Intriguing diverse chemistry and unique molecular mechanisms: new medicines with diverse pharmacological activities from cephalopods ink

References

• Al-Madhagy SA, Gad SS, Mostafa ES, Angeloni S, Saad MA, Sabry OM, Caprioli G, El-Hawary SS. 2022. A new arsenal of polyphenols to make Parkinson’s disease extinct: HPLC-MS/MS profiling, very interesting MAO-B inhibitory activity and antioxidant activity of Otostegia fruticosa. Nat Prod Res. 22:1–6.
   Google Scholar
• Asakawa M, Umezaki Kaneko Yu Gomez-Delan Tomano, Noguchi Ohtsuka. 2019. Toxicity and toxin composition of the greater blue-ringed octopus hapalochlaena lunulata from Ishigaki Island, Okinawa Prefecture, Japan. Toxins. 11(5):245.
   PubMed Web of Science ®Google Scholar
• Ayu Shazwani Z, Rabeta R. 2020. Enzymatic hydrolysis as an approach to produce alternative protein from cephalopods ink powder: a short review. Food Res. 4(5):1383–1390.
   Google Scholar
• Besednova NN, Zaporozhets TS, Kovalev NN, Makarenkova ID, Yakovlev Y. 2017. Cephalopods: The potential for their use in medicine. Russ J Mar Biol. 43(2):101–110.
   Web of Science ®Google Scholar
• Bush SL, Robison BH. 2007. Ink utilization by mesopelagic squid. Mar Biol. 152(3):485–494.
   Web of Science ®Google Scholar
• Chen S, Wang J, Xue C, Li H, Sun B, Xue Y, Chai W. 2010. Sulfation of a squid ink polysaccharide and its inhibitory effect on tumor cell metastasis. Carbohydr Polym. 81(3):560–566.
   Web of Science ®Google Scholar
• Chen S, Xue CH, Xue Y, Li ZJ, Gao X, Ma Q. 2007. Studies on the free radical scavenging activities of melanin from squid ink. Chin J Mar Drugs. 26:24–27.
   Google Scholar
• Derby C. 2014. Cephalopod ink: production, chemistry, functions and applications. Mar Drugs. 12(5):2700–2730.
   PubMed Web of Science ®Google Scholar
• Diaz JHJ, Thilaga RD. 2016. Screening Of Antimicrobial Activities In The Ink Of Cephalopods Against Human Pathogens. World J Pharm Pharm Sci. 5(6):9.
   Google Scholar
• Fahmy R, Soliman AM. 2013. In vitro antioxidant, analgesic and cytotoxic activities of Sepia officinalis ink and Coelatura aegyptiaca extracts. Afr J Pharm Pharmacol. 7(22):1512–1522.
   Google Scholar
• Fatimah Zaharah MY, Rabeta MS. 2017. Antioxidant and antimicrobial activities of squid ink powder. Food Res. 2(1):82–88.
   Google Scholar
• Fitrial Y, Khotimah IK. 2021. The antibacterial activity of melanin in the Cuttlefish (Sepia sp.) Ink against Aeromonas sp. Egypt J Aquat Biol Fish. 25(4):689–704.
   Google Scholar
• Francis WR, Christianson LM, Haddock SHD. 2017. Symplectin evolved from multiple duplications in bioluminescent squid. PeerJ. 5:e3633.
   PubMed Web of Science ®Google Scholar
• Girija S, Duraipandiyan V, Kuppusamy PS, Gajendran H, Rajagopal R. 2014. Chromatographic characterization and GC-MS evaluation of the bioactive constituents with antimicrobial potential from the pigmented ink of Loligo duvauceli. Int Sch Res Not. 2014:1–7.
   Google Scholar
• Girija S, Priyadharshini JV, Pandi SK. 2011. Isolation and characterization of Lolduvin-S: a novel antimicrobial protein from the Ink of Indian Squid Loligo duvauceli. Int J Curr Res. 7:4–14.
   Google Scholar
• Gu YP, Yang XM, Duan ZH, Luo P, Shang JH, Xiao W, Tao YX, Zhang DY, Zhang YB, Liu HZ. 2017. Inhibition of chemotherapy‑induced apoptosis of testicular cells by squid ink polysaccharide. Exp Ther Med. 14(6):5889–5895.
   PubMed Web of Science ®Google Scholar
• Hanlon RT, Messenger JB. 2018. Cephalopod behaviour. Cambridge, UK: Cambridge University Press.
   Google Scholar
• Hernández-Zazueta MS, Luzardo-Ocampo I, García-Romo JS, Noguera-Artiaga L, Carbonell-Barrachina ÁA, Taboada-Antelo P, Campos-Vega R, Rosas-Burgos EC, Burboa-Zazueta MG, Ezquerra-Brauer JM, et al. 2021. Bioactive compounds from Octopus vulgaris ink extracts exerted anti-proliferative and anti-inflammatory effects in vitro. Food Chem Toxicol. 151:112119.
   PubMed Web of Science ®Google Scholar
• Hossain MP, M.S R, T HA. 2018. Medicinal and therapeutic properties of cephalopod ink: a short review. Food Res. 3(3):188–198.
   Google Scholar
• Huang F, Yang Z, Yu D, Wang J, Li R, Ding G. 2012. Sepia ink oligopeptide induces apoptosis in prostate cancer cell lines via caspase-3 activation and elevation of bax/Bcl-2 ratio. Mar Drugs. 10(10):2153–2165.
   PubMed Web of Science ®Google Scholar
• Hwang DF, Arakawa O, Saito T, Noguchi T, Simidu U, Tsukamoto K, Shida Y, Hashimoto K. 1989. Tetrodotoxin-producing bacteria from the blue-ringed octopus Octopus maculosus. Mar Biol. 100(3):327–332.
   Web of Science ®Google Scholar
• Islamy RA. 2019. Antibacterial activity of cuttlefish Sepia sp. (Cephalopoda,) ink extract against aeromonas hydrophila. TradMedJ. 24(3):184.
   Google Scholar
• Kim SY, Kim SH, Song KB. 2003. Partial purification and characterization of an angiotensin-converting enzyme inhibitor from squid ink. J Appl Biol Chem. 46(3):122–123.
   Google Scholar
• Kumar P, Kannan M, ArunPrasanna V, Vaseeharan B, Vijayakumar S. 2018. Proteomics analysis of crude squid ink isolated from Sepia esculenta for their antimicrobial, antibiofilm and cytotoxic properties. Microb Pathog. 116:345–350.
   PubMed Web of Science ®Google Scholar
• Lee W, Lee J, Kulkarni R, Kim M-A, Hwang JS, Na M, Bae J-S. 2016. Antithrombotic and antiplatelet activities of small-molecule alkaloids from Scolopendra subspinipes mutilans. Sci Rep. 6(1):21956.
   PubMedGoogle Scholar
• Lei M, Wang J, Wang Y, Pang L, Wang Y, Xu W, Xue C. 2007. Study of the radio-protective effect of cuttlefish ink on hemopoietic injury. Asia Pac. J. Clin. Nutr. 16(Suppl 1):239–243.
   PubMedGoogle Scholar
• Lin L-C, Chen W-T. 2005. The study of antioxidant effects in melanins extracted from various tissues of animals. Asian Australas J Anim Sci. 18(2):277–281.
   Web of Science ®Google Scholar
• Liu H, Luo P, Chen S, Shang J. 2011. Effects of Squid Ink on Growth Performance, Antioxidant Functions and Immunity in Growing Broiler Chickens. Asian Australas J Anim Sci. 24(12):1752–1756.
   Web of Science ®Google Scholar
• Lucero MT, Farrington H, Gilly WF. 1994. Quantification of L-dopa and dopamine in squid ink: implications for chemoreception. Biol Bull. 187(1):55–63.
   PubMed Web of Science ®Google Scholar
• Luo P. 2013. Antioxidant ability of squid ink polysaccharides as well as their protective effects on deoxyribonucleic acid DNA damage in vitro. Afr J Pharm Pharmacol. 7(21):1382–1388.
   Google Scholar
• Madaras F, Gerber JP, Peddie F, Kokkinn MJ. 2010. The effect of sampling methods on the apparent constituents of ink from the squid Sepioteuthis australis. J Chem Ecol. 36(11):1171–1179.
   PubMed Web of Science ®Google Scholar
• Mimura T, Maeda K, Hariyama H, Aonuma S, Satake M, Fujita T. 1982. “Studies on biological activities of melanin from marine animals. I. Purification of melanin from Ommastrephes bartrami Lesuel and its inhibitory activity on gastric juice secretion in rats.” Chemical and Pharmaceutical Bulletin. 30(4):1381–1386.
   PubMed Web of Science ®Google Scholar
• Mimura T, Itoh S, Tsujikawa K, Nakajima H, Satake M, Kohama Y, Okabe M. 1987. Studies on biological activities of melanin from marine animals. V. Anti-inflammatory activity of low-molecular-weight melanoprotein from squid (Fr. SM II). Chem Pharm Bull (Tokyo). 35(3):1144–1150.
   PubMed Web of Science ®Google Scholar
• Mochizuki A. 1979. An antiseptic effect of cuttlefish ink. Bull Jpn Soc Sci Fish. 45(11):1401–1403 [Internet]. [accessed 2022 May 1].
   Google Scholar
• Naraoka T, Chung H-S, Uchisawa H, Sasaki J, Matsue H. 2000. Tyrosinase activity in antitumor compounds of squid ink. FSTR. 6(3):171–175.
   Google Scholar
• Nirmale V, Nayak BB, Kannappan S, Basu S. 2002. Antibacterial effect of the Indian squid, Loligo duvauceli. J Indian Fish Assoc. 29:65–69.
   Google Scholar
• Nisha N, Suja DS. 2018. Phyto chemical evalution and antioxidant activity of methanol extract of Loligo duvauceli Ink. J Pharmacogn Phytochem. 7(1):1764–1767.
   Google Scholar
• Nithya M, Ambikapathy V, Panneerselvam A. 2011. Effect of pharaoh’s cuttlefish ink against bacterial pathogens. Asian J. Plant Sci. Res. 1(4):49–55.
   Google Scholar
• Rajaganapathi J, Thyagarajan SP, Edward JK. 2000. Study on cephalopod’s ink for anti-retroviral activity. Indian J Exp Biol. 38(5):519–520. PMID: 11272422.
   PubMedGoogle Scholar
• Riyad Y, Rizk A, Mohammed N. 2020. Active components of squid ink and food applications. Egypt J Food Sci. 0(0):0–0.
   Google Scholar
• Robison BH, Reisenbichler KR, Hunt JC, Haddock SHD. 2003. Light production by the arm tips of the deep-sea cephalopod Vampyroteuthis infernalis. Biol Bull. 205(2):102–109.
   PubMed Web of Science ®Google Scholar
• Sabry OM, Sabry MO, El-Sonbaty SM, Meselhy KM. 2021. In-vivo and in-silico studies of Eucalyptus kino polyphenolics: outstanding activity in quenching solid liver tumors through inhibition of MMP-9 and TGF-β gene expression. Nat Prod Res. :1–5. doi: 10.1080/14786419.2021.1961254
   Web of Science ®Google Scholar
• Saleh H, Soliman AM, Mohamed AS, Marie M-AS. 2015. Antioxidant effect of sepia ink extract on extrahepatic cholestasis induced by bile duct ligation in rats. Biomed Environ Sci BES. 28(8):582–594.
   PubMed Web of Science ®Google Scholar
• Sasaki J, Ishita K, Takaya Y, Uchisawa H, Matsue H. 1997. Anti-tumor activity of squid ink. J Nutr Sci Vitaminol (Tokyo). 43(4):455–461.
   PubMed Web of Science ®Google Scholar
• Schroeder RL, Double KL, Gerber JP. 2015. Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin–a critical review. J Chem Neuroanat. 64-65:20–32.
   PubMed Web of Science ®Google Scholar
• Soliman A, Fahmy S, El-Abied S. 2015. Anti-neoplastic activities of sepia officinalis ink and Coelatura aegyptiaca extracts against ehrlich ascites carcinoma in swiss Albino Mice. Int J Clin Exp Pathol. 8(4):3543–3555.
   PubMed Web of Science ®Google Scholar
• Takai M, Kawai Y, Inoue N, Shinano H. 1992. Comparative studies on microbiological and chemical characteristics of Ika-shiokara akazukuri and Ika-shiokara kurozukuri. Nippon Suisan Gakkaishi. 58(12):2373–2378.
   Web of Science ®Google Scholar
• Takaya Y, Uchisawa H, Matsue H, Okuzaki B, Narumi F, Sasaki J, Ishida K. 1994. An Investigation of the antitumor peptidoglycan fraction from squid ink. Biol Pharm Bull. 17(6):846–849.
   PubMed Web of Science ®Google Scholar
• Vate N, Benjakul S. 2013. Antioxidative activity of melanin-free ink from splendid squid (Loligo formosana). Int Aquat Res. 5(1):9.
   Google Scholar
• Vennila R, Kumar RKR, Kanchana S, Arumugam M, Balasubramanian T. 2011. Investigation of antimicrobial and plasma coagulation property of some molluscan ink extracts: Gastropods and cephalopods. Afr J Biochem Res. 5(1):8.
   Google Scholar
• Wang S, Cheng Y, Wang F, Sun L, Liu C, Chen G, Li Y, Ward SG, Qu X. 2008. Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2. Biomed Pharmacother. 62(5):297–302.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Sun L, Zhou G, Xie P, Ye J. 2017. Sepia ink oligopeptide induces apoptosis and growth inhibition in human lung cancer cells. Oncotarget. 8(14):23202–23212.
   PubMedGoogle Scholar
• Zhong J-P, Wang G, Shang J-H, Pan J-Q, Li K, Huang Y, Liu H-Z. 2009. Protective effects of squid ink extract towards hemopoietic injuries induced by cyclophosphamine. Mar Drugs. 7(1):9–18.
   PubMed Web of Science ®Google Scholar
• Zong A, Zhao T, Zhang Y, Song X, Shi Y, Cao H, Liu C, Cheng Y, Qu X, Cao J, et al. 2013. Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink. Carbohydr Polym. 91(1):403–409.
   PubMed Web of Science ®Google Scholar