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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 19
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Research Articles

New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III

Yun-Fang ZhaoState Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China; View further author information
,
Yu-Wei ZhangState Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China; View further author information
,
Yinru WangState Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China; View further author information
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Susan L. Morris-NatschkeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA; View further author information
,
Wei LiuNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA; ;Department of Pharmacology, Nanjing Medical University, Nanjing, ChinaView further author information
,
Ting-Ting ShangState Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China; View further author information
,
Hong YinState Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China; View further author information
,
Kuo-Hsiung LeeNatural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA; Correspondence[email protected]
View further author information
&
Xue-Feng HuangState Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China; ;Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA; Correspondence[email protected]
View further author information
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Pages 2755-2761 | Received 22 May 2018, Accepted 09 Jul 2018, Published online: 20 Nov 2018

References

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  • Liu ZY, Jiang WX, Wu B, Huang CG. 2013. New saponins from timosaponin BIII by acid hydrolysis. Asian J Chem. 25(5):2503–2505.
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  • Zhang JY, Meng ZY, Zhang MY, Ma DS, Xu SX, Kodama H. 1999. Effect of six steroidal asponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood. Clin. Chim. Acta. 289(1–2):79–88.
  • Zhao Y, Jiang TC, Han BQ, Lu L, Feng B, Kang LP, Zhang J, Fang Y, Xiong CQ, Jia DX, Ma BP. 2015. Preparation of some metabolites of timosaponin B II by biotransformation in vitro. Process Biochem. 50(12):2182–2187.
  • Zhu FT, Huang XF, Kong LY. 2012. Steroidal saponins from Anemarrhena asphodeloides Bge. Nat. Prod. Res. Dev. 34:1497–1501.

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