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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 10
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Research Articles

A hederagenin-type triterpene saponin, sumbulianoside a from Cephalaria sumbuliana and its potent immunomodulatory activity against seasonal flu virus H3N2

Huseyin Abacia Faculty of Science, Department of Chemistry, Ege University, Bornova, Turkey
,
Gulsah Akagacb Faculty of Engineering, Department of Bioengineering, Ege University, Bornova, Turkey
,
Ayse Nalbantsoyb Faculty of Engineering, Department of Bioengineering, Ege University, Bornova, Turkey
&
Nazli Boke Sarikahyaa Faculty of Science, Department of Chemistry, Ege University, Bornova, TurkeyCorrespondence[email protected]
Pages 2495-2503 | Received 22 Jan 2021, Accepted 25 Mar 2021, Published online: 11 Apr 2021

References

  • Caliş I, Zor M, Saracoğlu I, Işimer A, Rüegger H. 1996. Four novel cycloartane glycosides from Astragalus oleifolius. J Nat Prod. 59(11):1019–1023.
  • Davis PH. 1972. Flora of Turkey and the East Aegean Islands. Vol. 4. Edinburgh: University of Edinburgh Press; p. 585–592.
  • Desai SD, Desai DG, Kaur H. 2009. Saponins and their biological activities. Pharma Times. 41:16.
  • Godjevac D, Vajs V, Menkovic N, Tesevic V, Janackovic P, Milosavljevic S. 2004. Flavonoids from flowers of Cephalaria pastricensis and their antiradical activity. J Serb Chem Soc. 69(11):883–886.
  • Gokturk RS, Sumbul H, Celebi A, Acik L. 2012. Two new species of Cephalaria (Caprifoliaceae) from Turkey. Turk J Bot. 36:311–321.
  • Goral I, Wojciechowski K. 2020. Surface activity and foaming properties of saponin-rich plants extracts. Adv Colloid Interface Sci. 279:102145.
  • Halay E, Kirmizigul S. 2010. Glycosides from Cephalaria Species. Z Naturforsch. 65(11):1384–1392.
  • Jung KY, Son KH, Do JC. 1993. Triterpenoids from the roots of Dipsacus asper. Arch Pharm Res. 16(1):32–35.
  • Kawai H, Kuroyanagi M, Umehara K, Ueno A, Satake M. 1988. Studies on the saponins of Lonicera japonica Thunb. Chem Pharm Bull (Tokyo)). 36(12):4769–4775.
  • Kayce P, Sarikahya N, Kirmizigul S. 2014. Two novel saponins from Cephalaria davisiana (Dipsacaceae). Phyt Lett. 10:324–329.
  • Lacaille-Dubois MA, Wagner H. 1996. A review of the biological and pharmacological activities of saponins. Phytomedicine. 2(4):363–386.
  • Lin HC, Ding HY, Wu YC. 1998. Two novel compounds from Paeonia suffructicosa. J Nat Prod. 61(3):343–346.
  • Morrissey JP, Osbourn AE. 1999. Fungal resistance to plant antibiotics as a mechanism of pathogenesis. Microbiol Mol Biol Rev. 63(3):708–724.
  • Movsumov IS, Garaev EA, Isaev MI. 2009. Flavonoids from Cephalaria grossheimii. Chem Nat Compd. 45(3):422–423.
  • Mukhamedziev MM, Alimbaeva PK, Gorovits TT, Abubakirov NK. 1971. Structure of the triterpenoid glycoside from Dipsacus azureus. Dipsacoside B. Khim Prir Soedin. 7:153–158.
  • Mustafayeva K, Mahiou-Leddet V, Suleymanov T, Kerimov Y, Ollivier E, Elias R. 2011. Chemical constituents from the roots of Cephalaria kotschyi. Chem Nat Compd. 47(5):839–842.
  • Nakamura T, Kamogawa Y, Bottomly K, Flavell RA. 1997. Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. J Immunol. 158(3):1085–1094.
  • Nalbantsoy A, Nesil T, Erden S, Çalış İ, Bedir E. 2011. Adjuvant effects of Astragalus saponins macrophyllosaponin B and astragaloside VII. J Ethnopharmacol. 134(3):897–903.
  • Sarikahya NB. 2014. Aristatosides A-C, hederagenin-type triterpene saponins from Cephalaria aristata. Phytochem Lett. 8:149–155.
  • Sarikahya NB, Kirmizigul S. 2010. Antimicrobial triterpenoid glycosides from Cephalaria scoparia. J Nat Prod. 73(5):825–830.
  • Sarikahya NB, Kirmizigul S. 2012. Antimicrobially active hederagenin glycosides from Cephalaria elmaliensis. Planta Med. 78(8):828–833.
  • Sarikahya NB, Mkouboi MC, Nalbantsoy A, Elibol M. 2020. Cytotoxic and immunomodulator potential of hederagenin saponins from Cephalaria tchihatchewii. Phytochem Lett. (in decision).
  • Sarikahya NB, Nalbantsoy A, Top H, Gokturk RS, Sumbul H, Kirmizigul S. 2018. Immunomodulatory, hemolytic and cytotoxic activity potentials of triterpenoid saponins from eight Cephalaria species. Phytomedicine. 38:135–144.
  • Sparg SG, Light ME, Van Staden J. 2004. Biological activities and distribution of plant saponins. J Ethnopharmacol. 94(2–3):219–243.
  • Tabatadze N, Elias R, Faure R, Gerkens P, De Pauw-Gillet MC, Kemertelidze E, Chea A, Ollivier E. 2007. Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantean. Chem Pharm Bull (Tokyo)). 55(1):102–105.
  • Top H, Sarikahya NB, Nalbantsoy A, Kirmizigul S. 2017. Immunomodulatory, hemolytic properties and cytotoxic activity potent of triterpenoid saponins from Cephalaria balansae. Phytochemistry. 137:139–147.
  • Yakuboğulları N, Genç R, Çöven F, Nalbantsoy A, Bedir E. 2019. Development of adjuvant nanocarrier systems for seasonal influenza A (H3N2) vaccine based on Astragaloside VII and gum tragacanth (APS). Vaccine. 37(28):3638–3645.
  • Yuan LJ, Wang Y, Ma XD, Cui XM, Lu MQ, Guan R, Chi XQ, Xu W, Hu SH. 2020. Sunflower seed oil combined with ginseng stem-leaf saponins as an adjuvant to enhance the immune response elicited by Newcastle disease vaccine in chickens. Vaccine. 38(33):5343–5354.

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