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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 6
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Polyphenolic profile and antioxidant properties of Momordica charantia L. ‘Enaja’ cultivar grown in Romania

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Pages 1060-1066 | Received 19 Jan 2023, Accepted 04 May 2023, Published online: 21 May 2023

References

  • Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. 2015. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015:496169.
  • Busuioc AC, Botezatu AVD, Furdui B, Vinatoru C, Maggi F, Caprioli G, Dinica RM. 2020. Comparative study of the chemical compositions and antioxidant activities of fresh juices from Romanian Cucurbitaceae varieties. Molecules. 25(22):5468.
  • CABI. 2014. Invasive species compendium. https://www.cabi.org/isc/datasheet/34678.
  • Chokki M, Cudălbeanu M, Zongo C, Dah-Nouvlessounon D, Ghinea IO, Furdui B, Raclea R, Savadogo A, Baba-Moussa L, Avamescu SM, et al. 2020. Exploring antioxidant and enzymes (A-Amylase and B-Glucosidase) inhibitory activity of Morinda lucida and Momordica charantia leaves from benin. Foods. 9(4):434.
  • Choudhary SK, Chhabra G, Sharma D, Vashishta A, Ohri S, Dixit A. 2012. Comprehensive evaluation of anti-hyperglycemic activity of fractionated Momordica charantia seed extract in alloxan-induced diabetic rats. Evid Based Complement Alternat Med. 2012:293650.
  • Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D, Hollman PCH. 2015. Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial. Am J Clin Nutr. 101(5):914–921.
  • Fan M, Lee J, Ryu Y, Choi Y, Tang Y, Oh M, Moon S, Lee B, Kim E. 2021. Comparative analysis of metabolite profiling of Momordica charantia leaf and the anti-obesity effect through regulating lipid metabolism. IJERPH. 18(11):5584.
  • Hani NM, Torkamani AE, Zainul Abidin S, Mahmood WAK, Juliano P. 2017. The effects of ultrasound assisted extraction on antioxidative activity of polyphenolics obtained from Momordica charantia fruit using response surface approach. Food Biosci. 17:7–16.
  • Harinantenaina L, Tanaka M, Takaoka S, Oda M, Mogami O, Uchida M, Asakawa Y. 2006. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem Pharm Bull (Tokyo). 54(7):1017–1021.
  • Horax R, Hettiarachchy N, Islam S. 2006. Total phenolic contents and phenolic acid constituents in 4 varieties of bitter melons (Momordica charantia) and antioxidant activities of their extracts. J Food Sci. 70(4):C275–C280.
  • Huang HJ, Chen SL, Chang YT, Chyuan JH, Hsieh-Li HM. 2018. Administration of Momordica charantia enhances the neuroprotection and reduces the side effects of LiCl in the treatment of Alzheimer’s disease. Nutrients. 10(12):1888.
  • Jia S, Shen M, Zhang F, Xie J. 2017. Recent advances in Momordica charantia: functional components and biological activities. IJMS. 18(12):2555.
  • Keseru A, Andronie L, Pop I, Rotaru A, Maniutiu D, Coroian A, Raducu C. 2016a. Characterization of Momordica charantia using FT-IR spectroscopy. BUASVMCN-HORT. 73(2):245.
  • Keseru A, Borsai O, Buta E, Măniuțiu DN. 2018. The influence of technological parameters on chemical composition of Momordica charantia fruits. Agricultura. 105(1–2):71–76.
  • Keseru A, Buta E, Borsai O, Negrusier C, Manutiu D. 2016b. The influence of cultivation method on crop production of bitter gourd (Momordica charantia L.). BUASVMCN-HORT. 73(2):247.
  • Kikuchi H, Yuan B, Hu X, Okazaki M. 2019. Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents. Am J Cancer Res. 9(8):1517–1535.
  • Krawinkel MB, Ludwig C, Swai ME, Yang R, YuChun KP, Habicht SD. 2018. Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania. J Ethnopharmacol. 216:1–7.
  • Kubola J, Siriamornpun S. 2008. Phenolic contents and antioxidant activities of bitter gourd (Momordica charantia L.) leaf, stem and fruit fraction extracts in vitro. Food Chem. 2008 Oct 15;110(4):881–90. doi: 10.1016/j.foodchem.2008.02.076. Epub 2008 Mar 4. PMID: 26047274.
  • Laczkó-Zöld E, Bacsadi B, Horváth A, Csupor D. 2021. Development and validation of a RP-HPLC-DAD method for quantification of charantin in Momordica charantia products. J Food Compos Anal. 104:104161.
  • Lin Y-S, Huang W-Y, Ho P-Y, Hu S-Y, Lin Y-Y, Chen C, Chang M, Huang S. 2020. Effects of storage time and temperature on antioxidants in juice from Momordica charantia L. and Momordica charantia L. var. abbreviata Ser. Molecules. 25(16):3614.
  • Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. 2008. Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr. 88(4):1018–1025.
  • Nagarani G, Abirami A, Siddhuraju P. 2014a. Food prospects and nutraceutical attributes of Momordica species: a potential tropical bioresources – a review. Food Sci Hum Wellness. 3(3–4):117–126.
  • Nagarani G, Abirami A, Siddhuraju P. 2014b. A comparative study on antioxidant potentials, inhibitory activities against key enzymes related to metabolic syndrome, and anti-inflammatory activity of leaf extract from different Momordica species. Food Sci Hum Wellness. 3(1):36–46.
  • Peter EL, Kasali FM, Deyno S, Mtewa A, Nagendrappa PB, Tolo CU, Ogwang PE, Sesaazi D. 2019. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: systematic review and meta-analysis. J Ethnopharmacol. 231:311–324.
  • Peter EL, Mtewa AG, Nagendrappa PB, Kaligirwa A, Sesaazi CD. 2020. Systematic review and meta-analysis protocol for efficacy and safety of Momordica charantia L. on animal models of type 2 diabetes mellitus. Syst Rev. 9(1):7.
  • Pop AE, Vamanu A, Pop OV, Vamanu E. 2015. Preliminary in vitro activity and correlation with chemical composition of Momordica charantia, Vaccinium myrtillus and Vaccinium vitis-idaea after enzymatic extraction process. Rev Chim. 66(10):1687–1691.
  • Popescu R, Daliborca CV, Cimporescu A, Vlad CS, Verdes D, Botau D, Filimon MN, Pauliuc I, Citu C, Dumitrascu V. 2016. Chemical properties and in vitro antitumor effects of Momordica charantia extracts in different solvents. Rev Chim. 67(1):69–73.
  • Rahman IU, Khan RU, Rahman KU, Bashir M. 2015. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 14(1):13.
  • Saini RK, Assefa AD, Keum Y-S. 2017. Fatty acid and carotenoid composition of bitter melon (Momordica charantia L.) seed arils: a potentially valuable source of lycopene. Food Measure. 11(3):1266–1273.
  • Sur S, Ray RB. 2020. Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy. Cancers (Basel). 2020 Jul 27; 12(8):2064. doi: 10.3390/cancers12082064. PMID: 32726914; PMCID: PMC7464160.
  • Suthar AC, Deshmukh A, Babu V, Mohan VS, Chavan MV, Kumar D, Chauhan V, Sharma S, Sharma M. 2016. Efficacy and safety of Glycebal (PDM011011) capsules as adjuvant therapy in subjects with type 2 diabetes mellitus: an open label, randomized, active controlled, phase II trial. Clin Diabetol. 5(3):88–94.
  • Svobodova B, Barros L, Calhelha RC, Heleno S, Alves MJ, Walcott S, Bittova M, Kuban V, Ferreira ICFR. 2017. Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago. Ind Crops Prod. 95:365–373.
  • Tan S, Stathopoulos C, Parks S, Roach P. 2014. An optimised aqueous extract of phenolic compounds from bitter melon with high antioxidant capacity. Antioxidants (Basel). 3(4):814–829.
  • Tan SP, Parks SE, Stathopoulos CE, Roach PD. 2014. Greenhouse-grown bitter melon: production and quality characteristics. J Sci Food Agric. 94(9):1896–1903.
  • Thomas T, Pfeiffer AF. 2012. Foods for the prevention of diabetes: how do they work? Diabetes Metab Res Rev. 2012 Jan; 28(1):25–49. doi: 10.1002/dmrr.1229. PMID: 21695766.
  • Trakoon-Osot W, Sotanaphun U, Phanachet P, Porasuphatana S, Udomsubpayakul U, Komindr S. 2013. Pilot study: hypoglycemic and antiglycation activities of bitter melon (Momordica charantia L.) in type 2 diabetic patients. J Pharm Res. 6(8):859–864.
  • Tridge. 2023. [Accessed 2023 Feb 14]. https://www.tridge.com/intelligences/bitter-gourd.
  • Venkatakrishnan K, Chiu H-F, Wang C-K. 2019. Extensive review of popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials. Food Funct. 10(5):2313–2329.
  • Wang X, Sun W, Cao J, Qu H, Bi X, Zhao Y. 2012. Structures of new triterpenoids and cytotoxicity activities of the isolated major compounds from the fruit of Momordica charantia L. J Agric Food Chem. 60(15):3927–3933.
  • Zanker K, Mang B, Wolters M, Hahn A. 2012. Personalized diabetes and cancer medicine: a rationale for anti-diabetic nutrition (bitter melon) in a supportive setting. CCTR. 8(1):66–77.
  • Zeng K, He YN, Yang D, Cao JQ, Xia XC, Zhang SJ, Bi XL, Zhao YQ. 2014. New compounds from acid hydrolyzed products of the fruits of Momordica charantia L. and their inhibitory activity against protein tyrosine phosphatas 1B. Eur J Med Chem. 81:176–180.
  • Zubair MF, Atolani O, Ibrahim SO, Oguntoye OS, Abdulrahim HA, Oyegoke RA, Olatunji GA. 2018. Chemical and biological evaluations of potent antiseptic cosmetic products obtained from Momordica charantia seed oil. Sustain Chem Pharm. 9:35–41.

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