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Natural Product Research
Formerly Natural Product Letters
Volume 30, 2016 - Issue 8
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Research Articles

One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia

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Pages 973-978 | Received 06 Apr 2015, Accepted 05 Aug 2015, Published online: 05 Nov 2015

References

  • Akihisa T, Higo N, Tokuda H, Ukiya M, Akazawa H, Tochigi Y, Kimura Y, Suzuki T, Nishino H. 2007. Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects. J Nat Prod. 70:1233–1239.10.1021/np068075p
  • Bao B, Chen YG, Zhang L, Na Xu YL, Wang X, Liu J, Qu W. 2013. Momordica charantia (bitter melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues. PloS One 8:e84075.10.1371/journal.pone.0084075
  • Battelli MG, Polito L, Bolognesi A, Lafleur L, Fradet Y, Stirpe F. 1996. Toxicity of ribosome-inactivating proteins-containing immunotoxins to a human bladder carcinoma cell line. Int J Cancer. 65:485–490.10.1002/(ISSN)1097-0215
  • Chen JC, Liu WQ, Lu L, Qiu MH, Zheng YT, Yang LM, Zhang XM, Zhou L, Li ZR. 2009. Kuguacins F–S, cucurbitane triterpenoids from Momordica charantia. Phytochemistry 70:133–140.10.1016/j.phytochem.2008.10.011
  • Cheng BH, Chen JC, Liu JQ, Zhou L, Qiu MH. 2013. Cucurbitane-type triterpenoids from Momordica charantia. Helv Chim Acta. 96:1111–1120.10.1002/hlca.v96.6
  • El-Gengaihi S, Karawya MS, Selim MA, Motawe HM, Ibrahim N, Faddah LM. 1995. A novel pyrimidine glycoside from Momordica charantia L. Pharmazie. 50:361–362.
  • Erharuyi O, Engel-Lutz N, Ahomafor J, Imieje V, Falodun A, Nebe B, Langer P. 2014. Anticancer activity of five forest crops used in African folklore: antiproliferative and pro-apoptotic effects. Nat Prod Res. 28:740–745. doi:10.1080/14786419.2013.879475
  • Fatope MO, Takeda Y, Yamashita H, Okabe H, Yamauchi T. 1990. New cucurbitane triterpenoids from Momordica charantia. J Nat Prod. 53:1491–1497.10.1021/np50072a014
  • Harinantenaina L, Tanaka M, Takaoka S, Oda M, Mogami O, Uchida M, Asakawa Y. 2006. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem Pharm Bull. 54:1017–1021.10.1248/cpb.54.1017
  • Keller AC, Ma J, Kavalier A, He K, Brillantes AB, Kennelly EJ. 2011. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine 19:32–37.10.1016/j.phymed.2011.06.019
  • Lin KW, Yang SC, Lin CN. 2011. Antioxidant constituents from the stems and fruits of Momordica charantia. Food Chem. 127:609–614.10.1016/j.foodchem.2011.01.051
  • Liu JQ, Chen JC, Wang CF, Qiu MH. 2010. New cucurbitane triterpenoids and steroidal glycoside from Momordica charantia. Molecules 1:4804–4813.
  • Liu CH, Yen MH, Tsang SF, Gan KH, Hsu HY, Lin CN. 2010. Antioxidant triterpenoids from the stems of Momordica charantia. Food Chem. 118:751–756.10.1016/j.foodchem.2009.05.058
  • Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 65:55–63.10.1016/0022-1759(83)90303-4
  • Mulholland DA, Sewram V, Osborne R, Pegel KH, Connolly JD. 1997. Cucurbitane triterpenoids from the leaves of Momordica foetida. Phytochemistry 45:391–395.10.1016/S0031-9422(96)00814-X
  • Murakami T, Emoto A, Matsuda H, Yoshikawa M. 2001. Medicinal foodstuffs. xxi. structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L. Chem Pharm Bull 49:54–63.10.1248/cpb.49.54
  • Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T. 2010. Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci. 101:2234–2240.10.1111/cas.2010.101.issue-10
  • Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T. 2011. Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf. Cancer Lett. 306:142–150.10.1016/j.canlet.2011.02.041
  • Popovich DG, Lee Y, Li L, Zhang W. 2011. Momordica charantia seed extract reduces pre-adipocyte viability, affects lactate dehydrogenase release, and lipid accumulation in 3T3-L1 cells. J Med Food. 14:201–208.10.1089/jmf.2010.1150
  • Ray RB, Raychoudhuri A, Steele R, Nerurkar P. 2010. Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis. Cancer Res. 70:1925–1931.10.1158/0008-5472.CAN-09-3438
  • Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, Chen T, Weiss HC, Gesing ER, Rowland A, James DE, Ye Y. 2008. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 15:263–273.10.1016/j.chembiol.2008.01.013
  • Yaldız G, Sekeroglu N, Kulak M, Demirkol G. 2015. Antimicrobial activity and agricultural properties of bitter melon (Momordica charantia L.) grown in northern parts of Turkey: a case study for adaptation. Nat Prod Res. 29: 543–545.10.1080/14786419.2014.949706
  • Zhang J, Huang Y, Kikuchi T, Tokuda H, Suzuki N, Inafuku KI, Miura M, Motohashi S, Suzuki T, Akihisa T. 2012. Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities. Chem Biodivers. 9:428–440.10.1002/cbdv.v9.2

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