Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
867
Views
19
CrossRef citations to date
0
Altmetric
Review

Lepidium meyenii (Maca) in male reproduction

, , , , , , & show all
Pages 4550-4559 | Received 20 Sep 2019, Accepted 14 Nov 2019, Published online: 05 Dec 2019

References

  • Abdulsalam A, Abubakar U, Abdulkadir M, Opara JA, Ajibol OF. 2019. Role of exercise, fitness and nutrition in prevention of male sexual dysfunction. Int J Stu Adv Med Sci. 1(1):22–28.
  • Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L. 2008. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause. 15(6):1157–1162.
  • Bustos-Obregon E, Yucra S, Gonzales GF. 2005. Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice. Asian J Androl. 7:71–76.
  • Chung F, Rubio J, Gonzales C, Gasco M, Gonzales GF. 2005. Dose- response effects of Lepidium meyenii (Maca) acqueous extract on testicular function and weight of different organs in adult rats. J Ethnopharmacol. 98(1–2):143–147.
  • Ciani F, Cocchia N, d’Angelo D, Tafuri S. 2015. Influence of ROS on Ovarian Functions. In: Wu B, editor. New discoveries in embryology. London, UK: Intechopen; 41–73.
  • Ciani F, Cocchia N, Del Prete C, Palumbo V, Carotenuto D, Pasolini MP, Tafuri S. 2017. Sperm cromatin integrity in stallions with Lepidium meyenii (Maca) dietary supplementation. Reprod Domest Anim. 52(3):77.
  • Ciani F, Tafuri S, Troiano A, Cimmino A, Fioretto BS, Guarino AM, Pollice A, Vivo M, Evidente A, Carotenuto D, Calabrò V. 2018. Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells. J Ethnopharmacol. 211:285–294.
  • Cicero AFG, Bandieri E, Arletti R. 2001. Lepidium meyenii Walp. Improves sexual behavior in male rats independently from its action on spontaneous locomotor activity. J Ethnopharmacol. 75(2–3):225–229.
  • Cicero AFG, Piacente S, Plaza A, Sala E, Arletti R, Pizza C. 2002. Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts. Andrologia. 34(3):177–179.
  • Clément C, Kneubuhler J, Urwler A, Witschi U, Kreuzer M. 2010a. Effect of Maca supplementation on bovine sperm quantity and quality followed over two spermatogenic cycles. Theriogenology. 74:173–183.
  • Clément C, Diaz Grados DA, Avula B, Khan IA, Mayer AC, Ponce Aguirre DD, Manrique I, Kreuzer M. 2010b. Influence of colour type and previous cultivation on secondary metabolites in hypocotyls and leaves of Maca (Lepidium meyenii Walpers). J Sci Food Agric. 90(5):861–869.
  • Clément C, Witschi U, Kreuzer M. 2012. The potential influence of plant-based feed supplementson sperm quantity and quality in livestock: A review. Anim Reprod Sci. 132:1–10.
  • Cocchia N, Ciani F, El-Rass R, Russo M, Borzacchiello G, Esposito V, Montagnaro S, Avallone L, Tortora G, Lorizio R. 2010. Cryopreservation of feline epididymal spermatozoa from dead and alive animals and its use in assisted reproduction. Zygote. 18(1):1–8.
  • Cocchia N, Corteggio A, Altamura G, Tafuri S, Rea S, Rosapane I, Sica A, Landolfi F, Ciani F. 2015. The effects of superoxide dismutase addition to the transport medium on cumulus-oocyte complex apoptosis and IVF outcome in cats (Felis catus). Reprod Biol. 15(1):56–64.
  • Costantino M, Giuberti G, Caraglia A, Caraglia M, Lombardi A, Misso G, Abbruzzese A, Ciani F, Lampa E. 2009. Possible antioxidant role of SPA therapy with chlorine-sulphur-bicarbonate mineral water. Amino Acids. 36(2):161–165.
  • Del Prete C, Cocchia N, Ciani F, Tafuri S, Carotenuto D, Napoleone G, Pasolini MP. 2015. Influence of diet supplementation with Lepidium meyenii on quality of cooled equine semen. Reprod Domest Anim. 50(3):27–32.
  • Del Prete C, Tafuri S, Ciani F, Pasolini MP, Ciotola F, Albarella S, Carotenuto D, Peretti V, Cocchia N. 2018. Influences of dietary supplementation with Lepidium meyenii (Maca) on stallion sperm production and on preservation of sperm quality during storage at 5 °C. Andrology. 6(2):351–361.
  • Del Prete C, Ciani F, Tafuri S, Pasolini MP, Della Valle G, Palumbo V, Abbondante L, Calamo A, Barbato V, Gualtieri R, et al. 2018. Effect of superoxide dismutase, catalase, and glutathione peroxidase supplementation in the extender on chilled semen of fertile and hypofertile dogs. J Vet Sci. 19(5):667–675.
  • Esparza E, Hadzich A, Kofer W, Mithöfer A, Cosio EG. 2015. Bioactive Maca (Lepidium meyenii) alkamides are a result of traditional Andean postharvest drying practices. Phytochemistry. 116:138–148.
  • Fano D, Vásquez-Velásquez C, Gonzales-Castañeda C, Guajardo-Correa E, Orihuela PA, Gonzales GF. 2017. N-Butanol and aqueous fractions of red Maca methanolic extract exerts opposite effects on androgen and oestrogens receptors (alpha and beta) in rats with testosterone-induced benign prostatic hyperplasia. Evid Based Complement Alternat Med. 2017:1.
  • Gasco M, Villegas L, Yucra S, Rubio J, Gonzales GF. 2007. Dose-response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate. Phytomed. 14(7–8):460–464.
  • Gasco M, Aguilar J, Gonzales GF. 2007. Effect of chronic treatment with three varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA quantification in adult male rats. Androl. 39(4):151–158.
  • Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto D, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan I, Gonzales GF. 2016. Acceptability, safety, and efficacy of oral administration of extracts of black or red Maca (Lepidium meyenii) in adult human subjects: A randomized, double-blind, placebo-controlled study. Pharmaceuticals (Basel). 9(3):49.
  • Gonzales C, Rubio J, Gasco M, Nieto J, Yucra S, Gonzales GF. 2006. Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (Maca) on spermatogenesis in rats. J Ethnopharmacol. 103(3):448–454.
  • Gonzales C, Rubio J, Gasco M, Nieto J, Yucra S, Gonzales GF. 2006. Effect of Black Maca (Lepidium meyenii) on one spermatogenic cycle in rats. Andrologia. 38(5):166–172.
  • Gonzales GF, Ruiz A, Gonzales C, Villegas L, Cordova A. 2001. Effect on Lepidium meyenii (Maca) roots on spermatogenesis in male rats. Asian J Androl. 3(3):231–233.
  • Gonzales GF, Cordova A, Gonzales C, Chung A, Vega K, Villena A. 2001. Lepidium meyenii (Maca) improved semen parameters in adult men. Asian J Androl. 3(4):301–303.
  • Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C, Castillo S. 2002. Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrology. 34(6):367–372.
  • Gonzales GF, Rubio J, Chung A, Gasco M, Villegas L. 2003. Effect of alcoholic of Lepidium meyenii (Maca) on testicular function of male rats. Asian J Androl. 5(4):349–352.
  • Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C. 2003. Effect of Lepidium meyenii (Maca) a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men. J Endocrinol. 176(1):163–168.
  • Gonzales GF, Gasco M, Córdova A, Chung A, Rubio J, Villegas L. 2004. Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m). J Endocrinol. 180(1):87–95.
  • Gonzales GF, Miranda S, Nieto J, Fernandez G, Yucra S, Rubio J, Yi P, Gasco M. 2005. Red Maca (Lepidium meyenii) reduced prostate size in rats. Reprod Biol Endocrinol. 3:1–5.
  • Gonzales GF. 2006c. Biological effects of Lepidium meyenii, Maca, a plant from the highlands of Peru. In: Singh VK, Boardwalk R, Govil JN, Sharma RK, editors. Natural Products. Series: Recent Progress in Medical Plants.India: Stadium Press; 15:217–242.
  • Gonzales GF, Vasquez V, Rodriguez D, Maldonado C, Mormontoy J, Portella J, Pajuelo M, Villegas L, Gasco M, Mathur PP. 2007. Effect of two different extract of Red Maca in male rats with testosterone-induced prostatic hyperplasia. Asian J Andrology. 9(2):245–251.
  • Gonzales GF, Gasco M, Malheiros-Pereira A, Gonzales-Castañeda C. 2008. Antagonist effect of Lepidium meyenii (Red Maca) on prostatic hyperplasia in adult mice. Andrology. 40(3):179–185.
  • Gonzales GF, Gonzales C, Gonzales-Castañeda C. 2009. Lepidium meyenii (Maca): A Plant from the Highlands of Peru – from Tradition to Science. Forsch Komplementmed. 16(6):373–380.
  • Gonzales GF. 2012. Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands. Evid Based Complement Alternat Med. 2012:193496.
  • Gonzales GF, Vasquez VB, Gasco M. 2013. The transillumination technique as a method for the assessment of spermatogenesis using medicinal plants: the effect of extracts of Black Maca (Lepidium meyenii) and camu camu (Myrciaria dubia) on stages of the spermatogenic cycle in male rats. Toxicol Mech Methods. 23(8):559–565.
  • Gonzales GF, Gonzales-Castaneda C, Gasco M. 2013. A mixture of extracts from Peruvian plants (Black Maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabetes. Toxicol Mech Methods. 23(7):509–518.
  • Gonzales GF, Villaorduna L, Gasco M, Rubio J, Gonzales C. 2014. Maca (Lepidium meyenii Walp), una revision sobre sus propiedades biologicas. Rev Peru Med Exp Salud Publica. 31(1):100–110.
  • Lavana A, Vazquez R, Palma-Irizarry M, Orihuela A. 2013. Effect of Maca (Lepidium meyenii) supplementation on some libido and semen characteristics in hair sheep rams (Ovis aries). B Latinoam Caribe Pl. 12(3):238–242.
  • Lentz A, Gravitt K, Carson CC, Marson L. 2007. Acute and chronic dosing of Lepidium meyenii (Maca) on male rat sexual behavior. J Sex Med. 4(2):332–339.
  • Rubio J, Dang H, Gong M, Liu X, Chen SL, Gonzales GF. 2007. Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice. Food Chem Toxicol. 45(10):1882–1890.
  • Rubio J, Riqueros MI, Gasco M, Yucra S, Miranda S, Gonzales GF. 2006. Lepidium meyenii (Maca) reversed the lead acetate induced-damage on reproductive function in male rats. Food Chem Toxicol. 44(7):1114–1122.
  • Sanchez-Salazar L, Gonzales GF. 2018. Aqueous extract of Yellow Maca (Lepidium meyenii) improves sperm count in experimental animals but response depends on hypocotyl size, pH and routes of administration. Andrologia. 50(3):e12929.
  • Tafuri S, Ciani F, Iorio EL, Esposito L, Cocchia N. 2015. Reactive oxygen species (ROS) and male fertility. In: Wu B, editor. New Discoveries in Embryology. London, UK: Intechopen; 19–40.
  • Tafuri S, Marullo A, Ciani F, Della Morte R, Montagnaro S, Fiorito F, De Martino L. 2018. Reactive oxygen metabolites in alpha-herpesvirus-seropositive Mediterranean buffaloes (Bubalus bubalis): a preliminary study. Pol J Vet Sci. 21(3):639–642.
  • Tafuri S, Cocchia N, Carotenuto D, Vassetti A, Staropoli A, Mastellone V, Peretti V, Ciotola F, Albarella S, Del Prete C, et al. 2019. Chemical analysis of Lepidium meyenii (Maca) and its effects on redox status and on reproductive biology in stallions. Molecules. 24(10):1981..
  • Tang Y, Zhu ZY, Pan LC, Sun H, Song QY, Zhang Y. 2019. Structure analysis and anti-fatigue activity of a polysaccharide from Lepidium meyenii Walp. Nat Prod Res. 33(17):2480–2489.
  • Tello J, Hermann M, Calderón A. 1992. La Maca (Lepidium meyenii Walp.): Cultivo Alimenticio Potencial para las Zonas Altoandinas. Boletín de Lima. 81:59–66.
  • Valdivia-Cuya M, Yarasca D, Lévano-Sánchez G, Vásquez CJ, Temoche-García H, Torres-Torres L, Cruz-Ornetta V. 2016. Effect of Lepidium meyenii (Maca) on testicular function of mice with chemically and physically induced subfertility. Andrologia. 48:927–934.
  • Valerio LG, Jr, Gonzales GF. 2005. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical synopsis. Toxicol Rev. 24(1):11–35.
  • Ye YQ, Ma ZH, Yang QF, Sun YQ, Zhang RQ, Wu RF, Ren X, Mu LJ, Jiang ZY, Zhou M. 2019. Isolation and synthesis of a new benzylated alkamide from the roots of Lepidium meyenii. Nat Prod Res. 33(19):2731–2737.
  • Yucra S, Gasco M, Rubio J, Nieto J, Gonzales GF. 2008. Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats. Fertil Steril. 89(5):1461–1467.
  • Zenico T, Cicero AFG, Valmorri L, Mercuriali M, Bercovich E. 2009. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial. Andrologia. 41(2):95–99.
  • Zhang Y, Zhou F, Ge F. 2019. Effects of combined extracts of Lepidium meyenii and Allium tuberosum Rottl. on erectile dysfunction. BMC Complement Altern Med. 19(1):135.
  • Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, Lu Y, Yan SJ, Qien LC, Zheng QY. 2000. Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats. Urology. 55(4):598–602.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.