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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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Short Communications

Development and validation of a new HPTLC-HRMS method for the quantification of a potent pancreatic lipase inhibitory lead Echitamine from Alstonia scholaris

Ginson GeorgeLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani-333031 (BITS Pilani), Pilani, Rajasthan, IndiaView further author information
,
Dileep P. SLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani-333031 (BITS Pilani), Pilani, Rajasthan, IndiaView further author information
&
Atish T. PaulLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani-333031 (BITS Pilani), Pilani, Rajasthan, IndiaCorrespondence[email protected]
View further author information
Pages 4680-4684 | Received 03 Oct 2019, Accepted 03 Dec 2019, Published online: 24 Dec 2019

References

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  • Egloff M P, Marguet F, Buono G, Verger R, Cambillau C, van Tilbeurgh H. 1995. The 2.46. ANG. Resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. Biochemistry. 34(9):2751–2762.
  • Heck AM, Yanovski JA, Calis KA. 2000. Orlistat, a new lipase inhibitor for the management of obesity. Pharmacother J Hum Pharmacol Drug Ther. 20(3):270–279.
  • Khyade MS, Kasote DM, Vaikos NP. 2014. Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 153(1):1–18.
  • Lowe ME. 1994. Pancreatic triglyceride lipase and colipase: Insights into dietary fat digestion. Gastroenterology. 107(5):1524–1536.
  • Maurya A, Verma RK, Srivastava SK. 2015. Silica-based monolithic coupled column for the simultaneous determination of echitamine, N-Demethylalstogustine, and loganetin in Alstonia scholaris by RP-HPLC and optimization of extraction method. J Liq Chromatogr Relat Technol. 38(5):543–549.
  • Sridhar SNC, Ginson G, Reddy POV, Tantak MP, Kumar D, Paul AT. 2017. Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors. Bioorg Med Chem. 25(2):609–620.
  • World Health Organisation. 2018. Obesity and overweight. [cited 2019 Mar 23]. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/.

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