Metabolomic profiling and cytotoxic potential of three endophytic fungi of the genera Aspergillus, Penicillium and Fusarium isolated from Nigella sativa seeds assisted with docking studies

References

• Ahmad MF, Ahmad FA, Ashraf SA, Saad HH, Wahab S, Khan MI, Ali M, Mohan S, Hakeem KR, Athar MT. 2021. An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties. J Herb Med. 25:100404.
   PubMed Web of Science ®Google Scholar
• Ansary J, Giampieri F, Forbes-Hernandez TY, Regolo L, Quinzi D, Gracia Villar S, Garcia Villena E, Tutusaus Pifarre K, Alvarez-Suarez JM, Battino M, et al. 2021. Nutritional value and preventive role of Nigella sativa L. and its main component thymoquinone in cancer: an evidenced-based review of preclinical and clinical studies. Molecules. 26(8):2108.
   PubMed Web of Science ®Google Scholar
• Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F. 2020. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 8(2):e191–e203.
   PubMed Web of Science ®Google Scholar
• Attia EZ, Farouk HM, Abdelmohsen UR, Mo’men H. 2020. Antimicrobial and extracellular oxidative enzyme activities of endophytic fungi isolated from alfalfa (Medicago sativa) assisted by metabolic profiling. S Afr J Bot. 134:156–162.
   Web of Science ®Google Scholar
• Datta AK, Saha A, Bhattacharya A, Mandal A, Paul R, Sengupta S. 2012. Black cumin (Nigella sativa L.)–a review. J Plant Dev Sci. 4(1):1–43.
   Google Scholar
• De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B. 2019. The NMR‐based characterization of the FTY720‐SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET‐PP2A interaction. FASEB J. 33(6):7647–7666.
   PubMed Web of Science ®Google Scholar
• El‐Hawary SS, Mohammed R, Bahr HS, Attia EZ, El‐Katatny M, Abelyan N, Al‐Sanea MM, Moawad AS, Abdelmohsen UR. 2021. Soybean‐associated endophytic fungi as potential source for anti‐COVID‐19 metabolites supported by docking analysis. J Appl Microbiol. 131(3):1193–1211.
   PubMed Web of Science ®Google Scholar
• El‐Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA. 2005. Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells. Int J Cancer. 117(3):409–417.
   PubMed Web of Science ®Google Scholar
• Gadallah M, Asaad NY, Shabaan M, Elkholy SS, Samara MY, Taie D. 2022. Role of SET oncoprotein in hepatocellular carcinoma: an immunohistochemical study. J Immunoassay Immunochem. (4):420-434.
   PubMedGoogle Scholar
• Gholamnezhad Z, Keyhanmanesh R, Boskabady MH. 2015. Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: a review of basic and clinical evidence. J Funct Foods. 17:910–927.
   Web of Science ®Google Scholar
• Gouda S, Das G, Sen SK, Shin H-S, Patra JK. 2016. Endophytes: a treasure house of bioactive compounds of medicinal importance. Front Microbiol. 7:1538.
   PubMed Web of Science ®Google Scholar
• Guo B, Wang Y, Sun X, Tang K. 2008. Bioactive natural products from endophytes: a review. Appl Biochem Microbiol. 44(2):136–142.
   Web of Science ®Google Scholar
• Hisham M, Hassan HA, Gomaa HA, Youssif BG, Hayallah AM, Abdel-Aziz M. 2022. Structure-based design, synthesis and antiproliferative action of new quizoline-4-one/chalcone hybrids as EGFR inhibitors. J Mol Struct. 1254:132422.
   Google Scholar
• Korak T, Ergül E, Sazci A. 2020. Nigella sativa and cancer: A review focusing on breast cancer, inhibition of metastasis and enhancement of natural killer cell cytotoxicity. Curr Pharm Biotechnol. 21(12):1176–1185.
   PubMed Web of Science ®Google Scholar
• Latosińska JN, Latosińska M. 2013. Anticancer drug discovery—from serendipity to rational design. In Jolanta Natalia Latosińska and Magdalena Latosińska: Drug discovery. Poland: InTech; p. 35–74.
   Google Scholar
• Salim EI, Fukushima S. 2003. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer. 45(2):195–202.
   PubMed Web of Science ®Google Scholar
• Sayed AM, Sherif NH, El-Gendy AO, Shamikh YI, Ali AT, Attia EZ, El-Katatny M, Khalifa BA, Hassan HM, Abdelmohsen UR. 2022. Metabolomic profiling and antioxidant potential of three fungal endophytes derived from Artemisia annua and Medicago sativa. Nat Prod Res. 36(9):2404–2408.
   PubMed Web of Science ®Google Scholar
• Shady NH, Abdelmohsen UR, AboulMagd AM, Amin MN, Ahmed S, Fouad MA, Kamel M. 2021. Cytotoxic potential of the Red Sea sponge Amphimedon sp. supported by in silico modelling and dereplication analysis. Nat Prod Res. 35(24):6093–6098.
   PubMed Web of Science ®Google Scholar
• Srivastava A, Srivastava P, Pandey A, Khanna V, Pant A. 2019. Phytomedicine: a potential alternative medicine in controlling neurological disorders. In A.Srivastava: New look to phytomedicine. Elsevier; p. 625–655.
   Google Scholar
• Thabrew MI, Mitry RR, Morsy MA, Hughes RD. 2005. Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells. Life Sci. 77(12):1319–1330.
   PubMed Web of Science ®Google Scholar
• Vasundhara M, Reddy MS, Kumar A. 2019. Secondary metabolites from endophytic fungi and their biological activities. In Vijai Kumar Gupta and Anita Pandey: New and future developments in microbial biotechnology and bioengineering; Netherlands: Elsevier, p. 237–258.
   Google Scholar