Betalains: colours for human health

References

• Abderrahim F, Huanatico E, Segura R, Arribas S, Gonzalez MC, Condezo-Hoyos L. 2015. Physical features, phenolic compounds, betalains and total antioxidant capacity of coloured quinoa seeds (Chenopodium quinoa Willd.) from Peruvian Altiplano. Food Chem. 183:83–90.
   Google Scholar
• Abedimanesh N, Asghari S, Mohammadnejad K, Daneshvar Z, Rahmani S, Shokoohi S, Farzaneh AH, Hosseini SH, Jafari Anarkooli I, Noubarani M, et al. 2021. The anti-diabetic effects of betanin in streptozotocin-induced diabetic rats through modulating AMPK/SIRT1/NF-κB signaling pathway. Nutr Metab (Lond). 18(1):92.
   PubMedGoogle Scholar
• Albano C, Negro C, Tommasi N, Gerardi C, Mita G, Miceli A, De Bellis L, Blando F. 2015. Betalains, phenols and antioxidant capacity in Cactus Pear [Opuntia ficus-indica (L.) Mill.] fruits from Apulia (South Italy) genotypes. Antioxidants (Basel). 4(2):269–280.
   PubMedGoogle Scholar
• Al-Dosari M, et al. 2011. Effect of Beta vulgaris L. on cholesterol rich diet-induced hypercholesterolemia in rats. Farmacia. 59.5:669–678.
   Google Scholar
• Allegra M, Ianaro A, Tersigni M, Panza E, Tesoriere L, Livrea MA. 2014. Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy. J Nutr. 144(2):185–192.
   PubMed Web of Science ®Google Scholar
• Angulo-Bejarano PI, Gómez-García MDR, Valverde ME, Paredes-López O. 2019. Nopal (Opuntia spp.) and its effects on metabolic syndrome: new insights for the use of a millenary plant. Curr Pharm Des. 25(32):3457–3477.
   PubMedGoogle Scholar
• Ashor AW, Jajja A, Sutyarjoko A, Brandt K, Qadir O, Lara J, Siervo M. 2015. Effects of beetroot juice supplementation on microvascular blood flow in older overweight and obese subjects: a pilot randomised controlled study. J Hum Hypertens. 29(8):511–513.
   PubMedGoogle Scholar
• Attanzio A, Tesoriere L, Vasto S, Pintaudi AM, Livrea MA, Allegra M. 2018. Short-term cactus pear [Opuntia ficus-indica (L.) Mill] fruit supplementation ameliorates the inflammatory profile and is associated with improved antioxidant status among healthy humans. Food Nutr Res. 20:62.
   Google Scholar
• Attanzio A, Frazzitta A, Busa' R, Tesoriere L, Livrea MA, Allegra M. 2019. Indicaxanthin from Opuntia ficus indica (L. Mill) inhibits oxidized LDL-mediated human endothelial cell dysfunction through inhibition of NF-κB activation. Oxid Med Cell Longev. 2019:3457846.
   PubMed Web of Science ®Google Scholar
• Baker RG, Hayden MS, Ghosh S. 2011. NF-κB, inflammation, and metabolic disease. Cell Metab. 13(1):11–22.
   PubMed Web of Science ®Google Scholar
• Beals JW, Binns SE, Davis JL, Giordano GR, Klochak AL, Paris HL, Schweder MM, Peltonen GL, Scalzo RL, Bell C. 2017. Concurrent beet juice and carbohydrate ingestion: influence on glucose tolerance in obese and nonobese adults. J Nutr Metab. 2017:6436783.
   PubMedGoogle Scholar
• Belhadj Slimen I, Najar T, Abderrabba M. 2017. Chemical and antioxidant properties of betalains. J Agric Food Chem. 65(4):675–689.
   PubMed Web of Science ®Google Scholar
• Budinsky A, Wolfram R, Oguogho A, Efthimiou Y, Stamatopoulos Y, Sinzinger H. 2001. Regular ingestion of opuntia robusta lowers oxidation injury. Prostaglandins Leukot Essent Fatty Acids. 65(1):45–50.
   PubMed Web of Science ®Google Scholar
• Butera D, Tesoriere L, Di Gaudio F, Bongiorno A, Allegra M, Pintaudi AM, Kohen R, Livrea MA. 2002. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J Agric Food Chem. 50(23):6895–6901.
   PubMed Web of Science ®Google Scholar
• Cai Y, Sun M, Corke H. 2003. Antioxidant activity of betalains from plants of the amaranthaceae. J Agric Food Chem. 51(8):2288–2294.
   PubMed Web of Science ®Google Scholar
• Cai Y, Sun M, Corke H. 2005. HPLC characterization of betalains from plants in the amaranthaceae. J Chromatogr Sci. 43(9):454–460.
   PubMedGoogle Scholar
• Cheok A, George TW, Rodriguez-Mateos A, Caton PW. 2020. The effects of betalain-rich cacti (dragon fruit and cactus pear) on endothelial and vascular function: a systematic review of animal and human studies. Food Funct. 11(8):6807–6817.
   PubMedGoogle Scholar
• Clemente A, Desai PV. 2011. Evaluation of the hematological, hypoglycemic, hypolipidemic and antioxidant properties of Amaranthus tricolor leaf extract in rat. Trop J Pharm Res. 10(5):595–602.
   Google Scholar
• Clifford T, Howatson G, West DJ, Stevenson EJ. 2015. The potential benefits of red beetroot supplementation in health and disease. Nutrients. 7(4):2801–2822.
   PubMed Web of Science ®Google Scholar
• de Castro APRB, da Cunha DT, Antunes AEC, Corona LP, Bezerra RMN. 2019. Effect of freeze-dried red beet (Beta vulgaris L.) leaf supplementation on biochemical and anthropometrical parameters in overweight and obese individuals: a pilot study. Plant Foods Hum Nutr. 74(2):232–234.
   PubMedGoogle Scholar
• Del Socorro Santos Díaz M, Barba de la Rosa AP, Héliès-Toussaint C, Guéraud F, Nègre-Salvayre A. 2017. Opuntia spp.: characterization and benefits in chronic diseases. Oxid Med Cell Longev. 2017:8634249.
   PubMedGoogle Scholar
• Dhananjayan I, Kathiroli S, Subramani S, Veerasamy V. 2017. Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats. Biomed Pharmacother. 88:1069–1079.
   PubMedGoogle Scholar
• El Gamal AA, AlSaid MS, Raish M, Al-Sohaibani M, Al-Massarani SM, Ahmad A, Hefnawy M, Al-Yahya M, Basoudan OA, Rafatullah S. 2014. Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Mediators Inflamm. 2014:983952.
   PubMed Web of Science ®Google Scholar
• Esatbeyoglu T, Wagner AE, Motafakkerazad R, Nakajima Y, Matsugo S, Rimbach G. 2014. Free radical scavenging and antioxidant activity of betanin: electron spin resonance spectroscopy studies and studies in cultured cells. Food Chem Toxicol. 73:119–126.
   PubMed Web of Science ®Google Scholar
• Esatbeyoglu T, Wagner AE, Schini-Kerth VB, Rimbach G. 2015. Betanin–a food colorant with biological activity. Mol Nutr Food Res. 59(1):36–47.
   PubMed Web of Science ®Google Scholar
• Galati EM, Mondello MR, Lauriano ER, Taviano MF, Galluzzo M, Miceli N. 2005. Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. Phytother Res. 19(9):796–800.
   PubMed Web of Science ®Google Scholar
• Garoby-Salom S, Guéraud F, Camaré C, de la Rosa AP, Rossignol M, Santos Díaz Mdel S, Salvayre R, Negre-Salvayre A. 2016. Dietary cladode powder from wild type and domesticated Opuntia species reduces atherogenesis in apoE knock-out mice. J Physiol Biochem. 72(1):59–70.
   PubMedGoogle Scholar
• Gandía-Herrero F, García-Carmona F, Escribano J. 2005. Fluorescent pigments: new perspectives in betalain research and applications. Food Res Int. 38(8–9):879–884.
   Google Scholar
• Gandía-Herrero F, Escribano J, García-Carmona F. 2012. Purification and antiradical properties of the structural unit of betalains. J Nat Prod. 75(6):1030–1036.
   PubMedGoogle Scholar
• Gandía-Herrero F, Escribano J, García-Carmona F. 2016. Biological activities of plant pigments betalains. Crit Rev Food Sci Nutr. 56(6):937–945.
   PubMed Web of Science ®Google Scholar
• Gentile C, Tesoriere L, Allegra M, Livrea MA, D'Alessio P. 2004. Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression. Ann N Y Acad Sci. 1028:481–486.
   PubMed Web of Science ®Google Scholar
• Ghissing U, Goswami A, Mitra A. 2021. Temporal accumulation of pigments during colour transformation from white to red in Combretum indicum (L.) DeFilipps (syn. Quisqualis indica L.) flowers. Nat Prod Res. 1–5.
   PubMedGoogle Scholar
• González-Ponce HA, Martínez-Saldaña MC, Tepper PG, Quax WJ, Buist-Homan M, Faber KN, Moshage H. 2020. Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure. Food Res Int. 137:109461.
   PubMedGoogle Scholar
• Guerrero-Rubio MA, Hernández-García S, García-Carmona F, Gandía-Herrero F. 2019. Extension of life-span using a RNAi model and in vivo antioxidant effect of Opuntia fruit extracts and pure betalains in Caenorhabditis elegans. Food Chem. 274:840–847.
   PubMedGoogle Scholar
• Hadipour E, Fereidoni M, Tayarani-Najaran Z. 2020. Betanin attenuates oxidative stress induced by 6-OHDA in PC12 cells via SAPK/JNK and PI3 K pathways. Neurochem Res. 45(2):395–403.
   PubMedGoogle Scholar
• Hadipour E, Taleghani A, Tayarani-Najaran N, Tayarani-Najaran Z. 2020. Biological effects of red beetroot and betalains: a review. Phytother Res. 34(8):1847–1867.
   PubMed Web of Science ®Google Scholar
• Han J, Zhang Z, Yang S, Wang J, Yang X, Tan D. 2014. Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway. Food Chem Toxicol. 70:100–106.
   PubMed Web of Science ®Google Scholar
• Herbach KM, Stintzing FC, Carle R. 2006. Betalain stability and degradation—structural and chromatic aspects. J Food Science. 71(4):R41–R50.
   Web of Science ®Google Scholar
• Heuer S, Wray V, Metzger JW, Strack D. 1992. Betacyanins from flowers of Gomphrena globosa. Phytochemistry. 31(5):1801–1807.
   Google Scholar
• Hobbs DA, George TW, Lovegrove JA. 2013. The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev. 26(2):210–222.
   PubMedGoogle Scholar
• Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA. 2012. Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr. 108(11):2066–2074.
   PubMed Web of Science ®Google Scholar
• Holy B, Nnamdi IN, Ojoye NB. 2017. Post-prandial effect of beetroot (Beta vulgaris) juice on glucose and lipids levels of apparently healthy subjects. Eur J Pharm Med Res. 4(05):60–62.
   Google Scholar
• Jajja A, Sutyarjoko A, Lara J, Clio O, Rennie K, Brandt K, Siervo M. 2015. Effects of beetroot juice on daily and 24-hour ambulatory blood pressure monitoring in older overweight and obese subjects. Proc Nutr Soc. 74(OCE1):E109.
   Google Scholar
• Jerz G, Skotzki T, Fiege K, Winterhalter P, Wybraniec S. 2008. Separation of betalains from berries of Phytolacca americana by ion-pair high-speed counter-current chromatography. J Chromatogr A. 1190(1–2):63–73.
   PubMedGoogle Scholar
• Kanner J, Harel S, Granit R. 2001. Betalains–a new class of dietary cationized antioxidants. J Agric Food Chem. 49(11):5178–5185.
   PubMed Web of Science ®Google Scholar
• Keller J, Camaré C, Bernis C, Astello-García M, de la Rosa AP, Rossignol M, del Socorro Santos Díaz M, Salvayre R, Negre-Salvayre A, Guéraud F. 2015. Antiatherogenic and antitumoral properties of Opuntia cladodes: inhibition of low density lipoprotein oxidation by vascular cells, and protection against the cytotoxicity of lipid oxidation product 4-hydroxynonenal in a colorectal cancer cellular model. J Physiol Biochem. 71(3):577–587.
   PubMed Web of Science ®Google Scholar
• Khan MI. 2016. Plant betalains: safety, antioxidant activity, clinical efficacy, and bioavailability. Compr Rev Food Sci Food Saf. 15(2):316–330.
   PubMed Web of Science ®Google Scholar
• Kong M, Xie K, Lv M, Li J, Yao J, Yan K, Wu X, Xu Y, Ye D. 2021. Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: lessons learned and future promise. Biomed Pharmacother. 133:110975.
   PubMedGoogle Scholar
• Krantz C, Monier M, Wahlström B. 1980. Absorption, excretion, metabolism and cardiovascular effects of beetroot extract in the rat. Food Cosmet Toxicol. 18(4):363–366.
   PubMedGoogle Scholar
• Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikołajczyk K, Jodynis-Liebert J. 2009. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J Agric Food Chem. 57(6):2570–2575.
   PubMed Web of Science ®Google Scholar
• Kumar JK, Sinha AK. 2004. Resurgence of natural colourants: a holistic view. Nat Prod Res. 18(1):59–84.
   PubMed Web of Science ®Google Scholar
• Lin SM, Lin BH, Hsieh WM, Ko HJ, Liu CD, Chen LG, Chiou RY. 2010. Structural identification and bioactivities of red-violet pigments present in Basella alba fruits. J Agric Food Chem. 58(19):10364–10372.
   PubMedGoogle Scholar
• Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N. 2001. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 50(8):1844–1850.
   PubMed Web of Science ®Google Scholar
• Martínez EMM, Sandate-Flores L, Rodríguez-Rodríguez J, Rostro-Alanis M, Parra-Arroyo L, Antunes-Ricardo M, Serna-Saldívar SO, Iqbal HMN, Parra-Saldívar R. 2021. Underutilized Mexican Plants: Screening of Antioxidant and Antiproliferative Properties of Mexican Cactus Fruit Juices. Plants (Basel). 10(2):368.
   Google Scholar
• Miguel MG. 2018. Betalains in some species of the amaranthaceae family: a review. Antioxidants (Basel). 7(4):53.
   PubMedGoogle Scholar
• Mollazadeh H, Hosseinzadeh H. 2016. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iran J Basic Med Sci. 19(12):1258–1270.
   PubMed Web of Science ®Google Scholar
• Monteiro R, Azevedo I. 2010. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010:1–10.
   Web of Science ®Google Scholar
• Page J, Henry D. 2000. Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem. Arch Intern Med. 160(6):777–784.
   PubMed Web of Science ®Google Scholar
• Pem D, Jeewon R. 2015. Fruit and vegetable intake: benefits and progress of nutrition education interventions- narrative review article. Iran J Public Health. 44(10):1309–1321.
   PubMed Web of Science ®Google Scholar
• Pietrzkowski Z, Nemzer B, Spórna A, Stalica P, Tresher W, Keller R, Jiminez R, Michalowski T, Wybraniec S. 2010. Influence of betaline-rich extracts on the reduction of discomfort associated with osteoarthritis. New Med. 1:12–17.
   Google Scholar
• Rahimi P, Abedimanesh S, Mesbah-Namin SA, Ostadrahimi A. 2019. Betalains, the nature-inspired pigments, in health and diseases. Crit Rev Food Sci Nutr. 59(18):2949–2978.
   PubMed Web of Science ®Google Scholar
• Rahimi P, Mesbah-Namin SA, Ostadrahimi A, Abedimanesh S, Separham A, Asghary Jafarabadi M. 2019. Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease. Food Funct. 10(12):8286–8297.
   PubMedGoogle Scholar
• Rahman K. 2007. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2(2):219–236.
   PubMed Web of Science ®Google Scholar
• Raish M, Ahmad A, Ansari MA, Alkharfy KM, Ahad A, Khan A, Ali N, Ganaie MA, Hamidaddin MAA. 2019. Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats. 3 Biotech. 9(4):147.
   PubMedGoogle Scholar
• Raubenheimer K, Hickey D, Leveritt M, Fassett R, Ortiz de Zevallos Munoz J, Allen J, Briskey D, Parker T, Kerr G, Peake J, et al. 2017. Acute effects of nitrate-rich beetroot juice on blood pressure, hemostasis and vascular inflammation markers in healthy older adults: a randomized, placebo-controlled crossover study. Nutrients. 9(11):1270.
   PubMedGoogle Scholar
• Reddy MK, Alexander-Lindo RL, Nair MG. 2005. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J Agric Food Chem. 53(23):9268–9273.
   PubMed Web of Science ®Google Scholar
• Reynoso RC, Giner TV, de Mejia EG. 1999. Safety of a filtrate of fermented garambullo fruit: biotransformation and toxicity studies. Food Chem Toxicol. 37(8):825–830.
   PubMedGoogle Scholar
• Saani M, Lawrence R, Lawrence K. 2018. Evaluation of pigments from methanolic extract of Tagetes erecta and Beta vulgaris as antioxidant and antibacterial agent. Nat Prod Res. 32(10):1208–1211.
   PubMed Web of Science ®Google Scholar
• Sadowska-Bartosz I, Bartosz G. 2021. Biological properties and applications of betalains. Molecules. 26(9):2520.
   PubMedGoogle Scholar
• Sakihama Y, Maeda M, Hashimoto M, Tahara S, Hashidoko Y. 2012. Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage. Free Radic Res. 46(1):93–99.
   PubMed Web of Science ®Google Scholar
• Salma K, ObaShinya. 2013. Bioactive substances in leaves of two amaranth species, Amaranthus tricolor and A. hypochondriacus. Can. J. Plant Sci. 93:47–58.
   Google Scholar
• Serafini M, Peluso I. 2016. Functional foods for health: the interrelated antioxidant and anti-inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans. Curr Pharm Des. 22(44):6701–6715.
   PubMed Web of Science ®Google Scholar
• Skalicky M, Kubes J, Shokoofeh H, Tahjib-Ul-Arif M, Vachova P, Hejnak V. 2020. Betacyanins and Betaxanthins in Cultivated Varieties of Beta vulgaris L. Compared to Weed Beets. Molecules. 25(22):5395.
   Google Scholar
• Song H, Chu Q, Xu D, Xu Y, Zheng X. 2016. Purified betacyanins from hylocereus undatus peel ameliorate obesity and insulin resistance in high-fat-diet-fed mice. J Agric Food Chem. 64(1):236–244.
   PubMedGoogle Scholar
• Song H, Chu Q, Yan F, Yang Y, Han W, Zheng X. 2016. Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice. J Gastroenterol Hepatol. 31(8):1462–1469.
   PubMedGoogle Scholar
• Stintzing FC, Schieber A, Carle R. 2002. Identification of betalains from yellow beet (Beta vulgaris L.) and cactus pear [Opuntia ficus-indica (L.) Mill.] by high-performance liquid chromatography-electrospray ionization mass spectrometry. J Agric Food Chem. 50(8):2302–2307.
   PubMed Web of Science ®Google Scholar
• Stintzing FC, Carle R. 2004. Functional properties of anthocyanins and betalains in plants, food and in human nutrition. Trends in Food Science & Technology. 15(1):19–38.
   Web of Science ®Google Scholar
• Stintzing FC, Herbach KM, Mosshammer MR, Carle R, Yi W, Sellappan S, Akoh CC, Bunch R, Felker P. 2005. Color, betalain pattern, and antioxidant properties of cactus pear (Opuntia spp.) clones. J Agric Food Chem. 53(2):442–451.
   PubMed Web of Science ®Google Scholar
• Tan D, Wang Y, Bai B, Yang X, Han J. 2015. Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat. Food Chem Toxicol. 78:141–146.
   PubMed Web of Science ®Google Scholar
• Terzo S, Attanzio A, Calvi P, Mulè F, Tesoriere L, Allegra M, Amato A. 2021. Indicaxanthin from opuntia ficus-indica fruit ameliorates glucose dysmetabolism and counteracts insulin resistance in high-fat-diet-fed mice. Antioxidants. 11(1):80.
   Google Scholar
• Tesoriere L, Allegra M, Butera D, Livrea MA. 2004. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am J Clin Nutr. 80(4):941–945.
   PubMed Web of Science ®Google Scholar
• Tesoriere L, Attanzio A, Allegra M, Gentile C, Livrea MA. 2013. Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress. Br J Nutr. 110(2):230–240.
   PubMedGoogle Scholar
• Tesoriere L, Attanzio A, Allegra M, Gentile C, Livrea MA. 2014. Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells. Br J Nutr. 111(3):415–423.
   PubMedGoogle Scholar
• Tesoriere L, Butera D, D'Arpa D, Di Gaudio F, Allegra M, Gentile C, Livrea MA. 2003. Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radic Res. 37(6):689–696.
   PubMed Web of Science ®Google Scholar
• Tesoriere L, Butera D, Allegra M, Fazzari M, Livrea MA. 2005. Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. J Agric Food Chem. 53(4):1266–1270.
   PubMed Web of Science ®Google Scholar
• Tesoriere L, Fazzari M, Angileri F, Gentile C, Livrea MA. 2008. In vitro digestion of betalainic foods. Stability and bioaccessibility of betaxanthins and betacyanins and antioxidative potential of food digesta. J Agric Food Chem. 56(22):10487–10492.
   PubMed Web of Science ®Google Scholar
• Tesoriere L, Gentile C, Angileri F, Attanzio A, Tutone M, Allegra M, Livrea MA. 2013. Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix. Eur J Nutr. 52(3):1077–1087.
   PubMed Web of Science ®Google Scholar
• Ting Y, Jiang Y, Ho CT, Huang Q. 2014. Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals. J Funct Foods. 7:112–128.
   Web of Science ®Google Scholar
• Tsai PJ, Sheu CH, Wu PH, Sun YF. 2010. Thermal and pH stability of betacyanin pigment of djulis (Chenopodium formosanum) in Taiwan and their relation to antioxidant activity. J Agric Food Chem. 58(2):1020–1025.
   PubMedGoogle Scholar
• Vidal PJ, López-Nicolás JM, Gandía-Herrero F, García-Carmona F. 2014. Inactivation of lipoxygenase and cyclooxygenase by natural betalains and semi-synthetic analogues. Food Chem. 154:246–254.
   PubMed Web of Science ®Google Scholar
• Vieira Teixeira da Silva D, Dos Santos Baião D, de Oliveira Silva F, Alves G, Perrone D, Mere Del Aguila E, M Flosi Paschoalin V. 2019. Betanin, a natural food additive: stability, bioavailability, antioxidant and preservative ability assessments. Molecules. 24(3):458.
   PubMedGoogle Scholar
• Winkler C, Wirleitner B, Schroecksn K, Schennach H, Fuchs D. 2005. In vitro effects of beet root juice on stimulated and unstimulated peripheral blood mononuclear cells. Am J Biochem Biotechnol. 1(4):180–185.
   Google Scholar
• Wroblewska M, Juskiewicz J, Wiczkowski W. 2011. Physiological properties of beetroot crisps applied in standard and dyslipidaemic diets of rats. Lipids Health Dis. 10:178.
   PubMedGoogle Scholar
• Wybraniec S, Mizrahi Y. 2002. Fruit flesh betacyanin pigments in Hylocereus cacti. J Agric Food Chem. 50(21):6086–6089.
   PubMed Web of Science ®Google Scholar
• Wybraniec S, Jerz G, Gebers N, Winterhalter P. 2010. Ion-pair high-speed counter current chromatography in fractionation of a high-molecular weight variation of acyl-oligosaccharide linked betacyanins from purple bracts of Bougainvillea glabra. J Chromatogr B Analyt Technol Biomed Life Sci. 878(5–6):538–550.
   PubMedGoogle Scholar
• Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. 2016. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 64(1):73–84.
   PubMed Web of Science ®Google Scholar
• Yahaghi L, Yaghmaei P, Hayati-Roodbari N, Irani S, Ebrahim-Habibi A. 2020. Betanin effect on PPAR-α and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis. Physiol Int. 107(1):67–81.
   PubMedGoogle Scholar
• Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP, Li HB. 2015. Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules. 20(12):21138–21156.
   PubMed Web of Science ®Google Scholar
• Zhao C, Yang C, Wai STC, Zhang Y, P Portillo M, Paoli P, Wu Y, San Cheang W, Liu B, Carpéné C, et al. 2019. Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus. Crit Rev Food Sci Nutr. 59(6):830–847.
   PubMed Web of Science ®Google Scholar