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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 20
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Research Articles

Two new polyketides isolated from a diethyl sulphate mutant of marine-derived Penicillium purpurogenum G59

Chang-Jing WuState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China; ;College of life science and agronomy, Zhoukou Normal University, Zhoukou, China; ORCID Iconhttp://orcid.org/0000-0001-9196-8532View further author information
ORCID Icon,
Hua QiaoState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; View further author information
,
Cheng-Bin CuiState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China; View further author information
,
Yu YangState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China; View further author information
,
Rui XuState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China; View further author information
,
Chun-Xiao SunKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, ChinaView further author information
,
De-Hai LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, ChinaView further author information
&
Chang-Wei LiState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China; View further author information
 show all
Pages 2977-2981 | Received 23 May 2018, Accepted 17 Aug 2018, Published online: 10 Nov 2018

References

  • Fang S-M, Cui C-B, Li C-W, Wu C-J, Zhang Z-J, Li L, Huang X-J, Ye W-C. 2012. Purpurogemutantin and purpurogemutantidin, new drimenyl cyclohexenone derivatives produced by a mutant obtained by diethyl sulfate mutagenesis of a marine-derived Penicillium purpurogenum G59. Mar Drugs 10(6):1266–1287.
  • Fang S-M, Wu C-J, Li C-W, Cui C-B. 2014. A practical strategy to discover new antitumor compounds by activating silent metabolite production in fungi by diethyl sulphate mutagenesis. Mar Drugs 12(4):1788–1814.
  • Hu Z-Y, Li Y-Y, Lu C-H, Lin T, Hu P, Shen Y-M. 2010. Seven novel linear polyketides from Xylaria sp. NCY2. J Nat Prod. 93(5):925–933.
  • Li C-W, Wu C-J, Cui C-B, Xu L-L, Cao F, Zhu H-J. 2016. Penicimutamides A–C: rare carbamate-containing alkaloids from a mutant of the marine-derived Penicillium purpurogenum G59. RSC Adv. 6(77):73383–73387.
  • Li C-W, Xia M-W, Cui C-B, Peng J-X, Li D-H. 2016. A novel oxaphenalenone, penicimutalidine: Activated production of oxaphenalenones by the diethyl sulphate mutagenesis of marine-derived fungus Penicillium purpurogenum G59. RSC AdvAdv. 6(85):82277–73387.
  • Tian C-K, Cui C-B, Han X-X. 2008. Isolation of fungal strains in unusual environment and screening for their antitumor activity. J Int Pharm Res. 35:401–405.
  • Wiese J, Ohlendorf B, Blümel M, Schmaljohann R, Imhoff JF. 2011. phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites. Mar Drugs 9(4):561–585.
  • Wu C-J, Li C-W, Cui C-B. 2014. Seven new and two known lipopeptides as well as five known polyketides: the activated production of silent metabolites in a marine-derived fungus by chemical mutagenesis strategy using diethyl sulphate. Mar Drugs 12(4):1815–1838.
  • Wu C-J, Li C-W, Gao H, Huang X-J, Cui C-B. 2017. Penicimutamides D–E: two new prenylated indole alkaloids from a mutant of the marine-derived Penicillium purpurogenum G59. RSC Adv. 7(40):24718–24722.
  • Xia M-W, Cui C-B, Li C-W, Wu C-J. 2014. Three new and eleven known unusual C25 steroids: activated production of silent metabolites in a marine-derived fungus by chemical mutagenesis strategy using diethyl sulphate. Mar Drugs 12(3):1545–1568.
  • Xia M-W, Cui C-B, Li C-W, Wu C-J, Peng J-X, Li D-H. 2015. Rare chromones from a fungal mutant of the marine-derived Penicillium purpurogenum G59. Mar Drugs 13(8):5219–5236.
  • Xia M-W, Yang Y, Xu R, Li C-W, Cui C-B. 2018. A new polyketide purpurogenic acid: the activated production of polyketides by the diethyl sulphate mutagenesis of marine-derived Penicillium purpurogenum G59. Nat Prod Res. 32:1. DOI: 10.1080/14786419.2018.1434644.

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