264
Views
24
CrossRef citations to date
0
Altmetric
Review

Oxfendazole: a promising agent for the treatment and control of helminth infections in humans

, , , &
Pages 51-56 | Received 31 Jul 2018, Accepted 14 Nov 2018, Published online: 10 Dec 2018

References

  • Geary TG, Woo K, McCarthy JS, et al. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol. 2010 Jan;40(1):1–13.
  • Garcia HH, Nash TE, Del Brutto OH. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol. 2014;13:1202–1215.
  • 41-4-Oxfendazole. UN FAO web site 2003 [cited 2018 Jul 25]; Available from: https://web.archive.org/web/20170518153340/ftp.fao.org/ag/agn/jecfa/vetdrug/41-4-oxfendazole.pdf
  • Codd EE, Ng HH, McFarlane C, et al. Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies. Int J Toxicol. 2015 Mar-Apr;34(2):129–137.
  • Villeneuve V, Beugnet F, Bourdoiseau G. Efficacy of oxfendazole for the treatment of giardiosis in dogs. Experiments in dog breeding kennels. Parasite. 2000;7(3):221–226.
  • Duncan JL, Reid JF. An evaluation of the efficacy of oxfendazole against the common nematode parasites of the horse. Vet Rec. 1978;103(15):332–334.
  • FDA. Animal & Veterinary NADA 140-854 Synanthic® - original approval- summary. 1990; Available from: https://web.archive.org/web/20171115071339/https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM478234.pdf
  • Torres A, Plancarte A, Villalobos AN, et al. Praziquantel treatment of porcine brain and muscle Taenia solium cysticercosis. 3. Effect of 1-day treatment. Parasitol Res. 1992;78(2):161–164.
  • Gonzalez AE, Garcia HH, Gilman RH, et al. Treatment of porcine cysticercosis with albendazole. Am J Trop Med Hyg. 1995 Nov;53(5):571–574.
  • Gonzalez AE, Garcia HH, Gilman RH, et al. Effective, single-dose treatment or porcine cysticercosis with oxfendazole. Am J Trop Med Hyg. 1996 Apr;54(4):391–394.
  • Gonzalez AE, Falcon N, Gavidia C, et al. Treatment of porcine cysticercosis with oxfendazole: a dose-response trial. Vet Rec. 1997 Oct;141(16):420–422.
  • Mkupasi EM, Ngowi HA, Sikasunge CS, et al. Efficacy of ivermectin and oxfendazole against Taenia solium cysticercosis and other parasitoses in naturally infected pigs. Acta Trop. 2013 Oct;128(1):48–53.
  • Gonzalez AE, Falcon N, Gavidia C, et al. Time-response curve of oxfendazole in the treatment of swine cysticercosis. Am J Trop Med Hyg. 1998 Nov;59(5):832–836.
  • Gonzalez AE, Bustos JA, Jimenez JA, et al. Efficacy of diverse antiparasitic treatments for cysticercosis in the pig model. Am J Trop Med Hyg. 2012 Aug;87(2):292–296.
  • Gonzalez AE, Bustos JA, Garcia HH, et al. Successful antiparasitic treatment for cysticercosis is associated with a fast and marked reduction of circulating antigen levels in a naturally infected pig model. Am J Trop Med Hyg. 2015 Dec;93(6):1305–1310.
  • Vargas-Calla A, Gomez-Puerta LA, Calcina J, et al. Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs. Asian Pac J Trop Med. 2016 Jan;9(1):23–26.
  • Garcia HH, Gonzalez AE, Gilman RH, et al. Combined human and porcine mass chemotherapy for the control of T. solium. Am J Trop Med Hyg. 2006 May;74(5):850–855.
  • Gonzalez AE, Gavidia C, Falcon N, et al. Protection of pigs with cysticercosis from further infections after treatment with oxfendazole. Am J Trop Med Hyg. 2001 Jul;65(1):15–18.
  • Garcia HH, Gonzalez AE, Tsang VC, et al. Elimination of Taenia solium transmission in Northern Peru. N Engl J Med. 2016 Jun 16;374(24):2335–2344.
  • Chilundo AG, Johansen MV, Pondja A, et al. Piloting the effectiveness of pig health education in combination with oxfendazole treatment on prevention and/or control of porcine cysticercosis, gastrointestinal parasites, African swine fever and ectoparasites in Angónia District, Mozambique. Trop Anim Health Prod. 2018 Mar;50(3):589–601.
  • Okello AL, Thomas L, Inthavong P, et al. Assessing the impact of a joint human-porcine intervention package for Taenia solium control: results of a pilot study from northern Lao PDR. Acta Trop. 2016 Jul;159:185–191.
  • Pondja A, Neves L, Mlangwa J, et al. Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. PLoS Negl Trop Dis. 2012;6(5):e1651.
  • M.C.I.-Santé-Animale. Paranthic 10%-internal anthelminthic for cattle and swine, M.C.I. Mohammedia, MAROC: Santé Animale; 2015.
  • WHO. (May 22, 2017) First ever licensed vaccine and anthelmintic against the major cause of epilepsy in the developing world. Neglected Tropical Diseases. Available from: http://www.who.int/neglected_diseases/news/First-licensed-vaccine-and-anthelmintic-against-epilepsy/en/
  • Blanton RE, Wachira TM, Zeyhle EE, et al. Oxfendazole treatment for cystic hydatid disease in naturally infected animals. Antimicrob Agents Chemother. 1998 Mar;42(3):601–605.
  • Gavidia CM, Gonzalez AE, Lopera L, et al. Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep. Am J Trop Med Hyg. 2009 Mar;80(3):367–372.
  • Gavidia CM, Gonzalez AE, Barron EA, et al. Evaluation of oxfendazole, praziquantel and albendazole against cystic echinococcosis: a randomized clinical trial in naturally infected sheep. PLoS Negl Trop Dis. 2010 Feb 23;4(2):e616.
  • Gomez-Puerta LA, Gavidia C, Lopez-Urbina MT, et al. Efficacy of a single oral dose of oxfendazole against Fasciola hepatica in naturally infected sheep. Am J Trop Med Hyg. 2012 Mar;86(3):486–488.
  • Gomez-Puerta LA, Gonzalez AE, Gavidia C, et al. Oxfendazole as successful treatment of Taenia hydatigena metacestodes in naturally infected pigs. Asian Pacific J Trop Biomed. 2015 Nov;5(11):971–973.
  • Ngomuo A, Marriner S, Bogan J. The pharmacokinetics of fenbendazole and oxfendazole in cattle. Vet Res Communicat. 1984;8(1):187–193.
  • Gokbulut C, Bilgili A, Hanedan B, et al. Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs. Vet Parasitol. 2007;148:279–287.
  • Moreno L, Lopez-Urbina MT, Farias C, et al. A high oxfendazole dose to control porcine cysticercosis: pharmacokinetics and tissue residue profiles. Food Chem Toxicol. 2012;50(10):3819–3825.
  • Gow J Pharmacokinetics and bioavailability of oxfendazole in Sprague-Dawley rats. Menlo Park, CA: SRI International; 2010 November 3. (Report No. B381-10).
  • Colella V, Maia C, Pereira A, et al. Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs. PLoS Negl Trop Dis. 2018 Jan 29;12(1):e0006218.
  • Hubner MP, Martin C, Specht S, et al. Oxfendazole treatment has a macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca gutturosa adult worm motility in vitro. Abstract 2088, presented at the 67th Annual Meeting of the American Society of Tropical Medicne and Hygiene, November 1, 2018, New Orleans, USA.
  • Mackenzie CD, Geary TG. Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. Expert Rev Anti Infect Ther. 2011;9:497–501.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.