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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 23
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Short Communications

Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora

Allan Patrick G. Macabeoa Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, PhilippinesCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-7972-106XView further author information
ORCID Icon,
Angeli Izza G. Floresa Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, PhilippinesView further author information
,
Rey Arturo T. Fernandeza Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, PhilippinesView further author information
,
Simon Buddeb Institut fur Organische Chemie, Universität Regensburg, Regensburg, GermanyView further author information
,
Christian Faderlb Institut fur Organische Chemie, Universität Regensburg, Regensburg, GermanyView further author information
,
Hans-Martin Dahsec Leibniz-Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute (HKI), Jena, GermanyView further author information
&
Scott G. Franzblaud Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USAView further author information
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Pages 5229-5232 | Received 12 Oct 2019, Accepted 05 Mar 2020, Published online: 23 Mar 2020

References

  • Jolad SD, Hoffmann JJ, Schram KH, Cole JR, Tempesta MS, Bates RB. 1981. Structures of zeylenol and zeylena, constituents of Uvaria zeylanica (Annonaceae). J Org Chem. 46(21):4267–4272.
  • Macabeo APG, Letada AG, Budde S, Faderl C, Dahse H-M, Franzblau SG, Alejandro GJD, Pierens GK, Garson MJ. 2017a. Antitubercular and cytotoxic chlorinated seco-cyclohexenes from Uvaria alba. J Nat Prod. 80(12):3319–3323.
  • Macabeo APG, Lopez ADA, Schmidt S, Heilmann J, Dahse HM, Alejandro GJD, Franzblau SG. 2014a. Antitubercular and cytotoxic constituents from Goniothalamus gitingensis. Rec Nat Prod. 8:41–45.
  • Macabeo APG, Martinez FPA, Kurtán T, Tóth L, Mándi A, Schmidt S, Heilmann J, Alejandro GJD, Knorn M, Dahse H-M, et al. 2014b. Tetrahydroxanthene-1,3(2H)-dione derivatives from Uvaria valderramensis. J Nat Prod. 77(12):2711–2715.
  • Macabeo APG, Rubio PYM, Higuchi T, Umezawa N, Faderl C, Budde S, Bangcaya PS, Alejandro GJD. 2017b. Polyoxygenated seco-cyclohexenes and other constituents from Uvaria valderramensis. Biochem Syst Ecol. 71:200–204.
  • Macabeo APG, Rubio PYM, Knorn M, Alejandro GJD. 2015. An α-glucosidase inhibitor from the Philippine endemic Annonaceae plant, Drephananthus philippinensis. Proceedia Chem. 14:36–39.
  • Macabeo APG, Tudla FA, Alejandro GJD, Kouam SF, Hussain H, Krohn K. 2010. Benzoylated derivatives from Uvaria rufa. Biochem. Syst. Ecol. 38(4):857–860.
  • Macabeo APG, Tudla FA, Krohn K, Franzblau SG. 2012. Antitubercular activity of the semi-polar extractives of Uvaria rufa. Asian Pacific J Trop Med. 5(10):777–780.
  • Nkunya MHH, Weenen H, Koyi NJ, Thijs L, Zwanenburg B. 1987. Cyclohexene epoxides, (+)-pandoxide, (+)-β-senepoxide and (−)-pipoxide, from Uvaria pandensis. Phytochemistry. 26:2563–2565.
  • Notarte KIR, Devanadera MKP, Mayor ABR, Cada MCA, Pecundo MH, Macabeo A. 2019. Toxicity, antibacterial, and antioxidant activities of fungal endophytes Colletotrichum and Nigrospora spp. isolated from Uvaria grandiflora. Phil J Sci. 148:503–510.
  • Paragas EM, Gehle D, Krohn K, Franzblau SG, Macabeo A. 2014. Antitubercular flavonol derivatives from Uvaria rufa. Res J Pharm Biol Chem Sci. 5:856–859.
  • Takeuchi Y, Shi Q, Sugiyama T, Oritani T. 2002. Polyoxygenated cyclohexenes from the Chinese tree, Uvaria purpurea. Biosci Biotechnol Biochem. 66(3):537–542.
  • Tudla FA, Aguinaldo AM, Hussain H, Krohn K, Macabeo APG. 2007. Highly oxygenated cyclohexene metabolites from Uvaria rufa. Biochem. Syst. Ecol. 35(1):45–47.

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