Design and synthesis of novel camptothecin/5-fluorouracil conjugates as cytotoxic agents

References

• Campos , J , Domínguez , JF , Gallo , MA and Espinosa , A . 2000 . From a classic approach in cancer chemotherapy towards differentiation therapy: acyclic and cyclic seven-membered 5-fluorouracil O,N-acetals . Current Pharmaceutical Design , 6 ( 18 ) : 1797 – 1809 .
   Google Scholar
• Chen , SW , Tian , X and Tu , YQ . 2004 . Synthesis and cytotoxic activity of novel derivatives of 4′-demethylepipodophyllotoxin . Bioorganic and Medicinal Chemistry Letters , 14 ( 20 ) : 5063 – 5066 .
   Google Scholar
• Chen , SW , Xiang , R , Liu , J and Tian , X . 2009 . Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents . Bioorganic and Medicinal Chemistry , 17 ( 8 ) : 3111 – 3117 .
   Google Scholar
• Driver , RW and Yang , LX . 2005 . Synthesis and pharmacology of new camptothecin drugs . Mini-reviews in Medical Chemistry , 5 ( 5 ) : 425 – 439 .
   Google Scholar
• Du , W . 2003 . Towards new anticancer drugs: a decade of advances in synthesis of camptothecins and related alkaloids . Tetrahedron , 59 ( 44 ) : 8649 – 8687 .
   Web of Science ®Google Scholar
• Greenwald , RB , Pendri , A , Conover , CD , Lee , C , Choe , YH Gilbert , C . 1998 . Camptothecin-20-PEG ester transport forms: the effect of spacer groups on antitumor activity . Bioorganic and Medicinal Chemistry , 6 ( 5 ) : 551 – 562 .
   Google Scholar
• Guichard , S , Hennebelk , I , Bugat , R and Cana , P . 1998 . Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line . Biochemical Pharmacology , 55 ( 5 ) : 667 – 676 .
   Google Scholar
• He , XG , Lu , W , Jiang , XQ , Cai , JC , Zhang , XW and Ding , J . 2004 . Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins . Bioorganic and Medicinal Chemistry , 12 ( 15 ) : 4003 – 4008 .
   PubMed Web of Science ®Google Scholar
• Li , QY , Zu , YG , Shi , RZ and Yao , LP . 2006 . Review camptothecin: current perspectives . Current Medicinal Chemistry , 13 ( 17 ) : 2021 – 2039 .
   PubMed Web of Science ®Google Scholar
• Liew , ST and Yang , LX . 2008 . Design, synthesis and development of novel camptothecin drugs . Current Pharmaceutical Design , 14 ( 11 ) : 1078 – 1097 .
   PubMed Web of Science ®Google Scholar
• Liu , YQ , Liu , YQ , Tian , X and Yang , L . 2008 . Synthesis of novel derivatives of bispodophyllotoxin as potential antineoplastic agents – Part XVI . Natural Product Research , 22 ( 4 ) : 285 – 291 .
   PubMed Web of Science ®Google Scholar
• Liu , YQ , Yang , H and Tian , X . 2006 . Design, synthesis and biological evaluation of novel etoposide analogues as cytotoxic agents . Chinese Journal of Chemistry , 24 ( 6 ) : 785 – 790 .
   Web of Science ®Google Scholar
• Liu , YQ , Yang , L and Tian , X . 2007 . Podophyllotoxin: current perspectives . Current Bioactive Compounds , 3 ( 1 ) : 37 – 66 .
   Google Scholar
• Longley , DB , Harkin , DP and Johnston , PG . 2003 . 5-Fluorouracil: mechanisms of action and clinical strategies . Nature Reviews Cancer , 3 : 330 – 338 .
   PubMed Web of Science ®Google Scholar
• Lorence , A and Nessler , CL . 2004 . Camptothecin, over four decades of surprising findings . Phytochemistry , 65 ( 20 ) : 2735 – 2749 .
   PubMed Web of Science ®Google Scholar
• Ohtsu , H , Nakanishi , Y , Bastow , KF , Lee , FY and Lee , KH . 2003 . Antitumor agents 216. Synthesis and evaluation of paclitaxel–camptothecin conjugates as novel cytotoxic agents . Bioorganic and Medicinal Chemistry , 11 ( 8 ) : 1851 – 1857 .
   Google Scholar
• Peters , GJ , van der Wilt , CL , van Moorsel , CJA , Kroep , JR , Bergman , AM and Ackland , SP . 2000 . Basis for effective combination cancer chemotherapy with antimetabolites . Pharmacology and Therapeutics , 87 ( 2 ) : 227 – 253 .
   Google Scholar
• Shi , Q , Wang , HK , Bastow , KF , Tachibana , Y , Chen , K Lee , FY . 2001 . Antitumor agents 210. Synthesis and evaluation of taxoid–epipodophyllotoxin conjugates as novel cytotoxic agents . Bioorganic and Medicinal Chemistry , 9 ( 11 ) : 2999 – 3004 .
   Google Scholar
• Slichenmyer , WJ , Rowinsky , EK , Donehower , RC and Kaufmann , SH . 1993 . The current status of camptothecin analogues as antitumor agents . Journal of the National Cancer Institute , 85 ( 4 ) : 271 – 291 .
   PubMed Web of Science ®Google Scholar
• Takimoto , CH , Wright , J and Arbuck , SG . 1998 . Clinical applications of the camptothecins . Biochimica et Biophysica Acta , 1400 ( 1 ) : 107 – 109 .
   Google Scholar
• Tatsuzaki , J , Taniguchi , M , Bastow , KF , Nakagawa-Goto , K , Morris-Natschke , SL Itokawa , H . 2007 . Antitumor agents 255: Novel glycyrrhetinic acid–dehydrozingerone conjugates as cytotoxic agents . Bioorganic and Medicinal Chemistry , 15 ( 18 ) : 6193 – 6199 .
   Google Scholar
• Tietze , LF , Bell , HP and Chandrasekhar , S . 2003 . Natural product hybrids as new leads for drug discovery . Angewandte Chemie International Edition , 42 ( 34 ) : 3996 – 4028 .
   Google Scholar
• Verma , RP and Hansch , C . 2009 . Camptothecins: a SAR/QSAR study . Chemical Reviews , 109 ( 1 ) : 213 – 235 .
   Google Scholar