Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 16
624
Views
21
CrossRef citations to date
0
Altmetric
Article

Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes

, ORCID Icon, , , , , , & ORCID Icon show all
Pages 2660-2667 | Received 03 Jul 2019, Accepted 11 Aug 2019, Published online: 05 Sep 2019

References

  • Acquaviva R, Di Giacomo C, Vanella L, Santangelo R, Sorrenti V, Barbagallo I, Genovese C, Mastrojeni S, Ragusa S, Iauk L. 2013. Antioxidant activity of extracts of Momordica foetida Schumach. et Thonn. Molecules. 18(3):3241–3249.
  • Acquaviva R, Sorrenti V, Santangelo R, Cardile V, Tomasello B, Malfa G, Vanella L, Amodeo A, Mastrojeni S, Pugliese M. 2016. Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human colon cancer cell cultures. Oncol Rep. 36(4):2298–2304.
  • Barbagallo I, Vanella L, Cambria MT, Tibullo D, Godos J, Guarnaccia L, Zappalà A, Galvano F, Li Volti G. 2016. Silibinin regulates lipid metabolism and differentiation in functional human adipocytes. Front Pharmacol. 21:6–309.
  • Cardile V, Graziano AC, Venditti A. 2015. Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management. Nat Prod Res. 29(23):2256–2260.
  • Chillemi R, Cardullo N, Greco V, Malfa G, Tomasello B, Sciuto S. 2015. Synthesis of amphiphilic resveratrol lipoconjugates and evaluation of their anticancer activity towards neuroblastoma SH-SY5Y cell line. Eur J Med Chem. 96:467–481.
  • Cristancho AG, Lazar MA. 2011. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol. 12(11):722–734.
  • Di Renzo L, Galvano F, Orlandi C, Bianchi A, Di Giacomo C, La Fauci L, Acquaviva R, De Lorenzo A. 2010. Oxidative stress in normal-weight obese syndrome. Obesity (Silver Spring). 18(11):2125–2130.
  • Fallico B, Ballistreri G, Arena E, Brighina S, Rapisarda P. 2017. Bioactive compounds in blood oranges (Citrus sinensis (L.) Osbeck): level and intake. Food Chem. 215:67–75.
  • Fu Y, Luo N, Klein RL, Garvey WJ. 2005. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res. 46(7):1369–1379.
  • Green H, Kehinde O. 1975. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell. 5(1):19–27.
  • Hallows WC, Lee S, Denu JM. 2006. Sirtuins deacetylate and activate mammalian acetylCoA synthetases. Proc Natl Acad Sci USA. 103(27):10230–10235.
  • Huh JY, Park YJ, Ham M, Kim JB. 2014. Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol Cell. 37(5):365–371.
  • Kopelman PG. 2000. Obesity as a medical problem. Nature. 404(6778):635–643.
  • Kowalska K, Olejnik A. 2016. Current evidence on the health-beneficial effects of berry fruits in the prevention and treatment of metabolic syndrome. Curr Opin Clin Nutr Metab Care. 19(6):446–452.
  • Larsen S, Nielsen J, Hansen CN, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel R, Helge JW, Dela F, et al. 2012. Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol (Lond). 590(14):3349–3360.
  • Liu GS, Chan EC, Higuchi M, Dusting GJ, Jiang F. 2012. Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response. Cell. 1(4):976–993.
  • Long X, Zeng X, Yan H, Xu M, Zeng Q, Xu C, Xu Q, Liang Y, Zhang J. 2019. Flavonoids composition and antioxidant potential assessment of extracts from Gannanzao Navel Orange (Citrus sinensis Osbeck Cv. Gannanzao) peel. Nat Prod Res. 3:1–5.
  • Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, et al. 2001. PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 50(9):2094–2099.
  • Malfa GA, Tomasello B, Sinatra F, Villaggio G, Amenta F, Avola R, Renis M. 2014. “Reactive” response evaluation of primary human astrocytes after methylmercury exposure. J Neurosci Res. 92(1):95–103.
  • Musumeci L, Maugeri A, Cirmi S, Lombardo GE, Russo C, Gangemi S, Calapai G, Navarra M. 2019. Citrus fruits and their flavonoids in inflammatory bowel disease: an overview. Nat Prod Res. 16:1–15.
  • Naseri R, Farzaei F, Haratipour P, Nabavi SF, Habtemariam S, Farzaei MH, Khodarahmi R, Tewari D, Momtaz S. 2018. Anthocyanins in the management of metabolic syndrome: a pharmacological and biopharmaceutical review. Front Pharmacol. 9:1310.
  • Ntambi JM, Young-Cheul K. 2000. Adipocyte differentiation and gene expression. J Nutr. 130(12):3122S–3126S.
  • Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. 2000. Transcriptional regulation of adipogenesis. Genes Dev. 14(11):1293–1307.
  • Stern JH, Rutkowski JM, Scherer PE. 2016. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 23(5):770–784.
  • Tomasello B, Malfa G, Galvano F, Renis M. 2011. DNA damage in normal-weight obese syndrome measured by comet assay. Mediterr J Nutr Metab. 4(2):99–104.
  • Vázquez-Vela MEF, Torres N, Tovar AR. 2008. White adipose tissue as endocrine organ and its role in obesity. Arch Med Res. 39(8):715–728.
  • Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, Czech M, Corvera S. 2003. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol. 23(3):1085–1094.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.