Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 8
Submit an article Journal homepage
544
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Synthesis of chalcone derivatives by Claisen-Schmidt condensation and in vitro analyses of their antiprotozoal activities

Gabriella B. Souzaa Departamento de Química, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilORCID Iconhttps://orcid.org/0000-0003-4117-531X
ORCID Icon,
Tamiris A. C. Santosb Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilORCID Iconhttps://orcid.org/0000-0002-7804-7533
ORCID Icon,
Amanda P. S. Silvac Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil
,
André L. B. S Barreirosa Departamento de Química, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilORCID Iconhttps://orcid.org/0000-0002-7263-1907
ORCID Icon,
Victória Brandão Nardellid Departamento de Química, Universidade Federal do Amazonas, Manaus, AM, Brasil
,
Ingrid B. Siqueirac Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil
,
Silvio S. Dolabellac Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilORCID Iconhttps://orcid.org/0000-0001-5576-3214
ORCID Icon,
Emmanoel.V. Costad Departamento de Química, Universidade Federal do Amazonas, Manaus, AM, BrasilORCID Iconhttps://orcid.org/0000-0002-0153-822X
ORCID Icon,
Péricles B. Alvesa Departamento de Química, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilORCID Iconhttps://orcid.org/0000-0002-8955-9614
ORCID Icon,
Ricardo Scherc Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilORCID Iconhttps://orcid.org/0000-0001-7318-1867
ORCID Icon &
Roberta P. M. Fernandesb Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, BrasilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1467-3946
ORCID Icon show all
Pages 1326-1333 | Received 29 May 2022, Accepted 16 Oct 2022, Published online: 04 Nov 2022

References

  • Bello ML, Chiaradia LD, Dias LRS, Pacheco LK, Stumpf TR, Mascarello A, Steindel M, Yunes RA, Castro HC, Nunes RJ, et al. 2011. Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure–activity relationship (SAR. Bioorg Med Chem. 19(16):5046–5052.
  • Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, et al. 2017. Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds. Eu J Med Chem. 126:1129–1135. 1129e1135.
  • Cabrera M, Cerecetto H, González M. 2016. New hybrid bromopyridine-chalcones as in vivo phase II enzyme inducers: potential chemopreventive agents. Med Chem Commun. 7(12):2395–2409.
  • Camargo EP. 1999. Phytomonas and other trypanosomatid parasites of plants and fruit. Adv Parasitol. 42:29–112.
  • De Mello TFP, Cardoso BM, Bitencourt HR, Donatti L, Aristides SMA, Lonardoni MVC, Silveira TGV. 2016. Ultrastructural and morphological changes in Leishmania (Viannia) braziliensis treated with synthetic chalcones. Exp Parasitol. 160:23–30.
  • Dollet M. 1984. Plant diseases caused by flagellate protozoa (Phytomonas). Annu Rev Phytopathol. 22(1):115–132.
  • Duggal SD, Rongpharpi SR, Duggal AK, Kumar A, Biswal I. 2017. Role of Acanthamoeba in granulomatous encephalitis: a review. J Infect Dis Immune Ther. 1:1000103.
  • Espinoza-Hicks JC, Chácon-Vargas KF, Hernandéz-Rivera JL, Nogueda-Torres B, Tamariz J, Sánchez-Torres LE, Camacho-d’Avila A. 2019. Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: design, synthesis and evaluation. Eur J Med Chem. 167:402–413.
  • Harrison WT, Lecky B, Hulette CM. 2018. Fatal granulomatous amebic encephalitis in a heart transplant patient: clinical, radiographic, and autopsy findings. J Neuropathol Exp Neurol. 77(11):1001–1004.
  • Jaskowska E, Butler C, Preston G, Kelly S. 2015. Phytomonas: trypanosomatids adapted to plant environments. PLoS Pathog. 11(1):e1004484.
  • Mahapatra DK, Bharti SK, Asati V. 2015. Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives. Eur J Med Chem. 101:496–524.
  • Orlikova B, Tasdemir D, Golais F, Dicato M, Diederich M. 2011. Dietary chalcones with chemopreventive and chemotherapeutic potential. Genes Nutr. 6(2):125–147.
  • Passalacqua TG, Dutra LA, De Almeida L, Velásquez AMA, Torres FAE, Yamasaki PR, Dos Santos Bastos M, Regasini LO, Michels PAM, Da Silva Bolzani V, et al. 2015. Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds. Bioorg Med Chem Lett. 25(16):3342–3345.
  • Santos ALS, d‘Avila-Levy CM, Elias CGR, Vermelho AB, Branquinha MH. 2007. Phytomonas serpens: immunological similarities with the human trypanosomatid pathogens. Microbes Infect. 9(8):915–921.
  • Spagnuolo C, Moccia S, Russo GL. 2018. Anti-inflammatory effects of flavonoids in neurodegenerative disorders. Eur J Med Chem. 153:105–115.
  • Syahri J, Yuanita E, Nurohmah BA, Armunanto R, Purwono B. 2017. Chalcone analogue as potent anti-malarial compounds against Plasmodium falciparum: Synthesis, biological evaluation, and docking simulation study. Asian Pac J Trop Biomed. 7(8):675–679.
  • Tajuddeen N, Isah MB, Suleiman MA, Heerden FRV, Ibrahim MA. 2018. The chemotherapeutic potential of chalcones against leishmaniases: a review. Int J Antimicrob Agents. 51(3):311–318.
  • Upegui Y, Gil JF, Quiñones W, Torres F, Escobar G, Robledo SM, Echeverri F. 2014. Preparation of rotenone derivatives and in vitro analysis of their antimalarial, antileishmanial and selective cytotoxic activities. Molecules. 19(11):18911–18922.
  • Wang G, Liu W, Gong Z, Huang Y, Li Y, Peng Z. 2020. Synthesis, biological evaluation, and molecular modeling of new naphthalene-chalcone derivatives as potential anticancer agents onMCF-7 breast cancer cells by targeting tubulincolchicine binding site. J Enzyme Inhib Med Chem. 35(1):139–144.
  • Wang TY, Li Q, Bi KS. 2018. Bioactive flavonoids in medicinal plants: Structure, activity and biological fate. Asian J Pharm Sci. 13(1):12–23.
  • WHO 2021. World Health Organization. Leishmaniasis. [Accessed: 2021 Dec 10] https://www.who.int/data/gho/data/themes/topics/gho-ntd-leishmaniasis
  • Yazdan SK, Sagar DV, Shaik AB. 2015. Chemical and biological potentials of chalcones: a review. Org Med Chem I J. 1:555553.
  • Zaidi SL, Mittal S, Rajala MS, Avecilla F, Husain M, Azam A. 2015. Synthesis, characterization and antiamoebic activity of chalcones bearing N-substituted ethanamine tail. Eur J Med Chem. 98:179–189.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.