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Expert Review of Anti-infective Therapy Volume 15, 2017 - Issue 8
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Original Research

Impact of total body weight on 30-day mortality in patients with gram-negative bacteremia

Ronald G. HallDepartment of Pharmacy Practice, Texas Tech University Health Sciences Center, DallasTX, USA;Department of Medical Service for RGH, EMM; Department of Pharmacy Service for CAA, VA North Texas Health Care System, DallasTX, USA;Department of Internal Medicine for RGH; Department of General Internal Medicine for EMM, CAA, University of Texas Southwestern Medical Center, DallasTX, USA;Dose Optimization and Outcomes Research (DOOR) Program, DallasTX, USACorrespondence[email protected]
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,
Eunice D. YooDepartment of Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA, USAView further author information
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Andrew C. FaustDepartment of Pharmacy for AF, TS; Department of Internal Medicine for ELG, Texas Health Presbyterian Dallas, USAView further author information
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Terri SmithDepartment of Pharmacy for AF, TS; Department of Internal Medicine for ELG, Texas Health Presbyterian Dallas, USAView further author information
,
Edward L. GoodmanDepartment of Pharmacy for AF, TS; Department of Internal Medicine for ELG, Texas Health Presbyterian Dallas, USAView further author information
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Eric M. MortensenDepartment of Medical Service for RGH, EMM; Department of Pharmacy Service for CAA, VA North Texas Health Care System, DallasTX, USA;Department of Internal Medicine for RGH; Department of General Internal Medicine for EMM, CAA, University of Texas Southwestern Medical Center, DallasTX, USAView further author information
,
Steven RichardsonDepartment of Pharmacy Practice, Texas Tech University Health Sciences Center, DallasTX, USAView further author information
&
Carlos A. AlvarezDepartment of Pharmacy Practice, Texas Tech University Health Sciences Center, DallasTX, USA;Department of Medical Service for RGH, EMM; Department of Pharmacy Service for CAA, VA North Texas Health Care System, DallasTX, USA;Department of Internal Medicine for RGH; Department of General Internal Medicine for EMM, CAA, University of Texas Southwestern Medical Center, DallasTX, USAView further author information
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Pages 797-803 | Received 29 Jul 2016, Accepted 19 Apr 2017, Published online: 17 May 2017

References

  • Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009 Jan 1;48(1):1–12.
  • Enoch DA, Phillimore N, Mlangeni DA, et al. Outcome for gram-negative bacteraemia when following restrictive empirical antibiotic guidelines. QJM. 2011 May;104(5):411–419.
  • Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N Engl J Med. 2010 May 13;362(19):1804–1813.
  • Wu CJ, Lee HC, Lee NY, et al. Predominance of gram-negative bacilli and increasing antimicrobial resistance in nosocomial bloodstream infections at a university hospital in southern Taiwan, 1996–2003. J Microbiol Immunol Infect. 2006 Apr;39(2):135–143.
  • Suljagic V, Cobeljic M, Jankovic S, et al. Nosocomial bloodstream infections in ICU and non-ICU patients. Am J Infect Control. 2005 Aug;33(6):333–340.
  • Hall RG 2nd, Swancutt MA, Meek C, et al. Weight drives caspofungin pharmacokinetic variability in overweight and obese people: fractal power signatures beyond two-thirds or three-fourths. Antimicrob Agents Chemother. 2013 May;57(5):2259–2264.
  • Hall RG 2nd, Swancutt MA, Meek C, et al. Ethambutol pharmacokinetic variability is linked to body mass in overweight, obese, and extremely obese people. Antimicrob Agents Chemother. 2012 Mar;56(3):1502–1507.
  • Hall RG, Swancutt MA, Gumbo T. Fractal geometry and the pharmacometrics of micafungin in overweight, obese, and extremely obese people. Antimicrob Agents Chemother. 2011 Nov;55(11):5107–5112.
  • Forse RA, Karam B, MacLean LD, et al. Antibiotic prophylaxis for surgery in morbidly obese patients. Surgery. 1989 Oct;106(4):750–756. discussion 756–757.
  • Cheatham SC, Fleming MR, Healy DP, et al. Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients. Int J Antimicrob Agents. 2013 Jan;41(1):52–56.
  • Hollenstein UM, Brunner M, Schmid R, et al. Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing. Int J Obes Relat Metab Disord. 2001 Mar;25(3):354–358.
  • Allard S, Kinzig M, Boivin G, et al. Intravenous ciprofloxacin disposition in obesity. Clin Pharmacol Ther. 1993 Oct;54(4):368–373.
  • Sligl WI, Dragan T, Smith SW. Nosocomial gram-negative bacteremia in intensive care: epidemiology, antimicrobial susceptibilities, and outcomes. Int J Infect Dis. 2015 Aug;37:129–134.
  • Gaynes R, Edwards JR. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis. 2005 Sep 15;41(6):848–854.
  • Ogden CL, Fryar CD, Carroll MD, et al. Mean body weight, height, and body mass index, United States 1960–2002. Adv Data. 2004 Oct 27;(347):1–17.
  • Chow JW, Shlaes DM. Imipenem resistance associated with the loss of a 40 kDa outer membrane protein in Enterobacter aerogenes. J Antimicrob Chemother. 1991 Oct;28(4):499–504.
  • Chow JW, Yu VL. Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: a commentary. Int J Antimicrob Agents. 1999 Jan;11(1):7–12.
  • Concato J, Feinstein AR, Holford TR. The risk of determining risk with multivariable models. Ann Intern Med. 1993 Feb 1;118(3):201–210.
  • Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health. 1989 Mar;79(3):340–349.
  • Smith RL, Chong TW, Hedrick TL, et al. Does body mass index affect infection-related outcomes in the intensive care unit? Surg Infect (Larchmt). Dec. 2007;8(6):581–588.
  • Wurzinger B, Dunser MW, Wohlmuth C, et al. The association between body-mass index and patient outcome in septic shock: a retrospective cohort study. Wien Klin Wochenschr. 2010 Jan;122(1–2):31–36.
  • Huttunen R, Laine J, Lumio J, et al. Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia. BMC Infect Dis. 2007;7:13.
  • Chen CY, Chen YH, Lu PL, et al. Proteus mirabilis urinary tract infection and bacteremia: risk factors, clinical presentation, and outcomes. J Microbiol Immunol Infect. 2012 Jun;45(3):228–236.
  • Lee J, Kim K, Jo YH, et al. Severe thinness is associated with mortality in patients with community-acquired pneumonia: a prospective observational study. Am J Emerg Med. 2015 Feb;33(2):209–213.
  • Reunes S, Rombaut V, Vogelaers D, et al. Risk factors and mortality for nosocomial bloodstream infections in elderly patients. Eur J Intern Med. 2011 Oct;22(5):e39–44.
  • Deulofeu F, Cervello B, Capell S, et al. Predictors of mortality in patients with bacteremia: the importance of functional status. J Am Geriatr Soc. 1998 Jan;46(1):14–18.

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