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Review

Managing recurrent urinary tract infections in kidney transplant patients

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Pages 723-732 | Received 11 Jul 2018, Accepted 06 Aug 2018, Published online: 21 Aug 2018

References

  • Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the infectious diseases society of america and the european society for microbiology and infectious diseases. Clin Infect Dis. 2011;52(5):e103–120.
  • Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the infectious diseases society of america. Clin Infect Dis. 2010;50(5):625–663.
  • Parasuraman R, Julian K. Practice ASTIDCo. Urinary tract infections in solid organ transplantation. Am J Transplant. 2013;13(Suppl 4):327–336.
  • Pelle G, Vimont S, Levy PP, et al. Acute pyelonephritis represents a risk factor impairing long-term kidney graft function. Am J Transplant. 2007;7(4):899–907.
  • Giral M, Pascuariello G, Karam G, et al. Acute graft pyelonephritis and long-term kidney allograft outcome. Kidney Int. 2002;61(5):1880–1886.
  • Chuang P, Parikh CR, Langone A. Urinary tract infections after renal transplantation: a retrospective review at two US transplant centers. Clin Transplant. 2005;19(2):230–235.
  • Bodro M, Sanclemente G, Lipperheide I, et al. Impact of urinary tract infections on short-term kidney graft outcome. Clin Microbiol Infect. 2015;21(12):1104e1101–1108.
  • Tawab KA, Gheith O, Al Otaibi T, et al. Recurrent urinary tract infection among renal transplant recipients: risk factors and long-term outcome. Exp Clin Transplant. 2017;15(2):157–163.
  • Bodro M, Sanclemente G, Lipperheide I, et al. Impact of antibiotic resistance on the development of recurrent and relapsing symptomatic urinary tract infection in kidney recipients. Am J Transplant. 2015;15(4):1021–1027.
  • Britt NS, Hagopian JC, Brennan DC, et al. Effects of recurrent urinary tract infections on graft and patient outcomes after kidney transplantation. Nephrol Dial Transplant. 2017;32(10):1758–1766.
  • Korayem GB, Zangeneh TT, Matthias KR. Recurrence of urinary tract infections and development of urinary-specific antibiogram for kidney transplant recipients. J Glob Antimicrob Resist. 2018;12:119–123.
  • Lim JH, Cho JH, Lee JH, et al. Risk factors for recurrent urinary tract infection in kidney transplant recipients. Transplant Proc. 2013;45(4):1584–1589.
  • Saemann M, Horl WH. Urinary tract infection in renal transplant recipients. Eur J Clin Invest. 2008;38(Suppl 2):58–65.
  • de Souza RM, Olsburgh J. Urinary tract infection in the renal transplant patient. Nat Clin Pract Nephrol. 2008;4(5):252–264.
  • Rabkin DG, Stifelman MD, Birkhoff J, et al. Early catheter removal decreases incidence of urinary tract infections in renal transplant recipients. Transplant Proc. 1998;30(8):4314–4316.
  • Dantas SR, Kuboyama RH, Mazzali M, et al. Nosocomial infections in renal transplant patients: risk factors and treatment implications associated with urinary tract and surgical site infections. J Hosp Infect. 2006;63(2):117–123.
  • Maraha B, Bonten H, van Hooff H, et al. Infectious complications and antibiotic use in renal transplant recipients during a 1-year follow-up. Clin Microbiol Infect. 2001;7(11):619–625.
  • Khosroshahi HT, Mogaddam AN, Shoja MM. Efficacy of high-dose trimethoprim-sulfamethoxazol prophylaxis on early urinary tract infection after renal transplantation. Transplant Proc. 2006;38(7):2062–2064.
  • Trouillhet I, Benito N, Cervera C, et al. Influence of age in renal transplant infections: cases and controls study. Transplantation. 2005;80(7):989–992.
  • Meier-Kriesche HU, Ojo A, Hanson J, et al. Increased immunosuppressive vulnerability in elderly renal transplant recipients. Transplantation. 2000;69(5):885–889.
  • Pleass HC, Clark KR, Rigg KM, et al. Urologic complications after renal transplantation: a prospective randomized trial comparing different techniques of ureteric anastomosis and the use of prophylactic ureteric stents. Transplant Proc. 1995;27(1):1091–1092.
  • Erturk E, Burzon DT, Orloff M, et al. Outcome of patients with vesicoureteral reflux after renal transplantation: the effect of pretransplantation surgery on posttransplant urinary tract infections. Urology. 1998;51(5ASuppl):27–30.
  • Tavakoli A, Surange RS, Pearson RC, et al. Impact of stents on urological complications and health care expenditure in renal transplant recipients: results of a prospective, randomized clinical trial. J Urol. 2007;177(6): 2260–2264. discussion 2264.
  • Illesy L, Kovacs DA, Szabo RP, et al. Autosomal dominant polycystic kidney disease transplant recipients after kidney transplantation: a single-center experience. Transplant Proc. 2017;49(7):1522–1525.
  • Almond PS, Matas A, Gillingham K, et al. Risk factors for chronic rejection in renal allograft recipients. Transplantation. 1993;55(4):752–756. discussion 756–757.
  • Goya N, Tanabe K, Iguchi Y, et al. Prevalence of urinary tract infection during outpatient follow-up after renal transplantation. Infection. 1997;25(2):101–105.
  • Alangaden GJ, Thyagarajan R, Gruber SA, et al. Infectious complications after kidney transplantation: current epidemiology and associated risk factors. Clin Transplant. 2006;20(4):401–409.
  • Kamath NS, John GT, Neelakantan N, et al. Acute graft pyelonephritis following renal transplantation. Transpl Infect Dis. 2006;8(3):140–147.
  • Pilmis B, Scemla A, Join-Lambert O, et al. ESBL-producing enterobacteriaceae-related urinary tract infections in kidney transplant recipients: incidence and risk factors for recurrence. Infect Dis (Lond). 2015;47(10):714–718.
  • Silva C, Afonso N, Macario F, et al. Recurrent urinary tract infections in kidney transplant recipients. Transplant Proc. 2013;45(3):1092–1095.
  • Pinheiro HS, Mituiassu AM, Carminatti M, et al. Urinary tract infection caused by extended-spectrum beta-lactamase-producing bacteria in kidney transplant patients. Transplant Proc. 2010;42(2):486–487.
  • Finer G, Landau D. Pathogenesis of urinary tract infections with normal female anatomy. Lancet Infect Dis. 2004;4(10):631–635.
  • Brumfitt W, Gargan RA, Hamilton-Miller JM. Periurethral enterobacterial carriage preceding urinary infection. Lancet. 1987;1(8537):824–826.
  • Ae B, Jp N, Am S, et al. Urinary tract infections: current and emerging management strategies. Clin Infect Dis. 2013;57(5):719–724.
  • Wright KJ, Seed PC, Hultgren SJ. Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cell Microbiol. 2007;9(9):2230–2241.
  • Jc R, Peng T, Yf K, et al. Renal allograft injury is associated with urinary tract infection caused by Escherichia coli bearing adherence factors. Am J Transplant. 2006;6(10):2375–2383.
  • Piovesan AC, Torricelli FC, Antonopoulos IM, et al. Histologic inflammatory changes on the prostatic gland due to immunosuppression for kidney transplantation. Urology. 2012;79(3):662–664.
  • Puliatti C, Stephens MR, Kenche J, et al. Cyst infection in renal allograft recipients with adult polycystic kidney disease: the diagnostic value of labeled leukocyte scanning: case reports. Transplant Proc. 2007;39(6):1841–1842.
  • Migali G, Annet L, Lonneux M, et al. Renal cyst infection in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2008;23(1):404–405.
  • Vidal E, Torre-Cisneros J, Blanes M, et al. Bacterial urinary tract infection after solid organ transplantation in the RESITRA cohort. Transpl Infect Dis. 2012;14(6):595–603.
  • Di Cocco P, Orlando G, Mazzotta C, et al. Incidence of urinary tract infections caused by germs resistant to antibiotics commonly used after renal transplantation. Transplant Proc. 2008;40(6):1881–1884.
  • Bodro M, Sabe N, Tubau F, et al. Risk factors and outcomes of bacteremia caused by drug-resistant ESKAPE pathogens in solid-organ transplant recipients. Transplantation. 2013;96(9):843–849.
  • Linares L, Cervera C, Cofan F, et al. Risk factors for infection with extended-spectrum and AmpC beta-lactamase-producing gram-negative rods in renal transplantation. Am J Transplant. 2008;8(5):1000–1005.
  • Linares L, Cervera C, Cofan F, et al. Epidemiology and outcomes of multiple antibiotic-resistant bacterial infection in renal transplantation. Transplant Proc. 2007;39(7):2222–2224.
  • Wu SW, Liu KS, Lin CK, et al. Community-acquired urinary tract infection in kidney transplantation: risk factors for bacteremia and recurrent infection. J Formos Med Assoc. 2013;112(3):138–143.
  • Brizendine KD, Richter SS, Cober ED, et al. Carbapenem-resistant Klebsiella pneumoniae urinary tract infection following solid organ transplantation. Antimicrob Agents Chemother. 2015;59(1):553–557.
  • Pouch SM, Kubin CJ, Satlin MJ, et al. Epidemiology and outcomes of carbapenem-resistant Klebsiella pneumoniae bacteriuria in kidney transplant recipients. Transpl Infect Dis. 2015;17(6):800–809.
  • Lopez-Medrano F, Garcia-Bravo M, Morales JM, et al. Urinary tract infection due to Corynebacterium urealyticum in kidney transplant recipients: an underdiagnosed etiology for obstructive uropathy and graft dysfunction-results of a prospective cohort study. Clin Infect Dis. 2008;46(6):825–830.
  • Kicia M, Wesolowska M, Kopacz Z, et al. Prevalence and molecular characteristics of urinary and intestinal microsporidia infections in renal transplant recipients. Clin Microbiol Infect. 2016;22(5):462e465–469.
  • Golebiewska JE, Debska-Slizien A, Rutkowski B. Urinary tract infections during the first year after renal transplantation: one center’s experience and a review of the literature. Clin Transplant. 2014;28(11):1263–1270.
  • Fiorante S, Lopez-Medrano F, Lizasoain M, et al. Systematic screening and treatment of asymptomatic bacteriuria in renal transplant recipients. Kidney Int. 2010;78(8):774–781.
  • Ariza-Heredia EJ, Beam EN, Lesnick TG, et al. Impact of urinary tract infection on allograft function after kidney transplantation. Clin Transplant. 2014;28(6):683–690.
  • Barbouch S, Cherif M, Ounissi M, et al. Urinary tract infections following renal transplantation: a single-center experience. Saudi J Kidney Dis Transpl. 2012;23(6):1311–1314.
  • Esezobor CI, Nourse P, Gajjar P. Urinary tract infection following kidney transplantation: frequency, risk factors and graft function. Pediatr Nephrol. 2012;27(4):651–657.
  • Rivera-Sanchez R, Delgado-Ochoa D, Flores-Paz RR, et al. Prospective study of urinary tract infection surveillance after kidney transplantation. BMC Infect Dis. 2010;10:245.
  • Akoh JA, Rana T. Effect of ureteric stents on urological infection and graft function following renal transplantation. World J Transplant. 2013;3(1):1–6.
  • Abbott KC, Swanson SJ, Richter ER, et al. Late urinary tract infection after renal transplantation in the United States. Am J Kidney Dis. 2004;44(2):353–362.
  • Muller V, Becker G, Delfs M, et al. Do urinary tract infections trigger chronic kidney transplant rejection in man? J Urol. 1998;159(6):1826–1829.
  • Audard V, Amor M, Desvaux D, et al. Acute graft pyelonephritis: a potential cause of acute rejection in renal transplant. Transplantation. 2005;80(8):1128–1130.
  • Dupont PJ, Psimenou E, Lord R, et al. Late recurrent urinary tract infections may produce renal allograft scarring even in the absence of symptoms or vesicoureteric reflux. Transplantation. 2007;84(3):351–355.
  • Nagano H, Nadeau KC, Kusaka M, et al. Infection-associated macrophage activation accelerates chronic renal allograft rejection in rats. Transplantation. 1997;64(11):1602–1605.
  • Ciszek M, Paczek L, Bartlomiejczyk I, et al. Urine cytokines profile in renal transplant patients with asymptomatic bacteriuria. Transplantation. 2006;81(12):1653–1657.
  • Vidal E, Cervera C, Cordero E, et al. Management of urinary tract infection in solid organ transplant recipients: consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI). Enferm Infecc Microbiol Clin. 2015;33(10):679e671–679 e621.
  • Munoz P. Management of urinary tract infections and lymphocele in renal transplant recipients. Clin Infect Dis. 2001;33(Suppl 1):S53–57.
  • Cervera C, van Delden C, Gavalda J, et al. Multidrug-resistant bacteria in solid organ transplant recipients. Clin Microbiol Infect. 2014;20(Suppl 7):49–73.
  • Dinckan A, Aliosmanoglu I, Kocak H, et al. Surgical correction of vesico-ureteric reflux for recurrent febrile urinary tract infections after kidney transplantation. BJU Int. 2013;112(4):E366–371.
  • Grodstein EI, Baggett N, Wayne S, et al. An evaluation of the safety and efficacy of simultaneous bilateral nephrectomy and renal transplantation for polycystic kidney disease: A 20-year experience. Transplantation. 2017;101(11):2774–2779.
  • Jean RA, Alexandre M, Yoo PS. Kidney transplantation with and without native nephrectomy for polycystic kidney disease: results of the national inpatient sample and the rationale for a 2-staged procedure. J Am Coll Surg. 2018;226(6):1079–1084.
  • Shoma AM, Eraky I, El-Kappany HA. Pretransplant native nephrectomy in patients with end-stage renal failure: assessment of the role of laparoscopy. Urology. 2003;61(5):915–920.
  • Bergamin PA, Kiosoglous AJ. Surgical management of recurrent urinary tract infections: a review. Transl Androl Urol. 2017;6(Suppl 2):S153–S162.
  • Zelichenko G, Steinberg D, Lorber G, et al. Prevention of initial biofilm formation on ureteral stents using a sustained releasing varnish containing chlorhexidine: in vitro study. J Endourol. 2013;27(3):333–337.
  • Er T, Sa H, Ml N, et al. Early versus late ureteric stent removal after kidney transplantation. Cochrane Database Syst Rev. 2018;1:CD011455.
  • Patel P, Rebollo-Mesa I, Ryan E, et al. Prophylactic ureteric stents in renal transplant recipients: a multicenter randomized controlled trial of early versus late removal. Am J Transplant. 2017;17(8):2129–2138.
  • Origuen J, Lopez-Medrano F, Fernandez-Ruiz M, et al. Should asymptomatic bacteriuria be systematically treated in kidney transplant recipients? Results from a randomized controlled trial. Am J Transplant. 2016;16(10):2943–2953.
  • Maki DG, Fox BC, Kuntz J, et al. A prospective, randomized, double-blind study of trimethoprim-sulfamethoxazole for prophylaxis of infection in renal transplantation. Side effects of trimethoprim-sulfamethoxazole, interaction with cyclosporine. J Lab Clin Med. 1992;119(1):11–24.
  • Wilson CH, Rix DA, Manas DM. Routine intraoperative ureteric stenting for kidney transplant recipients. Cochrane Database Syst Rev. 2013;(6):CD004925.
  • Green H, Rahamimov R, Gafter U, et al. Antibiotic prophylaxis for urinary tract infections in renal transplant recipients: a systematic review and meta-analysis. Transpl Infect Dis. 2011;13(5):441–447.
  • Eells SJ, Bharadwa K, McKinnell JA, et al. Recurrent urinary tract infections among women: comparative effectiveness of 5 prevention and management strategies using a markov chain monte carlo model. Clin Infect Dis. 2014;58(2):147–160.
  • Guay DR. Cranberry and urinary tract infections. Drugs. 2009;69(7):775–807.
  • Pagonas N, Horstrup J, Schmidt D, et al. Prophylaxis of recurrent urinary tract infection after renal transplantation by cranberry juice and L-methionine. Transplant Proc. 2012;44(10):3017–3021.
  • Barbosa-Cesnik C, Brown MB, Buxton M, et al. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trial. Clin Infect Dis. 2011;52(1):23–30.
  • Perrotta C, Aznar M, Mejia R, et al. Oestrogens for preventing recurrent urinary tract infection in postmenopausal women. Obstet Gynecol. 2008;112(3):689–690.
  • Huttner A, Hatz C, van den Dobbelsteen G, et al. Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial. Lancet Infect Dis. 2017;17(5):528–537.
  • Zarate G, Nader-Macias ME. Influence of probiotic vaginal lactobacilli on in vitro adhesion of urogenital pathogens to vaginal epithelial cells. Lett Appl Microbiol. 2006;43(2):174–180.
  • Osset J, Bartolome RM, Garcia E, et al. Assessment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells. J Infect Dis. 2001;183(3):485–491.
  • Uehara S, Monden K, Nomoto K, et al. A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection. Int J Antimicrob Agents. 2006;28(Suppl 1):S30–34.
  • Schwenger EM, Tejani AM, Loewen PS. Probiotics for preventing urinary tract infections in adults and children. Cochrane Database Syst Rev. 2015;(12):CD008772.
  • Tariq R, Pardi DS, Tosh PK, et al. Fecal microbiota transplantation for recurrent clostridium difficile infection reduces recurrent urinary tract infection frequency. Clin Infect Dis. 2017;65(10):1745–1747.

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