Flavonoids as key bioactive components of Oxytropis falcata bunge, a traditional anti-inflammatory and analgesic Tibetan medicine

Reference

• Akashi T, Sasaki K, Aoki T, Ayabe S, Yazaki K. 2009. Molecular cloning and characterization of a cDNA for pterocarpan 4-dimethylallyltransferase catalyzing the key prenylation step in the biosynthesis of glyceollin, a soybean phytoalexin. Plant Physiol. 149(2):683–693.
   PubMed Web of Science ®Google Scholar
• Athar M, Kim AL, Ahmad N, Mukhtar H, Gautier J, Bickers DR. 2000. Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53. Biochem Biophys Res Commun. 277(1):107–111.
   PubMed Web of Science ®Google Scholar
• Belizario JE, Alves J, Occhiucci JM, Garay-Malpartida M, Sesso A. 2007. A mechanistic view of mitochondrial death decision pores. Braz J Med Biol Res. 40(8):1011–1024.
   PubMed Web of Science ®Google Scholar
• Berton TR, Pavone A, Fischer SM. 2001. Ultraviolet-B irradiation alters the cell cycle machinery in murine epidermis in vivo. J Invest Dermatol. 117(5):1171–1178.
   PubMed Web of Science ®Google Scholar
• Chen JS, Yang QL, Liu XL, Li HN, Lin XF. 2016. Research progress of chemical composition, pharmacological action and toxicology of Tibetan medicine Oxytropis. Chin Pharm. 27:3945.
   Google Scholar
• Chen JX, Hong JN, Du QY, Li MX. 2011. Prevention of flavonoids from Oxytropis falcata Bunge against UVB-induced damage to HaCaT keratinocytes. Pharm J Chin P L A. 27:289–292.
   Google Scholar
• Chen WH. 2009. Investigation on the chemical constituents of tridax procumbens and Oxytropis falcata and total synthesis of a new pterocarpan [doctor]. Lanzhou University.
   Google Scholar
• Chen WH, Wang R, Shi YP. 2010. Flavonoids in the poisonous plant Oxytropis falcata. J Nat Prod. 73(8):1398–1403.
   PubMed Web of Science ®Google Scholar
• Chen XH, Cheng H, Deng Y, Yang G, Pan Y. 2017. Effect of Tibetan Medicine Oxytropis falcata on mitochondrial transmembrane potential and expression of apoptosis related proteins in SMMC-7721. J Nanjing Univ Tradit Chin Med. 33:54–58.
   Google Scholar
• Chen ZP, Qu MM, Chen HX, Liu D, Xiao YY, Chen J, Lu TL, Cai BC. 2011. The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcata Bunge extraction after transdermal administration in rats. Fitoterapia. 82(3):426–433.
   PubMed Web of Science ®Google Scholar
• Cui HB. 1998a. Oxytropis DC. Flora Reipublicae Popularis Sinicae. 42:001.
   Google Scholar
• Cui HB. 1998b. Oxytropis DC. Flora Reipublicae Popularis Sinicae. 42:140.
   Google Scholar
• Dai XP, Zhang GH, Ban CH, Guan XM. 2010. Study on the analgesic and anti-inflammatory activity of total extracts from Oxytropis falcata Bunge. Chin J Biological Pharms. 31:313–315.
   Google Scholar
• Dai YM, Yang H, Tong L, Cai BC. 2008. Preliminary study on hemostatic effect of Oxytropis falcata Bunge. J Nanjing Uni. 24:107–108.
   Google Scholar
• Du H, Liu MC, Li FA, Ren SC, Ma JB, Zhang DJ. 2013. Influence of Oxytropis falcata Bunge on expression of Bcl-2 and Bax of myocardial ischemia and reperfusion injury in rats. J Qinghai Med Coll. 34:203–206.
   Google Scholar
• Gebhardt YH, Witte S, Steuber H, Matern U, Martens S. 2007. Evolution of flavone synthase I from parsley flavanone 3 beta-hydroxylase by site-directed mutagenesis. Plant Physiol. 144(3):1442–1454.
   PubMed Web of Science ®Google Scholar
• Gu Q, Cai YN, Yang GM, Cai BC, Pan Y. 2013. Study on chemical constituents and antitumor activity of Oxytropis falcata. Chin J Exp Tradit Med Formulae. 21:72–75.
   Google Scholar
• Gu QL, Huang CL, Zhang L, Jiang H. 2014. A preliminary study on anti-inflammatory effects of rhamnocitrin from Oxytropis falcata Bunge. Inf Tradit Chin Med. 21:48–50.
   Google Scholar
• Hong Z, Qin L, Zhen L, Mei YW, Guo YL. 2008. The protection of Bcl-2 overexpression on rat cortical neuronal injury caused by analogous ischemia/reperfusion in vitro. Neurosci Res. 62:140–146.
   PubMed Web of Science ®Google Scholar
• Hu YB. 2009. Mechanism and clinical research of the peripheral analgesia. Med Recapitulate. 15:772–774.
   Google Scholar
• Ichihashi M, Ueda M, Budiyanto A, Bito T, Oka M, Fukunaga M, Tsuru K, Horikawa T. 2003. UV-induced skin damage. Toxicology. 189(1–2):21–39.
   PubMed Web of Science ®Google Scholar
• Jeong YJ, An CH, Park SC, Pyun JW, Lee J, Kim SW, Kim HS, Kim H, Jeong JC, Kim CY. 2018. Methyl jasmonate increases isoflavone production in soybean cell cultures by activating structural genes involved in isoflavonoid biosynthesis. J Agric Food Chem. 66(16):4099–4105.
   PubMed Web of Science ®Google Scholar
• Jiang H, Hu JR, Cheng XH, Liu X. 2014. Antibacterial activity of total flavonoid aglycones from Oxytropis falcata Bunge. Nat Prod Res Dev. 383:26:407–409.
   Google Scholar
• Jiang H, Hu JR, Liu X. 2006. Research progress of Oxytropis falcata Bunge. Chin Tradit Herb Drugs. 37:314–315.
   Google Scholar
• Jiang H, Zhan WQ, Liu X, Jiang SX. 2008. Antioxidant activities of extracts and flavonoid compounds from Oxytropis falcata Bunge. Nat Prod Res. 22(18):1650–1656.
   PubMed Web of Science ®Google Scholar
• Jiang H, Hu JR, Zhan WQ, Liu X. 2009. Screening for fractions of Oxytropis falcata Bunge with antibacterial activity. Nat Prod Res. 23(10):953–959.
   PubMed Web of Science ®Google Scholar
• Kaimoyo E, VanEtten HD. 2008. Inactivation of pea genes by RNAi supports the involvement of two similar O-methyltransferases in the biosynthesis of (+)-pisatin and of chiral intermediates with a configuration opposite that found in (+)-pisatin. Phytochemistry. 69(1):76–87.
   PubMed Web of Science ®Google Scholar
• Kivity S, Hochhauser E, Offen D, Barhum Y, Pannet H, Shneyvays V, Shainberg A, Tobar A, Mamedova LK, Goldshtaub V, et al. 2002. The importance of Bax gene in myocardial ischemia and reperfusion (I/R) injury. J Mol Cell Cardiol. 34(6):A34.
   Web of Science ®Google Scholar
• Li F, Xu XJ. 2007. Studies on Tibetan Medicinal flavone constituents of Oxytropis falcata Bunge. Chin J Chin Mater Medica. 32:318–320.
   Google Scholar
• Li MX, Lan ZH, Fan PC, Yu LL, Jia ZP. 2009. Research Progress of Tibetan Medicine Oxytropis. J Chin Med Mater. 32:1318–1322.
   Google Scholar
• Lou CH, Wang MY, Yang GM, Tong L, Cai BC. 2009. Experimental study on the antitumor activity of flavonoids from Oxytropis variabilis in vitro. J Nanjing Univ Tradit Chin Med. 25:46–50.
   Google Scholar
• Lozovaya VV, Lygin AV, Zernova OV, Ulanov AV, Li S, Hartman GL, Widholm JM. 2007. Modification of phenolic metabolism in soybean hairy roots through down regulation of chalcone synthase or isoflavone synthase. Planta. 225(3):665–679.
   PubMed Web of Science ®Google Scholar
• Lv F, Xu XJ. 2006. Studies on Tibetan Medicinal Chemical Constituents of Oxytropis falcata Bunge. Zhong Yao Cai. 29:1303–1304.
   Google Scholar
• Peng XL, Wang Z, Liu Y, Peng X, Liu Y, Zhu S, Zhang Z, Qiu Y, Jin M, Wang R, et al. 2018. Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways. Life Sci. 206:35–44.
   PubMed Web of Science ®Google Scholar
• Que S. 2003. Studies on Tibetan Medicinal chemical constituents of Oxytropis falcata Bunge [master]. Northwest Normal University.
   Google Scholar
• Seshime Y, Juvvadi PR, Fujii I, Kitamoto K. 2005. Genomic evidences for the existence of a phenylpropanoid metabolic pathway in Aspergillus oryzae. Biochem Biophys Res Commun. 337(3):747–751.
   PubMed Web of Science ®Google Scholar
• Sheng YQ, Zou M, Wang Y, Li Q. 2015. 2′,4′-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis. Oncol Lett. 10(6):3737–3741.
   PubMed Web of Science ®Google Scholar
• Song LR. 2002. Chinese materia medica. Shanghai: Shanghai Scientific & Technical Publishers.
   Google Scholar
• Tian YQ, ZhaO HB, Liu H, Tian M, Hou XM. 2010. Study on chemical constituents of Oxytropis falcata Bunge. J Anhui Agric Sci. 38:14340–14341.
   Google Scholar
• Wang D. 2010. Flavonoids contents and evaluation of anti-inflammatory and antioxidant activities of flavonoids from Tibetan medicine Oxytropis falcata Bunge [master]. Nanjing University Of Chinese Medicine.
   Google Scholar
• Wang D, Tang W, Yang GM, Cai BC. 2011. Anti-inflammatory, antioxidant and cytotoxic activities of flavonoids from Oxytropis falcata Bunge. Chin J Nat Med. 8(6):461–465.
   Google Scholar
• Wang D, Yang H, Dai YP, Tong L, Cai BC. 2008. Studies on chemical constituents of Oxytropis falcata (II). Chin Pharmacol J. 43:1292–1294.
   Google Scholar
• Wang D, Yang H, Tong L, Cai BC. 2008. Analgesic and anti-inflammatory activity of Tibetan medicine Oxytropis falcata. Pharm Clin Res. 16:90–93.
   Google Scholar
• Wang SS, Zhang XJ, Que S, Liang H, Tu P, Zhang Q. 2018. Structurally diverse glycoconjugated volatile compounds from Oxytropis falcata Bunge. Phytochem Lett. 27:143–147.
   Web of Science ®Google Scholar
• Wang SS, Zhang XJ, Que S, Tu GZ, Wan D, Cheng W, Liang H, Ye J, Zhang QY. 2012. 3-Hydroxy-3-methylglutaryl flavonol glycosides from Oxytropis falcata. J Nat Prod. 75(7):1359–1364.
   PubMed Web of Science ®Google Scholar
• Wang WD, Tao YD, Jiao LJ, Fan MX, Shao Y, Wang QL, Mei LJ, Dang J. 2017. Efficient separation of high-purity compounds from Oxytropis falcata using two-dimensional preparative chromatography. J Sep Sci. 40(18):3593–3601.
   PubMed Web of Science ®Google Scholar
• Wu C, Xu HQ. 2010. Experimental study on the effect of anti-inflammatory and hemostasis of 2′,4′-dihydroxy chalcone in Oxytropis falcata Bunge. J Pharm Pract. 28:431–432.
   Google Scholar
• Wu LJ. 2011. Natural medicinal chemistry. Beijing: People’s Medical Publishing House (PMPH).
   Google Scholar
• Yang G, Yan K, Gu Q, Li J, Pan Y, Cai B. 2013. Effect of Tibetan Medicine Oxytropis falcata on Cell Apoptosis and Expression of Bcl-2 and Bax Protein in SMMC-7721 Cells. Chin Pharm J. 48:2113–2116.
   Google Scholar
• Yang GM, Yan R, Wang ZX, Zhang FF, Pan Y, Cai BC. 2013. Antitumor effects of two extracts from Oxytropis falcata on hepatocellular carcinoma in vitro and in vivo. Chin J Nat Med. 11(5):519–524.
   PubMed Web of Science ®Google Scholar
• Yan HY, Gao LM. 2009. Study on the chemical constituents of Oxytropis falcata Bunge. Nat Prod Res Dev. 21:246–248.
   Google Scholar
• Yang H. 2008. Study on the anti-inflammatory activity and chemical constituents of Tibetan Medicie Herba Oxytropis [doctor]. Nanjing University of Chinese Medicine.
   Google Scholar
• Yang H, Wan D, Tong L, Cai BC. 2008. Studies on chemical constituents of Oxytropis falcata (IV. Chin Pharmacol J. 43:1538–1540. ).
   Google Scholar
• Yang H, Wang D, Li T, Cai BC. 2009. Flavonoid aglycones of Oxytropis falcata. Chem Nat Compd Mar. 45:239–241.
   Web of Science ®Google Scholar
• Yang H, Wang D, Tong L, Cai BC. 2008a. Studies on chemical constituents of Oxytropis falcata (III). J Nanjing Univ Tradit Chin Med. 24:43–44.
   Google Scholar
• Yang H, Wang D, Tong L, Cai BC. 2008b. Studies on chemical constituents of Oxytropis falcata (I). Chin Pharmacol J. 43:338–340.
   Google Scholar
• Yang LX, Wang Z, Jiang L, Sun W, Fan Q, Liu T. 2017. Total flavonoids extracted from Oxytropis falcata Bunge improve insulin resistance through regulation on the IKK beta/NF-kappa B inflammatory pathway. Evidence-Based Complementary Altern Med. 6:2405124.
   Google Scholar
• Yao SY, Ma YB, Tang Y, Chen JJ, Zhang XM. 2008. Studies on chemical constituents of Oxytropis falcata. Chin J of Chin Mater Med. 33:1418–1421.
   Google Scholar
• Zhang DJ, Jiang R, Hong EK, Tan G, Lu D, Li Y, Yuan W. 2017. The pharmacologically active components of Oxytropis falcata Bunge reduce ischemic-reperfusion injury in the rat heart. Legume Res. 40:264–270.
   Web of Science ®Google Scholar
• Zhang L, Jiang H, Huang CL. 2015. Studies on anti-inflammatory effects of flavonoid aglycones from Oxytropis falcata. J Tradit Chin Med. 28:50–52.
   Google Scholar
• Zhang XJ, Li LY, Gesang LB, Wang SS, Que S, Cheng W, Liang H, Zhao YY, Zhang QY. 2014. Flavonoids from Tibetan medicine Oxytropis falcata Bunge. J Chin Pharm Sci. 23:99–105.
   Google Scholar
• Zhang XJ, Li LY, Wang SS, Que S, Yang WZ, Zhang FY, Gong NB, Cheng W, Liang H, Ye M, et al. 2013. Oxyfadichalcones A-C: three chalcone dimers fused through a cyclobutane ring from Tibetan medicine Oxytropis falcata Bunge. Tetrahedron. 69(52):11074–11079.
   Web of Science ®Google Scholar