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Review

Challenges in laboratory diagnosis of acute viral central nervous system infections in the era of emerging infectious diseases: the syndromic approach

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Pages 829-836 | Received 13 May 2016, Accepted 19 Jul 2016, Published online: 31 Jul 2016

References

  • Venkatesan A, Tunkel AR, Bloch KC, et al. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. 2013;57:1114–1128.
  • Solomon T, Michael BD, Smith PE, et al. Management of suspected viral encephalitis in adults–Association of British Neurologists and British Infection Association National Guidelines. J Infect. 2012;64:347–373.
  • Ashton RA, Kefyalew T, Batisso E, et al. The usefulness of school-based syndromic surveillance for detecting malaria epidemics: experiences from a pilot project in Ethiopia. BMC Public Health. 2015;16:20.
  • Granerod J, Cunningham R, Zuckerman M, et al. Causality in acute encephalitis: defining aetiologies. Epidemiol Infect. 2010;138:783–800.
  • Williamson PR, Nash TE, Williamson KC, et al. CNS infections in 2015: emerging catastrophic infections and new insights into neuroimmunological host damage. Lancet Neurol. 2016;15:17–19.
  • Reimann CA, Hayes EB, DiGuiseppi C, et al. Epidemiology of neuroinvasive arboviral disease in the United States, 1999-2007. Am J Trop Med Hyg. 2008;79:974–979.
  • Papa A. West Nile virus infections in humans-Focus on Greece. J Clin Virol. 2013;58:351–353.
  • Murray KO, Garcia MN, Rahbar MH, et al. Survival analysis, long-term outcomes, and percentage of recovery up to 8 years post-infection among the Houston West Nile virus cohort. PLoS One. 2014;9:e102953.
  • Anastasiadou A, Kakoulidis I, Butel D, et al. Follow-up study of Greek patients with West Nile virus neuroinvasive disease. Int J Infect Dis. 2013;17:e494–497.
  • Gaensbauer JT, Lindsey NP, Messacar K, et al. Neuroinvasive arboviral disease in the United States: 2003 to 2012. Pediatrics. 2014;134:e642–e650.
  • Mlakar J, Korva M, Tul N, et al. Zika virus associated with microcephaly. N Engl J Med. 2016;374:951–958.
  • Martines RB, Bhatnagar J, De Oliveira Ramos AM, et al. Pathology of congenital Zika syndrome in Brazil: a case series. Lancet. Forthcoming 2016. pii: S0140-6736(16)30883-2.
  • Tang H, Hammack C, Ogden SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell. 2016;18:587–590.
  • Carteaux G, Maquart M, Bedet A, et al. Zika virus associated with meningoencephalitis. N Engl J Med. 2016;374:1595–1596.
  • Mécharles S, Herrmann C, Poullain P, et al. Acute myelitis due to Zika virus infection. Lancet. 2016;387:1481.
  • Cao-Lormeau VM, Blake A, Mons S, et al. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 2016;387:1531–1539.
  • Angelini R, Finarelli AC, Angelini P, et al. An outbreak of chikungunya fever in the province of Ravenna, Italy. Euro Surveill. 2007;12:E070906–070901.
  • Papa A, Paraforou T, Papakonstantinou I, et al. Severe encephalitis caused by Toscana virus, Greece. Emerg Infect Dis. 2014;20:1417–1419.
  • Maier T, Schwarting A, Mauer D, et al. Management and outcomes after multiple corneal and solid organ transplantations from a donor infected with rabies virus. Clin Infect Dis. 2010;50:1112–1119.
  • Ross RS, Wolters B, Hoffmann B, et al. Instructive even after a decade: complete results of initial virological diagnostics and re-evaluation of molecular data in the German rabies virus “outbreak” caused by transplantations. Int J Med Microbiol. 2015;305:636–643.
  • Ong KC, Wong KT. Henipavirus encephalitis: recent developments and advances. Brain Pathol. 2015;25:605–613.
  • Edison L, Knust B, Petersen B, et al. Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak. Emerg Infect Dis. 2014;20:291–295.
  • Knust B, Ströher U, Edison L, et al. Lymphocytic choriomeningitis virus in employees and mice at multipremises feeder-rodent operation, United States, 2012. Emerg Infect Dis. 2014;20:240–247.
  • Donoso Mantke O, Vaheri A, Ambrose H, et al. Analysis of the surveillance situation for viral encephalitis and meningitis in Europe. Euro Surveill. 2008;13. pii: 8017.
  • Debiasi RL, Tyler KL. Molecular methods for diagnosis of viral encephalitis. Clin Microbiol Rev. 2004;17:903–925.
  • Huhtamo E, Hasu E, Uzcátegui NY, et al. Early diagnosis of dengue in travelers: comparison of a novel real-time RT-PCR, NS1 antigen detection and serology. J Clin Virol. 2010;47:49–53.
  • Bloch KC, Glaser CA. Encephalitis surveillance through the emerging infections program, 1997-2010. Emerg Infect Dis. 2015;21:1562–1567.
  • Frantzidou F, Kamaria F, Dumaidi K, et al. Aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. Eur J Neurol. 2008;15:995–997.
  • De Ory F, Avellón A, Echevarría JE, et al. Viral infections of the central nervous system in Spain: a prospective study. J Med Virol. 2013;85:554–562.
  • Glaser CA, Honarmand S, Anderson LJ, et al. Beyond viruses: clinical profiles and etiologies associated with encephalitis. Clin Infect Dis. 2006;43:1565–1577.
  • Glaser CA, Gilliam S, Schnurr D, et al. In search of encephalitis etiologies: diagnostic challenges in the California Encephalitis project, 1998-2000. Clin Infect Dis. 2003;36:731–742.
  • Granerod J, Ambrose HE, Davies NW, et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010;10:835–844.
  • Murata T, Tsurumi T. Switching of EBV cycles between latent and lytic states. Rev Med Virol. 2014;24:142–153.
  • Macsween KF, Crawford DH. Epstein-Barr virus-recent advances. Lancet Infect Dis. 2003;3:131–140.
  • Ward KN, Leong HN, Thiruchelvam AD, et al. Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. J Clin Microbiol. 2007;45:1298–1304.
  • Kupila L, Vuorinen T, Vainionpäā R, et al. Diagnosis of enteroviral meningitis by use of polymerase chain reaction of cerebrospinal fluid, stool, and serum specimens. Clin Infect Dis. 2005;40:982–987.
  • World Health Organization. WHO Expert consultation on Rabies. Second report. Technical Report Series 982. Geneva: World Health Organization; 2013.
  • Barzon L, Pacenti M, Franchin E, et al. Excretion of West Nile virus in urine during acute infection. J Infect Dis. 2013;208:1086–1092.
  • Papa A, Testa T, Papadopoulou E. Detection of West Nile virus lineage 2 in the urine of acute human infections. J Med Virol. 2014;86:2142–2145.
  • Caracciolo I, Bassetti M, Paladini G, et al. Persistent viremia and urine shedding of tick-borne encephalitis virus in an infected immunosuppressed patient from a new epidemic cluster in North-Eastern Italy. J Clin Virol. 2015;69:48–51.
  • Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci. 2001;184:101–122.
  • Phares TW, Stohlman SA, Bergmann CC. Intrathecal humoral immunity to encephalitic RNA viruses. Viruses. 2013;5:732–752.
  • Tunkel AR, Glaser CA, Bloch KC, et al. The management of encephalitis: clinical practice guidelines by the infectious diseases society of America. Clin Infect Dis. 2008;47:303–327.
  • Gould LH, Fikrig E. West Nile virus: a growing concern? J Clin Invest. 2004;113:1102–1107.
  • Charrel RN, Gallian P, Navarro-Mari JM, et al. Emergence of Toscana virus in Europe. Emerg Infect Dis. 2005;11:1657–1663.
  • Papa A, Karabaxoglou D, Kansouzidou A. Acute West Nile virus neuroinvasive infections: cross-reactivity with dengue virus and tick-borne encephalitis virus. J Med Virol. 2011;83:1861–1865.
  • Kam YW, Pok KY, Eng KE, et al. Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients. PLoS Negl Trop Dis. 2015;9:e3445.
  • Mayo DR, Beckwith WH 3rd. Inactivation of West Nile virus during serologic testing and transport. J Clin Microbiol. 2002;40:3044–3046.
  • Raschilas F, Wolff M, Delatour F, et al. Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study. Clin Infect Dis. 2002;35:254–260.
  • Cleton N, Koopmans M, Reimerink J, et al. Come fly with me: review of clinically important arboviruses for global travelers. J Clin Virol. 2012;55:191–203.
  • Tan Le V, Van Doorn HR, Nghia HD, et al. Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. MBio. 2013;4:e00231–00213.
  • Zhou C, Zhang S, Gong Q, et al. A novel gemycircularvirus in an unexplained case of child encephalitis. Virol J. 2015;12:197.
  • Da Rocha AJ, Nunes RH, Maia AC Jr., et al. Recognizing autoimmune-mediated encephalitis in the differential diagnosis of limbic disorders. AJNR Am J Neuroradiol. 2015;36:2196–2205.
  • Gable MS, Sheriff H, Dalmau J, et al. The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis. 2012;54:899–904.
  • Armangue T, Leypoldt F, Málaga I, et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol. 2014;75:317–323.
  • Armangue T, Moris G, Cantarín-Extremera V, et al. Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology. 2015;85:1736–1743.
  • Kotsenas AL, Watson RE, Pittock SJ, et al. MRI findings in autoimmune voltage-gated potassium channel complex encephalitis with seizures: one potential etiology for mesial temporal sclerosis. AJNR Am J Neuroradiol. 2014;35:84–89.
  • Buehler JW, Hopkins RS, Overhage JM, et al., Group CDCW. Framework for evaluating public health surveillance systems for early detection of outbreaks: recommendations from the CDC Working Group. MMWR Recomm Rep. 2004;53:1–11.
  • Henning KJ. What is syndromic surveillance? MMWR Morb Mortal Wkly Rep. 2004;Supp1:5–11.
  • Carme B, Sobesky M, Biard MH, et al. Non-specific alert system for dengue epidemic outbreaks in areas of endemic malariaA hospital-based evaluation in Cayenne (French Guiana). Epidemiol Infect. 2003;130:93–100.
  • Han MH, Zunt JR. Neurologic aspects of infections in international travelers. Neurologist. 2005;11:30–44.
  • Cleton NB, Reusken CB, Wagenaar JF, et al. Syndromic approach to arboviral diagnostics for global travelers as a basis for infectious disease surveillance. PLoS Negl Trop Dis. 2015;9:e0004073.
  • Cleton NB, Godeke GJ, Reimerink J, et al. Spot the difference-development of a syndrome based protein microarray for specific serological detection of multiple flavivirus infections in travelers. PLoS Negl Trop Dis. 2015;9:e0003580.
  • Akhvlediani T, Bautista CT, Shakarishvili R, et al. Etiologic agents of central nervous system infections among febrile hospitalized patients in the country of Georgia. PLoS One. 2014;9:e111393.
  • Huang C, Morse D, Slater B, et al. Multiple-year experience in the diagnosis of viral central nervous system infections with a panel of polymerase chain reaction assays for detection of 11 viruses. Clin Infect Dis. 2004;39:630–635.
  • Hsu CC, Tokarz R, Briese T, et al. Use of staged molecular analysis to determine causes of unexplained central nervous system infections. Emerg Infect Dis. 2013;19:1470–1477.
  • Liu Y, Duan C, Zhang C, et al. Evaluation of a viral microarray based on simultaneous extraction and amplification of viral nucleotide acid for detecting human herpesviruses and enteroviruses. PLoS One. 2015;10:e0117626.
  • Mannonen L, Vainionpää R, Kauppinen J, et al. Evaluation of multiplex polymerase chain reaction and microarray-based assay for rapid herpesvirus diagnostics. Diagn Microbiol Infect Dis. 2012;73:74–79.
  • Boriskin YS, Rice PS, Stabler RA, et al. DNA microarrays for virus detection in cases of central nervous system infection. J Clin Microbiol. 2004;42:5811–5818.
  • Chan BK, Wilson T, Fischer KF, et al. Deep sequencing to identify the causes of viral encephalitis. PLoS One. 2014;9:e93993.
  • Greninger AL, Naccache SN, Messacar K, et al. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015;15:671–682.
  • Reinke SN, Resch L, Maingat F, et al. Metagenomic and metabolomic characterization of rabies encephalitis: new insights into the treatment of an ancient disease. J Infect Dis. 2013;207:1451–1456.
  • Naccache SN, Peggs KS, Mattes FM, et al. Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing. Clin Infect Dis. 2015;60:919–923.
  • Goldberg B, Sichtig H, Geyer C, et al. Making the leap from research laboratory to clinic: challenges and opportunities for next-generation sequencing in infectious disease diagnostics. MBio. 2015;6:e01888–e01815.

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