Bioactive natural products in donkey and camel milk: a perspective review

References

• Actor JK, Hwang S-A, Kruzel ML. 2009. Lactoferrin as a natural immune modulator. Curr Pharm Des. 15(17):1956–1973.
   PubMed Web of Science ®Google Scholar
• Aghraz A, Gonçalves S, Rodríguez-Solana R, Dra LA, Di Stefano V, Dugo G, Cicero N, Larhsini M, Markouk M, Romano A. 2018. Antioxidant activity and enzymes inhibitory properties of several extracts from two Moroccan Asteraceae species. S Afr J Bot. 118:58–64.
   Web of Science ®Google Scholar
• Ahamad SR, Raish M, Ahmad A, Shakeel F. 2017. Potential health benefits and metabolomics of camel milk by GC-MS and ICP-MS. Biol Trace Elem Res. 175(2):322–330.
   PubMed Web of Science ®Google Scholar
• Akan E. 2021. An evaluation of the in vitro antioxidant and antidiabetic potentials of camel and donkey milk peptides released from casein and whey proteins. J Food Sci Technol. 58(10):3743–3751.
   PubMed Web of Science ®Google Scholar
• Aktories K, Jakobs K, Schultz G. 1980. Nicotinic acid inhibits adipocyte adenylate cyclase in a hormone—like manner. FEBS Lett. 115(1):11–14.
   PubMed Web of Science ®Google Scholar
• Al haj OA, Al Kanhal HA. 2010. Compositional, technological and nutritional aspects of dromedary camel milk. Int Dairy J. 20(12):811–821.
   Web of Science ®Google Scholar
• Al-Ayadhi LY, Elamin NE. 2013. Camel milk as a potential therapy as an antioxidant in autism spectrum disorder (ASD). Evidence-Based Complemen Alternat Med. 2013:1–8.
   Web of Science ®Google Scholar
• Al-Khafaji AH, Jepsen SD, Christensen KR, Vigsnaes LK. 2020. The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota. J Funct Foods. 74:104176.
   Web of Science ®Google Scholar
• Alhaj OA, Taufik E, Handa Y, Fukuda K, Saito T, Urashima T. 2013. Chemical characterisation of oligosaccharides in commercially pasteurised dromedary camel (Camelus dromedarius) milk. Int Dairy J. 28(2):70–75.
   Web of Science ®Google Scholar
• Arab HH, Salama SA, Abdelghany TM, Omar HA, Arafa E-SA, Alrobaian MM, Maghrabi IA. 2017. Camel milk attenuates rheumatoid arthritis via inhibition of mitogen activated protein kinase pathway. Cell Physiol Biochem. 43(2):540–552.
   PubMedGoogle Scholar
• Aspri M, Economou N, Papademas P. 2017. Donkey milk: an overview on functionality, technology, and future prospects. Food Rev Int. 33(3):316–333.
   Google Scholar
• Beg OU, von Bahr-Lindström H, Zaidi ZH, Jörnvall H. 1986. Characterization of a camel milk protein rich in proline identifies a new β-casein fragment. Regul Pept. 15(1):55–61.
   PubMedGoogle Scholar
• Benkerroum N, Boughdadi A, Bennani N, Hidane K. 2003. Microbiological quality assessment of Moroccan camel's milk and identification of predominating lactic acid bacteria. World J Microbiol Biotechnol. 19(6):645–648.
   Web of Science ®Google Scholar
• Berhe T, Seifu E, Ipsen R, Kurtu MY, Hansen EB. 2017. Processing challenges and opportunities of camel dairy products. Int J Food Sci. 2017:9061757.
   PubMedGoogle Scholar
• Berlutti F, Pantanella F, Natalizi T, Frioni A, Paesano R, Polimeni A, Valenti P. 2011. Antiviral properties of lactoferrin—a natural immunity molecule. Molecules. 16(8):6992–7018.
   PubMed Web of Science ®Google Scholar
• Bertino E, Agosti M, Peila C, Corridori M, Pintus R, Fanos V. 2022. The donkey milk in infant nutrition. Multidisciplinary Digital Publishing Institute; p. 403.
   Google Scholar
• Bode L. 2015. The functional biology of human milk oligosaccharides. Early Hum Dev. 91(11):619–622. 2015/11//
   PubMed Web of Science ®Google Scholar
• Boehm G, Stahl B. 2007. Oligosaccharides from milk. J Nutr. 137(3 Suppl 2):847S–849S. 2007/03//
   PubMed Web of Science ®Google Scholar
• Buggy AK, McManus JJ, Brodkorb A, Carthy NM, Fenelon MA. 2017. Stabilising effect of α-lactalbumin on concentrated infant milk formula emulsions heat treated pre-or post-homogenisation. Dairy SciTechnol. 96(6):845–859.
   Web of Science ®Google Scholar
• Camillo F, Rota A, Biagini L, Tesi M, Fanelli D, Panzani D. 2018. The current situation and trend of donkey industry in Europe. J Equine Vet Sci. 65:44–49.
   Web of Science ®Google Scholar
• Cammilleri G, Graci S, Collura R, Buscemi MD, Vella A, Macaluso A, Giaccone V, Giangrosso G, Cicero A, Lo Dico GM, et al. 2019. Aflatoxin M1 in cow, sheep, and donkey milk produced in Sicily, Southern Italy. Mycotoxin Res. 35(1):47–53.
   PubMed Web of Science ®Google Scholar
• Colson C, Ghandour RA, Dufies O, Rekima S, Loubat A, Munro P, Boyer L, Pisani DF. 2019. Diet supplementation in ω3 polyunsaturated fatty acid favors an anti-inflammatory basal environment in mouse adipose tissue. Nutrients 11(2):438.
   PubMed Web of Science ®Google Scholar
• Cox PA, Metcalf JS. 2017. Traditional food items in Ogimi, Okinawa: L-serine content and the potential for neuroprotection. Curr Nutr Rep. 6(1):24–31.
   PubMedGoogle Scholar
• Cunsolo V, Saletti R, Muccilli V, Gallina S, Di Francesco A, Foti S. 2017. Proteins and bioactive peptides from donkey milk: The molecular basis for its reduced allergenic properties. Food Res Int. 99(Pt 1):41–57.
   PubMedGoogle Scholar
• D'Auria E, Mandelli M, Ballista P, Di Dio F, Giovannini M. 2011. Growth impairment and nutritional deficiencies in a cow's milk-allergic infant fed by unmodified donkey's milk. Case Rep Pediatr. 2011:1–4.
   Google Scholar
• De Koning T. 2006. Treatment with amino acids in serine deficiency disorders. J Inherit Metab Dis. 29(2-3):347–351.
   PubMed Web of Science ®Google Scholar
• De Leoz MLA, Kalanetra KM, Bokulich NA, Strum JS, Underwood MA, German JB, Mills DA, Lebrilla CB. 2015. Human milk glycomics and gut microbial genomics in infant feces show a correlation between human milk oligosaccharides and gut microbiota: a proof-of-concept study. J Proteome Res. 14(1)2015/01/02/:491–502.
   PubMed Web of Science ®Google Scholar
• Derdak R, Sakoui S, Pop OL, Muresan CI, Vodnar DC, Addoum B, Vulturar R, Chis A, Suharoschi R, Soukri A, et al. 2020. Insights on health and food applications of Equus asinus (donkey) milk bioactive proteins and peptides—an overview. Foods 9(9):1302.
   PubMed Web of Science ®Google Scholar
• Devaki SJ, Raveendran RL. 2017. Sources, functions, sensing and analysis, vitamin C. Amal H. Hamza: IntechOpen; p. 2–10.
   Google Scholar
• Dubey US, Lal M, Mittal A, Kapur S. 2016. Therapeutic potential of camel milk. Emir J Food Agric. 28(3):164–176.
   Google Scholar
• Duncan PI, Aitio O, Heiskanen A, Niemelä R, Saarinen J, Helin J, Porta N, Fiaux M, Moënnoz D, Golliard M. 2007. Structure and function of bovine whey derived oligosaccharides showing synbiotic epithelial barrier protective properties. Nutrients 12:2020.
   Google Scholar
• El-Agamy E. 2007. The challenge of cow milk protein allergy. Small Ruminant Res. 68(1-2):64–72.
   Web of Science ®Google Scholar
• El-Agamy EI. 2009. Bioactive components in camel milk. Bioactive Compon Milk Dairy Prod. 107:159–192.
   Google Scholar
• El-Fakharany EM, El Baky NA, Linjawi MH, Aljaddawi AA, Saleem TH, Nassar AY, Osman A, Redwan EM. 2017. Influence of camel milk on the hepatitis C virus burden of infected patients. Experim Therapeut Med. 13:1313–1320.
   PubMed Web of Science ®Google Scholar
• Ereifej KI, Alu’datt MH, AlKhalidy HA, Alli I, Rababah T. 2011. Comparison and characterisation of fat and protein composition for camel milk from eight Jordanian locations. Food Chem. 127(1):282–289.
   Web of Science ®Google Scholar
• Fukuda K, Yamamoto A, Ganzorig K, Khuukhenbaatar J, Senda A, Saito T, Urashima T. 2010. Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum. J Dairy Sci. 93(12):5572–5587. 2010/12/01/
   PubMed Web of Science ®Google Scholar
• Fumia A, Cicero N, Gitto M, Nicosia N, Alesci A. 2021. Role of nutraceuticals on neurodegenerative diseases: neuroprotective and immunomodulant activity. Nat Prod Res. 1–18.
   PubMed Web of Science ®Google Scholar
• Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML. 2004. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells1. J Lipid Res. 45(10):1835–1845.
   PubMed Web of Science ®Google Scholar
• Garofalo K, Penno A, Schmidt BP, Lee H-J, Frosch MP, Von Eckardstein A, Brown RH, Hornemann T, Eichler FS. 2011. Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. J Clin Invest. 121(12):4735–4745.
   PubMed Web of Science ®Google Scholar
• Gastaldi D, Bertino E, Monti G, Baro C, Fabris C, Lezo A, Medana C, Baiocchi C, Mussap M, Galvano F. 2010. Donkey’s milk detailed lipid composition. Front Biosci E. 2:537–546.
   PubMedGoogle Scholar
• Habib HM, Ibrahim WH, Schneider-Stock R, Hassan HM. 2013. Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities. Food Chem. 141(1):148–152.
   PubMed Web of Science ®Google Scholar
• Hamid NAA, Hasrul MA, Ruzanna RJ, Ibrahim IA, Baruah PS, Mazlan M, Yusof YAM, Ngah WZW. 2011. Effect of vitamin E (Tri E®) on antioxidant enzymes and DNA damage in rats following eight weeks exercise. Nutr J. 10:37–37.
   PubMed Web of Science ®Google Scholar
• Hamley IW. 2017. Small bioactive peptides for biomaterials design and therapeutics. Chem Rev. 117(24):14015–14041.
   PubMed Web of Science ®Google Scholar
• Hanstock HG, Edwards JP, Walsh NP. 2019. Tear lactoferrin and lysozyme as clinically relevant biomarkers of mucosal immune competence. Front Immunol. 10:1178.
   PubMed Web of Science ®Google Scholar
• Homayouni-Tabrizi M, Shabestarin H, Asoodeh A, Soltani M. 2016. Identification of two novel antioxidant peptides from camel milk using digestive proteases: impact on expression gene of superoxide dismutase (SOD) in hepatocellular carcinoma cell line. Int J Pept Res Ther. 22(2):187–195.
   Web of Science ®Google Scholar
• Ibrahem SA, El Zubeir IE. 2016. Processing, composition and sensory characteristic of yoghurt made from camel milk and camel–sheep milk mixtures. Small Ruminant Res. 136:109–112.
   Web of Science ®Google Scholar
• Jirillo F, Jirillo E, Magrone T. 2010. Donkey's and goat's milk consumption and benefits to human health with special reference to the inflammatory status. Curr Pharm Des. 16(7):859–863.
   PubMed Web of Science ®Google Scholar
• Jrad Z, El Hatmi H, Adt I, Girardet J-M, Cakir-Kiefer C, Jardin J, Degraeve P, Khorchani T, Oulahal N. 2014. Effect of digestive enzymes on antimicrobial, radical scavenging and angiotensin I-converting enzyme inhibitory activities of camel colostrum and milk proteins. Dairy Sci Technol. 94(3):205–224.
   Web of Science ®Google Scholar
• Kalyankar S, Khedkar C, Patil A, Deosarkar S. 2016. Milk: sources and composition.
   Google Scholar
• Kappeler S. 1998. Compositional and structural analysis of camel milk proteins with emphasis on protective proteins ETH Zurich.
   Google Scholar
• Khalesi M, Salami M, Moslehishad M, Winterburn J, Moosavi-Movahedi AA. 2017. Biomolecular content of camel milk: a traditional superfood towards future healthcare industry. Trends Food Sci Technol. 62:49–58.
   Web of Science ®Google Scholar
• Konuspayeva G, Faye B. 2021. Recent advances in camel milk processing. Animals 11(4):1045.
   Web of Science ®Google Scholar
• Lara-Villoslada F, Olivares M, Xaus J. 2005. The balance between caseins and whey proteins in cow's milk determines its allergenicity. J Dairy Sci. 88(5):1654–1660.
   PubMed Web of Science ®Google Scholar
• Levy A, Steiner L, Yagil R. 2013. Camel milk: disease control and dietary laws. J Health Sci. 1:48–53.
   Google Scholar
• Li L, Liu X, Guo H. 2018. The nutritional ingredients and antioxidant activity of donkey milk and donkey milk powder. Food Sci Biotechnol. 27(2):393–400.
   PubMed Web of Science ®Google Scholar
• Liddle DM, Hutchinson AL, Wellings HR, Power KA, Robinson LE, Monk JM. 2017. Integrated immunomodulatory mechanisms through which long-chain n-3 polyunsaturated fatty acids attenuate obese adipose tissue dysfunction. Nutrients 9(12):1289.
   PubMed Web of Science ®Google Scholar
• Maessen SE, Derraik JGB, Binia A, Cutfield WS. 2020. Perspective: human milk oligosaccharides: fuel for childhood obesity prevention? Adv Nutr. 11(1)2020/01/01/:35–40.
   PubMed Web of Science ®Google Scholar
• Mallet E, Henocq A. 1992. Long-term prevention of allergic diseases by using protein hydrolysate formula in at-risk infants. J Pediatr. 121(5):S95–S100.
   PubMed Web of Science ®Google Scholar
• Martemucci G, D’Alessandro AG. 2012. Fat content, energy value and fatty acid profile of donkey milk during lactation and implications for human nutrition. Lipids Health Dis. 11(1):14.
   PubMedGoogle Scholar
• Martini M, Salari F, Licitra R, La Motta C, Altomonte I. 2019. Lysozyme activity in donkey milk. Int Dairy J. 96:98–101.
   Web of Science ®Google Scholar
• Merin U, Bernstein S, Bloch-Damti A, Yagil R, Van Creveld C, Lindner P, Gollop N. 2001. A comparative study of milk serum proteins in camel (Camelus dromedarius) and bovine colostrum. Livestock Prod Sci. 67(3):297–301.
   Google Scholar
• Metro D, Tardugno R, Papa M, Bisignano C, Manasseri L, Calabrese G, Gervasi T, Dugo G, Cicero N. 2018. Adherence to the Mediterranean diet in a Sicilian student population. Nat Prod Res. 32(15):1775–1781.
   PubMed Web of Science ®Google Scholar
• Mohamed H, Nagy P, Agbaba J, Kamal-Eldin A. 2021. Use of near and mid infra-red spectroscopy for analysis of protein, fat, lactose and total solids in raw cow and camel milk. Food Chem. 334:127436.
   PubMed Web of Science ®Google Scholar
• Mulder AM, Connellan PA, Oliver CJ, Morris CA, Stevenson LM. 2008. Bovine lactoferrin supplementation supports immune and antioxidant status in healthy human males. Nutr Res. 28(9)2008/09//undefined:583–589.
   PubMed Web of Science ®Google Scholar
• Nagy P, Juhász J, Reiczigel J, Császár G, Kocsis R, Varga L. 2019. Circannual changes in major chemical composition of bulk dromedary camel milk as determined by FT-MIR spectroscopy, and factors of variation. Food Chem. 278:248–253.
   PubMed Web of Science ®Google Scholar
• Nayak CM, Ramachandra C, Kumar GM. 2020. A comprehensive review on composition of donkey milk in comparison to human, cow, buffalo, sheep, goat, camel and horse milk. Mysore J Agric Sci. 54:42–50.
   Google Scholar
• Ozturkoglu-Budak S. 2018. Effect of different treatments on the stability of lysozyme, lactoferrin and β‐lactoglobulin in donkey's milk. Int J Dairy Technol. 71:36–45.
   Web of Science ®Google Scholar
• Park YW, Juárez M, Ramos M, Haenlein GFW. 2007. Physico-chemical characteristics of goat and sheep milk. Small Rumin Res. 68(1-2):88–113.
   Web of Science ®Google Scholar
• Park YW, Nam MS. 2015. Bioactive peptides in milk and dairy products: a review. Korean J Food Sci Anim Resour. 35(6):831–840.
   PubMed Web of Science ®Google Scholar
• Pérez-Escalante E, Alatorre-Santamaría S, Castañeda-Ovando A, Salazar-Pereda V, Bautista-Ávila M, Cruz-Guerrero AE, Flores-Aguilar JF, González-Olivares LG. 2022. Human milk oligosaccharides as bioactive compounds in infant formula: recent advances and trends in synthetic methods. Crit Rev Food Sci Nutr. 62(1):181–214.
   PubMed Web of Science ®Google Scholar
• Picariello G, Ferranti P, Mamone G, Klouckova I, Mechref Y, Novotny MV, Addeo F. 2012. Gel-free shotgun proteomic analysis of human milk. J Chromatogr A. 1227:219–233.
   PubMed Web of Science ®Google Scholar
• Piovesana S, Capriotti AL, Cavaliere C, La Barbera G, Samperi R, Chiozzi RZ, Laganà A. 2015. Peptidome characterization and bioactivity analysis of donkey milk. J Proteomics. 119:21–29.
   PubMed Web of Science ®Google Scholar
• Rahman MS, Al-Hakmani H, Al-Alawi A, Al-Marhubi I. 2012. Thermal characteristics of freeze-dried camel milk and its major components. Thermochim Acta. 549:116–123.
   Web of Science ®Google Scholar
• Restani P, Gaiaschi A, Plebani A, Beretta B, Cavagni G, Fiocchi A, Poiesi C, Velona T, Ugazio A, Galli C. 1999. Cross-reactivity between milk proteins from different animal species. Clin Exp Allergy. 29(7):997–1004.
   PubMed Web of Science ®Google Scholar
• Ross AC, Caballero BH, Cousins RJ, Tucker KL, Ziegler TR. 2012. Modern nutrition in health and disease: Wolters Kluwer Health Adis (ESP).
   Google Scholar
• Salami M, Yousefi R, Ehsani MR, Dalgalarrondo M, Chobert J-M, Haertlé T, Razavi SH, Saboury AA, Niasari-Naslaji A, Moosavi-Movahedi AA. 2008. Kinetic characterization of hydrolysis of camel and bovine milk proteins by pancreatic enzymes. Int Dairy J. 18(12):1097–1102.
   Web of Science ®Google Scholar
• Salimei E. 1999. Latte di equide: dalla storia, una proposta dietetica e terapeutica. Proceedings of the 1° Convegno Della Società Italiana di Ippologia (SIDI) e Della Università Molise;
   Google Scholar
• Santini A, Cicero N. 2020. Development of food chemistry, natural products, and nutrition research: targeting new frontiers. Multidisciplinary Digital Publishing Institute; p. 482.
   Google Scholar
• Schanbacher F, Talhouk R, Murray F, Gherman L, Willett L. 1998. Milk-borne bioactive peptides. Int Dairy J. 8(5-6):393–403.
   Web of Science ®Google Scholar
• Shabo Y, Barzel R, Margoulis M, Yagil R. 2005. Camel milk for food allergies in children. Isr Med Assoc J. 7(12):796–798.
   PubMed Web of Science ®Google Scholar
• Shabo Y, Barzel R, Yagil R. 2008. Etiology of Crohn's disease and camel milk treatment. J Camel Pract Res. 15:55–59.
   Web of Science ®Google Scholar
• Shori AB. 2012. Comparative study of chemical composition, isolation and identification of micro-flora in traditional fermented camel milk products: Gariss, Suusac, and Shubat. J Saudi Soc Agric Sci. 11(2):79–88.
   Google Scholar
• Shori AB. 2015. Camel milk as a potential therapy for controlling diabetes and its complications: a review of in vivo studies. J Food Drug Anal. 23(4):609–618.
   PubMed Web of Science ®Google Scholar
• Singh R, Mal G, Kumar D, Patil N, Pathak K. 2017. Camel milk: an important natural adjuvant. Agric Res. 6(4):327–340.
   Web of Science ®Google Scholar
• Sousa YRF, Medeiros LB, Pintado MME, Queiroga RCRE. 2019. Goat milk oligosaccharides: composition, analytical methods and bioactive and nutritional properties. Trends Food Sci Technol. 92:152–161. 2019/10/01/
   Web of Science ®Google Scholar
• Tjader I, Berg A, Wernerman J. 2007. Exogenous glutamine—compensating a shortage? Crit Care Med. 35(9 Suppl):S553–S556.
   PubMed Web of Science ®Google Scholar
• Tsakalidou E, Papadimitriou K. 2016. Non-bovine milk and milk products. Academic Press.
   Google Scholar
• Wang Y, Zhou X, Gong P, Chen Y, Feng Z, Liu P, Zhang P, Wang X, Zhang L, Song L. 2020. Comparative major oligosaccharides and lactose between Chinese human and animal milk. Int Dairy J. 108:104727.
   Web of Science ®Google Scholar
• Wernerman J. 2008. Clinical use of glutamine supplementation. J Nutr. 138(10):2040S–2044S.
   PubMed Web of Science ®Google Scholar
• Wold A, Adlerberth I. 1998. Does breastfeeding affect the infant's immune responsiveness? Acta Paediatr. 87(1):19–22.
   PubMed Web of Science ®Google Scholar
• Wu G, Bazer FW, Davis TA, Kim SW, Li P, Marc Rhoads J, Carey Satterfield M, Smith SB, Spencer TE, Yin Y. 2009. Arginine metabolism in development, health and disease. Amino Acids. 37(1):153–168.
   PubMed Web of Science ®Google Scholar
• Yaqoob M, Nawaz H. 2007. Potential of Pakistani camel for dairy and other uses. Animal Sci J. 78(5):467–475.
   Web of Science ®Google Scholar
• Yvon S, Olier M, Leveque M, Jard G, Tormo H, Haimoud-Lekhal DA, Peter M, Eutamène H. 2018. Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth’s cells in a model of ileitis in mice. Eur J Nutr. 57(1):155–166.
   PubMed Web of Science ®Google Scholar
• Zhao D-b, Bai Y-h, Niu Y-w 2015. Composition and characteristics of Chinese Bactrian camel milk. Small Ruminant Res. 127:58–67.
   Web of Science ®Google Scholar
• Ziane M, Couvert O, Le Chevalier P, Moussa-Boudjemaa B, Leguerinel I. 2016. Identification and characterization of aerobic spore forming bacteria isolated from commercial camel’s milk in south of Algeria. Small Ruminant Res. 137:59–64.
   Web of Science ®Google Scholar