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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 12
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Research Articles

Invalidation of geraniin as a potential inhibitor against SARS-CoV-2 main protease

Rui ZhangInstitute for Drug Screening and Evaluation, Wannan Medical College, Wuhu, P. R. ChinaView further author information
,
Haohao YanInstitute for Drug Screening and Evaluation, Wannan Medical College, Wuhu, P. R. ChinaView further author information
,
Jiahao ZhouInstitute for Drug Screening and Evaluation, Wannan Medical College, Wuhu, P. R. ChinaView further author information
,
Xiaoping LiuInstitute for Drug Screening and Evaluation, Wannan Medical College, Wuhu, P. R. ChinaView further author information
&
Yunyu ChenInstitute for Drug Screening and Evaluation, Wannan Medical College, Wuhu, P. R. ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2750-8221View further author information
ORCID Icon
Pages 2078-2081 | Received 24 Apr 2023, Accepted 19 Jul 2023, Published online: 03 Aug 2023

References

  • Arokiyaraj S, Stalin A, Kannan BS, Shin H. 2020. Geranii herba as a potential inhibitor of SARS-CoV-2 Main 3CLpro, Spike RBD, and regulation of unfolded protein response: an in silico approach. Antibiotics (Basel). 9(12):863. doi:10.3390/antibiotics9120863.
  • Guo S, Xie H, Lei Y, Liu B, Zhang L, Xu Y, Zuo Z. 2021. Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation. Bioorg Chem. 110:104767. doi:10.1016/j.bioorg.2021.104767.
  • Kim YS, Chung HS, Noh SG, Lee B, Chung HY, Choi JG. 2021. Geraniin inhibits the entry of SARS-CoV-2 by blocking the interaction between spike protein RBD and human ACE2 receptor. Int J Mol Sci. 22(16):8604. doi:10.3390/ijms22168604.
  • Li Z, Li X, Huang YY, Wu Y, Liu R, Zhou L, Lin Y, Wu D, Zhang L, Liu H, et al. 2020. Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs. Proc Natl Acad Sci U S A. 117(44):27381–27387. doi:10.1073/pnas.2010470117.
  • Ma C, Wang J. 2021. Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors. Proc Natl Acad Sci U S A. 118(8):e2024420118. doi:10.1073/pnas.2024937118.
  • Sacco MD, Hu Y, Gongora MV, Meilleur F, Kemp MT, Zhang X, Wang J, Chen Y. 2022. The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition. Cell Res. 32(5):498–500. doi:10.1038/s41422-022-00640-y.
  • Yan G, Li D, Lin Y, Fu Z, Qi H, Liu X, Zhang J, Si S, Chen Y. 2021. Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors. Cell Biosci. 11(1):199. doi:10.1186/s13578-021-00720-3.
  • Yan H, Zhang R, Yan G, Liu Z, Liu X, Liu X, Chen Y. 2023. Production of a versatile SARS-CoV-2 main protease biosensor based on a dimerization-dependent red fluorescent protein. J Med Virol. 95(1):e28342.
  • Yu WD, Jin QY, Zeng MS, Liu JY, Xu PP. 2022. Geraniin as a potential inhibitor of SARS-CoV-2 3CLpro. Nat Prod Res. 36(23):6060–6063. doi:10.1080/14786419.2022.2043308.
  • Zhang J, Yan H, Yan G, Liu X, Wang Y, Chen Y. 2022. Protocol for high-throughput screening of SARS-CoV-2 main protease inhibitors using a robust fluorescence polarization assay. STAR Protoc. 3(4):101794. doi:10.1016/j.xpro.2022.101794.
  • Zhang T, Zhou X, Wang K, Sun L, Zhuang Y. 2022. A review: extraction, phytochemicals, and biological activities of rambutan (Nephelium lappaceum L) peel extract. Heliyon. 8(11):e11314.

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