878
Views
0
CrossRef citations to date
0
Altmetric
Review

Reproductive health in adults with congenital heart disease: a review on fertility, sexual health, assisted reproductive technology and contraception

, , , ORCID Icon &
Pages 519-529 | Received 03 Apr 2023, Accepted 06 Jun 2023, Published online: 21 Jun 2023

References

  • Bouma BJ, Mulder BJM. Changing landscape of congenital heart disease. Circ Res. 2017;120(6):908–922. doi: 10.1161/CIRCRESAHA.116.309302
  • van der Linde D, Konings EE, Slager MA, et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011;58(21):2241–2247. doi: 10.1016/j.jacc.2011.08.025
  • Wu W, He J, Shao X. Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990-2017. Medicine (Baltimore). 2020;99(23):e20593. doi: 10.1097/MD.0000000000020593
  • Collaborators GBDCo D, Abate D, Abate KH. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392(10159):1736–1788. doi: 10.1016/S0140-6736(18)32203-7
  • Moons P, Bovijn L, Budts W, et al. Temporal trends in survival to adulthood among patients born with congenital heart disease from 1970 to 1992 in Belgium. Circulation. 2010;122(22):2264–2272. doi: 10.1161/CIRCULATIONAHA.110.946343
  • Baumgartner H, De Backer J. The ESC clinical practice guidelines for the management of adult congenital heart disease 2020. Eur Heart J. 2020;41(43):4153–4154. doi: 10.1093/eurheartj/ehaa701
  • Stout KK, Daniels CJ, Aboulhosn JA, et al. 2018 AHA/ACC guideline for the management of adults with congenital heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73(12):1494–1563. doi: 10.1016/j.jacc.2018.08.1028
  • Skakkebaek NE, Lindahl-Jacobsen R, Levine H, et al. Environmental factors in declining human fertility. Nat Rev Endocrinol. 2022;18(3):139–157. doi: 10.1038/s41574-021-00598-8
  • (WHO) WHO. International Classification of Diseases, 11th Revision (ICD-11). Geneva: WHO; 2018.
  • Winters BR, Walsh TJ. The epidemiology of male infertility. Urol Clin North Am. 2014;41(1):195–204. doi: 10.1016/j.ucl.2013.08.006
  • Abrao MS, Muzii L, Marana R. Anatomical causes of female infertility and their management. Int J Gynaecol Obstet. 2013;123 Suppl 2:S18–24. doi: 10.1016/j.ijgo.2013.09.008
  • Homan GF, Davies M, Norman R. The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update. 2007;13(3):209–223. doi: 10.1093/humupd/dml056
  • Mascarenhas MN, Flaxman SR, Boerma T, et al. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLOS Med. 2012;9(12):e1001356. doi: 10.1371/journal.pmed.1001356
  • Drenthen W, Pieper PG, Roos-Hesselink JW, et al. Pregnancy and delivery in women after Fontan palliation. Heart. 2006;92(9):1290–1294. doi: 10.1136/hrt.2005.085407
  • Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018;39(34):3165–3241. doi: 10.1093/eurheartj/ehy340
  • Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update. 2014;20(3):370–385. doi: 10.1093/humupd/dmt062
  • Matsushita KA, Izumi M, Miyake C, et al. Reduced ovarian function in women with complex congenital heart disease. Int J Cardiol Congenit Heart Dis. 2022;7(100317):100317. doi: 10.1016/j.ijcchd.2021.100317
  • Gouton M, Nizard J, Patel M, et al. Maternal and fetal outcomes of pregnancy with Fontan circulation: a multicentric observational study. Int J Cardiol. 2015;187:84–89. doi: 10.1016/j.ijcard.2015.03.344
  • Chien SJ, Lin YJ, Lo MH, et al. Congenital heart diseases impair female fertility. Front Pediatr. 2021;9:687276. doi: 10.3389/fped.2021.687276
  • Udholm LF, Arendt LH, Knudsen UB, et al. Congenital heart disease and fertility: a Danish nationwide cohort study including both men and women. J Am Heart Assoc. 2023;12(2):e027409. doi: 10.1161/JAHA.122.027409
  • Opic P, Roos-Hesselink JW, Cuypers JA, et al. Sexual functioning is impaired in adults with congenital heart disease. Int J Cardiol. 2013;168(4):3872–3877. doi: 10.1016/j.ijcard.2013.06.029
  • Canobbio MM, Rapkin AJ, Perloff JK, et al. Menstrual patterns in women with congenital heart disease. Pediatr Cardiol. 1995;16(1):12–15. doi: 10.1007/BF02310327
  • Drenthen W, Hoendermis ES, Moons P, et al. Menstrual cycle and its disorders in women with congenital heart disease. Congenit Heart Dis. 2008;3(4):277–283. doi: 10.1111/j.1747-0803.2008.00202.x
  • Vigl M, Kaemmerer M, Niggemeyer E, et al. Sexuality and reproductive health in women with congenital heart disease. Am J Cardiol. 2010;105(4):538–541. doi: 10.1016/j.amjcard.2009.10.025
  • Cook SC, Arnott LM, Nicholson LM, et al. Erectile dysfunction in men with congenital heart disease. Am J Cardiol. 2008;102(12):1728–1730. doi: 10.1016/j.amjcard.2008.08.017
  • Vigl M, Hager A, Bauer U, et al. Sexuality and subjective wellbeing in male patients with congenital heart disease. Heart. 2009;95(14):1179–1183. doi: 10.1136/hrt.2008.156695
  • Shiri R, Koskimaki J, Hakkinen J, et al. Cardiovascular drug use and the incidence of erectile dysfunction. Int J Impot Res. 2007;19(2):208–212. doi: 10.1038/sj.ijir.3901516
  • Fischer AJ, Grundlach C, Helm PC, et al. Erectile dysfunction in men with adult congenital heart disease: a prevalent but neglected issue. Korean Circ J. 2022;52(3):233–242. doi: 10.4070/kcj.2021.0184
  • Zegers-Hochschild F, Adamson GD, de Mouzon J, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009;92(5):1520–1524. doi: 10.1016/j.fertnstert.2009.09.009
  • Kushnir VA, Barad DH, Albertini DF, et al. Systematic review of worldwide trends in assisted reproductive technology 2004-2013. Reprod Biol Endocrinol. 2017;15(1):6. doi: 10.1186/s12958-016-0225-2
  • Qin J, Liu X, Sheng X, et al. Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies. Fertil Steril. 2016;105(1):73-85 e1–6. doi:10.1016/j.fertnstert.2015.09.007
  • Helmerhorst FM, Perquin DA, Donker D, et al. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004;328(7434):261. doi: 10.1136/bmj.37957.560278.EE
  • Pandey S, Shetty A, Hamilton M, et al. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(5):485–503. doi: 10.1093/humupd/dms018
  • El-Shawarby S, Margara R, Trew G, et al. A review of complications following transvaginal oocyte retrieval for in-vitro fertilization. Hum Fertil (Camb). 2004;7(2):127–133. doi: 10.1080/14647270410001699081
  • Fujitake E, Jaspal R, Monasta L, et al. Acute cardiovascular changes in women undergoing in vitro fertilisation (IVF), a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2020;248:245–251. doi: 10.1016/j.ejogrb.2020.01.033
  • Drenthen W, Boersma E, Balci A, et al. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J. 2010;31(17):2124–2132. doi: 10.1093/eurheartj/ehq200
  • Gnanaraj JAP, Surendran A, Susikar A, et al. Pregnancy outcomes in women with heart disease: the madras medical college pregnancy and cardiac (M-PAC) Registry from India. Eur Heart J. 2023;44(17):1530–1540. doi: 10.1093/eurheartj/ehad003
  • Roos-Hesselink J, Baris L, Johnson M, et al. Pregnancy outcomes in women with cardiovascular disease: evolving trends over 10 years in the ESC Registry of Pregnancy and Cardiac disease (ROPAC). Eur Heart J. 2019;40(47):3848–3855. doi: 10.1093/eurheartj/ehz136
  • Silversides CK, Grewal J, Mason J, et al. Pregnancy outcomes in women with heart disease: the CARPREG II Study. J Am Coll Cardiol. 2018;71(21):2419–2430. doi: 10.1016/j.jacc.2018.02.076
  • Lu CW, Shih JC, Chen SY, et al. Comparison of 3 risk estimation methods for predicting cardiac outcomes in pregnant women with congenital heart disease. Circ J. 2015;79(7):1609–1617. doi: 10.1253/circj.CJ-14-1368
  • Dayan N, Laskin CA, Spitzer K, et al. Pregnancy complications in women with heart disease conceiving with fertility therapy. J Am Coll Cardiol. 2014;64(17):1862–1864. doi: 10.1016/j.jacc.2014.07.977
  • Quien MM, Hausvater A, Maxwell SM, et al. Assisted reproductive technology outcomes in women with heart disease. Front Cardiovasc Med. 2022;9:842556. doi: 10.3389/fcvm.2022.842556
  • Skorupskaite K, Joy E, Balen A, et al. Assisted reproduction in patients with cardiac disease: a retrospective review. Eur J Obstet Gynecol Reprod Biol. 2022;276:199–203. doi: 10.1016/j.ejogrb.2022.07.020
  • Costello MF, Horrowitz S, Steigrad S, et al. Transcervical intrauterine topical local anesthetic at hysterosalpingography: a prospective, randomized, double-blind, placebo-controlled trial. Fertil Steril. 2002;78(5):1116–1122. doi: 10.1016/S0015-0282(02)03362-9
  • Gemzell-Danielsson K, Mansour D, Fiala C, et al. Management of pain associated with the insertion of intrauterine contraceptives. Hum Reprod Update. 2013;19(4):419–427. doi: 10.1093/humupd/dmt022
  • Joris JL, Noirot DP, Legrand MJ, et al. Hemodynamic changes during laparoscopic cholecystectomy. Anesth Analg. 1993;76(5):1067–1071. doi: 10.1213/00000539-199305000-00027
  • Snabes MC, Poindexter AN 3rd. Laparoscopic tubal sterilization under local anesthesia in women with cyanotic heart disease. Obstet Gynecol. 1991;78(3 Pt 1):437–440.
  • Van Eyk N, van Schalkwyk JN. 275-antibiotic prophylaxis in gynaecologic procedures. J Obstet Gynaecol Can. 2018;40(10):e723–e33. doi: 10.1016/j.jogc.2018.07.007
  • Ujvari D, Hulchiy M, Calaby A, et al. Lifestyle intervention up-regulates gene and protein levels of molecules involved in insulin signaling in the endometrium of overweight/obese women with polycystic ovary syndrome. Hum Reprod. 2014;29(7):1526–1535. doi: 10.1093/humrep/deu114
  • Balen AH. Ovulation induction in the management of anovulatory polycystic ovary syndrome. Mol Cell Endocrinol. 2013;373(1–2):77–82. doi: 10.1016/j.mce.2012.10.008
  • Weiss NS, Nahuis M, Bayram N, et al. Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome. Cochrane Database Of Systematic Reviews. 2015;2015(9):CD010290. doi: 10.1002/14651858.CD010290.pub2
  • Lin H, Li Y, Li L, et al. Is a GnRH antagonist protocol better in PCOS patients? A meta-analysis of RCTs. PLoS ONE. 2014;9(3):e91796. doi: 10.1371/journal.pone.0091796
  • Manau D, Balasch J, Arroyo V, et al. Circulatory dysfunction in asymptomatic in vitro fertilization patients. Relationship with hyperestrogenemia and activity of endogenous vasodilators. J Clin Endocrinol Metab. 1998;83(5):1489–1493. doi: 10.1210/jc.83.5.1489
  • Chan WS, Dixon ME. The “ART” of thromboembolism: a review of assisted reproductive technology and thromboembolic complications. Thromb Res. 2008;121(6):713–726. doi: 10.1016/j.thromres.2007.05.023
  • Farquhar C, Marjoribanks J. Assisted reproductive technology: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2018;8(8):CD010537. doi:10.1002/14651858.CD010537.pub5
  • Levi-Setti PE, Cirillo F, Scolaro V, et al. Appraisal of clinical complications after 23,827 oocyte retrievals in a large assisted reproductive technology program. Fertil Steril. 2018;109(6):1038–43 e1. doi: 10.1016/j.fertnstert.2018.02.002
  • Habib G, Lancellotti P, Antunes MJ, et al. ESC Guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075–3128. doi: 10.1093/eurheartj/ehv319
  • Kametas NA, McAuliffe F, Krampl E, et al. Maternal cardiac function in twin pregnancy. Obstet Gynecol. 2003;102(4):806–815. doi: 10.1097/00006250-200310000-00024
  • Ombelet W, Martens G, De Sutter P, et al. Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVF-assisted reproduction: a cohort study. Hum Reprod. 2006;21(4):1025–1032. doi: 10.1093/humrep/dei419
  • Ramlakhan KP, Roos-Hesselink JW. Promising perspectives on pregnancy in women with congenital heart disease. Eur Heart J. 2021;42(41):4261–4263. doi: 10.1093/eurheartj/ehab692
  • Flinter FA. Preimplantation genetic diagnosis. BMJ. 2001;322(7293):1008–1009. doi: 10.1136/bmj.322.7293.1008
  • De Backer J, Bondue A, Budts W, et al. Genetic counselling and testing in adults with congenital heart disease: a consensus document of the ESC Working group of grown-up congenital heart disease, the ESC Working Group on Aorta and Peripheral Vascular Disease and the European Society of Human Genetics. Eur J Prev Cardiol. 2020;27(13):1423–1435. doi: 10.1177/2047487319854552
  • Zaidi S, Brueckner M. Genetics and genomics of congenital heart disease. Circ Res. 2017;120(6):923–940. doi: 10.1161/CIRCRESAHA.116.309140
  • Delvigne A, Rozenberg S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Hum Reprod Update. 2002;8(6):559–577. doi: 10.1093/humupd/8.6.559
  • Humaidan P, Quartarolo J, Papanikolaou EG. Preventing ovarian hyperstimulation syndrome: guidance for the clinician. Fertil Steril. 2010;94(2):389–400. doi: 10.1016/j.fertnstert.2010.03.028
  • Humaidan P, Nelson SM, Devroey P, et al. Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials. Hum Reprod. 2016;31(9):1997–2004. doi: 10.1093/humrep/dew149
  • Nelson SM, Greer IA. The potential role of heparin in assisted conception. Hum Reprod Update. 2008;14(6):623–645. doi: 10.1093/humupd/dmn031
  • Sennstrom M, Rova K, Hellgren M, et al. Thromboembolism and in vitro fertilization - a systematic review. Acta Obstet Gynecol Scand. 2017;96(9):1045–1052. doi: 10.1111/aogs.13147
  • Chan WS. The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology. Curr Opin Obstet Gynecol. 2009;21(3):207–218. doi: 10.1097/GCO.0b013e328329c2b8
  • Henriksson P, Westerlund E, Wallen H, et al. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study. BMJ. 2013;346(jan15 3):e8632. doi: 10.1136/bmj.e8632
  • Karsenty C, Zhao A, Marijon E, et al. Risk of thromboembolic complications in adult congenital heart disease: a literature review. Arch Cardiovasc Dis. 2018;111(10):613–620. doi: 10.1016/j.acvd.2018.04.003
  • Dangas GD, Weitz JI, Giustino G, et al. Prosthetic Heart Valve Thrombosis. J Am Coll Cardiol. 2016;68(24):2670–2689. doi: 10.1016/j.jacc.2016.09.958
  • Roudaut R, Serri K, Lafitte S. Thrombosis of prosthetic heart valves: diagnosis and therapeutic considerations. Heart. 2007;93(1):137–142. doi: 10.1136/hrt.2005.071183
  • Ramlakhan KP, Malhame I, Marelli A, et al. Hypertensive disorders of pregnant women with heart disease: the ESC EORP ROPAC Registry. Eur Heart J. 2022;43(38):3749–3761. doi:10.1093/eurheartj/ehac308
  • Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011;25(4):391–403. doi: 10.1016/j.bpobgyn.2011.01.006
  • Hayward RM, Foster E, Tseng ZH. Maternal and fetal outcomes of admission for delivery in women with congenital heart disease. JAMA Cardiol. 2017;2(6):664–671. doi: 10.1001/jamacardio.2017.0283
  • Tulay P, Atilan O. Oocyte donors’ awareness on donation procedure and risks: a call for developing guidelines for health tourism in oocyte donation programmes. J Turk Ger Gynecol Assoc. 2019;20(4):236–242. doi: 10.4274/jtgga.galenos.2018.2018.0110
  • Storgaard M, Loft A, Bergh C, et al. Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis. BJOG: Int J Obstet Gy. 2017;124(4):561–572. doi: 10.1111/1471-0528.14257
  • Reid GJ, Webb GD, Barzel M, et al. Estimates of life expectancy by adolescents and young adults with congenital heart disease. J Am Coll Cardiol. 2006;48(2):349–355. doi: 10.1016/j.jacc.2006.03.041
  • Marelli AJ, Mackie AS, Ionescu-Ittu R, et al. Congenital heart disease in the general population: changing prevalence and age distribution. Circulation. 2007;115(2):163–172. doi: 10.1161/CIRCULATIONAHA.106.627224
  • Oliver JM, Gallego P, Gonzalez AE, et al. Risk factors for excess mortality in adults with congenital heart diseases. Eur Heart J. 2017;38(16):1233–1241. doi: 10.1093/eurheartj/ehw590
  • Brandao P, Garrido N. Commercial surrogacy: an overview gestacao de substituicao comercial: uma visao global. Rev Bras Ginecol Obstet. 2022;44(12):1141–1158. doi: 10.1055/s-0042-1759774
  • Roos-Hesselink JW, Cornette J, Sliwa K, et al. Contraception and cardiovascular disease. Eur Heart J. 2015;36(27):1728-34, 34a–34b. doi: 10.1093/eurheartj/ehv141
  • Trussell J. Contraceptive failure in the United States. Contraception. 2011;83(5):397–404. doi: 10.1016/j.contraception.2011.01.021
  • Lindley KJ, Teal SB. Contraception in women with cardiovascular disease. JAMA. 2022;328(6):577–578. doi: 10.1001/jama.2022.11541
  • Silversides CK, Sermer M, Siu SC. Choosing the best contraceptive method for the adult with congenital heart disease. Curr Cardiol Rep. 2009;11(4):298–305. doi: 10.1007/s11886-009-0043-7