Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
333
Views
9
CrossRef citations to date
0
Altmetric
Research Articles

Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities

, , , , , , , & show all
Pages 4433-4441 | Received 06 Dec 2019, Accepted 19 Jan 2020, Published online: 10 Feb 2020

References

  • Alhasani RH, Biswas L, Tohari AM, Zhou X, Reilly J, He JF, Shu X. 2018. Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 112:76–85.
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394–424.
  • Chen DJ, Hu HG, Xing SF, Liu HM, Piao XL. 2015. Metabolite profiling of gypenoside LVI in rat after oral and intravenous administration. Arch Pharm Res. 38(6):1157–1167.
  • Denicourt C, Dowdy SF. 2004. Targeting apoptotic pathways in cancer cells. Science. 305(5689):1411–1413.
  • Gao D, Zhao M, Qi X, Liu Y, Li N, Liu Z, Bian Y. 2016. Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats. Arch Pharm Res. 39(2):221–230.
  • Jia D, Rao C, Xue S, Lei J. 2015. Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum. Carbohydr Polym. 122:93–100.
  • Kim MJ, Yun HS, Hong EH, Lee SJ, Baek JH, Lee CW, Yim JH, Kim JS, Park JK, Um HD, et al. 2013. Depletion of end-binding protein 1 (EB1) promotes apoptosis of human non-small-cell lung cancer cells via reactive oxygen species and Bax-mediated mitochondrial dysfunction. Cancer Lett. 339(1):15–24.
  • Kim YA, Kong CS, Lee JI, Kim H, Park HY, Lee HS, Lee C, Seo Y. 2012. Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea. Bioorg Med Chem Lett. 22(13):4318–4322.
  • Lee KH, Yeh MH, Kao ST, Hung CM, Liu CJ, Huang YY, Yeh CC. 2010. The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells. Toxicol Lett. 194(1–2):42–49.
  • Liou CJ, Huang WC, Kuo ML, Yang RC, Shen JJ. 2010. Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin-sensitized mice. Food Chem Toxicol. 48(10):2592–2598.
  • Liu JS, Chiang TH, Wang JS, Lin LJ, Chao WC, Inbaraj BS, Lu JF, Chen BH. 2015. Induction of p53-independent growth inhibition in lung carcinoma cell A549 by gypenosides. J Cell Mol Med. 19(7):1697–1709.
  • Lu HF, Chen YS, Yang JS, Chen JC, Lu KW, Chiu TH, Liu KC, Yeh CC, Chen GW, Lin HJ, et al. 2008. Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells. In Vivo. 22(2):215–221.
  • Nguyen PH, Gauhar R, Hwang SL, Dao TT, Park DC, Kim JE, Song H, Huh TL, Oh WK. 2011. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorg Med Chem. 19(21):6254–6260.
  • Piao XL, Wu Q, Yang J, Park SY, Chen DJ, Liu HM. 2013. Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells. Arch Pharm Res. 36(7):874–879.
  • Piao XL, Xing SF, Lou CX, Chen DJ. 2014. Novel dammarane saponins from Gynostemma pentaphyllum and their cytotoxic activities against HepG2 cells. Bioorg Med Chem Lett. 24(20):4831–4833.
  • Shang X, Chao Y, Zhang Y, Lu C, Xu C, Niu W. 2016. Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum Makino in immunosuppressed mice. Molecules. 21(8):1085.
  • Shen CY, Jiang JG, Shi MM, Yang HL, Wei H, Zhu W. 2018. Comparison of the effects and inhibitory pathways of the constituents from Gynostemma pentaphyllum against LPS-induced inflammatory response. J Agric Food Chem. 66(43):11337–11346.
  • Shi L, Lu F, Zhao H, Zhao YQ. 2012. Two new triterpene saponins from Gynostemma pentaphyllum. J Asian Nat Prod Res. 14(9):856–861.
  • Wang X, Yang L, Yang L, Xing F, Yang H, Qin L, Lan Y, Wu H, Zhang B, Shi H, et al. 2017. Gypenoside IX Suppresses p38 MAPK/Akt/NFkappaB signaling pathway activation and inflammatory responses in astrocytes stimulated by proinflammatory mediators. Inflammation. 40(6):2137–2150.
  • Xing SF, Jang M, Wang YR, Piao XL. 2016. A new dammarane-type saponin from Gynostemma pentaphyllum induces apoptosis in A549 human lung carcinoma cells. Bioorg Med Chem Lett. 26(7):1754–1759.
  • Xing SF, Lin M, Wang YR, Chang T, Cui WY, Piao XL. 2020. Novel dammarane-type saponins from Gynostemma pentaphyllum and their neuroprotective effect. Nat Prod Res. 34(5):651–658.
  • Yang K, Zhang H, Luo Y, Zhang J, Wang M, Liao P, Cao L, Guo P, Sun G, Sun X. 2017. Gypenoside XVII prevents atherosclerosis by attenuating endothelial apoptosis and oxidative stress: Insight into the ERalpha-mediated PI3K/Akt pathway. IJMS. 18(2):77.
  • Yin F, Hu L, Lou F, Pan R. 2004. Dammarane-type glycosides from Gynostemma pentaphyllum. J Nat Prod. 67(6):942–952.
  • Yu H, Guan Q, Guo L, Zhang H, Pang X, Cheng Y, Zhang X, Sun Y. 2016. Gypenosides alleviate myocardial ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function in rat heart. Cell Stress Chaperones. 21(3):429–437.
  • Zhang X, Shi G, Liu M, Chen R, Wu X, Zhao Y. 2019. Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities. Nat Prod Res. 33(11):1605–1611.
  • Zhang X, Shi G, Wu X, Zhao Y. 2018. Gypensapogenin H from hydrolyzate of total Gynostemma pentaphyllum saponins induces apoptosis in human breast carcinoma cells. Nat Prod Res. doi: https://doi.org/10.1080/14786419.2018.1525370.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.