Pre-clinical evidence for the therapeutic effect of Pitaya (Hylocereus lemairei) on diabetic intestinal microenvironment

References

• Branco CS, Duong A, Machado AK, Scola G, Andreazza AC, Salvador M. 2018. Modulation of mitochondrial and epigenetic targets by polyphenols-rich extract from Araucaria angustifolia in larynx carcinoma. Anticancer Agents Med Chem. 18
   Google Scholar
• Branco CS, Duong A, Machado AK, Wu A, Scola G, Andreazza AC, Salvador M. 2019. Araucaria angustifolia (Bertol.) Kuntze has neuroprotective action through mitochondrial modulation in dopaminergic SH-SY5Y cells. Mol Biol Rep. 46(6):6013–6025.
   PubMed Web of Science ®Google Scholar
• Cavicchi M, Whittle BJR. 1999. Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: Influence of cell differentiation. Br J Pharmacol. 128(3):705–715.
   PubMed Web of Science ®Google Scholar
• Chen L, Teng H, Cao H. 2019. Chlorogenic acid and caffeic acid from Sonchus oleraceus Linn synergistically attenuate insulin resistance and modulate glucose uptake in HepG2 cells. Food Chem Toxicol. 127:182–187.
   PubMed Web of Science ®Google Scholar
• Chen XM, Kitts DD. 2015. Evidence for inhibition of nitric oxide and inducible nitric oxide synthase in Caco-2 and RAW 264.7 cells by a Maillard reaction product [5-(5,6-dihydro-4H-pyridin-3-ylidenemethyl)furan-2-yl]-methanol. Mol Cell Biochem. 406(1–2):205–215.
   PubMed Web of Science ®Google Scholar
• El-Bassossy H, Badawy D, Neamatallah T, Fahmy A. 2016. Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: effect on endothelial-dependent relaxation. Chem Biol Interact. 254:191–197.
   PubMed Web of Science ®Google Scholar
• FAO. 2017. Food and Agriculture Organization of the United Nations. Rome: Global initiative on Food Loss and Waste.
   Google Scholar
• Gertsch J. 2011. Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta Med. 77(11):1086–1098.
   PubMed Web of Science ®Google Scholar
• Ghorbani A. 2017. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 96:305–312.
   PubMed Web of Science ®Google Scholar
• Guo Y, Huang Z, Sang D, Gao Q, Li Q. 2020. The role of nutrition in the prevention and intervention of type 2 diabetes. Front Bioeng Biotechnol. 8:575442–575415.[33042976.
   PubMed Web of Science ®Google Scholar
• Hadi NA, Mohamad M, Rohin MAK, Yusof RM. 2012. Effects of red pitaya fruit (Hylocereus polyrhizus) consumption on blood glucose level and lipid profile in type 2 diabetic subjects. Borneo Sci. 31:127–142.
   Google Scholar
• Hajialyani M, Farzaei MH, Echeverría J, Nabavi SM, Uriarte E, Eduardo SS. 2019. Hesperidin as a neuroprotective agent: A review of animal and clinical evidence. Molecules. 24(3):648.
   PubMed Web of Science ®Google Scholar
• Hua Q, Chen C, Tel Zur N, Wang H, Wu J, Chen J, Zhang Z, Zhao J, Hu G, Qin Y. 2018. Metabolomic characterization of pitaya fruit from three red-skinned cultivars with different pulp colors. Plant Physiol Biochem. [Internet]126:117–125.
   PubMed Web of Science ®Google Scholar
• Joshi M, Prabhakar B. 2020. Phytoconstituents and pharmaco-therapeutic benefits of pitaya: A wonder fruit. J Food Biochem. 44(7):1–15.
   Web of Science ®Google Scholar
• Nazir N, Zahoor M, Ullah R, Ezzeldin E, Mostafa GAE. 2020. Curative effect of catechin isolated from Elaeagnus umbellata Thunb. berries for diabetes and related complications in streptozotocin-induced diabetic rats model. Molecules. 26(1):137.
   PubMed Web of Science ®Google Scholar
• Nyane NA, Tlaila TB, Malefane TG, Ndwandwe DE, Owira PMO. 2017. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: molecular and pharmacological insights. Eur J Pharmacol. 803:103–111.
   PubMed Web of Science ®Google Scholar
• Pappis L, Ramos AP, Fontana T, Sangoi GG, Dornelles RC, Dolwitsch CB, Sagrillo MR, Cadoná FC, Machado AK, Bauermann L de F. 2021. Randia ferox (Cham & Schltdl) DC.: phytochemical composition, in vitro cyto- and genotoxicity analyses. Nat Prod Res.:1–7.
   Google Scholar
• Patterson EE, Ryan PM, Cryan JF, Dinan TG, Paul Ross R, Fitzgerald GF, Stanton CE. 2016. Gut microbiota, obesity and diabetes. Postgrad Med J. 92(1087):286–300.
   PubMed Web of Science ®Google Scholar
• Phenol Bank. 2020. Database polyphen content foods.
   Google Scholar
• Suh DH, Lee S, Heo DY, Kim YS, Cho SK, Lee S, Lee CH. 2014. Metabolite profiling of red and white pitayas (Hylocereus polyrhizus and Hylocereus undatus) for comparing betalain biosynthesis and antioxidant activity. J Agric Food Chem. 62(34):8764–8771.
   PubMed Web of Science ®Google Scholar
• Sun H, Chow ECY, Liu S, Du Y, Pang KS. 2008. The Caco-2 cell monolayer: usefulness and limitations. Expert Opin Drug Metab Toxicol. 4(4):395–411.
   PubMed Web of Science ®Google Scholar
• Testa R, Bonfigli AR, Prattichizzo F, La Sala L, De Nigris V, Ceriello A. 2017. The “metabolic memory” theory and the early treatment of hyperglycemia in prevention of diabetic complications. Nutrients. 9(5):437.
   PubMed Web of Science ®Google Scholar
• Thaiss CA, Levy M, Grosheva I, Zheng D, Soffer E, Blacher E, Braverman S, Tengeler AC, Barak O, Elazar M, et al. 2018. Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection. Science. 359(6382):1376–1383.
   PubMed Web of Science ®Google Scholar
• Variya BC, Bakrania AK, Patel SS. 2020. Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-γ and Akt signaling. Phytomedicine. 73:152906.
   PubMed Web of Science ®Google Scholar
• Vlachos D, Malisova S, Lindberg FA, Karaniki G. 2020. Dietary interventions for optimizing postprandial hyperglycemia in patients with T2 diabetes: a review. Nutrients. 12(6):1561. (
   PubMed Web of Science ®Google Scholar
• Xue Y, Huang F, Tang R, Fan Q, Zhang B, Xu Z, Sun X, Ruan Z. 2019. Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague–Dawley rats. Food Chem Toxicol. 133:110751.
   PubMed Web of Science ®Google Scholar