Do all patients with asymptomatic severe aortic stenosis need treatment?

References

• Vahanian A, Beyersdorf F, Praz F, et al. ESC/EACTS guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European Society of Cardiology (Esc) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021;43(7):561–632.
   Web of Science ®Google Scholar
• Otto C, Nishimura R, Bonow R, et al. ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2020;143(5):e35–e71.
   PubMed Web of Science ®Google Scholar
• Siontis GCM, Overtchouk P, Cahill T, et al. Transcatheter aorti valve implantation vs surgical aortic valve replacement for treatment of symptomatic aortic stenosis: un updated meta-analysis. Eur Heart J. 2019;40(38):3143–3153.
   PubMed Web of Science ®Google Scholar
• Rosenhek R, Zilberszak R, Schemper M, et al. Natural history of very severe aortic stenosis. Circulation. 2010;121(1):150–156.
   Web of Science ®Google Scholar
• Pellikka P, Sarano ME, Nishimura RA, et al. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation. 2005;111:3290–3295.
   PubMed Web of Science ®Google Scholar
• Chizner MA, Pearle DL, deLeon AC Jr. The natural history of aortic stenosis in adults. Am Heart. 1980;99(4):419–424.
   PubMed Web of Science ®Google Scholar
• Heuvelman HJ, van Geldorp MWA, Kappetein AP, et al. Clinical course of patients diagnosed with severe aortic stenosis in the Rotterdam area: insights from the AVARIJN study. Neth Heart J. 2012;20(12):487–493.
   PubMed Web of Science ®Google Scholar
• Pellikka P, Nishimura RA, Bailey KR, et al. The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis. J Am Coll Cardiol. 1990: 1102–1107
   PubMed Web of Science ®Google Scholar
• Malaisrie SC, McDonalad E, Kruse J, et al. Mortality while waiting for aortic valve replacement. Ann Thorac Surg. 2014;98(5):1564–1571.
   PubMed Web of Science ®Google Scholar
• Das P, Rimington H, Chambers JB. Exercise testing to stratify risk in aortic stenosis. Eur Heart J. 2005;26(13):1309–1313.
   PubMed Web of Science ®Google Scholar
• Iung B, Delgado V, Rosenhek R, et al. Contemporary presentation and management of valvular heart disease: the Eurobservational research programme valvular heart disease ii survey. Circulation. 2019;140(14):1156–1169.
   PubMed Web of Science ®Google Scholar
• Rosenhek R, Binder T, Porenta G, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med. 2000;343(9):611–617.
   PubMed Web of Science ®Google Scholar
• Lancellotti P, Magne J, Dulgheru R, et al. Outcomes of patients with asymptomatic aortic stenosis followed up in heart valve clinics. JAMA Cardiol. 2018;3(11):1060–1068.
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Morimoto T, Shiomi H, et al. Initial surgical versus conservative strategies in patients with asymptomatic severe aortic stenosis. J Am Coll Cardiol. 2015;66(25):2827–2838.
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Morimoto T, Shiomi H, et al. Sudden death in patients with severe aortic stenosis: observations from the current as registry. J Am Heart Assoc. 2018;7(11):1.
   Web of Science ®Google Scholar
• Kang D-H, Park S-J, Lee S-A, et al. Early surgery or conservative care for aortic stenosis. New Eng J Med. 2020;382(2):111–119.
   PubMed Web of Science ®Google Scholar
• Banovic M, Putnik S, Penicka M, et al. Aortic valve replacement versus conservative treatment in asymptomatic severe aortic stenosis. Circulation. 2022;148(9):648–658.
   Google Scholar
• Tsampasian V, Grafton-Clarke C, Ramos AEG, et al. Management of asymptomatic severe aortic stenosis: a systematic review and meta-analysis. Open Heart. 2022;9(1):e001982.
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Morimoto T, Shiomi H, et al. Initial surgical versus conservative strategies in patients with asymptomatic severe aortic stenosis. J Am Coll Cardiol. 2015;66(25):2827–2838.
   PubMed Web of Science ®Google Scholar
• Kang D-H, Park S-J, Rim JH, et al. Early surgery versus conventional treatment in asymptomatic very severe aortic stenosis. Circulation. 2010;121(13):1502–1509.
   PubMed Web of Science ®Google Scholar
• Pai RG, Varadarajan P, Razzouk A. Survival benefit of aortic valve replacement in patients with severe aortic stenosis with low ejection fraction and low gradient with normal ejection fraction. Ann Thorac Surg. 2008;86(6):1781–1789.
   PubMed Web of Science ®Google Scholar
• Masri A, Goodman AL.Barr T, et al. Predictors of long-term outcomes in asymptomatic patients with severe aortic stenosis and preserved left ventricular systolic function undergoing exercise echocardiography. Circ Cardiovasc Img. 2016;9(7):e004689.
   PubMed Web of Science ®Google Scholar
• Bohbot Y, Pasquet A, Rusinaru D, et al. Asymptomatic severe aortic stenosis with preserved ejection fraction: early surgery versus conservative management. J Am Coll Cardiol. 2018;72(23):2938.
   PubMed Web of Science ®Google Scholar
• Campo J, Tsoris A, Kruse J, et al. Prognosis of severe asymptomatic aortic stenosis with and without surgery. Ann Thorac Surg. 2019;108(1):74–79.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Kim JB, Kim HR, et al. Impact of valve replacement on long-term survival in asymptomatic patients with severe aortic stenosis. Am J Cardiol. 2019;123(8):1321–1328.
   PubMed Web of Science ®Google Scholar
• Le Tourneau TL, Pellikka PA, Brown ML, et al. Clinical outcome of asymptomatic severe aortic stenosis with medical and surgical management: importance of STS score at diagnosis. Ann Thorac Surg. 2010;90(6):1876–1883.
   PubMed Web of Science ®Google Scholar
• Kvaslerud AB, Santic K, Hussain AI, et al. Outcomes in asymptomatic, severe aortic stenosis. PLoS One. 2021;16(4):e0249610.
   PubMed Web of Science ®Google Scholar
• Celik M, Milojevic M, Durko AP, et al. Asymptomatic patients with severe aortic stenosis and impact of intervention. J Cardiovasc Dev Dis. 2021;8(4):35.
   PubMed Web of Science ®Google Scholar
• Gahl B, Çelik M, Head SJ, et al. Natural history of asymptomatic severe aortic stenosis and the association of early intervention with outcomes: a systematic review and meta-analysis. JAMA Cardiol. 2020;5(10):1102–1112.
   PubMed Web of Science ®Google Scholar
• Genereux P, Pibarot P, Redfords B, et al. Staging classification of aortic stenosis based on the extent of cardiac damage. Eur Heart J. 2017;38(45):3351–3358.
   PubMed Web of Science ®Google Scholar
• Genereux P, Pibarot P, Redfords B, et al. Evolution and prognostic impact of cardiac damage after aortic valve replacement. J Am Coll Cardiol. 2022;80(8):783–800.
   PubMed Web of Science ®Google Scholar
• Hachicha Z, Dumesnil JG, Pibarot P. Usefulness of the valvuloarterial impedance to predict adverse outcome in asymptomatic aortic stenosis. J Am Coll Cardiol. 2009;54(11):1003–1011.
   PubMed Web of Science ®Google Scholar
• Banovic M, Brkovic V, Vujisic-Tesic B, et al. Valvulo-arterial impedance is the best mortality predictor in asymptomatic aortic stenosis patients. J Heart Valve Dis. 2015;24(2):165–263.
   Web of Science ®Google Scholar
• Banovic M, Vujisic-Tesic B, Brkovic V, et al. Prognostic value of coronary flow reserve in asymptomatic moderate or severe aortic stenosis with preserved ejection fraction and nononbstructed coronary arteries. Echocardiography. 2014;4(4):428–433.
   Google Scholar
• Vollema EM, Sugimoto T, Shen M, et al. Association of left ventricular global longitudinal strain with asymptomatic severe aortic stenosis. JAMA Cardiol. 2018;3(9):839–847.
   PubMed Web of Science ®Google Scholar
• Banovic M, Mileva N, Moya A, et al. Myocardial work predicts outcome in asymptomatic aortic stenosis: subanalysis of randomized AVATAR trial. Submitted to JACC Img.
   Google Scholar
• Musa TA, Treibel TA, Vassiliou V, et al. Myocardial scar and mortality in severe aortic stenosis. Circulation. 2018;138(18):1935–1947.
   PubMed Web of Science ®Google Scholar
• Krishnaswamy A, Isogai T, Agrawal A, et al. Feasibility and safety of same-day discharge following transfemoral transcatheter aortic valve replacement. J Am Coll Cardiol Intv. 2022;15(6):575–589.
   Google Scholar
• Mazine A, David TE, Stoklosa K, et al. Improved outcomes following the ross procedure compared with bioprosthetic aortic valve replacement. J Am Coll Cardiol. 2022;79(10):993–1005.
   PubMed Web of Science ®Google Scholar
• Carabello B. Aortic valve replacement should be operated on before symptom onset. Circulation. 2012;126(1):112–117.
   PubMed Web of Science ®Google Scholar
• Banovic M, Nikolic SD, Putnik S. A randomized trial in patients with asymptomatic severe aortic stenosis: a future has begun! J Am Coll Cardiol. 2016;16(16):1970–1971.
   Google Scholar
• Amrane H, Deeb GM, Popma JJ, et al. Causes of death in intermediate-risk patients: the randomized surgical replacement and transcatheter aortic valve implantation trial. J Thorac Cardiovasc Surg. 2019;158(3):718–28.e3.
   PubMed Web of Science ®Google Scholar
• Sevilla T, Revilla-Orodea A, San Roman SJ. Timing of intervention in asymptomatic patients with severe aortic stenosis. Euro Cardiol Rev. 2021;16:e32.
   PubMed Web of Science ®Google Scholar