Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 5
283
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Anti-inflammatory effect of a pomegranate extract on LPS-stimulated HepG2 cells

ORCID Icon, ORCID Icon & ORCID Icon
Pages 727-734 | Received 17 Jan 2023, Accepted 22 Mar 2023, Published online: 08 Apr 2023

References

  • Aruna P, Venkataramanamma D, Singh AK, Singh RP. 2016. Health benefits of punicic acid: a review. Compr Rev Food Sci Food Saf. 15(1):16–27.
  • Bedel HA, Turgut NT, Kurtoglu AU, Usta C. 2017. Effects of nutraceutical punicic acid. Pharm Sci. 79:328–334.
  • Caruso A, Barbarossa A, Tassone A, Ceramella J, Carocci A, Catalano A, Basile G, Fazio A, Iacopetta D, Franchini C, et al. 2020. Pomegranate: nutraceutical with promising benefits on human health. Appl Sci. 10(19):6915.
  • Choudhury S, Ghosh S, Mukherjee S, Gupta P, Bhattacharya S, Adhikary A, Chattopadhyay S. 2016. Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells. J Nutr Biochem. 38:25–40.
  • Dai Z, Nair V, Khan M, Ciolino HP. 2010. Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. Oncol Rep. 24(4):1087–1091.
  • Du L, Li J, Zhang X, Wang L, Zhang W, Yang M, Hou C. 2019. Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4/NF-κB pathway activation. Food Nutr Res. 63:3392.
  • Duval AP, Troquier L, de Souza Silva O, Demartines N, Dormond O. 2019. Diclofenac potentiates sorafenib-based treatments of hepatocellular carcinoma by enhancing oxidative stress. Cancers (Basel). 11(10):1453.
  • Erdèlyi K, Kiss A, Bakondi E, Bai P, Szabó C, Gergely P, Erdödi F, Virag L. 2005. Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells. Mol Pharmacol. 68(3):895–904.
  • Esposito C, Santarcangelo C, Di Minno A, Sacchi R, Sommella E, De Lellis LF, De Pasquale MA, Montarolo F, Campiglia P, Baldi A, et al. 2022. Chemical characterization and preliminary evaluation of the efficacy and tolerability of a food supplement based on pomegranate extract, B vitamins, and vitamin C against prolonged fatigue in healthy consumers. Processes. 10(2):208.
  • Ghosh SS, Wang J, Yannie PJ, Ghosh S. 2020. Intestinal barrier dysfunction, LPS translocation, and disease development. J Endocr Soc. 4(2):bvz039.
  • Guerville M, Boudry G. 2016. Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation. Am J Physiol Gastrointest Liver Physiol. 311(1):G1–G15.
  • Hyemee K, Qunzhe W, Yuri I, Jing Y, Dahee K, Jeong HK. 2022. Anti-inflammatory effects of gallotannin in combination with Lactobacillus plantarum in a DSS-induced colitis mouse model. Curr Dev Nutr. 6:298.
  • Johanningsmeier SD, Harris GK. 2011. Pomegranate as a functional food and nutraceutical source. Annu Rev Food Sci Technol. 2:181–201.
  • Kandylis P, Kokkinomagoulos E. 2020. Food applications and potential health benefits of pomegranate and its derivatives. Foods. 9(2):122.
  • Kanmani P, Kim H. 2018. Protective effects of lactic acid bacteria against TLR4 induced inflammatory response in hepatoma HepG2 cells through modulation of toll-like receptor negative regulators of mitogen-activated protein kinase and NF-κB signaling. Front Immunol. 9:1537.
  • Lansky EP, Newman A. 2007. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 109(2):177–206.
  • Larrosa M, González-Sarrías A, Yáñez-Gascón MJ, Selma MV, Azorín-Ortuño M, Toti S, Tomás-Barberán F, Dolara P, Espín JC. 2010. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J Nutr Biochem. 21(8):717–725.
  • Li J, Wang G, Hou C, Li J, Luo Y, Li B. 2019. Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria. Food Agric Immunol. 30(1):897–912.
  • Liu T, Zhang L, Joo D, Sun SC. 2017. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2:17023–17023.
  • Makled MN, El-Awady MS, Abdelaziz RR, Atwan N, Guns ET, Gameil NM, Shehab El-Din AB, Ammar EM. 2016. Pomegranate protects liver against cecal ligation and puncture-induced oxidative stress and inflammation in rats through TLR4/NF-κB pathway inhibition. Environ Toxicol Pharmacol. 43:182–192.
  • Mastrogiovanni F, Mukhopadhya A, Lacetera N, Ryan MT, Romani A, Bernini R, Sweeney T. 2019. Anti-inflammatory effects of pomegranate peel extracts on in vitro human intestinal Caco-2 cells and ex vivo porcine colonic tissue explants. Nutrients. 11(3):548.
  • Melgarejo-Sánchez P, Núñez-Gómez D, Martínez-Nicolás JJ, Hernández F, Legua P, Melgarejo P. 2021. Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review. Bioresour Bioprocess. 8(1)
  • Noori M, Jafari B, Hekmatdoost A. 2017. Pomegranate juice prevents development of non-alcoholic fatty liver disease in rats by attenuating oxidative stress and inflammation. J Sci Food Agric. 97(8):2327–2332.
  • Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. 2005. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 16(6):360–367.
  • Seo HY, Lee SH, Han E, Hwang JS, Han S, Kim MK, Jang BK. 2022. Evogliptin directly inhibits inflammatory and fibrotic signaling in isolated liver cells. Int J Mol Sci. 23(19):11636.
  • Shabbir MA, Khan MR, Saeed M, Pasha I, Khalil AA, Siraj N. 2017. Punicic acid: a striking health substance to combat metabolic syndromes in humans. Lipids Health Dis. 16(1):99.
  • Shaygannia E, Bahmani M, Zamanzad B, Rafieian-Kopaei M. 2016. A review study on Punica granatum L. J Evid Based Complementary Altern Med. 21(3):221–227.
  • Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM. 2008. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. J Inflamm (Lond). 5:9.
  • Wang K, Shindoh H, Inoue T, Horii I. 2002. Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines. J Toxicol Sci. 27(3):229–237.
  • Xu J, Cao K, Liu X, Zhao L, Feng Z, Liu J. 2021. Punicalagin regulates signaling pathways in inflammation-associated chronic diseases. Antioxidants (Basel). 11(1):29.
  • Yang L, He, J. 2022. Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NF-κB signaling pathway. BMC Complement Med Ther. 22(1):55.
  • Zarate MA, Nguyen LM, De Dios RK, Zheng L, Wright CJ. 2020. Maturation of the acute hepatic TLR4/NF-κB mediated innate immune response is p65 dependent in mice. Front Immunol. 11:1892.
  • Zhou Z, Xu MJ, Gao B. 2016. Hepatocytes: a key cell type for innate immunity. Cell Mol Immunol. 13(3):301–315.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.