al. Representation of chronic kidney disease in randomized controlled trials among patients with heart failure with reduced ejection fraction: a systematic review. Curr Probl Cardiol. 2021 Nov 14:101047.
  • Arnett DK, Blumenthal RS, Albert MA, et al. ACC/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019 Sep 10;74(10):1376–1414.
  • McDonagh TA, Metra M, Adamo M, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599–3726.
  • Marwick TH Ejection fraction pros and cons: JACC state-of-the-art review. J Am Coll Cardiol. 2018 Nov 6;72(19):2360–2379.
  • Bozkurt B, Ezekowitz J Substance and substrate: LVEF and sex subgroup analyses of PARAGON-HF and PARADIGM-HF trials. Circulation. 2020 Feb 4;141(5):362–366.
  • Solomon SD, Vaduganathan M, Lc B, et al. Sacubitril/valsartan across the spectrum of ejection fraction in heart failure. Circulation. 2020 Feb 4;141(5):352–361.
  • Cleland JGF, Bunting KV, Flather MD, et al. Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials. Eur Heart J. 2018 Jan 1;39(1):26–35.
  • Solomon SD, Claggett B, Lewis EF, et al. Influence of ejection fraction on outcomes and efficacy of spironolactone in patients with heart failure with preserved ejection fraction. Eur Heart J. 2016 Feb 1;37(5):455–462.
  • Hinder M, Yi BA, Langenickel TH Developing drugs for heart failure with reduced ejection fraction: what have we learned from clinical trials? Clin Pharmacol Ther. 2018 May;103(5):802–814.
  • Ponikowski P, Voors AA, Anker SD, et al. 2016 Aug ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 18(8):891–975.
  • Anker SD, Butler J, Filippatos G, et al. Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med. 2021 Oct 14;385(16):1451–1461.

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