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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 24
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Research Articles

First synthetic report and antioxidant potential of natural product (±)-5,7-dihydroxy-8-methyl-3-(2',4'-dihydroxybenzyl)chroman-4-one from Chinese medicine Gan Luo Xin pill

Ninad V. Puranika Bioprospecting Group, MACS, Agharkar Research Institute, Pune, Maharashtra, India;b Savitribai Phule Pune University, Pune, Maharashtra, IndiaView further author information
,
Garima Mishraa Bioprospecting Group, MACS, Agharkar Research Institute, Pune, Maharashtra, IndiaView further author information
,
Swapnaja Gulawania Bioprospecting Group, MACS, Agharkar Research Institute, Pune, Maharashtra, India;b Savitribai Phule Pune University, Pune, Maharashtra, IndiaView further author information
&
Pratibha Srivastavaa Bioprospecting Group, MACS, Agharkar Research Institute, Pune, Maharashtra, India;b Savitribai Phule Pune University, Pune, Maharashtra, IndiaCorrespondence[email protected]
View further author information
Pages 6259-6266 | Received 07 Oct 2021, Accepted 02 Jan 2022, Published online: 20 Jan 2022

References

  • Ahmad S, Ahmad H, Khan HU, Shahzad A, Khan E, Ali Shah SA, Ali M, Wadud A, Ghufran M, Naz H, et al. 2016. Crystal structure, phytochemical study and enzyme inhibition activity of Ajaconine and Delectinine. J Mol Struct. 1123:441–448.
  • Ahmad H, Ahmad S, Khan E, Shahzad A, Ali M, Tahir MN, Shaheen F, Ahmad M. 2017. Isolation, crystal structure determination and cholinesterase inhibitory potential of isotalatizidine hydrate from Delphinium denudatum. Pharm Biol. 55(1):680–686.
  • Atanasov AG, Zotchev SB, Dirsch VM. 2021. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discovery. 20:201–216.
  • Damodar K, Lee JT, Kim JK, Jun JG. 2018. Synthesis and in vitro evaluation of homoisoflavonoids as potent inhibitors of nitric oxide production in RAW-264.7 cells. Bioorg Med Chem Lett. 28(11):2098–2102.
  • Elliger CA. 1985. Deoxygenation of aldehydes and ketones with sodium cyanoborohydride. Synth Commun. 15(14):1315–1324.
  • Hawranik DJ, Anderson KS, Simmonds R, Sorensen JL. 2009. The chemoenzymatic synthesis of usnic acid. Bioorg Med Chem Lett. 19(9):2383–2385.
  • Hussein RA, El-Anssary AA. 2018. Plants secondary metabolites: the key drivers of the pharmacological actions of medicinal plants. IntechOpen Book Series Book Chapter. 2:11–30.
  • Lee B, Basavarajappa HD, Sulaiman RS, Fei X, Seo SY, Corson TW. 2014. The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. Org Biomol Chem. 12(39):7673–7677.
  • Li LM, Yuan QP, Chen G. 2014. Four homoisoflavonoids isolated from traditional Chinese medicine: "Gan Luo Xin". J Asian Nat Prod Res. 16 (8):813–818.
  • Li Y, Yu B, Wang R. 2016. Efficient synthesis of rottlerin and its two subunits. Tetrahedron Lett. 57(17):1856–1859.
  • Liu J, Li Z, Tong P, Xie Z, Zhang Y, Ying L. 2015. TMSI-promoted vinylogous Michael addition of siloxyfuran to 2-substituted chromones: a general approach for the total synthesis of chromanone lactone natural products. J Org Chem. 80(3):1632–1643.
  • Nguyen AT, Fontaine J, Malonne H, Duez P. 2006. Homoisoflavanones from Disporopsis aspera. Phytochemistry. 67(19):2159–2164.
  • Puranik NV, Srivastava P. 2017. First synthesis of rugosaflavonoid and its derivatives and their activity against breast cancer. RSC Adv. 7(52):33052–33060.
  • Puranik NV, Swamy S, Misar AV, Mamgain R, Gulawani S, Sarkar D, Srivastava P. 2021. The first synthesis of podocarflavone A and its analogs and evaluation of their antimycobacterial potential against Mycobacterium tuberculosis, with the support of virtual screening. Nat. Prod. Res. 1–8.
  • Shaikh MM, Kruger HG, Bodenstein J, Smith P, Toit K. 2012. Anti-inflammatory activities of selected synthetic homoisoflavanones. Nat Prod Res. 26(16):1473–1482.
  • Shaikh MM, Kruger HG, Bodenstein J, Smith P, Toit K. 2013. Does nature provide the best therapeutic options? Synthesis and anti-inflammatory activity of a naturally occurring homoisoflavanone and its enantiomer. J Pharm Res. 6(1):21–25.
  • Srivastava P, Raut HN, Wagh RS, Puntambekar HM, Kulkarni MJ. 2012. Purification and characterization of an antioxidant protein (∼16 kDa) from Terminalia chebula fruit. Food Chem. 131(1):141–148.
  • Zheng SY, Li XP, Tan HS, Yu CH, Zhang JH, Shen ZW. 2013. Studies on the total synthesis of hirtellanine A: regioselective synthesis of benzopyran. Eur J Org Chem. 2013(7):1356–1366.
  • Tsai Y-C, Chiang S-Y, El-Shazly M, Wu C-C, Beerhues L, Lai W-C, Wu S-F, Yen M-H, Wu Y-C, Chang F-R. 2013. The oestrogenic and anti-platelet activities of dihydrobenzofuroisocoumarins and homoisoflavonoids from Liriope platyphylla roots. Food Chem. 140(1–2):305–314.
  • Zhao H, Wang QL, Hou SB, Chen G. 2019. Chemical constituents from the rhizomes of Polygonatum sibiricum Red. and anti-inflammatory activity in RAW264.7 macrophage cells. Nat Prod Res. 33(16):2359–2362.
  • Zhou WL, Tan HB, Qiu SX, Chen GY, Liu HX, Zheng C. 2017. Biomimetic total synthesis and structure confirmation of myrtucommulone K. Tetrahedron Lett. 58(19):1817–1821.
  • Zhou X, Li J. 2015. Chemical constituents of the Genus Polygonatum and their role in medicinal treatment. Nat. Prod Comm. 10:683–688.
  • Zhou X, Zhang Y, Zhao H, Liang J, Zhang Y, Shi S. 2015. Antioxidant homoisoflavonoids from Polygonatum odoratum. Food Chem. 186:63–68.

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