Suppression of breast cancer: modulation of estrogen receptor and downregulation of gene expression using natural products

References

• Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S, et al. 2022. Current and future burden of breast cancer: global statistics for 2020 and 2040. Breast. 66:15–23. doi: 10.1016/j.breast.2022.08.010.
   PubMed Web of Science ®Google Scholar
• Austin JR, Li K, Rivera Rodríguez R, Lantvit DD, Murphy BT, Burdette JE., 2021. Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors. J Nat Prod. 84(12):3090–3099. doi: 10.1021/acs.jnatprod.1c00835.
   PubMed Web of Science ®Google Scholar
• Bak MJ, Gupta SD, Wahler J, Suh N. 2016. Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. In: Seminars in cancer biology. Vol. 40, Elsevier. GA, USA: Academic Press; p. 170–191. doi: 10.1016/j.semcancer.2016.03.001.
   Google Scholar
• Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN. 2022. Soy isoflavones and breast cancer risk: a meta-analysis. In Vivo. 36(2):556–562. doi: 10.21873/invivo.12737.
   PubMed Web of Science ®Google Scholar
• Brzezinski A, Debi A. 1999. Phytoestrogens: the “natural” selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol. 85(1):47–51. doi: 10.1016/s0301-2115(98)00281-4.
   PubMed Web of Science ®Google Scholar
• Chen M, Gowd V, Wang M, Chen F, Cheng KW. 2021. The apple dihydrochalcone phloretin suppresses growth and improves chemosensitivity of breast cancer cells via inhibition of cytoprotective autophagy. Food Funct. 12(1):177–190. doi: 10.1039/d0fo02362k.
   PubMed Web of Science ®Google Scholar
• Chuwa AH, Sone K, Oda K, Tanikawa M, Kukita A, Kojima M, Oki S, Fukuda T, Takeuchi M, Miyasaka A, et al. 2018. Kaempferol, a natural dietary flavonoid, suppresses 17β‑estradiol‑induced survivin expression and causes apoptotic cell death in endometrial cancer. Oncol Lett. 16(5):6195–6201., doi: 10.3892/ol.2018.9340.
   PubMed Web of Science ®Google Scholar
• Cincin ZB, Kiran B, Baran Y, Cakmakoglu B. 2018. Hesperidin promotes programmed cell death by downregulation of nongenomic estrogen receptor signalling pathway in endometrial cancer cells. Biomed Pharmacother. 103:336–345. doi: 10.1016/j.biopha.2018.04.020.
   PubMed Web of Science ®Google Scholar
• Clemons M, Goss P. 2001. Estrogen and the risk of breast cancer. N Engl J Med. 344(4):276–285. doi: 10.1056/NEJM200101253440407.
   PubMed Web of Science ®Google Scholar
• Hickey TE, Selth LA, Chia KM, Laven-Law G, Milioli HH, Roden D, Jindal S, Hui M, Finlay-Schultz J, Ebrahimie E, et al. 2021. The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer. Nat Med. 27(2):310–320., doi: 10.1038/s41591-020-01168-7.
   PubMed Web of Science ®Google Scholar
• Hsu PH, Chen WH, Juan-Lu C, Hsieh SC, Lin SC, Mai RT, Chen SY. 2021. Hesperidin and chlorogenic acid synergistically inhibit the growth of breast cancer cells via estrogen receptor/mitochondrial pathway. Life. 11(9), 950.
   PubMedGoogle Scholar
• Jiang J, Slivova V, Sliva D. 2006. Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-κB signaling. Int J Oncol. 29(3):695–703. doi: 10.3892/ijo.29.3.695.
   PubMed Web of Science ®Google Scholar
• Kar S, Roy K. 2013. How far can virtual screening take us in drug discovery? Expert Opin Drug Discov. 8(3):245–261. doi: 10.1517/17460441.2013.761204.
   PubMed Web of Science ®Google Scholar
• Kavaz A, Işık M, Dikici E, Yüksel M. 2022. Anticholinergic, antioxidant, and antibacterial properties of vitex Agnus‐Castus L. seed extract: assessment of its phenolic content by LC/MS/MS. Chem Biodivers. 19(10):e202200143. doi: 10.1002/cbdv.202200143.
   PubMed Web of Science ®Google Scholar
• Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, et al. 2002. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 71(3):203–217., doi: 10.1023/a:1014405730585.
   PubMed Web of Science ®Google Scholar
• Kim HI, Quan FS, Kim JE, Lee NR, Kim HJ, Jo SJ, Lee CM, Jang DS, Inn KS. 2014. Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. Biochem Biophys Res Commun. 451(2):282–287. doi: 10.1016/j.bbrc.2014.07.115.
   PubMed Web of Science ®Google Scholar
• Laskar YB, Mazumder PB, Talukdar AD. 2023. Hibiscus sabdariffa anthocyanins are potential modulators of estrogen receptor alpha activity with favourable toxicology: a computational analysis using molecular docking, ADME/Tox prediction, 2D/3D QSAR and molecular dynamics simulation. J Biomol Struct Dyn. 41(2):611–633. doi: 10.1080/07391102.2021.2009914.
   PubMed Web of Science ®Google Scholar
• Leclercq G, Jacquot Y. 2014. Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer—considerations concerning related efficacy and safety. J Steroid Biochem Mol Biol. 139:237–244. doi: 10.1016/j.jsbmb.2012.12.010.
   PubMed Web of Science ®Google Scholar
• Lumachi F, Brunello A, Maruzzo M, Basso U, Basso SMM. 2013. Treatment of estrogen receptor-positive breast cancer. Curr Med Chem. 20(5):596–604. doi: 10.2174/092986713804999303.
   PubMed Web of Science ®Google Scholar
• Mahmoud M, Abdollah MR, Elsesy ME, Abou El Ella DA, Zada SK, Tolba MF. 2022. The natural isoflavone Biochanin‐A synergizes 5‐fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid‐phase carcinoma model. Phytother Res. 36(3):1310–1325. doi: 10.1002/ptr.7388.
   PubMed Web of Science ®Google Scholar
• Mezban SAT, Fox SW. 2023. Genistein and coumestrol reduce MCF-7 breast cancer cell viability and inhibit markers of preferential metastasis, bone matrix attachment and tumor-induced osteoclastogenesis. Arch Biochem Biophys. 740:109583. doi: 10.1016/j.abb.2023.109583.
   PubMed Web of Science ®Google Scholar
• Nguyen C, Baskaran K, Pupulin A, Ruvinov I, Zaitoon O, Grewal S, Scaria B, Mehaidli A, Vegh C, Pandey S. 2019. Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics. BMC Complement Altern Med. 19(1):1–14. doi: 10.1186/s12906-019-2505-9.
   PubMedGoogle Scholar
• Nguyen M, Osipo C. 2022. Targeting breast cancer stem cells using naturally occurring phytoestrogens. IJMS. 23(12):6813. doi: 10.3390/ijms23126813.
   Google Scholar
• Pang X, Fu W, Wang J, Kang D, Xu L, Zhao Y, Liu AL, Du GH. 2018. Identification of estrogen receptor α antagonists from natural products via in vitro and in silico approaches. Oxid Med Cell Longevity. 2018:1–11. doi: 10.1155/2018/6040149.
   Web of Science ®Google Scholar
• Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Pachmann B, Sterlini KL, Jäger W. 2017. The impacts of genistein and daidzein on estrogen conjugations in human breast cancer cells: a targeted metabolomics approach. Front Pharmacol. 8:699. doi: 10.3389/fphar.2017.00699.
   PubMed Web of Science ®Google Scholar
• Renoir JM, Marsaud V, Lazennec G. 2013. Estrogen receptor signaling as a target for novel breast cancer therapeutics. Biochem Pharmacol. 85(4):449–465. doi: 10.1016/j.bcp.2012.10.018.
   PubMed Web of Science ®Google Scholar
• Russo JIHR, Russo IH. 2006. The role of estrogen in the initiation of breast cancer. J Steroid Biochem Mol Biol. 102(1-5):89–96. doi: 10.1016/j.jsbmb.2006.09.004.
   PubMed Web of Science ®Google Scholar
• Scherbakov AM, Stasevich OV, Salnikova DI, Andreeva OE, Mikhaevich EI. 2021. Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells. Nat Prod Res. 35(24):6099–6105. doi: 10.1080/14786419.2020.1826479.
   PubMed Web of Science ®Google Scholar
• Simons R, Gruppen H, Bovee TF, Verbruggen MA, Vincken JP. 2012. Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs). Food Funct. 3(8):810–827. doi: 10.1039/c2fo10290k.
   PubMed Web of Science ®Google Scholar
• Situmorang H, Hestiantoro A, Purbadi S, Flamandita D, Sahlan M. 2021. IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor. Ann Med Surg (Lond). 67:102459. doi: 10.1016/j.amsu.2021.102459.
   PubMed Web of Science ®Google Scholar
• Sommer S, Fuqua SA. 2001. Estrogen receptor and breast cancer. Semin Cancer Biol . 11(5):339–352. Academic Press. doi: 10.1006/scbi.2001.0389.
   Google Scholar
• Sreepriya M, Bhimnaik S, Rumana A, Divya M. 2022. Antiproliferative effects of phytoestrogens formononetin and resveratrol against human pulmonary adenocarcinoma cells A 549. Biosci Biotechnol Res Asia. 19(2):309–319.
   Google Scholar
• Waks AG, Winer EP. 2019. Breast cancer treatment: a review. JAMA. 321(3):288–300. doi: 10.1001/jama.2018.19323.
   PubMed Web of Science ®Google Scholar
• Wilkinson L, Gathani T. 2022. Understanding breast cancer as a global health concern. British J Radiol. 95(1130), 20211033. doi: 10.3390/life11090950.
   PubMed Web of Science ®Google Scholar
• Wobser RW, Takov V. 2022. Black Cohosh. In StatPearls [Internet]. StatPearls Publishing, The British Journal of Radiology. London, United Kingdom.
   Google Scholar
• Yang CS, Wang X, Lu G, Picinich SC. 2009. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer. 9(6):429–439. doi: 10.1038/nrc2641.
   PubMed Web of Science ®Google Scholar
• Zhang H-W, Hu J-J, Fu R-Q, Liu X, Zhang Y-H, Li J, Liu L, Li Y-N, Deng Q, Luo Q-S, et al. 2018. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 8(1):1–13., doi: 10.1038/s41598-018-29308-7.
   PubMed Web of Science ®Google Scholar